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Site URL: www.thelancet.com/journals/lancet/issue/current

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Posts: 44

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[Comment] Cardiovascular benefit of blood-pressure lowering in chronic kidney disease

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00553-2/fulltext?rss=yes

Published: April 25, 2026 00:00

Chronic kidney disease (CKD) has long remained at the margins of the evidence base for the cardiovascular benefits of blood-pressure lowering. The absolute risk of cardiovascular events in people with CKD is among the highest across major clinical…

[Correspondence] Semaglutide, weight loss, and cardiovascular outcomes in the SELECT trial

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00256-4/fulltext?rss=yes

Published: April 25, 2026 00:00

John Deanfield and colleagues reported that semaglutide reduces major adverse cardiovascular events (MACE) independent of weight loss.1 However, this conclusion relies on conditioning on a post-randomisation mediator (weight loss), which is a method known…

[Correspondence] Non-coeliac gluten sensitivity: rethinking challenge studies

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00260-6/fulltext?rss=yes

Published: April 25, 2026 00:00

Jessica R Biesiekierski and colleagues1 provide a timely and comprehensive review of non-coeliac gluten sensitivity (NCGS), emphasising substantial heterogeneity in diagnostic approaches, challenge protocols, and symptom assessment. The authors conclude…

[Articles] Pharmacological blood-pressure lowering for the prevention of cardiovascular disease and death across the full spectrum of chronic kidney disease severity: an individual-participant data meta-analysis

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00367-3/fulltext?rss=yes

Published: April 25, 2026 00:00

In the context of cardiovascular risk reduction, the relative benefit of blood-pressure lowering in patients with CKD is similar to that in individuals without CKD, with consistent efficacy across all CKD stages, blood-pressure thresholds, and proteinuria…

[Comment] Antibody-based malaria prevention in an intense perennial transmission setting

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00663-X/fulltext?rss=yes

Published: April 25, 2026 00:00

Despite substantial progress in malaria control over the past two decades, malaria caused by Plasmodium falciparum remains a leading cause of morbidity and mortality in sub-Saharan Africa, particularly in young children.1 Achievement of malaria elimination…

[Correspondence] Microbiological governance and the Lancet Commission on Ukraine – Authors' reply

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00640-9/fulltext?rss=yes

Published: April 25, 2026 00:00

We welcome and appreciate the Correspondence from Guido Granata and colleagues. We agree that antimicrobial resistance (AMR) poses an existential global threat and has substantial implications for the sustainability of all health systems. Conflict raises…

[Articles] Safety and efficacy of the monoclonal antibody L9LS for malaria prevention in children exposed to perennial malaria transmission in Kenya: a randomised, double-blind, placebo-controlled, phase 2 trial

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00258-8/fulltext?rss=yes

Published: April 25, 2026 00:00

L9LS was protective against malaria in young children in western Kenya without evident safety concerns over 6–12 months. A higher dose of L9LS might be needed to achieve high-level efficacy against malaria in young children exposed to intense perennial P…

[Correspondence] Off-target benefits of influenza vaccination in cardiovascular disease – Authors' reply

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00705-1/fulltext?rss=yes

Published: April 25, 2026 00:00

We thank Ole Fröbert and colleagues for their interest in our study and proposing that vaccination might protect against cardiovascular disease through mechanisms beyond infection prevention, potentially through immunomodulatory effects. We agree this is…

[Correspondence] Systematic health destruction in Iran by Operation Epic Fury

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00689-6/fulltext?rss=yes

Published: April 25, 2026 00:00

The military campaign initiated on Feb 28, 2026, by the USA and Israel against Iran has rapidly evolved into a regional conflagration with catastrophic health consequences for Iran as well as for the region. The sheer ferocity and duration of the strikes…

[Correspondence] Off-target benefits of influenza vaccination in cardiovascular disease

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02366-9/fulltext?rss=yes

Published: April 25, 2026 00:00

We read with interest Craig S Anderson and colleagues’ PANDA II cluster-randomised trial of influenza vaccination in heart failure.1 Vaccination during admission improved survival and reduced readmissions at 12 months, with a number needed to vaccinate of…

[Correspondence] Semaglutide, weight loss, and cardiovascular outcomes in the SELECT trial

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00255-2/fulltext?rss=yes

Published: April 25, 2026 00:00

In prespecified analyses from the SELECT trial, semaglutide reduced major adverse cardiovascular events (MACE) compared with placebo, with only about one-third of benefit mediated by waist circumference change.1 John Deanfield and colleagues report…

[Correspondence] Microbiological governance and the Lancet Commission on Ukraine

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00259-X/fulltext?rss=yes

Published: April 25, 2026 00:00

We read with interest the Commission's Comment by Adrianna Murphy and colleagues, outlining a roadmap for the Ukrainian health system.1 A key issue requires urgent integration into the strategic framework—the emergence and dissemination of…

[Perspectives] Caring for the caregivers

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00763-4/fulltext?rss=yes

Published: April 25, 2026 00:00

Laura Mauldin's latest book begins with a story of falling in love. “I was the one”, she recalls of the start of her relationship with “J”. When J is diagnosed with leukaemia, Mauldin becomes not only her “life partner” but also her sole “life-support…

[Correspondence] Semaglutide, weight loss, and cardiovascular outcomes in the SELECT trial – Authors' reply

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00706-3/fulltext?rss=yes

Published: April 25, 2026 00:00

We thank Justin Tondt and Vernon M Chinchilli for their comments on our analyses of the relationship between adiposity measures and major adverse cardiovascular event (MACE) benefit from semaglutide in the SELECT trial. To explore evidence for weight…

[Correspondence] Unusual measles mortality in Bangladesh signals an immunisation emergency

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00687-2/fulltext?rss=yes

Published: April 20, 2026 22:30

Bangladesh is experiencing a measles resurgence with unprecedented numbers of severe paediatric cases. As of March 30, 2026, nationwide deaths increased to at least 38 children, including 32 deaths in March alone.1 The clinical pressure on hospitals is…

[Articles] Clinical and bacteriological effectiveness of three different short-course antibiotic regimens and single-dose fosfomycin for uncomplicated lower urinary tract infections in women (SCOUT): a pragmatic, multicentre, open-label, randomised clinical trial

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02171-3/fulltext?rss=yes

Published: April 20, 2026 11:30

Nitrofurantoin was the most effective treatment and single-dose fosfomycin the least effective treatment for UTIs. Adverse events were mild. The role of fosfomycin as a first-line antibiotic for uncomplicated UTI should be re-evaluated.

[Comment] Treatment of uncomplicated lower urinary tract infections in women

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02269-X/fulltext?rss=yes

Published: April 20, 2026 11:30

Lower urinary tract infections (UTIs; cystitis) are very frequent: at least 50% of women will have at least one episode during their lifetime, and many have more than one episode,1 making it a frequent reason for antibiotic prescription. Uncomplicated…

[Perspectives] Refiloe Masekela: building access to care for childhood lung disease

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00713-0/fulltext?rss=yes

Published: April 18, 2026 00:00

“In the 2000s, when the AIDS pandemic hit South Africa, we were seeing a lot of children dying from HIV. That was just before antiretroviral treatment had become fully accessible for people in the state sector”, recalls Refiloe Masekela, a paediatric…

[Correspondence] Rocatinlimab atopic dermatitis in two global phase 3 clinical trials

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00502-7/fulltext?rss=yes

Published: April 18, 2026 00:00

The study1 by Emma Guttman-Yassky and colleagues represents an important and innovative contribution to the evolving treatment landscape of moderate-to-severe atopic dermatitis, particularly by targeting OX40. Use of a placebo and allowance of rescue…

[Perspectives] On a heating planet, do humans and corals face a shared risk?

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00714-2/fulltext?rss=yes

Published: April 18, 2026 00:00

Corals have long captured the medical imagination. As Earth heats up, we might want to take our linked fates more seriously. It is easy to see how rising temperatures threaten humans and corals alike. Researchers initially dismissed the idea that carbon…

[Correspondence] Scheduled birth at term: benefit or trade-off? – Authors' reply

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00496-4/fulltext?rss=yes

Published: April 18, 2026 00:00

David Baud and colleagues are right to consider context and how their clinical setting compares with that where the trial was done. However, we maintain that personalised timing of birth for women at increased risk of pre-eclampsia is an intervention that…

[Correspondence] Parkinson's disease: extending collaboration to Latin America

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00638-0/fulltext?rss=yes

Published: April 18, 2026 00:00

We read with enthusiasm the Comment1 by Andrew Singleton and colleagues about the role of international collaboration in advancing understanding of Parkinson's disease biology. The identification of GBA1 as a major risk factor for Parkinson's disease in…

[Perspectives] Demon Copperhead and the reach of social realism

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00715-4/fulltext?rss=yes

Published: April 18, 2026 00:00

In a 1963 LIFE magazine interview, writer James Baldwin captured why books make us feel less alone: “You think your pain and your heartbreak are unprecedented in the history of the world”, he reflected, “but then you read. It was Dostoevsky and Dickens who…

[Correspondence] Structural erosion of epidemiology and Japan's next generation

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00644-6/fulltext?rss=yes

Published: April 18, 2026 00:00

Japan's scientific standing has faced a quiet crisis over the past two decades. Although it maintained high absolute research and development spending, Japan's global share of the top 10% of highly cited papers plummeted from fourth in the early 2000s to…

[Correspondence] Doorstep delivery outpaces continuity: Tamil Nadu's NCD care

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00639-2/fulltext?rss=yes

Published: April 18, 2026 00:00

We read with interest the World Report by Dinesh C Sharma on Makkalai Thedi Maruthuvam (MTM, which translates as Reaching out Health Services to People), describing the expansion of doorstep delivery for non-communicable disease (NCD) care in Tamil Nadu,…

[Correspondence] Meta-analyses of biased RCTs give biased results, even on individual data

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00548-9/fulltext?rss=yes

Published: April 18, 2026 00:00

We strongly disagree with Guo and colleagues,1 who suggest an overall benefit from blood pressure targets of less than 120 or 130 mm Hg. It would be surprising for this conclusion to be true given that there is currently no randomised controlled trial…

[Correspondence] Meta-analyses of biased RCTs give biased results, even on individual data – Authors' reply

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00549-0/fulltext?rss=yes

Published: April 18, 2026 00:00

We thank François Gueyffier and colleagues for their thoughtful comments on our Article.1 We believe that academic discussions are essential for advancing knowledge, and their feedback is of great importance to us. We welcome the opportunity to engage in…