Tips for Biostatisticians Collaborating with Non-Biostatistician Medical Researchers
https://fharrell.com/talk/collab/
Published: July 30, 2024 05:00
Slides
🦜 Statistical Thinking
@www.fharrell.com@rss-parrot.net
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Welcome to my blog! Here I write content about statistics, clinical trials, R, and much more.
Site URL: www.fharrell.com
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Posts: 10
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Rare Degenerative Diseases & Statistics:Methods for Analyzing Composite Patient Outcomes
https://fharrell.com/talk/cons/
Published: July 11, 2024 05:00
Event: Consilium Scientific Slides
Ordinal State Transition Models as a Unifying Risk Prediction Framework
https://fharrell.com/talk/icsa/
Published: June 17, 2024 05:00
Event: International Chinese Statistical Association Applied Statistics Symposium, Nashville, Tennessee USA Slides
Traditional Frequentist Inference Uses Unrealistic Priors
https://fharrell.com/post/uprior/
Published: June 10, 2024 04:00
Background Consider these four conditions: There is no reliable prior information about an effect and an uninformative prior is used in the Bayesian analysis There is only one look at the data The look was pre-planned and not data-dependent A one-sided…
Borrowing Information Across Outcomes
https://fharrell.com/post/yborrow/
Published: April 30, 2024 05:00
Background As explained here, the power for a group comparison can be greatly increased over that provided by a binary endpoint, with greater increase when an ordinal endpoint has several well-population categories or has a great many categories, in which…
Proportional Odds Model Power Calculations for Ordinal and Mixed Ordinal/Continuous Outcomes
https://fharrell.com/post/pop/
Published: April 22, 2024 05:00
Background A binary endpoint in a clinical trial is a minimum-information endpoint that yields the lowest power for treatment comparisons. A time-to-event outcome, when only a minority of subjects suffer the event, has little power gain over a pure binary…
The log-rank Test Assumes More Than the Cox Model
https://fharrell.com/post/logrank/
Published: March 28, 2024 05:00
Background The log-rank test is a Mantel-Haenszel “observed - expected frequency” type of test that was derived in a slightly ad hoc way by Nathan Mantel in 1966 and named the logrank test by R Peto and J Peto in 1972. It was later derived as the rank test…
What Does a Statistical Method Assume?
https://fharrell.com/post/assume/
Published: March 23, 2024 05:00
A Definition All statistical procedures have assumptions. Even the most simple response variable (Y) where the possible values are 0 and 1, when analyzed using the proportion that Y=1, assumes that Y is truly binary, every observation has the same…
Modernizing Clinical Trial Design and Analysis to Improve Efficiency & Flexibility
https://fharrell.com/talk/rcteff/
Published: March 14, 2024 05:00
UCLA Cardiology Grand Rounds 2020-10-23 | Video (better video below) Vanderbilt University Department of Biostatistics 2020-11-18 Vanderbilt Translational Research Forum 2021-11-04 | Video Consilium Scientific 2024-03-14 Slides
Overview of Composite Outcome Scales & Statistical Approaches for Analyzing Them
https://fharrell.com/talk/cos/
Published: January 30, 2024 06:00
Slides Elaborations Video