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[Obituary] Graham MacGregor

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02181-6/fulltext?rss=yes

Published: November 1, 2025 00:00

Physician, hypertension researcher, and early advocate for reduced salt and sugar in food. Born in St Albans, UK, on April 1, 1941, he died in Banbury, UK, on Sept 1, 2025, aged 84 years.

[Series] Partial progress in sexual and reproductive health and rights: the influence of sociocultural, behavioural, structural, and technological changes on epidemiological trends

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01188-2/fulltext?rss=yes

Published: November 1, 2025 00:00

The concept of sexual and reproductive health and rights has evolved in the 21st century from previous narrower conceptualisations. In 2018, the Guttmacher–Lancet Commission proposed a broader and integrated defining framework, together with a package of…

[Correspondence] A medical unemployment crisis in a desperate NHS

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01972-5/fulltext?rss=yes

Published: November 1, 2025 00:00

Recently published competition ratios for specialty training expose the unfolding unemployment crisis in the medical industry. There were 33 108 applicants for only 9479 training posts in the first round of recruitment for post-foundation training in the…

[Comment] Offline: The death of globalism (part 1)

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02204-4/fulltext?rss=yes

Published: November 1, 2025 00:00

Tempting as it is to write off the Trump phenomenon and its effects on medicine and global health as a temporary derangement of mass politics, one would be severely mistaken for doing so. The imitations and embodiments of Trumpism reach far across the…

[Correspondence] Striving for free health education in Greece after a financial crisis

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02056-2/fulltext?rss=yes

Published: November 1, 2025 00:00

Generations of medical students and trainee doctors in Greece have benefited from free education in public institutions, from textbooks to clinical training and doctoral degrees. Tuition fees have been restricted to specific postgraduate programmes.1…

[Correspondence] Health safeguards under the UN's reimposition of sanctions on Iran

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02055-0/fulltext?rss=yes

Published: November 1, 2025 00:00

On Sept 28, 2025, the UN Security Council snapback under Resolution 2231 reinstated multilateral sanctions on Iran related to insufficient compliance in international oversight of its nuclear programme.1 This Correspondence does not take a position on the…

[Comment] Progress in outcomes for patients with metastatic squamous non-small-cell lung cancer

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02172-5/fulltext?rss=yes

Published: November 1, 2025 00:00

The use of immunotherapy in patients with various types of cancer has led to dramatic increases in survival. Increased median survival and even cure have been reported in a subgroup of patients receiving immunotherapy, especially following the use of…

[Correspondence] Stratifying IL-2 therapy in ALS: integrating biomarkers – Authors' reply

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01958-0/fulltext?rss=yes

Published: November 1, 2025 00:00

We thank Yutaka Shimazu for his insightful comments. We agree that our positive findings1–4 highlight the urgent need for further work on biomarkers of neuronal damage and immune mechanisms in amyotrophic lateral sclerosis (ALS).

[Series] Who pays and what pays off in sexual and reproductive health? A review of the cost and cost-effectiveness of interventions and implications for future funding and markets

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01724-6/fulltext?rss=yes

Published: November 1, 2025 00:00

This Series paper provides a summary of what is known about the funding, cost, and cost-effectiveness of sexual and reproductive health and rights interventions, interrogates the likely impacts of increasing or reducing future sexual and reproductive…

[Perspectives] A quest for vaccine equity

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02179-8/fulltext?rss=yes

Published: November 1, 2025 00:00

For those working in global health, and especially on immunisation, it is difficult not to feel despair at the headwinds in 2025 that have been blowing forcefully against decades of collective efforts to improve the world's health through prevention of…

[Correspondence] Population screening for Helicobacter pylori to reduce gastric cancer – Authors' reply

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01957-9/fulltext?rss=yes

Published: November 1, 2025 00:00

We appreciate the thoughtful Correspondence by Alexander C Ford and Paul Moayyedi on our gastric cancer Seminar1 and value their dedication to advancing evidence-based approaches to gastric cancer prevention.

[Editorial] Health in the US Government shutdown

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02207-X/fulltext?rss=yes

Published: November 1, 2025 00:00

The US Federal Government is gridlocked. When the 2025 fiscal year ended, the Senate and House of Representatives had not passed a budget for 2026, and so federal agencies are required to pause all non-essential services. Republicans have endorsed a…

[Series] Challenges and opportunities in developing integrated sexual and reproductive health programmes

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01246-2/fulltext?rss=yes

Published: November 1, 2025 00:00

Sexual and reproductive health and rights are fundamental to both human and societal wellbeing and sustainable development, and encompass a broad array of sociocultural and clinical issues that affect all people across the life course. In 2018, the…

[Correspondence] Population screening for Helicobacter pylori to reduce gastric cancer

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01736-2/fulltext?rss=yes

Published: November 1, 2025 00:00

We read Raghav Sundar and colleagues’ Seminar on gastric cancer with interest.1 The optimal approach to managing any disease with a burden as high as gastric cancer will probably be, where possible, primary prevention. As Sundar and colleagues correctly…

[Comment] A rights-based imperative for young women

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02063-X/fulltext?rss=yes

Published: November 1, 2025 00:00

For young women like me living with HIV in South Africa, health systems too often treat our care as a series of disconnected tasks. Sexual and reproductive health and HIV care should be integrated for convenience given the high unmet need in young people,…

[Correspondence] A system under transformation, not collapse

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02022-7/fulltext?rss=yes

Published: November 1, 2025 00:00

The World Report1 by Dinesh C Sharma on the corruption scandal in Indian medical education brings to attention a serious episode involving regulatory malpractice that is currently under investigation by India's Central Bureau of Investigation. Allegations…

[Perspectives] Fitsum Tadesse: shaping malaria research in sub-Saharan Africa

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02178-6/fulltext?rss=yes

Published: November 1, 2025 00:00

“Over the last one and a half decades we have seen malaria incidence, morbidity, and mortality decreasing. Ethiopia was performing phenomenally”, comments malaria researcher Fitsum G Tadesse, a Wellcome Trust Research Fellow at the UK's London School of…

[Perspectives] Masking harm: dust, diseases, and industry

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02180-4/fulltext?rss=yes

Published: November 1, 2025 00:00

During the COVID-19 pandemic, we were all reminded of the long history of masks used as protection against disease, ranging from the iconic plague doctor's beaked mask to the cloth masks seen in historical paintings of past epidemics. Yet history holds its…

[World Report] Tobacco treaty wrestles with new nicotine products

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02206-8/fulltext?rss=yes

Published: November 1, 2025 00:00

As the 11th conference of the WHO Framework Convention on Tobacco Control approaches, experts debate how to respond to an expanding industry. Faith McLellan reports.

[World Report] The erosion of medical neutrality

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02159-2/fulltext?rss=yes

Published: November 1, 2025 00:00

From Gaza to Sudan, and Syria to Ukraine, the long-standing idea that health should not be targeted in conflict is being increasingly undermined. Sharmila Devi reports.

[Series] Biomedical innovations in contraception: gaps, obstacles, and solutions for sexual and reproductive health

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01187-0/fulltext?rss=yes

Published: November 1, 2025 00:00

Contraception and family planning are vital aspects of sexual and reproductive health and rights. Despite major advances in modern contraception over the past 60 years many gaps remain, and the rate of unplanned pregnancies and abortions remains high.…

[Correspondence] Stratifying IL-2 therapy in ALS: integrating biomarkers

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01737-4/fulltext?rss=yes

Published: November 1, 2025 00:00

In the MIROCALS trial, Gilbert Bensimon and colleagues1 showed that low-dose interleukin-2 (IL-2) added to riluzole did not significantly reduce mortality in an unadjusted analysis of patients with early-stage amyotrophic lateral sclerosis (ALS). However,…

[Series] Innovations in the biomedical prevention, diagnosis, and service delivery of HIV and other sexually transmitted infections

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00983-3/fulltext?rss=yes

Published: November 1, 2025 00:00

The interconnectedness of the global HIV and sexually transmitted infection (STI) epidemics necessitates integrated strategies to address both. This Series paper highlights the biological link between HIV and STIs, and describes the successful progress in…

[Editorial] Drug pricing and pharmaceutical innovation: a false promise

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02160-9/fulltext?rss=yes

Published: October 25, 2025 00:00

The UK is facing a pharma exodus. Major pharmaceutical companies have withdrawn about £2 billion in proposed investment from the country, blaming insufficient government investment. Central to the dispute is the amount of money that the National Health…

[Correspondence] Loans dominated COVID-19 funding: it's time to adjust

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01874-4/fulltext?rss=yes

Published: October 25, 2025 00:00

As the US foreign assistance architecture faces unprecedented dismantling, lessons from past crises take on urgent significance. Our new analysis of COVID-19 donor funding1 reveals a profound disconnect between the rhetoric of global solidarity and the…

[Correspondence] Drug-coated balloon angioplasty and stenting for coronary artery lesions – Authors' reply

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01861-6/fulltext?rss=yes

Published: October 25, 2025 00:00

We deeply appreciate the feedback provided by Tingquan Zhou, Pitt O Lim, Christian Spaulding and colleagues, Filippo Luca Gurgoglione and Bernardo Cortese, and Tuomas T Rissanen and colleagues. Introduced by Scheller and colleagues1 in 2004, drug-coated…

[Correspondence] Drug-coated balloon angioplasty and stenting for coronary artery lesions

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01859-8/fulltext?rss=yes

Published: October 25, 2025 00:00

The REC-CAGEFREE I trial1 by Chao Gao and colleagues describes the results of a multicentre trial in which a paclitaxel drug-coated balloon (DCB) did not reach expected non-inferiority compared with a drug-eluting stent (DES) in terms of the…

[Correspondence] Drug-coated balloon angioplasty and stenting for coronary artery lesions

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01860-4/fulltext?rss=yes

Published: October 25, 2025 00:00

In the REC-CAGEFREE I trial by Chao Gao and colleagues,1 an open-label, randomised, non-inferiority trial comparing a drug-coated balloon (DCB) with a drug-eluting stent (DES) in patients with de novo, non-complex coronary lesions, the DCB group did not…

[Department of Error] Department of Error

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02125-7/fulltext?rss=yes

Published: October 25, 2025 00:00

Landrigan PJ, Dunlop S, Treskova M, et al. The Lancet Countdown on health and plastics. Lancet 2025; 406: 1044–62—In this Health Policy, the author's name was corrected to Zhanyun Wang. This correction has been made to the online version as of Oct 23,…

[Correspondence] Drug-coated balloon angioplasty and stenting for coronary artery lesions

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01857-4/fulltext?rss=yes

Published: October 25, 2025 00:00

The conclusion in the REC-CAGEFREE-I trial by Chao Gao and colleagues1 that drug-coated balloon (DCB) angioplasty is inferior to drug-eluting stent (DES) deployment in patients with non-complex, de novo coronary artery disease is such a sweeping statement…

[World Report] What does the ceasefire plan mean for health in Gaza?

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02158-0/fulltext?rss=yes

Published: October 25, 2025 00:00

The recent ceasefire agreement is bringing a fragile peace to Gaza. Aside from a cessation of hostilities, it has important implications for health. John Zarocostas reports.

[Correspondence] Integrating preconception health into CVD prevention

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01299-1/fulltext?rss=yes

Published: October 25, 2025 00:00

The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma1 compellingly reframes coronary artery disease as a lifelong continuum, advocating for early prevention strategies rooted in atheroma detection. The Commission's…

[Obituary] Anthony Irvine Adams

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02120-8/fulltext?rss=yes

Published: October 25, 2025 00:00

Public health physician and former Chief Medical Officer of Australia. Born on Feb 25, 1936, in Adelaide, SA, Australia, he used voluntary assisted dying and died on Aug 7, 2025, in Gosford, NSW, Australia, aged 89 years.

[Correspondence] Drug-coated balloon angioplasty and stenting for coronary artery lesions

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01856-2/fulltext?rss=yes

Published: October 25, 2025 00:00

I have carefully reviewed the REC-CAGEFREE I trial by Chao Gao and colleagues1 and, although the study's methods and analytical approach are commendable, I have identified several limitations and areas for improvement that warrant consideration.

[Comment] Offline: “People have died”

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02151-8/fulltext?rss=yes

Published: October 25, 2025 00:00

The World Health Summit has proved itself the premier global health event of the year. Under the banner “Taking responsibility for health in a fragmenting world”—symbolised by a giant stage globe cracking during a flamboyant evening “signature…

[Comment] Optimising treatment strategies in older patients with mantle cell lymphoma

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02107-5/fulltext?rss=yes

Published: October 25, 2025 00:00

The integration of Bruton tyrosine kinase (BTK) inhibitors into first-line treatment regimens, in combination with immunochemotherapy, constitutes the new standard of care following the recent approval of ibrutinib and acalabrutinib for transplant-eligible…

[Perspectives] The troubled birth of aerobiology

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02117-8/fulltext?rss=yes

Published: October 25, 2025 00:00

“FACT: #COVID19 is NOT airborne”, declared a tweet from WHO in March, 2020. WHO did not officially accept until almost 2 years later that infection by SARS-CoV-2 could after all be caused by long-range airborne transmission. Throughout the worst ravages of…

[Correspondence] Plant-based diets for coronary artery disease prevention

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01297-8/fulltext?rss=yes

Published: October 25, 2025 00:00

We read with interest the Lancet Commission1 on rethinking coronary artery disease, which shifts focus from ischaemia to atherosclerosis. The prominence of diet as a risk factor for atherosclerotic coronary artery disease (ACAD) is rightfully highlighted…

[Department of Error] Department of Error

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02130-0/fulltext?rss=yes

Published: October 25, 2025 00:00

Ye C, Ebeling PR, Kline G. Osteoporosis. Lancet 2025; 406: 2003–16—In this Seminar, the middle initial of author Peter R Ebeling was not included and their affiliation should have been Department of Medicine, School of Clinical Sciences at Monash Health,…

[Correspondence] Rethinking atherosclerotic disease prevention

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01298-X/fulltext?rss=yes

Published: October 25, 2025 00:00

The Lancet Commission on rethinking coronary artery disease1 offers important advances in cardiovascular disease (CVD) prevention. The Commission argues, correctly in our opinion, that identification of adequate management of people with high blood…

[Perspectives] The cost of diagnosis

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02118-X/fulltext?rss=yes

Published: October 25, 2025 00:00

“It is a truth universally acknowledged”, Meghan O’Rourke writes in her memoir The Invisible Kingdom (2022), “that a young woman in possession of vague symptoms like fatigue and pain will be in search of a doctor who believes she is actually sick.”…

[Perspectives] Cinematic portrayals of euthanasia and ageing across the decades

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02119-1/fulltext?rss=yes

Published: October 25, 2025 00:00

Cinema can be enormously instructive in reflecting and informing public consciousness on societal issues. It is especially illuminating for exploring perceptions of ageing, a complex, diverse, and heterogeneous social experience. An early scene in Michael…

[Correspondence] Drug-coated balloon angioplasty and stenting for coronary artery lesions

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01858-6/fulltext?rss=yes

Published: October 25, 2025 00:00

We read with great interest the Article by Chao Gao and colleagues1 and compliment the authors for a large, well designed trial that is the first to compare drug-coated balloon (DCB) angioplasty with drug-eluting stent (DES) deployment in patients with de…