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@davidludwigmd @Nature I mean with prescribe lots of drugs with unknown long-term effects. Should we ban some new lipid lowering drugs👇because there are MR data suggesting increased Alzheimer’s risk? https://t.co/bpULYIC5Lu

https://x.com/nicknorwitz/status/1870525627180142892

Published: December 21, 2024 17:43

I mean with prescribe lots of drugs with unknown long-term effects. Should we ban some new lipid lowering drugs👇because there are MR data suggesting increased Alzheimer’s risk? pic.twitter.com/bpULYIC5Lu— Nick Norwitz (@nicknorwitz) December 21, 2024

First, I’m sure we can both think of numerous examples where exogenously produced vs exogenous consumed biomolecules have different implications Second, if faster assume the distinct LPC profiles would have distinct effects, rather than convergent. So I suppose it’s a “where do you place the burden of proof” question. That is a “place your bets,” in a way. Third, rules of metabolism shift when you have cancer. Fourth, isn’t planting dietary dice kinda the name of the game anyway 😂

https://x.com/nicknorwitz/status/1870508302079336850

Published: December 21, 2024 16:35

First, I’m sure we can both think of numerous examples where exogenously produced vs exogenous consumed biomolecules have different implications Second, if faster assume the distinct LPC profiles would have distinct effects, rather than convergent. So I…

@interesting_aIl This post has multiple errors. Eg an apple 🍎 does not have more fiber than an avocado 🥑. And if guava is your protein source… you’re screwed https://t.co/QO4vhUqqd3

https://x.com/nicknorwitz/status/1870490765203489134

Published: December 21, 2024 15:25

This post has multiple errors. Eg an apple 🍎 does not have more fiber than an avocado 🥑. And if guava is your protein source… you’re screwed pic.twitter.com/QO4vhUqqd3— Nick Norwitz (@nicknorwitz) December 21, 2024

@davidludwigmd @Nature Is DHA = lineoleic acid? Just as PUFA are diverse species, so are LPCs. I make this point in newsletter and upcoming video. Anticipated as a point of confusion ;). https://t.co/LiNertxcqa

https://x.com/nicknorwitz/status/1870490169943470107

Published: December 21, 2024 15:23

Is DHA = lineoleic acid? Just as PUFA are diverse species, so are LPCs. I make this point in newsletter and upcoming video. Anticipated as a point of confusion ;).https://t.co/LiNertxcqa— Nick Norwitz (@nicknorwitz) December 21, 2024

2/2) To better understand the implications of these findings, including with respect to fruit 🍌, fructose substitutes and more, see today’s Newsletter: https://t.co/PVASIysIzh

https://x.com/nicknorwitz/status/1870462837178724831

Published: December 21, 2024 13:34

2/2) To better understand the implications of these findings, including with respect to fruit 🍌, fructose substitutes and more, see today’s Newsletter: https://t.co/PVASIysIzh— Nick Norwitz (@nicknorwitz) December 21, 2024

🍩 Fructose Hijacks the Liver to Grow Cancer 🦠 1/2) In a new study in @Nature, the researchers find, “In all cases, diets supplemented with HFCS resulted in faster tumor growth compared with control diets.” This included skin, breast and cervical cancers. 👉 Background High… pic.twitter.com/RTd8sXQIbF

https://x.com/nicknorwitz/status/1870462833978392599

Published: December 21, 2024 13:34

🍩 Fructose Hijacks the Liver to Grow Cancer 🦠1/2) In a new study in @Nature, the researchers find, “In all cases, diets supplemented with HFCS resulted in faster tumor growth compared with control diets.”This included skin, breast and cervical cancers.👉…

@SBakerMD But what's more dangerous 😉? https://t.co/barvybF9XH

https://x.com/nicknorwitz/status/1870253716093448448

Published: December 20, 2024 23:43

But what's more dangerous 😉? pic.twitter.com/barvybF9XH— Nick Norwitz (@nicknorwitz) December 20, 2024

@MarcLobliner It’s a top 5 pasta shape for sure 😉 https://t.co/sBlBIGGhcn

https://x.com/nicknorwitz/status/1870177740546060563

Published: December 20, 2024 18:41

It’s a top 5 pasta shape for sure 😉 pic.twitter.com/sBlBIGGhcn— Nick Norwitz (@nicknorwitz) December 20, 2024

RT @saaiyer: Thank you @nicknorwitz Pls follow this brilliant man!

https://x.com/saaiyer/status/1870143346032947580

Published: December 20, 2024 16:31

Thank you @nicknorwitz Pls follow this brilliant man! https://t.co/VHZXeDGBrX— RewriteYourStory (@saaiyer) December 20, 2024

RT @alfredohinny: Great thread/video on seed oils. @nicknorwitz is the GOAT of these kind of nuanced and practical analysis, that’s why he’…

https://x.com/alfredohinny/status/1870130685887107558

Published: December 20, 2024 16:31

Great thread/video on seed oils. @nicknorwitz is the GOAT of these kind of nuanced and practical analysis, that’s why he’s such a great asset to our community. https://t.co/xGuFLCjbvY— Alfredo Hinny (@alfredohinny) December 20, 2024

@bigfatsurprise FDA: Saturated fat is bad. Me - immediately- I have two words for you: “Save Roquefort!” 🥺 https://t.co/tkTrmbyEQ5

https://x.com/nicknorwitz/status/1870123061954892053

Published: December 20, 2024 15:04

FDA: Saturated fat is bad.Me - immediately- I have two words for you: “Save Roquefort!” 🥺 pic.twitter.com/tkTrmbyEQ5— Nick Norwitz (@nicknorwitz) December 20, 2024

@robbwolf @SeedOilDsrspctr Dude killed Groot - who photosynthesizes! Makes no sense. None! https://t.co/OkPlprTeaH

https://x.com/nicknorwitz/status/1870122317071687939

Published: December 20, 2024 15:01

Dude killed Groot - who photosynthesizes! Makes no sense. None! pic.twitter.com/OkPlprTeaH— Nick Norwitz (@nicknorwitz) December 20, 2024

Within 1 hour of my seed oil video dropping on YouTube, I’ve been approached by legacy media journalists wanting to do a story on #SeedOils. For those who see my video, you’ll see I have a moderate stance on this controversial topic. 👉https://t.co/bdMPWcom1K But as with many things, my opinion is subject to change and I like to think I have a reasonable dose of humility on the topic insofar I have haven’t read “every” paper or thought about this from every angle. To that end, I’d like to act as a conduit to have diverse voices represented on the matter, names I’ll pass on to the journalist. Several come to mind @TuckerGoodrich @theproof @bigfatsurprise @NutritionMadeS3 @drcateshanahan @Gard

https://x.com/nicknorwitz/status/1870120436081520790

Published: December 20, 2024 14:53

Within 1 hour of my seed oil video dropping on YouTube, I’ve been approached by legacy media journalists wanting to do a story on #SeedOils. For those who see my video, you’ll see I have a moderate stance on this controversial topic.…

@robbwolf @nicknorwitz This is an extraordinary claim that is more harmful than helpful “More of things doesn’t equal more of things” I’m sure is true because “it’s complicated”. But, it’s generally true. https://t.co/hLBv0vx0cu

https://x.com/nicknorwitz/status/1870119311723114784

Published: December 20, 2024 14:49

@robbwolf @nicknorwitz This is an extraordinary claim that is more harmful than helpful “More of things doesn’t equal more of things” I’m sure is true because “it’s complicated”. But, it’s generally true. https://t.co/hLBv0vx0cu

@TraderTeddy @robbwolf I mean you’re right. There are an eerie number of similarities between myself and @robbwolf 👀… and not just good looks https://t.co/kCVSmX0e8t

https://x.com/nicknorwitz/status/1870117197047099514

Published: December 20, 2024 14:40

I mean you’re right. There are an eerie number of similarities between myself and @robbwolf 👀… and not just good looks pic.twitter.com/kCVSmX0e8t— Nick Norwitz (@nicknorwitz) December 20, 2024

6/6) I’m sure the discussion will continue, as it should. But for those who want a provocatively reasonable stance that acknowledges it’s about more than just calories but also tones down the fear-mongering, check out today’s video: https://t.co/m72YJBguOE

https://x.com/nicknorwitz/status/1870094994268205509

Published: December 20, 2024 13:12

6/6) I’m sure the discussion will continue, as it should. But for those who want a provocatively reasonable stance that acknowledges it’s about more than just calories but also tones down the fear-mongering, check out today’s video:…

1/6) 🔥Seed Oils and Science👀: What the Media Gets Wrong (and Right) (Sound On🔊) I bit the bullet and decided to provide my 2 cents on the Controversial Topic of Seed Oils. Here are some things you should know… “Seed Oils” is a term often poorly defined, leading to… pic.twitter.com/pRGRVFqklq

https://x.com/nicknorwitz/status/1870094983728169237

Published: December 20, 2024 13:12

1/6) 🔥Seed Oils and Science👀: What the Media Gets Wrong (and Right) (Sound On🔊) I bit the bullet and decided to provide my 2 cents on the Controversial Topic of Seed Oils. Here are some things you should know…“Seed Oils” is a term often poorly defined,…

@nicknorwitz: 🌶️Omega-6/3 Ratio & "Seed Oils" - Some Nuances to Know 🌶️ Tomorrow, I'll release a video all about on Seed Oils. One topic I was to 'tease' is that of Omega-6/3 ratio. Some things to know: 3 (Simple) True Facts You May Know 🔥 Omega-6 "overload" relative to Omega-3 can cause…

https://twitter.com/nicknorwitz/status/1869735248298205280

Published: December 19, 2024 13:23

🌶️Omega-6/3 Ratio & "Seed Oils" - Some Nuances to Know 🌶️Tomorrow, I'll release a video all about on Seed Oils. One topic I was to 'tease' is that of Omega-6/3 ratio. Some things to know:3 (Simple) True Facts You May Know🔥 Omega-6 "overload" relative to…

@nicknorwitz: @TuckerGoodrich That's misleading. Peroxidation index is here literally defined as "the density of double bonds in the membrane." The definition of the measure is literally "how much PUFA." That's entirely different than claiming only PUFA contribute to oxidative stress.

https://twitter.com/nicknorwitz/status/1869467193169301888

Published: December 18, 2024 19:38

That's misleading. Peroxidation index is here literally defined as "the density of double bonds in the membrane." The definition of the measure is literally "how much PUFA." That's entirely different than claiming only PUFA contribute to oxidative stress.…

@nicknorwitz: @TuckerGoodrich “only fat on that list that can induce oxidative stress” - what? That’s not true. It’s simply not true.

https://twitter.com/nicknorwitz/status/1869437425371722189

Published: December 18, 2024 17:39

“only fat on that list that can induce oxidative stress” - what? That’s not true. It’s simply not true. pic.twitter.com/UU8FEAOZhr— Nick Norwitz (@nicknorwitz) December 18, 2024

@nicknorwitz: 🍭New Data on How #Fructose Fuels #Cancer🍭 A study published in @Nature revealed how fructose, after fluxing through the liver, ultimately supports the production of building blocks for multiple tumors. In several of the experiments, they used high-fructose corn syrup (HFCS)…

https://twitter.com/nicknorwitz/status/1869409842093248884

Published: December 18, 2024 15:50

🍭New Data on How #Fructose Fuels #Cancer🍭A study published in @Nature revealed how fructose, after fluxing through the liver, ultimately supports the production of building blocks for multiple tumors.In several of the experiments, they used high-fructose…

@nicknorwitz: Is @BioLayne Really this Transparent? It looks desperate. Needy, even. What Happened? If I were just responding to put @BioLayne in his Lane, I wouldn’t make this post. But I see a teaching moment here. Let’s begin by highlighting the obvious... 🤑This is a sales tactic: The…

https://twitter.com/nicknorwitz/status/1869390084442657217

Published: December 18, 2024 14:31

Is @BioLayne Really this Transparent? It looks desperate. Needy, even. What Happened? If I were just responding to put @BioLaynein his Lane, I wouldn’t make this post. But I see a teaching moment here. Let’s begin by highlighting the obvious... 🤑This is a…

@nicknorwitz: 9/9) For more images and details, check out today's #StayCurious Metabolism Newsletter:

https://twitter.com/nicknorwitz/status/1869121098971013297

Published: December 17, 2024 20:42

9/9) For more images and details, check out today's #StayCurious Metabolism Newsletter: https://t.co/sNRJPE5PEu pic.twitter.com/xVxJoO9HWg— Nick Norwitz (@nicknorwitz) December 17, 2024

@nicknorwitz: @JonMortensenV8Z As does my coverage of the topic But not only am I doubtful as to wether the original post was alluding to the fuel partitioning model of obesity, if it was then the verbal imprecision was so horrendous as to transform a physiological model of obesity

https://twitter.com/nicknorwitz/status/1869074742860447932

Published: December 17, 2024 17:38

As does my coverage of the topichttps://t.co/PmwWXWyIHTBut not only am I doubtful as to wether the original post was alluding to the fuel partitioning model of obesity, if it was then the verbal imprecision was so horrendous as to transform a physiological…

@nicknorwitz: Apparently a side effect of my ketogenic diet has been the atrophy of my tolerance for stupid 🙈👇 No, being “overweight” does not slow your metabolism. This is fat shaming + an insult to physiology and the human brain

https://twitter.com/nicknorwitz/status/1869069495207416285

Published: December 17, 2024 17:17

Apparently a side effect of my ketogenic diet has been the atrophy of my tolerance for stupid 🙈👇No, being “overweight” does not slow your metabolism. This is fat shaming + an insult to physiology and the human brain pic.twitter.com/N4vQ58TXlN— Nick Norwitz…

@nicknorwitz: Since I've been getting the question, My Favorite Chocolate is Taza Wicked Dark (95%). (No Affiliation). Here's why: 👉 Low Heavy Metals (Lead and Cadmium) 👉 Stone Ground = Preservation of Flavanols 👉 16 grams of Fiber (if you're into that). I don't target fiber but this mostly…

https://twitter.com/nicknorwitz/status/1869037003427230006

Published: December 17, 2024 15:08

Since I've been getting the question, My Favorite Chocolate is Taza Wicked Dark (95%). (No Affiliation). Here's why:👉 Low Heavy Metals (Lead and Cadmium)👉 Stone Ground = Preservation of Flavanols👉 16 grams of Fiber (if you're into that). I don't target…

@nicknorwitz: 5/5) TLDR, I do think dark chocolate can be a health food. But I don't think these data add much to the story and that the headlines are little more than headlines. Enjoy your chocolate, but don't target chocolate to prevent diabetes. For more nuance and details, see today's

https://twitter.com/nicknorwitz/status/1868689080285843893

Published: December 16, 2024 16:06

5/5) TLDR, I do think dark chocolate can be a health food. But I don't think these data add much to the story and that the headlines are little more than headlines. Enjoy your chocolate, but don't target chocolate to prevent diabetes. For more nuance and…

@nicknorwitz: RT @nicknorwitz: 1/3) Can Anti-Biotics Cause Depression 💊🧠? (🔗 at the end) It’s a provocative, but biologically reasonable question, and o…

https://twitter.com/nicknorwitz/status/1868282499748467125

Published: December 15, 2024 20:02

1/3) Can Anti-Biotics Cause Depression 💊🧠? (🔗 at the end)It’s a provocative, but biologically reasonable question, and one I’m forced to ask based on new data combined with a personal experience. Let’s start with the data.A new paper, published in Cell…

@nicknorwitz: @NTFabiano 1 sentence? *Cracks knuckles* … “The Lipid Energy Model posits that in certain individuals, particularly those adhering to a ketogenic or low-carbohydrate, high-fat diet, the body prioritizes the mobilization and utilization of fatty acids for energy, resulting in an increased

https://twitter.com/nicknorwitz/status/1868339221536092570

Published: December 15, 2024 16:55

1 sentence? *Cracks knuckles* … “The Lipid Energy Model posits that in certain individuals, particularly those adhering to a ketogenic or low-carbohydrate, high-fat diet, the body prioritizes the mobilization and utilization of fatty acids for energy,…

@nicknorwitz: @davidludwigmd I’m honored. Seems appropriate to reply with this God of Mischief GIF

https://twitter.com/nicknorwitz/status/1868332254864540110

Published: December 15, 2024 16:28

I’m honored. Seems appropriate to reply with this God of Mischief GIF pic.twitter.com/LHX7IckM56— Nick Norwitz (@nicknorwitz) December 15, 2024

@davidludwigmd: RT by @nicknorwitz: N=1 experiment: Prolonged total fast, just coffee & lytes. Completing Day 2 of planned 6 days. Surprisingly easy so far, no hunger, good energy (15k ride no prob). Will see about longterm benefits. (Immediate benefit, no flossing). (Seek expert guidance if trying first time)

https://twitter.com/davidludwigmd/status/1868300700888998183

Published: December 15, 2024 14:22

N=1 experiment:Prolonged total fast, just coffee & lytes.Completing Day 2 of planned 6 days.Surprisingly easy so far, no hunger, good energy (15k ride no prob).Will see about longterm benefits. (Immediate benefit, no flossing).(Seek expert guidance if…

@nicknorwitz: 3/3) What does this all mean? 🧬 Microbiome rhythms shape brain gene expression 🦠 The circadian stress axis is vulnerable to microbiome disruption 😭 This impacts stress resilience, and brain & mental health, and brain health. TLDR: The gut and brain are rhythmically dancing

https://twitter.com/nicknorwitz/status/1868282506333561031

Published: December 15, 2024 13:10

3/3) What does this all mean?🧬 Microbiome rhythms shape brain gene expression🦠 The circadian stress axis is vulnerable to microbiome disruption😭 This impacts stress resilience, and brain & mental health, and brain health.TLDR: The gut and brain are…