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Posts: 34

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[Correspondence] Unmasking inequity: emergency presentations in ovarian cancer care – Authors’ reply

Published: September 19, 2026 00:00

We thank Rui Wu and colleagues for their thoughtful commentary on the outlined objectives for the Lancet Commission on Ovarian Cancer.1 The authors have provided intriguing data regarding the percentage of women who are first diagnosed in emergency room…

[Editorial] The unmet needs of people living with severe asthma

Published: September 19, 2026 00:00

More than 260 million people worldwide live with asthma, and more than 400ā€ˆ000 die of the disease each year. 5–10% of people with asthma live with severe asthma, but it has an outsized effect—frequent disease exacerbations, poor lung function, and a…

[Correspondence] Making rehabilitation indicators disability-inclusive

Published: September 19, 2026 00:00

Global efforts to strengthen rehabilitation systems are urgently needed. The WHO Rehabilitation 2030 initiative and its work to develop standardised rehabilitation indicators1 are therefore important steps towards improving rehabilitation services and…

[Correspondence] Patient organisations are key implementation partners

Published: September 19, 2026 00:00

As President of the Mario Robles Ossio Foundation, a Mexican patient organisation, I strongly support the focus on implementation in the Health Policy by Tonelli and colleagues.1 Mexico has one of the highest burdens of kidney disease worldwide. In March,…

[Correspondence] Platinum-resistant ovarian cancers: lessons from KEYNOTE-B96 – Authors’ reply

Published: September 19, 2026 00:00

We thank Stanislas Quesada and colleagues for their thoughtful comments and for recognising the clinically meaningful benefit of pembrolizumab plus weekly paclitaxel, with or without bevacizumab, in platinum-resistant ovarian cancer.1 Because…

[Correspondence] Physical activity and exercise training in patients with HFrEF

Published: September 19, 2026 00:00

We read with great interest the Seminar by Antonio Cannata and colleagues1 on novel diagnosis and management approaches to heart failure with reduced ejection fraction (HFrEF). We were surprised by the omission of recent guideline-recommended regular…

[Correspondence] Platinum-resistant ovarian cancers: lessons from KEYNOTE-B96

Published: September 19, 2026 00:00

We congratulate Nicoletta Colombo and colleagues for the practice changing results of the ENGOT-ov65/KEYNOTE-B96 trial in platinum-resistant ovarian cancer.1 Their study reports clinically significant improvement in progression-free survival and clinically…

[Perspectives] The battle for better mental health systems needs us all

Published: September 19, 2026 00:00

When I was in my late 20s I stood on a bridge for a very long time. I was there, for many reasons. Fatigue being the greatest among them. This tiredness was not only caused by lack of sleep but also from exhaustion linked to 2 years spent as a Black woman…

[Correspondence] Unmasking inequity: emergency presentations in ovarian cancer care

Published: September 19, 2026 00:00

We highly commend Isabelle Ray-Coquard and colleagues for their Comment announcing the Lancet Commission on Ovarian Cancer,1 emphasising equity-driven reform. However, we believe they overlook a crucial barrier to improving population-level survival:…

[Perspectives] Tim Baker: bringing systems change to acute health-care provision

Published: September 12, 2026 00:00

ā€œGlobal health has traditionally focused on health promotion and preventing diseaseā€, says Tim Baker, Associate Professor at Muhimbili University of Health and Allied Sciences in Dar es Salaam, Tanzania. ā€œBut some people will get sick, and many become…

[Editorial] Gene-editing therapies: delivering safely for patients

Published: September 12, 2026 00:00

ā€œThe pain I would feel in my body was like being struck by lightning and hit by a freight train all at once.ā€ Victoria Gray's words will resonate with anyone who has experienced a sickle-cell disease crisis. In 2019, she became the first patient to have…

[Correspondence] Inverting power must begin with authorship

Published: September 12, 2026 00:00

The Johns Hopkins Centre for Humanitarian Health–Lancet Commission by Paul Spiegel and colleagues1 makes a claim that is both correct and overdue: the humanitarian system requires structural transformation, not incremental reform, and that transformation…

[Correspondence] Humanitarian lessons from UNRWA's experience in Gaza

Published: September 12, 2026 00:00

The Johns Hopkins Center for Humanitarian Health–Lancet Commission by Paul Spiegel and colleagues1 argues that the current humanitarian system is no longer fit for purpose. It identifies four recommendations: invert the power, end impunity, fix the money,…

[Correspondence] Global science to promote cooperation and understanding

Published: September 12, 2026 00:00

The idea that science might promote cooperation could sound naive in a world beset by war, sanctions, strategic rivalry, and institutional breakdown. Science cannot stop armies or resolve diplomatic failures. When formal political institutions weaken,…

[Perspectives] A positive difference: unimagined communities, reimagined research

Published: September 12, 2026 00:00

Existing narratives around race and ethnicity in medicine are overwhelmingly negative. Historians have documented overt bias and outright exploitation of Black and Brown people. Social scientists and policy researchers routinely evidence the harmful…

[Articles] Efficacy and safety of mitapivat in adults with transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE-T): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

Published: September 12, 2026 00:00

Mitapivat significantly reduced the transfusion burden and was generally well tolerated, showing a favourable benefit–risk profile. These findings support mitapivat as the first oral disease-modifying therapy for adults with transfusion-dependent…

[Comment] rVSVΔG-ZEBOV-GP vaccine-induced seroreactivity to Bundibugyo virus: a cross-protection dilemma

Published: September 12, 2026 00:00

The virus family Filoviridae includes several species known to cause severe and often fatal disease in humans. Within the genus Orthoebolvirus, the majority of clinical disease cases and associated deaths have been caused by Orthoebolavirus zairense (Ebola…

[Correspondence] Inverting power must begin with authorship – Authors’ reply

Published: September 12, 2026 00:00

We thank Qusai Khraisha for a critique that is at once generous and exacting. We appreciate that the Commission's central claim1—that transforming the humanitarian system is a question of power, of who decides, and on whose behalf—was read as clear and…

[Comment] Mitapivat for transfusion-dependent α-thalassaemia and β-thalassaemia

Published: September 12, 2026 00:00

Thalassaemias are the most common monogenic inherited diseases and are characterised by reduced production of globin chains of haemoglobin. The two most common forms are α-thalassaemia and β-thalassaemia, which affect the production of α-globin and…

[Correspondence] Naming palliative care in conflict and forced displacement

Published: September 12, 2026 00:00

The Johns Hopkins Center for Humanitarian Health–Lancet Commission by Paul Spiegel and colleagues offers a compelling account of humanitarian system failure and its consequences for people affected by conflict and forced displacement.1 The Commission calls…