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Pardon me 🤔🙋🏽‍♂️

https://x.com/nicknorwitz/status/1922679996079841768

Published: May 14, 2025 15:46

Pardon me 🤔🙋🏽‍♂️ pic.twitter.com/ZvO93JUcwx— Nick Norwitz (@nicknorwitz) May 14, 2025

This was an interesting Umbrella review on “seed oils,” or – more precisely – omega-6 fatty acids. It included analyses of meta-analyses of observational studies, covering 150 publications in total and 230 studies. The first sentence of the abstract’s conclusion reads, “Higher…

https://x.com/nicknorwitz/status/1922624531790709223

Published: May 14, 2025 12:06

This was an interesting Umbrella review on “seed oils,” or – more precisely – omega-6 fatty acids. It included analyses of meta-analyses of observational studies, covering 150 publications in total and 230 studies. The first sentence of the abstract’s…

Poll 🙋🙋‍♀️ - Seed Oil This summer I’m planning a “seed oil” self-experiment. 🎯Purpose: As usual, I’m designing it in such a way as do “break expectation,” providing a metabolic demonstration as a hook for deeper learning and nuanced discussion. ❌NOT the Purpose: Prove “seed…

https://x.com/nicknorwitz/status/1922303912809292103

Published: May 13, 2025 14:52

Poll 🙋🙋‍♀️ - Seed OilThis summer I’m planning a “seed oil” self-experiment. 🎯Purpose: As usual, I’m designing it in such a way as do “break expectation,” providing a metabolic demonstration as a hook for deeper learning and nuanced discussion.❌NOT the…

For More... This isn’t about hating on kale—it's about highlighting the power and value of personalized nutrition. We’re talking N = 1 Science and a curiosity-driven approach to understanding how YOUR body reacts to food. 👉Video:

https://x.com/nicknorwitz/status/1921887213148586302

Published: May 12, 2025 11:16

For More... This isn’t about hating on kale—it's about highlighting the power and value of personalized nutrition. We’re talking N = 1 Science and a curiosity-driven approach to understanding how YOUR body reacts to food.👉Video: https://t.co/fjdcx9MOzj—…

Kale spikes my blood sugar more than chocolate🧐😳 I know—it sounds insane, but it's true! And what's even more surprising? This could be true for you, too... In today’s video, we dive into the (goofy but real) experiment and the science behind it, using an N = 1 experiment as…

https://x.com/nicknorwitz/status/1921887211479298298

Published: May 12, 2025 11:16

Kale spikes my blood sugar more than chocolate🧐😳I know—it sounds insane, but it's true! And what's even more surprising? This could be true for you, too...In today’s video, we dive into the (goofy but real) experiment and the science behind it, using an N…

Happy #MothersDay ! 3 Mom Facts to Know! 1. Your mom gave you your mitochondria. Dad be slacking 2. You’re in your mom’s brain 🧠! During pregnancy fetal cells can migrate into the mother and seed in her brain. This “neuron microchimerism” means you are part of your mom’s…

https://x.com/nicknorwitz/status/1921519791044506090

Published: May 11, 2025 10:56

Happy #MothersDay ! 3 Mom Facts to Know!1. Your mom gave you your mitochondria. Dad be slacking 2. You’re in your mom’s brain 🧠! During pregnancy fetal cells can migrate into the mother and seed in her brain. This “neuron microchimerism” means you are part…

4/6) MPO inhibits fat browning. That means: More MPO = Less browning/beiging = Less Energy Burning. You can see how this sets up a vicious cycle whereby excess fat and less healthy fat tissue leads to the buildup of even more unhealthy fat. They even showed, in genetically…

https://x.com/nicknorwitz/status/1921163536178237508

Published: May 10, 2025 11:20

4/6) MPO inhibits fat browning. That means: More MPO = Less browning/beiging = Less Energy Burning.You can see how this sets up a vicious cycle whereby excess fat and less healthy fat tissue leads to the buildup of even more unhealthy fat.They even showed,…

2/6) Again, MPO is a blood marker of oxidative stress & an enzyme produced by inflammatory immune cells. 👉 It generates potentially harmful reactive oxygen species chemicals, like hypochlorous acid (HOCl), that can damage blood vessels. 👉 MPO also leads to the oxidation of…

https://x.com/nicknorwitz/status/1921163531128369662

Published: May 10, 2025 11:20

2/6) Again, MPO is a blood marker of oxidative stress & an enzyme produced by inflammatory immune cells.👉 It generates potentially harmful reactive oxygen species chemicals, like hypochlorous acid (HOCl), that can damage blood vessels.👉 MPO also leads to…

5/6) I also mentioned the hormone adiponectin. Adiponectin improves blood vessel function by making vessels less stiff. Adiponectin is basically yoga for your arteries. So, more MPO = Less adiponectin = Stiffer, worse-functioning blood vessels. What’s more, adiponectin itself…

https://x.com/nicknorwitz/status/1921163539068211235

Published: May 10, 2025 11:20

5/6) I also mentioned the hormone adiponectin. Adiponectin improves blood vessel function by making vessels less stiff.Adiponectin is basically yoga for your arteries.So, more MPO = Less adiponectin = Stiffer, worse-functioning blood vessels.What’s more,…

WHY is #Obesity a major risk factor for heart disease. I found these new data FASCINATING! (link 🔗 to more in 6/6) 1/6) Enter 🔥 Myeloperoxidase (MPO)🔥 a blood marker of oxidative stress & an enzyme produced by inflammatory immune cells Human Study: Researchers took patients…

https://x.com/nicknorwitz/status/1921163528309772598

Published: May 10, 2025 11:20

WHY is #Obesity a major risk factor for heart disease. I found these new data FASCINATING! (link 🔗 to more in 6/6)1/6) Enter 🔥 Myeloperoxidase (MPO)🔥 a blood marker of oxidative stress & an enzyme produced by inflammatory immune cellsHuman Study:…

3/6) MPO floats around inside blood vessels and can hurt them from the inside-out, directly damaging blood vessel lining and oxidizing LDL particles. But there is also fat tissue around blood vessels called “perivascular” adipose tissue MPO in the perivascular adipose tissue can…

https://x.com/nicknorwitz/status/1921163533812646189

Published: May 10, 2025 11:20

3/6) MPO floats around inside blood vessels and can hurt them from the inside-out, directly damaging blood vessel lining and oxidizing LDL particles. But there is also fat tissue around blood vessels called “perivascular” adipose tissueMPO in the…

6/6) So, what do you do with all this? Well, you can measure and track MPO (and blood and perivascular adipose tissue levels are thought to correlate quite tightly). And there are interventions that can lower MPO, including various nutrients, medications and even just sleep!…

https://x.com/nicknorwitz/status/1921163542046109780

Published: May 10, 2025 11:20

6/6) So, what do you do with all this? Well, you can measure and track MPO (and blood and perivascular adipose tissue levels are thought to correlate quite tightly).And there are interventions that can lower MPO, including various nutrients, medications…

A Hard Fact: despite its many benefits—including for obesity, diabetes, mental health, autoimmune and inflammatory conditions #ketodiet is still grossly misunderstood. Ketosis isn’t about specific foods—it’s about a metabolic state, where you’re producing ketone bodies You…

https://x.com/nicknorwitz/status/1920801153513574479

Published: May 9, 2025 11:20

A Hard Fact: despite its many benefits—including for obesity, diabetes, mental health, autoimmune and inflammatory conditions #ketodiet is still grossly misunderstood. Ketosis isn’t about specific foods—it’s about a metabolic state, where you’re producing…

2/2) For a step-by-step video guide, click here: 👉4 key steps for preparing to start your new lifestyle journey 👉9 favorite Medi-Keto foods 👉Common Q&A questions 👉Free #MediKeto recipes

https://x.com/nicknorwitz/status/1920801155501670497

Published: May 9, 2025 11:20

2/2) For a step-by-step video guide, click here: https://t.co/rDo6Y9ZUvi👉4 key steps for preparing to start your new lifestyle journey👉9 favorite Medi-Keto foods👉Common Q&A questions 👉Free #MediKeto recipes pic.twitter.com/F3SvWTlea0— Nick Norwitz…

RT by @nicknorwitz: Exactly as I had predicted and suggested. The authors were clearly silent while working through the process with the journal - nothing nefarious at all. The dose/response results from this study deeply challenges the lipid hypothesis. Doesn't mean LDL doesn't matter, but it's…

https://x.com/reallyoptimized/status/1920500615299437041

Published: May 8, 2025 15:26

Exactly as I had predicted and suggested.The authors were clearly silent while working through the process with the journal - nothing nefarious at all.The dose/response results from this study deeply challenges the lipid hypothesis. Doesn't mean LDL…

11/11) For an easy-read version of the thread, with hyperlinks and a bit more information, see: staycuriousmetabolism.substack.com/p/keto-cta-cla… For our LTE response letter: jacc.org/doi/10.1016/j.… For the Open Access Table: citizensciencefoundation.org/keto-cta/ For the Podcast with Chris @VivaLongevity and Dave:…

https://x.com/nicknorwitz/status/1920495181532364800

Published: May 8, 2025 15:05

11/11) For an easy-read version of the thread, with hyperlinks and a bit more information, see: staycuriousmetabolism.substack.com/p/keto-cta-cla… For our LTE response letter: jacc.org/doi/10.1016/j.… For the Open Access Table:…

10/11) Conclusion As researchers, we understand that scientific progress is rarely linear or universally accepted on first pass. The spirited debate surrounding this paper reflects how deeply people care about getting this right—and that’s a good thing. We’ve made mistakes,…

https://x.com/nicknorwitz/status/1920495178831270394

Published: May 8, 2025 15:05

10/11) Conclusion As researchers, we understand that scientific progress is rarely linear or universally accepted on first pass. The spirited debate surrounding this paper reflects how deeply people care about getting this right—and that’s a good thing.…

9/11) Open-Access Table: When Measures Diverge. We are freely releasing the data for all 100 participants at both visits, including the Total Plaque Score (TPS) and Coronary Artery Calcification (CAC) scores from the semi-quantitative analysis, and the Non-Calcified Plaque…

https://x.com/nicknorwitz/status/1920495170392342690

Published: May 8, 2025 15:05

9/11) Open-Access Table: When Measures Diverge.We are freely releasing the data for all 100 participants at both visits, including the Total Plaque Score (TPS) and Coronary Artery Calcification (CAC) scores from the semi-quantitative analysis, and the…

8/11) Match Analysis with Miami Heart Consider this: We conducted a match analysis to the Miami Heart population, including semi-quantitative and quantitative Total Plaque Score (TPS) and NCPV, respectively. This match was conducted 4.7 years, on average, after the KETO-CTA…

https://x.com/nicknorwitz/status/1920495167208906778

Published: May 8, 2025 15:05

8/11) Match Analysis with Miami Heart Consider this: We conducted a match analysis to the Miami Heart population, including semi-quantitative and quantitative Total Plaque Score (TPS) and NCPV, respectively. This match was conducted 4.7 years, on average,…

7/11) What is “Stable Plaque?” While there is no consensus on what “stable plaque” means for NCPV changes, we would like to emphasize that, since most participants showed low-baseline plaque values, relative changes are expected to be magnified. Furthermore, it’s true that most…

https://x.com/nicknorwitz/status/1920495164834926628

Published: May 8, 2025 15:05

7/11) What is “Stable Plaque?” While there is no consensus on what “stable plaque” means for NCPV changes, we would like to emphasize that, since most participants showed low-baseline plaque values, relative changes are expected to be magnified.…

6/11) It’s Still Not the ApoB Building on this, I think it’s fair to claim that ApoB doesn’t predict plaque progression in this cohort. That said, the statement “ApoB doesn’t predict plaque progression,” is distinct from, and consistent with, the statement “ApoB is causal in…

https://x.com/nicknorwitz/status/1920495162205073453

Published: May 8, 2025 15:05

6/11) It’s Still Not the ApoBBuilding on this, I think it’s fair to claim that ApoB doesn’t predict plaque progression in this cohort. That said, the statement “ApoB doesn’t predict plaque progression,” is distinct from, and consistent with, the statement…

5/11) What People Are Overlooking i. Saturation Effect One strength of our study is that it has the greatest spread of LDL-C (and ApoB), of any study ever conducted, if I’m not mistaken. Incredibly, we have LDL-C levels spanned >400 mg/dl range. Despite this, neither LDL-C nor…

https://x.com/nicknorwitz/status/1920495159084556430

Published: May 8, 2025 15:05

5/11) What People Are Overlookingi. Saturation EffectOne strength of our study is that it has the greatest spread of LDL-C (and ApoB), of any study ever conducted, if I’m not mistaken. Incredibly, we have LDL-C levels spanned >400 mg/dl range. Despite…

4/11) Owning Our Mistake, But Operating Through Preferred Channels Second, we made a mistake in not reporting the numerical values for NCPV progression. This was not an intentional omission, and the data were presented clearly and graphically in Figure 1, with a big, bold red…

https://x.com/nicknorwitz/status/1920495150616219688

Published: May 8, 2025 15:04

4/11) Owning Our Mistake, But Operating Through Preferred Channels Second, we made a mistake in not reporting the numerical values for NCPV progression. This was not an intentional omission, and the data were presented clearly and graphically in Figure 1,…

2/11) First and foremost, I encourage everyone to listen to this recent hour-long conversation between Dave Feldman and Chris MacAskill about the controversy. Truthfully, I think it was among the most honest, humble, and sincere conversations my ears have ever had the pleasure…

https://x.com/nicknorwitz/status/1920495144475779184

Published: May 8, 2025 15:04

2/11) First and foremost, I encourage everyone to listen to this recent hour-long conversation between Dave Feldman and Chris MacAskill about the controversy. Truthfully, I think it was among the most honest, humble, and sincere conversations my ears have…

3/11) The April 7th Paper was Fully Peer-Reviewed. But it Wasn’t Perfect Now, here are some points I’d like to make to begin to reanimate productive discussion and resolve confusions. First, let’s get this straight, the April 7th published paper was fully peer-reviewed and…

https://x.com/nicknorwitz/status/1920495147210408435

Published: May 8, 2025 15:04

3/11) The April 7th Paper was Fully Peer-Reviewed. But it Wasn’t Perfect Now, here are some points I’d like to make to begin to reanimate productive discussion and resolve confusions. First, let’s get this straight, the April 7th published paper was fully…

RT by @nicknorwitz: 🧵 #KetoCTAUpdate thread I have lots to share today on our recent Keto-CTA paper (#LMHRstudy). Let's unpack: ⏳ Background & study overview 🤼 #MiHeart match analysis 📊 Initial findings ⚠️ Controversy & missteps 💡 New discoveries 📀 #OpenData release ✅ Next steps

https://x.com/realDaveFeldman/status/1920491554780672299

Published: May 8, 2025 14:50

🧵 #KetoCTAUpdate threadI have lots to share today on our recent Keto-CTA paper (#LMHRstudy).Let's unpack:⏳ Background & study overview🤼 #MiHeart match analysis📊 Initial findings⚠️ Controversy & missteps💡 New discoveries📀 #OpenData release✅ Next steps— Dave…

6/6) Since I know some will see this post as some sort of pivot, let me clarify: it's not. The social media space around diet is so polarized that everyone assumes we all fall cleanly into one camp, one ideology. But I reject that notion. That's why - if you follow me closely -…

https://x.com/nicknorwitz/status/1920076314490397067

Published: May 7, 2025 11:20

6/6) Since I know some will see this post as some sort of pivot, let me clarify: it's not. The social media space around diet is so polarized that everyone assumes we all fall cleanly into one camp, one ideology. But I reject that notion. That's why - if…

How to Start a Mediterranean Ketogenic Diet: A Step-by-Step Guide (Link to more🔗 in 5/5) 1/6) I started a ketogenic diet on June 1, 2019, and it saved me from debilitating inflammatory bowel disease. But here’s a hard fact: despite its many benefits—including for obesity,…

https://x.com/nicknorwitz/status/1920076299944460595

Published: May 7, 2025 11:20

How to Start a Mediterranean Ketogenic Diet: A Step-by-Step Guide (Link to more🔗 in 5/5)1/6) I started a ketogenic diet on June 1, 2019, and it saved me from debilitating inflammatory bowel disease.But here’s a hard fact: despite its many…

2/6) Fatty Fish Fatty Fish are a great source of protein, healthy fats, and micronutrients to support muscle growth, brain health, healthspan and even longevity. Remember the acronym “SMASH” for Salmon, Mackerel, Anchovies, Sardines and Herring. For salmon, I’d give Wild…

https://x.com/nicknorwitz/status/1920076302645653554

Published: May 7, 2025 11:20

2/6) Fatty FishFatty Fish are a great source of protein, healthy fats, and micronutrients to support muscle growth, brain health, healthspan and even longevity.Remember the acronym “SMASH” for Salmon, Mackerel, Anchovies, Sardines and Herring.For salmon,…

3/6) Extra Virgin Olive Oil If I were to do a video on all the health benefits of a good, true extra virgin olive oil it would be longer than the entire Lord of the Rings Saga (aside: Gollum was definitely oxidized). But, practically speaking, what you need to know is how to…

https://x.com/nicknorwitz/status/1920076305283850728

Published: May 7, 2025 11:20

3/6) Extra Virgin Olive OilIf I were to do a video on all the health benefits of a good, true extra virgin olive oil it would be longer than the entire Lord of the Rings Saga (aside: Gollum was definitely oxidized).But, practically speaking, what you need…

4/6) Sesame Sesame and sesame products, in particular tahini, are great for adding texture to foods, like seafood, as dressings – like a garlic-anchovy-tahini dressing for roast zucchini or eggplant or fish. Sesame oil might be particularly ketogenic for reasons related its fat…

https://x.com/nicknorwitz/status/1920076308169502761

Published: May 7, 2025 11:20

4/6) SesameSesame and sesame products, in particular tahini, are great for adding texture to foods, like seafood, as dressings – like a garlic-anchovy-tahini dressing for roast zucchini or eggplant or fish.Sesame oil might be particularly ketogenic for…

5/6) For more foods from the list of 9, advice for preparing to start a ketogenic lifestyle, and answers to common questions like, “What about the keto flu?” - “Will a Ketogenic diet hurt my Thyroid?” - “What should my ketone goals be?” see Today’s StayCurious Metabolism…

https://x.com/nicknorwitz/status/1920076311076147653

Published: May 7, 2025 11:20

5/6) For more foods from the list of 9, advice for preparing to start a ketogenic lifestyle, and answers to common questions like, “What about the keto flu?” - “Will a Ketogenic diet hurt my Thyroid?” - “What should my ketone goals be?” see Today’s…