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The science of rejuvenation biotechnology. Advocacy for longer, healthier lives.
Site URL: www.fightaging.org
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Posts: 31
Followers: 2
Recombinant FGF19 as a Treatment to Increase Muscle Strength
Published: November 14, 2025 19:51
A number of approaches to inducing muscle growth or improving muscle strength have been demonstrated in laboratory animals, in early human clinical trials, and in recent years employed in medical tourism clinics. These approaches are compensatory in the…
High Cumulative Blood Pressure Correlates with a Sizable Increase in Dementia Risk
Published: November 14, 2025 11:22
The raised blood pressure of hypertension is damaging to sensitive tissues throughout the body, but particularly the brain. Alongside many other issues in the health and function of the vascular system, hypertension increases the pace of rupture of tiny…
Elastin-like Recombinamers Enable Regrowth of Damaged Enamel
Published: November 14, 2025 11:11
Provoking regrowth of tooth enamel by mimicking some of its structure appears to be a going concern in dental research, if judging from this paper and another similar approach using keratin. At the high level, the idea is to coat damaged enamel with…
The Endothelial-to-Mesenchymal Transition in the Aging of the Brain's Vasculature
Published: November 13, 2025 19:37
The aging of the blood vessels supplying the brain into a state of dysfunction provides an important contribution to the onset and progression of neurodegenerative conditions. There are many aspects to this vascular aging, including: loss of capillary…
NADP in the Cell Cytosol Influences Vascular Aging
https://www.fightaging.org/archives/2025/11/nadp-in-the-cell-cytosol-influences-vascular-aging/
Published: November 13, 2025 11:22
Nicotinamide adenine dinucleotide phosphate (NADP) has a different portfolio of functions in the cell to the better known nicotinamide adenine dinucleotide (NAD) that has been a focus for parts of the research community in recent years. NADP is thought to…
Minimally Invasive Delivery of Tissue Engineered Patches Promotes Regeneration of an Injured Heart
Published: November 13, 2025 11:19
Thin sheets of engineered artificial tissue can be readily manufactured because they do not require a vasculature, perfusion of fluids is sufficient to support the cells. For some years now, researchers have developed the capability to manufacture thin…
Further Investigation of PU.1 and Microglial Inflammation in the Aging Brain
Published: November 12, 2025 19:29
Microglia are innate immune cells resident in the brain. They are broadly similar in behavior to the macrophages found elsewhere in the body, with an added portfolio of duties relating to maintenance of the synaptic connections that link neurons to form…
Modest Levels of Exercise Slow Cognitive Decline in Early Alzheimer's Disease
Published: November 12, 2025 11:24
Epidemiological research has consistently demonstrated a sizable difference in outcomes between those who are sedentary and those who conduct even a modest, low level of physical activity. More exercise is better, of course, but some researchers have have…
Adipose Derived Stem Cell Therapy Encourages Regeneration of Bone Fractures
Published: November 12, 2025 11:04
Researchers here demonstrate a novel way of delivering stem cells as a therapy for bone fractures that occur in the context of osteoporosis, by forming spheroids of stem cells combined with a bone mineral scaffolding material. The approach appears to…
Manufacturing Advances are Key to the Further Development of Extracellular Vesicle Therapies
Published: November 11, 2025 18:48
Stem cell therapies have existed for a few decades now, and over that time have moved from experimental use for many conditions in the medical tourism industry to a much more formulaic, controlled use for some conditions in the more regulated markets such…
Progress Towards a Viable Heat Treatment for Dry Macular Degeneration
Published: November 11, 2025 11:22
Macular degeneration is a progressive blindness caused by forms of age-related damage that disable and destroy cells of the retina, such as the accumulation of persistent forms of metabolic waste. The dry variant of macular degeneration, in which there is…
Chaperone Mediated Autophagy is Necessary for for Brown Adipose Tissue Function
Published: November 11, 2025 11:09
Brown adipose tissue conducts thermogenesis and its activities have been found to be beneficial to the operation of metabolism. Thus a greater proportion of brown adipose tissue versus other types of fat tissue is protective in the context of aging.…
Glial Cell Dysfunction, Both Cause and Consequence of Brain Aging
Published: November 10, 2025 18:47
The broad category of glial cell includes all of the cells making up the nervous system that are not neurons. This includes the innate immune cells known as microglia, the astrocytes that manage brain metabolism and make up much of the brain's structure,…
Reviewing the Mechanisms of Muscle Aging Leading to Sarcopenia
Published: November 10, 2025 11:23
Aging begins long before evident loss of function arises. As researchers point out here, efforts to better map and intervene in the progression of these pre-symptomatic changes are not the primary focus of medical research and development. But attaining…
CCNA2 Expression Promotes Regeneration in Older Heart Muscle
Published: November 10, 2025 11:04
Researchers here find a potential way to induce greater regeneration in injured heart muscle, normally a tissue that regenerates only poorly following damage, and particularly so in older individuals. Inducing CCNA2 expression appears to promote…
Fight Aging! Newsletter, November 10th 2025
https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-november-10th-2025/
Published: November 9, 2025 12:15
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested…
Results from a Human Trial of Magnetic Mitohormesis
https://www.fightaging.org/archives/2025/11/results-from-a-human-trial-of-magnetic-mitohormesis/
Published: November 7, 2025 19:51
The use of electromagnetic fields to manipulate cellular biochemistry in favorable ways is a field very much in its infancy in comparison to the well established use of small molecule drugs. At the high level, it is quite similar to exploration with small…
Persistent Infection Correlations with Increased Risk of Cardiovascular Disease
Published: November 7, 2025 11:22
There is considerable debate over the degree to which persistent viral infections contribute to neurodegenerative conditions such as Alzheimer's disease. If persistent viral infection causes generalized pathology over time, such as via increased chronic…
Inflammation and Maladaptive Extracellular Matrix Remodeling in the Aging Heart
Published: November 7, 2025 11:11
Fibrosis is a feature of aging, in which the normal processes of tissue maintenance run awry and scar-like structures form to disrupt tissue structure and function. The proximate cause is altered behavior on the part of fibroblast cells that largely…
Is Herpes Simplex Virus Type 1 an Important Contribution to Alzheimer's Disease Risk?
Published: November 6, 2025 18:11
A growing body of literature is associated with the debate over whether persistent viral infection provides a significant contribution to Alzheimer's disease and other neurodegenerative conditions. Some viruses, such as varieties of herpes simplex virus…
A Profile of Sirtuins 1, 3, and 6 in Aging Humans
https://www.fightaging.org/archives/2025/11/a-profile-of-sirtuins-1-3-and-6-in-aging-humans/
Published: November 6, 2025 11:22
Sirtuins are involved in the regulation of metabolism in various ways, and are clearly quite important to cell function as their structure is very similar in species as divergent as yeast, flies, and humans. Sirtuin 1 as a target for interventions in aging…
Aging of the Gut Microbiome as a Contribution to Inflammation and Neurodegeneration
Published: November 6, 2025 11:11
Here find a review of what is known of the ways in which age-related changes in the gut microbiome can contribute to the chronic inflammation of aging and development of neurodegenerative conditions. The ability to accurately map the composition of the gut…
Inhibiting CXCL1-CXCR2 Interactions Slows the Progression of Heart Failure in an Animal Model
Published: November 5, 2025 19:32
Heart failure is the name given to a category of dysfunctions in which the heart cannot pump enough blood to sustain the body. It is characterized by structural changes in heart muscle, some of which are maladaptive, some of which are compensatory, and a…
The Potential for Stem Cell Derived Extracellular Vesicles to Treat Neurodegenerative Conditions
Published: November 5, 2025 11:22
A major trend in the world of stem cell therapies is the replacement of stem cell transplantation with the use of extracellular vesicles derived from those stem cells. Extracellular vesicles are much more easily managed as a basis for therapy, they are…
The Inherited Benefits of Ancestral Life-Extending Stresses Diminish Over Generations
Published: November 5, 2025 11:11
That offspring inherit epigenetic patterns of modifications to gene expression that reflect the environmental exposures of their parents was a relatively recent discovery. The evolutionary world is just a little bit Lamarkian, in that the ability to steer…
The Brain-Joint Axis, Bidirectional Relationships Between Neurodegeneration and Osteoarthritis
Published: November 4, 2025 19:22
Osteoarthritis is a prevalent degenerative joint disorder, in which cartilage and underlying bone becomes worn and damaged, while the normal processes of repair (even limited as they are in cartilage tissue) are impaired by aging. Neurodegenerative…
Reducing the Presence of Neutrophil Extracellular Traps as an Approach to Treat Vascular Aging
Published: November 4, 2025 11:22
One of the ways in which the immune cells known as neutrophils attack pathogens is to release structures called neutrophil extracellular traps into the intracellular environment. These traps can disable pathogens, but like much of the activity of the…
SAPS3 Inhibition in Mice Increases AMPK to Modestly Improve Metabolism and Slows Aging
Published: November 4, 2025 11:11
Researchers here report on a novel approach to slow aging and extend life in mice by interfering in the activity of a protein involved in the regulation of metabolism. The researchers find that SAPS3 expression increases with age, and deletion of this gene…
The Longevity-Associated Variant of BPIFB4 Can Be Provided Orally to Produce Benefits in Mice
Published: November 3, 2025 18:55
Proteins are largely quite delicate structures dependent on being manufactured and correctly folded and localized inside a cell. Thus no-one tries to make recombinant proteins or deliver them as a therapy for the vast majority of proteins. The exceptions…
Diluting Dietary Calorie Intake with Non-Digestible Fiber Slows Aging in Mice
Published: November 3, 2025 11:22
Researchers here demonstrate that diluting calorie intake with non-digestible fiber produces similar outcomes in the health and longevity of mice as does moderate calorie restriction. The researchers also combined this intervention with exome matching of…
Amyloid-β Aggregation Disrupts Circadian Rhythm in Supporting Cells in the Brain
Published: November 3, 2025 11:11
A fair sized body of evidence shows that circadian rhythm, the daily cycle of changed gene expression and behavior in cells, is important to tissue function but becomes disrupted with age and age-related disease. The regulation of circadian rhythm is…