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🚨 New Genetic Discovery: Why Some People Naturally Eat Less Sugar & Stay Lean 🍫➡️🚫 (link at the end) Scientists may have just uncovered a hidden biological quirk that makes some people naturally eat less sugar, crave less sugar, and stay lean. 1/5) A paper just published in…

https://x.com/nicknorwitz/status/1913922312572698987

Published: April 20, 2025 11:46

🚨 New Genetic Discovery: Why Some People Naturally Eat Less Sugar & Stay Lean 🍫➡️🚫 (link at the end)Scientists may have just uncovered a hidden biological quirk that makes some people naturally eat less sugar, crave less sugar, and stay lean.1/5) A paper…

5/5) For more food ideas – review of a fascinating study on apple cider vinegar, and important facts, see the video:

https://x.com/nicknorwitz/status/1913922332738879970

Published: April 20, 2025 11:46

5/5) For more food ideas – review of a fascinating study on apple cider vinegar, and important facts, see the video: https://t.co/tn2gIuliZ2— Nick Norwitz (@nicknorwitz) April 20, 2025

2/5) Researchers found that people with a Sucrase-isomaltase mutation that reduces this protein’s function not only consumed less sugar but also experienced better metabolic health overall. 🍭 Voluntarily ate less sugar 🥤 Drank less sugary fluids 🔁 AND released more GLP-1 in…

https://x.com/nicknorwitz/status/1913922315198345290

Published: April 20, 2025 11:46

2/5) Researchers found that people with a Sucrase-isomaltase mutation that reduces this protein’s function not only consumed less sugar but also experienced better metabolic health overall.🍭 Voluntarily ate less sugar🥤 Drank less sugary fluids🔁 AND…

3/5) The whole metabolic cascade isn’t fully understood yet, but another key player might be acetate, a molecule that increased in both the mice and humans with this mutation. Researchers suspect this acetate signals the brain and nervous system to boost GLP-1 levels and curb…

https://x.com/nicknorwitz/status/1913922323612049760

Published: April 20, 2025 11:46

3/5) The whole metabolic cascade isn’t fully understood yet, but another key player might be acetate, a molecule that increased in both the mice and humans with this mutation. Researchers suspect this acetate signals the brain and nervous system to boost…

4/5) But what if you weren’t lucky enough to be born with this sugar-blocking mutation? Are you out of luck? Not necessarily. Because it turns out, there might be a way to replicate this effect—without changing your DNA. Certain natural compounds found in everyday foods could…

https://x.com/nicknorwitz/status/1913922331132445054

Published: April 20, 2025 11:46

4/5) But what if you weren’t lucky enough to be born with this sugar-blocking mutation? Are you out of luck?Not necessarily.Because it turns out, there might be a way to replicate this effect—without changing your DNA. Certain natural compounds found in…

'Lettuce' Be Honest: Fiber Isn’t Always the Answer🥬🤥(Refs linked in letter at the end) 🧵 1/6) We’ve been told for years that fiber is a must-have for gut health—that without it, your microbiome will crumble faster than a stale bran muffin. But what if I told you… you don’t…

https://x.com/nicknorwitz/status/1913563095072383453

Published: April 19, 2025 11:59

'Lettuce' Be Honest: Fiber Isn’t Always the Answer🥬🤥(Refs linked in letter at the end) 🧵1/6) We’ve been told for years that fiber is a must-have for gut health—that without it, your microbiome will crumble faster than a stale bran muffin. But what if I…

8/8) For more, see today’s YouTube video: “Is Cyanide an ESSENTIAL Nutrient Keeping You Alive?!” piped.video/-S_jk5EdOzk

https://x.com/nicknorwitz/status/1913201549989339524

Published: April 18, 2025 12:02

8/8) For more, see today’s YouTube video: “Is Cyanide an ESSENTIAL Nutrient Keeping You Alive?!” piped.video/-S_jk5EdOzk

5/8) Mechanism 👉In an acidic compartment of the cell called the lysosome, the amino acid glycine can be converted into cyanide. 👉The cyanide can then diffuse out of this, like a ghost passing through a wall compartment, to act as a signaling molecule… 👉Boosting mitochondrial metabolism, attaching to and altering the functions of a buffet of proteins, and even protecting cells from injury. So, to summarize: Glycine supplementation causes an increase in the body’s own production of low-dose cyanide, which acts as a signaling molecule with several beneficial metabolic effects.

https://x.com/nicknorwitz/status/1913201544574488766

Published: April 18, 2025 12:02

5/8) Mechanism👉In an acidic compartment of the cell called the lysosome, the amino acid glycine can be converted into cyanide.👉The cyanide can then diffuse out of this, like a ghost passing through a wall compartment, to act as a signaling…

7/8) Now, let me first reinforce: DO NOT SUPPLEMENT CYANIDE. However, glycine—which may trigger your body to generate cyanide at safe signaling levels—is an over-the-counter supplement and a simple amino acid found in protein-containing food. Other literature shows that glycine levels drop in aging and certain metabolic diseases, like obesity and diabetes. And, at least in pre-clinical models, glycine supplementation does improve mitochondrial energy metabolism and muscle health. And because I know I’ll get asked about dose, a ballpark of 5–10 grams has been explored in human studies with glycine, with some positive effects, perhaps owing to cyanide. Science has a way of flipping everything

https://x.com/nicknorwitz/status/1913201548752015651

Published: April 18, 2025 12:02

7/8) Now, let me first reinforce: DO NOT SUPPLEMENT CYANIDE.However, glycine—which may trigger your body to generate cyanide at safe signaling levels—is an over-the-counter supplement and a simple amino acid found in protein-containing food. Other…

6/8) And, in terms of protective effects, what you’re looking at here is basically injury from a mouse heart attack, where blue indicates more dead tissue. Treatment with glycine, or a compound that increases cyanide production called amygdalin (a cyanide-producing compound),…

https://x.com/nicknorwitz/status/1913201546789089673

Published: April 18, 2025 12:02

6/8) And, in terms of protective effects, what you’re looking at here is basically injury from a mouse heart attack, where blue indicates more dead tissue. Treatment with glycine, or a compound that increases cyanide production called amygdalin (a…

3/8) The first step was to confirm that mammals’ tissues contain cyanide naturally. To do this, they blended up different tissues and organs and measured cyanide levels. They indeed found cyanide throughout the body, with the highest levels being in the liver. I know there are…

https://x.com/nicknorwitz/status/1913201539474215167

Published: April 18, 2025 12:02

3/8) The first step was to confirm that mammals’ tissues contain cyanide naturally. To do this, they blended up different tissues and organs and measured cyanide levels. They indeed found cyanide throughout the body, with the highest levels being in the…

4/8) Now, what about these blue bars? Here’s where things get interesting—and a bit more practical for you too. A major finding is that cyanide production by the body can be stimulated by the simple amino acid glycine. The blue bars (above) represent glycine treatment. And you can also see here microscope images of human liver cells treated with glycine, where red represents more cyanide. There is clearly more cyanide when glycine is present.

https://x.com/nicknorwitz/status/1913201541973975491

Published: April 18, 2025 12:02

4/8) Now, what about these blue bars?Here’s where things get interesting—and a bit more practical for you too.A major finding is that cyanide production by the body can be stimulated by the simple amino acid glycine. The blue bars (above) represent glycine…

Is Cyanide an ESSENTIAL Nutrient Keeping You Alive?!⚡️🤯 (link at the end) ⚠️NERDY⚠️ 1/8) What if I told you that Cyanide—one of the most infamous poisons in history—might actually be keeping you alive? Your body makes it. Your metabolism might need it. And science is only just uncovering its surprising benefits?! Quickly, what is cyanide anyway? Cyanide consists of a carbon atom triple bonded to a nitrogen atom. Cyanide is found in deadly hydrogen cyanide gas and can also be produced by certain plants as defense chemicals, as in the pits of apricots or raw cassava. It kills by blocking complex IV in mitochondria, effectively choking the energy-producing factory of the cell. The result: DEAT

https://x.com/nicknorwitz/status/1913201534986342847

Published: April 18, 2025 12:02

Is Cyanide an ESSENTIAL Nutrient Keeping You Alive?!⚡️🤯 (link at the end) ⚠️NERDY⚠️1/8) What if I told you that Cyanide—one of the most infamous poisons in history—might actually be keeping you alive? Your body makes it. Your metabolism might need it. And…

2/8) The researchers find that: 👉 “low concentrations of cyanide are generated endogenously in various mammalian tissues” 👉 “cyanide exerts stimulatory effects on mitochondrial bioenergetics” (i.e., boosts energy metabolism) 👉 “low-dose cyanide supplementation exhibits cytoprotective effects” Now, please DO NOT go overdose on cyanide. Give me a chance to unpack these data.

https://x.com/nicknorwitz/status/1913201537549021692

Published: April 18, 2025 12:02

2/8) The researchers find that:👉 “low concentrations of cyanide are generated endogenously in various mammalian tissues”👉 “cyanide exerts stimulatory effects on mitochondrial bioenergetics” (i.e., boosts energy metabolism)👉 “low-dose cyanide…

The art of medicine is making hard choices for the individual in front of you (or in the mirror), given incomplete or imperfect information. 🫀👇 From a clinical perspective, that is why we want to study #LMHR -- to get more information to inform individualized care. What we…

https://x.com/nicknorwitz/status/1912535601913462975

Published: April 16, 2025 15:56

The art of medicine is making hard choices for the individual in front of you (or in the mirror), given incomplete or imperfect information. 🫀👇From a clinical perspective, that is why we want to study #LMHR -- to get more information to inform…

Good Morning ☀️🙂! The purpose of this post is to compile resources for those looking for clarifications regarding our new paper. jacc.org/doi/10.1016/j.… 1. Please Watch Interview with Professor @BudoffMd @bschermd on @Metabolic_Mind (30m) x.com/Metabolic_Mind… 🚨 Main…

https://x.com/nicknorwitz/status/1912489160482451955

Published: April 16, 2025 12:52

Good Morning ☀️🙂! The purpose of this post is to compile resources for those looking for clarifications regarding our new paper. jacc.org/doi/10.1016/j.… 1. Please Watch Interview with Professor @BudoffMd @bschermd on @Metabolic_Mind (30m)…

Everyone should listen to the interview with @BudoffMd and @bschermd. Some thoughts/reactions/highlights 1. Primary outcome reported. Paper being updated (happily). **No conclusions have changed**. And more data coming in next paper. Thanks for waiting. 2. LMHR were not…

https://x.com/nicknorwitz/status/1912086124903686200

Published: April 15, 2025 10:10

Everyone should listen to the interview with @BudoffMd and @bschermd. Some thoughts/reactions/highlights1. Primary outcome reported. Paper being updated (happily). **No conclusions have changed**. And more data coming in next paper. Thanks for waiting.2.…

RT by @nicknorwitz: The punchline of the recent debate over the new keto / cholesterol study: 1) No data was "hidden" 2) The results did not show that keto caused rapid plaque progression 3) The primary finding stands: Neither high LDL-C nor ApoB correlated to coronary plaque progression 4) The…

https://x.com/janellison/status/1911912847187296625

Published: April 14, 2025 22:41

The punchline of the recent debate over the new keto / cholesterol study: 1) No data was "hidden"2) The results did not show that keto caused rapid plaque progression3) The primary finding stands: Neither high LDL-C nor ApoB correlated to coronary plaque…

I realize there has been a tremendous amount of excitement and confusion about our new data. Let me concisely (re)clarify some matters. 1 - We reported the primary outcome in Figure 1 of the paper. We are also happy to update the current manuscript for additional clarity and are…

https://x.com/nicknorwitz/status/1911853811435450661

Published: April 14, 2025 18:47

I realize there has been a tremendous amount of excitement and confusion about our new data. Let me concisely (re)clarify some matters. 1 - We reported the primary outcome in Figure 1 of the paper. We are also happy to update the current manuscript for…

Today’s @hubermanlab Podcast Episode #224 with @drmarkhyman was packed with discussion points that had me stroking my chin and clapping my hands 🧵 1/10) Here are my favorite two points from the episode. 🧪 “Cells Don’t Have a Political Ideology” 🧪 “Test, Don’t Guess” &…

https://x.com/nicknorwitz/status/1911789415510298707

Published: April 14, 2025 14:31

Today’s @hubermanlab Podcast Episode #224 with @drmarkhyman was packed with discussion points that had me stroking my chin and clapping my hands 🧵1/10) Here are my favorite two points from the episode.🧪 “Cells Don’t Have a Political Ideology”🧪 “Test,…

🧠Saffron for Mental Health – RCTs & Mechanisms🧠 The data on shockingly strong (🔗 and the end) 🧠 Saffron vs SSRI (RCT) In one RCT 6 weeks of saffron supplementation (30mg/d) performed equal to the SSRI Prozac (fluoxetine) for improving Depression Symptoms. There was also…

https://x.com/nicknorwitz/status/1911739376696013278

Published: April 14, 2025 11:12

🧠Saffron for Mental Health – RCTs & Mechanisms🧠 The data on shockingly strong (🔗 and the end) 🧠 Saffron vs SSRI (RCT)In one RCT 6 weeks of saffron supplementation (30mg/d) performed equal to the SSRI Prozac (fluoxetine) for improving Depression Symptoms.…

What if all *autoimmune diseases* were stemming from the same source, from a seed planted 2 Billion years ago that’s just beginning to flower? 🔥🤔🧵 1/6) That might sound wild—but it’s actually the central thesis of a perspectives paper published in @Nature, which proposes…

https://x.com/nicknorwitz/status/1911375047568089308

Published: April 13, 2025 11:04

What if all *autoimmune diseases* were stemming from the same source, from a seed planted 2 Billion years ago that’s just beginning to flower? 🔥🤔🧵1/6) That might sound wild—but it’s actually the central thesis of a perspectives paper published in @Nature,…