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The science of rejuvenation biotechnology. Advocacy for longer, healthier lives.
Site URL: www.fightaging.org
Feed URL: www.fightaging.org/feed
Posts: 22
Followers: 2
Platelet Factor 4, an Interesting Target for Modest Rejuvenation of the Aging Brain
Published: April 18, 2025 10:21
The ability of PF4 to reduce chronic inflammation and restore some degree of lost function in the aging brain has been a topic of interest for a few years now. We'll likely be hearing much more in the years ahead as researchers move from investigation to…
Transfer RNA May Allow Early Detection of Parkinson's Disease via Blood Test
Published: April 18, 2025 10:11
Given sufficient sensitivity and the right target, many age-related conditions could be detected in their earliest, pre-symptomatic stages. Early detection offers a greater opportunity to change course to slow progression, even with the techniques of…
A Study of OneSkin's Topical Senotherapeutic OS-1 on Skin Function
Published: April 17, 2025 18:22
Senescent cells accumulate with age in all tissues, including skin. These errant cells secrete inflammatory signals that degrade tissue structure and function when sustained for the long term. OneSkin is one of the earlier longevity industry companies,…
Particular Air Pollution Exposure Correlates with Worse Cognitive Function
Published: April 17, 2025 10:22
A sizable body of evidence demonstrates that exposure to particulate air pollution correlates with an increased risk of neurodegenerative conditions and cognitive decline with age. The most plausible biological explanations revolve around the harmful…
Exposure to Air Pollution Increases Frailty Risk
https://www.fightaging.org/archives/2025/04/exposure-to-air-pollution-increases-frailty-risk/
Published: April 17, 2025 10:04
The evidence for long term exposure to forms of air pollution to increase the risk of age-related disease and mortality is quite compelling, including large studies in very similar populations with different levels of exposure. The important underlying…
It is Never Too Late to Take Up Exercise, Even When Hypertensive
Published: April 16, 2025 18:54
There may be a tendency for the unfit to look at the fit and feel somewhat hopeless, that a mountain lies between where they stand in unfitness and any benefits that might result from exercise. In fact, the data on exercise and measures of health suggests…
Senescent Endothelial Cells Contribute to Atherosclerosis via CAP1 Signaling
Published: April 16, 2025 10:22
The inflammatory signaling produced by senescent cells is harmful when sustained over the long term, and the number of these cells grows with age. Much of the signaling produced by cells is carried in extracellular vesicles, and here researches identify…
Tim-3 Inhibition in Microglia Encourages Amyloid Clearance in the Brain
Published: April 16, 2025 10:11
The immune system of the central nervous system is distinct from that of the rest of the body, although there is a great deal of direct and indirect cross-talk between the two. The innate immune cells known as microglia are the central nervous system…
Elastin Expression May Reduce Cellular Senescence via Interactions with Mitochondria
Published: April 15, 2025 18:22
Elastin is an important component of the extracellular matrix in flexible tissues. It is, as the name might suggest, necessary for tissue elasticity. Elastin fibers in the extracellular matrix become damaged with age, and this process is thought to be…
Cell and Rejuvenation Therapies as a Basis to Treat Neurodegenerative Conditions
Published: April 15, 2025 10:22
We might think of medicine as largely a matter of exerting control over cells, beginning with changing their behavior in defined ways, and moving on to creating cells and complex structures made of cells as needed. For all that this is an age of…
Data Suggests Wealthier People Do More to Maintain their Health
Published: April 15, 2025 10:11
Researchers here look at differences in life expectancy by income over the period of time in which obesity emerged to became a major issue. Recall that income, wealth, status, education, intelligence, and life expectancy all tend to correlate with one…
Reviewing Current Options for the Upregulation of Neurogenesis in the Context of Aging and Alzheimer's Disease
Published: April 14, 2025 18:18
Neurogenesis is the process by which new neurons are created from neural stem cell populations, then mature, migrate, and integrate into neural circuits. This is necessary for memory, learning, normal tissue maintenance in the brain, and the small degree…
Results from the PEARL Trial of Rapamycin
https://www.fightaging.org/archives/2025/04/results-from-the-pearl-trial-of-rapamycin/
Published: April 14, 2025 10:22
The PEARL trial of rapamycin was crowdfunded by Lifespan.io, something that we should see happen more often, at a much larger scale, for all of the presently available low-cost treatments that might influence aging. While results were initially published…
Planarians Undergo Rejuvenation When Regrowing Lost Tissues
Published: April 14, 2025 10:01
Some lower animal species are capable of exceptional feats of regeneration. Planarians are capable of regrowing an entire new body after being cut in half, for example. One way of thinking about this is that some of these species blur the line between…
Fight Aging! Newsletter, April 14th 2025
https://www.fightaging.org/archives/2025/04/fight-aging-newsletter-april-14th-2025/
Published: April 13, 2025 10:55
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested…
Structural Features of DNA Differ Between Short-Lived Rats and Long-Lived Blind Mole Rats
Published: April 11, 2025 18:20
Which gene sequences are actively read by transcription machinery in the cell nucleus to produce RNA (some of which is then translated into proteins) is determined by the structure of nuclear DNA. The various assemblies of proteins making up that…
β-hydroxy-β-methylbutyrate Improves Health and Slightly Extends Life Span in Flies
Published: April 11, 2025 10:22
It is always interesting to see data on life span in short lived species for an intervention with a fair amount of human data for health benefits. The broad pattern is that short-lived species exhibit a much greater extension of life in response to…
Calorie Restriction and Calorie Restriction Mimetic Drugs Restore More Youthful Lipid Metabolism
Published: April 11, 2025 10:11
The practice of calorie restriction improves health and extends life, though the effect on life span is much larger in short-lived species such as mice than in long-lived species such as humans. Researchers here focus on changes in lipids in mice that…
IGF-1 Expression in Skin Can Drive Age-Related Hair Loss
Published: April 10, 2025 18:25
Aging is an accumulation of damage and dysfunction, but a quite specific collection of forms of damage and dysfunction. One can create conditions that look like premature aging, or very selective forms of premature aging of specific tissues and organs,…
Chronic Inflammation is Central to Aging
https://www.fightaging.org/archives/2025/04/chronic-inflammation-is-central-to-aging/
Published: April 10, 2025 10:22
While short-term inflammation is useful and necessary, such as in the response to infection or injury, that same inflammatory signaling sustained over the long term becomes harmful. It becomes disruptive to tissue structure and function, altering the…
Shingles Vaccination Correlates with Lower Dementia Risk
Published: April 10, 2025 10:07
Why would people who underwent shingles vaccination in later life exhibit a lower risk of later developing dementia? Firstly, one has to elect to take this vaccine, and so this could be selecting for people who tend to take better care of their health, and…
Extracellular Vesicles from the Brain Promote Regeneration Without Scarring in Skin
Published: April 9, 2025 18:44
Research can be interesting even if the future development of therapies based on that research seems challenging. Today's open access paper is chiefly interesting for its outline of the developmental and ongoing relationship between skin and the brain, and…