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Posts: 26

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[Correspondence] US disinvestment threatens progress on violence prevention

Published: June 7, 2025 00:00

Amid widespread concern about the global consequences of recent US funding cuts, violence prevention and response remain under-discussed.1 Nearly one in three women worldwide—approximately 736 million—have been victim to physical or sexual violence from an…

[Articles] Claudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial

Published: May 31, 2025 20:00

This is the first randomised controlled trial of CAR T-cell therapy in solid tumours globally. Satri-cel treatment resulted in a significant improvement in progression-free survival, with a manageable safety profile. These results support satri-cel as a…

[Correspondence] Global trends and projections in antimicrobial resistance

Published: May 31, 2025 00:00

The systematic analysis of the global burden of bacterial antimicrobial resistance (AMR) 1990–2021 by the GBD 2021 Antimicrobial Resistance Collaborators1 will help to improve understanding of global trends of AMR, but the authors’ interpretations of the…

[Comment] Safety of low-intensity monitoring after thrombolysis in acute ischaemic stroke

Published: May 31, 2025 00:00

30 years have passed since the landmark publication of the National Institute of Neurological Disorders and Stroke (NINDS) trial of tissue plasminogen activator for acute ischaemic stroke. The NINDS trial assessed neurological and functional improvements…

[Correspondence] Global trends and projections in antimicrobial resistance

Published: May 31, 2025 00:00

The GBD 2021 Antimicrobial Resistance Collaborators raised alarming concerns about worsening bacterial antimicrobial resistance (AMR), which they projected will kill 39 million people by 2050.1 However, we would like to offer a different perspective…

[Correspondence] Moving from evidence to prioritised action on AMR

Published: May 31, 2025 00:00

Reductions in global health funding heighten the need for improved prioritisation of the remaining funds. Antimicrobial resistance (AMR) is an agreed priority, predicted to account for 1·91 million attributable deaths annually in humans by 2050.1 Ambitious…

[Correspondence] Global trends and projections in antimicrobial resistance – Authors' reply

Published: May 31, 2025 00:00

We thank Manica Balasegaram, Edmond Siu-Keung Ma and colleagues, Abebaw Fekadu and colleagues, Sylvia Yang Liu and colleagues, and Vimalraj Selvaraj and colleagues for their insightful contributions to this important topic. To our knowledge, our systematic…

[Correspondence] Global trends and projections in antimicrobial resistance

Published: May 31, 2025 00:00

The GBD 2021 Antimicrobial Resistance Collaborators estimated the deaths associated with and attributable to bacterial antimicrobial resistance (AMR) from 1990 to 2021, and produced forecasts of AMR burden up to 2050 using robust methods.1 We provide…