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The science of rejuvenation biotechnology. Advocacy for longer, healthier lives.
Site URL: www.fightaging.org
Feed URL: www.fightaging.org/feed
Posts: 16
Followers: 2
Reviewing What is Known of the Ability of Reduced Protein Intake to Slow Aging
Published: August 7, 2026 18:09
Reduced protein intake is robustly demonstrated to improve long-term health and slow aging in animal studies, and the human evidence is supportive. Many of the sensors and triggers of the beneficial metabolic response to fasting and other forms of calorie…
Finding Commonalities in the Response to Different Calorie Restriction Mimetic Drugs
Published: August 7, 2026 10:22
Calorie restriction mimetic drugs reproduce some (usually small) fraction of the beneficial metabolic changes that take place with a reduced calorie intake. An increase in the efficiency of the cellular maintenance processes of autophagy appears to be the…
Non-Thyroidal Illness Syndrome in the Context of Metabolism and Aging
Published: August 7, 2026 10:11
The major hormones produced by the thyroid gland are broadly influential on metabolism and the function of many organs, and thyroid dysfunction is common enough in later life for this aspect of human biochemistry to be very well studied. A range of…
Anti-Aging Medicine, a Small Specialty, Will Spread in Some Form to the Whole of Medicine
Published: August 6, 2026 18:11
Anti-aging medicine has long been a small specialty field of practice culturally adjacent to sports medicine, but considerably less rigorous and more derided by the mainstream. The present development of a longevity industry, based on means to slow and…
How Important is Chronic Inflammation to the Progression of Aging?
Published: August 6, 2026 10:22
Questions regarding the relative importance of different mechanisms and dysfunctions to the progression of aging and eventual mortality are hard to answer definitively. Even given a straightforward class of therapies to target one specific mechanism of…
Exosome Therapy Reduces Scarring and Heart Failure Following a Heart Attack
Published: August 6, 2026 10:01
The heart regenerates poorly in comparison to other tissues, and the maladaptive inflammation that occurs following a heart attack does not help the situation. Fibrosis and scarring occurs in inflamed heart tissue, causing loss of function and heart…
Senescent Cell Inflammatory Signaling is Inhibited by Targeting SLC25A1
Published: August 5, 2026 18:23
Cells become senescent throughout life, because of stress or damage or reaching the Hayflick limit on replication, but senescent cells only begin to accumulate with age. When a cell becomes senescent, it grows in size, ceases to replicate, and turns its…
Time Restricted Feeding Improves Muscle Function in Middle-Aged Mice
Published: August 5, 2026 10:22
Researchers here restricted old mice to eating only during the 12 hours of the day in which they are usually inactive or asleep, for three days every week, and continued this restriction for a period of 8 weeks. The mice placed on time restricted feeding…
A New Pace of Aging Clock Derived from the Framingham Heart Study Offspring Cohort
Published: August 5, 2026 10:11
Aging clocks of many varieties have been produced in recent years by applying machine learning techniques to a wide range of biological data that changes with age. This approach yields a tool that is disconnected from our understanding of the mechanisms of…
PhenoAge Acceleration Correlates with Higher Mortality Risk Following Surgery
Published: August 4, 2026 18:22
A broad variety of aging clocks have been created in recent years. Such a clock is produced via machine learning techniques applied to any sufficiently complex set of biological data that tends to change with age. Everything from imaging to blood chemistry…
A Novel Senolytic Combination Incorporating Low Dose Navitoclax
Published: August 4, 2026 10:22
Navitoclax (or ABT-263) was one of the earliest chemotherapeutics assessed for its ability to selectively clear senescent cells as a senolytic drug. The side effects on platelet function are pronounced, which is probably why it has received less attention…
Clostridium Scindens in the Centenarian Gut Microbiome Reduces the Impact of Intestinal Aging
Published: August 4, 2026 10:11
The ability to accurately determine the composition of the gut microbiome via 16S rRNA sequencing is resulting a great deal of very interesting data on differences in the gut microbiome that are characteristic of aging, age-related diseases, and long-lived…
Reviewing the Present State of Development of Senomorphic Therapies
Published: August 3, 2026 18:39
Senescent cells accumulate with age and contribute to degenerative aging via their pro-growth, pro-inflammatory signaling. Even when less than 1% of all cells are senescent in a tissue, the signaling generated by those senescent cells alters the behavior…
Differences by Sex Observed in BCL-2/BCL-xL Senolytic Treatment for Intervertebral Disc Degeneration
Published: August 3, 2026 10:22
A number of prevalent age-related conditions are notably different in timing and progression between the sexes. No doubt the list of differences by sex will grow as the research community explores the first therapies that target important mechanisms of…
The Cribriform Plate Path for Cerebrospinal Fluid Drainage Also Has a Glymphatic System
Published: August 3, 2026 10:11
Cerebrospinal fluid drainage from the brain into the body is necessary to remove metabolic waste from the brain. The flow declines with age, and evidence strongly suggests that this is an important contribution to the build up of protein aggregates and…
Fight Aging! Newsletter, August 3rd 2026
https://www.fightaging.org/archives/2026/08/fight-aging-newsletter-august-3rd-2026/
Published: August 2, 2026 13:05
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested…