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((Triple Negative Breast Neoplasmspathology[MAJR])): Latest results from PubMed
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RAB7A-enriched extracellular vesicles drive early-metastasis and immune evasion in triple-negative breast cancer
Published: October 23, 2026 10:00
Early-metastatic triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer and responds poorly to immunotherapy. However, mechanisms of metastasis or immune evasion remain incompletely understood. This study demonstrates that…
Developing a Ferric(III) Agent for Targeted Inhibition of Growth and Metastasis of Triple-Negative Breast Cancer Based on Human Serum Albumin by Chemodynamic Therapy-Driven Synergistic Therapy
Published: October 23, 2026 10:00
Triple-negative breast cancer (TNBC) remains challenging due to its aggressiveness and the lack of targeted therapies. In this study, we proposed designing a ferric (Fe) agent based on human serum albumin (HSA) for chemodynamic therapy-driven synergistic…
Large Language Model Framework for Structured Biomarker Extraction and Triple-Negative Breast Cancer Identification From Pathology Reports: Development and Evaluation Study
Published: October 23, 2026 10:00
CONCLUSIONS: Using prompt-engineering techniques based on LLMs proved to be an efficient method of translating unstructured breast cancer pathology reports into structured clinical information. Moreover, it can be used to accurately identify the TNBC…
Direct S,S Coordination Suppresses Pt(II)-Thiol Reactivity to Mitigate Nephrotoxicity and Enable Chemo-Photodynamic Therapy against Metastatic Triple-Negative Breast Cancer
Published: October 23, 2026 10:00
Platinum chemotherapy is limited by the thiol reactivity of Pt(II), which promotes interactions with sulfur-containing biomolecules, causing nephrotoxicity and drug deactivation while providing limited efficacy against metastatic disease. Here, we show…
Age-related survival gaps in triple-negative breast cancer: a 10-year real-world analysis
Published: October 23, 2026 10:00
Triple-negative breast cancer (TNBC) is characterized by aggressive biological behavior and poor prognosis. While multimodal treatment is standard, it is frequently withheld from older adults. We evaluated age-related gaps in diagnosis, treatment, and…
Mitochondria-Targeted Prodrug Nanoassemblies Elicit Antitumor Immunity via Mitophagy-Boosted Ferroptosis in Triple-Negative Breast Cancer
Published: October 23, 2026 10:00
Ferroptosis, an immunogenic iron-dependent cell death driven by lipid peroxidation, holds promise for treating triple-negative breast cancer (TNBC). However, its efficacy is severely compromised by restricted iron availability and the potent GPX4/GSH…
Combination Therapeutic Effect of Psoralen and Paclitaxel-Loaded Superparamagnetic Iron Oxide Nanoparticles for the Treatment of Triple-Negative Breast Cancer
Published: October 22, 2026 10:00
CONCLUSION: P/P-TCNs facilitate the synchronized, safe, and highly efficient co-delivery of PTX and PSO. By maximizing nanocarrier‑facilitated combinatorial anti-TNBC efficacy while minimizing off-target toxicity, this biocompatible magnetic nanoplatform…
Single-cell and spatial transcriptomics reveal that THBS1 induces radiation resistance in TNBC through the interaction between myCAF and TOPBP1⁺ tumor cells
Published: October 21, 2026 10:00
CONCLUSIONS: THBS1 plays a pivotal role in mediating radioresistance in triple-negative breast cancer, positioning it as a promising therapeutic target.
PRKAR2A/RIIα as a candidate spatial cAMP-PKA signal router in triple-negative breast cancer metastasis: evidence boundaries, competing models and decisive experiments
Published: October 20, 2026 10:00
Metastatic relapse remains the principal lethal event in triple-negative breast cancer (TNBC), yet the contribution of PRKAR2A, which encodes the type IIα regulatory subunit (RIIα) of protein kinase A (PKA), remains unresolved. RIIα creates a mechanistic…
Sorting nexin 10 promotes triple-negative breast cancer progression through modulating cholesterol biosynthesis via stabilizing SREBP2
Published: October 19, 2026 10:00
CONCLUSION: SNX10 promoted TNBC progression through the regulation of cholesterol biosynthesis, which was mediated by interaction with SREBP2 and maintenance of its stability. SNX10 may be an effective therapeutic target for TNBC, and our study provides…
Identification of a novel inflammatory mast cell subpopulation in triple-negative breast cancer
Published: October 17, 2026 10:00
CONCLUSIONS: We identified an inflammation-associated mast cell subpopulation (C4) that may contribute to TNBC progression, providing a potential target for future therapeutic exploration.
Distinct Mitochondrial Recovery Dynamics Following Taxol Removal in Triple-Negative Breast Cancer Cells
Published: October 16, 2026 10:00
Drug resistance in TNBC is associated with metabolic plasticity, yet little is known about how mitochondrial and cellular states evolve after chemotherapeutic withdrawal. We used optical redox imaging (ORI) microscopy and complementary functional…
Deoxythymidylate Kinase (DTYMK)-Driven Pyrimidine Hypermetabolism Is Associated with a Folate-Dependent Macrophage Programme in Triple-Negative Breast Cancer
Published: October 16, 2026 10:00
Immune checkpoint blockade benefits only a minority of patients with triple-negative breast cancer (TNBC), and the tumour-intrinsic programmes that establish its immunosuppressive microenvironment remain poorly defined. Pyrimidine metabolism supplies…
Integrative multi-omics analysis identifies CCDC69 as a marker associated with germinal center B-cell infiltration in TNBC: development and validation
Published: October 15, 2026 10:00
Although coiled-coil domain containing 69 (CCDC69) has been implicated in tumor biology, its role in triple-negative breast cancer (TNBC) and immune regulation remains unclear. Bulk transcriptomic data, single-cell RNA sequencing datasets, and spatial…
Peptide surface structure flexibility controls gold nanoparticle uptake in triple-negative breast cancer cells
Published: October 15, 2026 10:00
Peptide-functionalized gold nanoparticles (AuNPs) provide a model for decoding how the surface-bound secondary structure regulates nano-bio interactions. AuNPs (30-40 nm) coated with small peptides, GSH, ECECG, GSSG and cyclic CEIEIEC exhibited a…
Non-Canonical Modulation of Vitamin D Receptor Signaling by Paclitaxel in Triple-Negative Breast Cancer
Published: October 14, 2026 10:00
Triple-negative breast cancer (TNBC) is characterized by a highly aggressive phenotype and limited therapeutic options. This study investigated whether the vitamin D receptor (VDR) modulates aggressiveness and chemotherapeutic response in TNBC and explored…
Targeting Integrins in Triple Negative Breast Cancer: Therapeutic Potential of Monoclonal Antibodies, PARP Inhibitors, Synthetic Peptides, and Aptamers
Published: October 13, 2026 10:00
Triple-negative breast cancers (TNBCs) are associated with poor prognosis and chemoresistance. Recent reports indicate that extracellular matrix (ECM) molecules, such as integrins, could influence TNBC development. Integrins are adhesion macromolecules…