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((Triple Negative Breast Neoplasmspathology[MAJR])): Latest results from PubMed
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Tumour specific HORMAD1 expression perturbs mitotic arrest and drives sensitivity to mitotic kinase inhibitors
Published: March 12, 2026 10:00
HORMAD1 expression is usually restricted to germ-line cells but is also aberrantly expressed in 60% of triple-negative breast cancers (TNBCs), where it is bi-modally expressed and associated with genomic instability. Here, we show that out-of-context…
Regulation of Cell Function and Myeloid-Derived Suppressor Cell Chemotaxis by hsa_circ_0006466-miR-1286-PDGFRA/B Axis in Triple Negative Breast Cancer
Published: March 11, 2026 10:00
CONCLUSIONS: Our study identifies hsa_circ_0006466 as an immune-related circRNA in TNBC, functioning as a ceRNA to sponge miR-1286 and upregulate PDGFRA/B expression, thereby promoting MDSC-mediated immunosuppression and TNBC progression. Targeting this…
Melatonin inhibits FAK signaling to suppress PD-L1 expression and enhance chemosensitivity in triple-negative breast cancer
Published: March 9, 2026 10:00
CONCLUSIONS: Melatonin suppresses TNBC progression by inhibiting proliferation and migration and by modulating the immune microenvironment through the FAK-PD-L1 axis. These findings highlight melatonin as a potential low-toxicity adjunct to enhance the…
CEBPB-high dormant tumor cells drive immune evasion via S100A8 orchestrated tumor-associated macrophages reprogramming
Published: March 9, 2026 10:00
CONCLUSIONS: Our study demonstrate a mechanistic link between tumor dormancy and immune evasion, highlighting the CEBPB-S100A8 axis as a promising therapeutic target to potentiate ICB efficacy in TNBC.
Primary SMARCA4-deficient triple-negative breast cancer: report of a case
Published: March 8, 2026 10:00
SMARCA4缺陷型肿瘤是一类具有独特分子特征和侵袭性临床行为的恶性肿瘤，最常见于胸部（纵隔/肺）和卵巢等，发生在乳腺的SMARCA4缺陷型肿瘤非常罕见。本文报道1例发生于26岁女性的SMARCA4基因第12~14号外显子大片段缺失的三阴性浸润性乳腺癌，探讨其临床病理和分子特征，以提高对该肿瘤的认识。.
FGFR1 mRNA expression in different molecular subtypes of breast cancer
Published: March 8, 2026 10:00
Objective: To investigate FGFR1 mRNA expression and gene characteristics in breast cancer tissue. Methods: Breast cancer samples from 45 female patients (10 HER2-positive, 15 triple-negative and 20 HR-positive/HER2-negative cases) were collected from…
Correlation of STAT6 and HER2-low expression with clinicopathological features and prognosis in triple negative breast cancer
Published: March 8, 2026 10:00
Objective: To investigate the expression of STAT6 and HER2 in triple negative breast cancer (TNBC) and their relationship with clinicopathological features and prognosis. Methods: A total of 189 TNBC samples, including 32 cases with tumor and surrounding…
A phase II study of atezolizumab in combination with stereotactic radiation for patients with triple-negative breast cancer and brain metastasis
Published: March 7, 2026 11:00
CONCLUSIONS: Concurrent SRS with atezolizumab was feasible in TNBC patients with brain metastases. However, disease outcomes were poor, and the development of effective therapies for these patients remains a significant unmet medical need.
Prognostic Significance of miR-145, NANOG, OCT4, and KLF4 in Triple-Negative Breast Cancer
Published: March 7, 2026 11:00
CONCLUSION: miR-145 and KLF4 are possible prognostic markers in TNBC. This was reflected by the positive correlations between miR-145 and both DFS and OS, and between KLF4 levels and DFS.
Denosumab Combined With PARP Inhibitors and Chemoradiotherapy for Treating Triple Negative Breast Cancer With Bone Metastasis: A Case Report
Published: March 7, 2026 11:00
CONCLUSION: This case suggests that the combination of denosumab with PARP inhibitors and chemoradiotherapy may provide a potential therapeutic strategy for TNBC patients with bone metastasis. Further studies are warranted to validate the efficacy and…
CXCL1 in triple‑negative breast cancer: Mechanisms, challenges, and therapeutic opportunities (Review)
Published: March 6, 2026 11:00
Triple negative breast cancer (TNBC) is an aggressive BC subtype with limited therapeutic options and poor clinical outcomes. This subtype accounts for 15‑20% of all BC cases and contributes to nearly 40% of BC mortalities. The chemokine C‑X‑C motif ligand…
Cost-effectiveness of sacituzumab tirumotecan in previously treated metastatic triple-negative breast cancer in China
Published: March 6, 2026 11:00
CONCLUSION: Sacituzumab tirumotecan was unlikely to be the cost-effective option for patients with metastatic TNBC compared with chemotherapy from the Chinese health-care system perspective, reduced the price of sacituzumab tirumotecan could increase its…
ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer
Published: March 3, 2026 11:00
Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapies and poor prognosis. Unc-51-like kinase 1 (ULK1), a central regulator of autophagy, has emerged as a potential therapeutic node in cancer but remains poorly…
Comprehensive genomic profiling of triple-negative breast cancer metastases identifies role of PKD1 in immunotherapy resistance
Published: March 2, 2026 11:00
The multi-omics data represented by genomic data from patients with metastatic triple-negative breast cancer (TNBC) is crucial for precision treatment, yet data on genomic alterations in metastatic cohorts and Chinese populations remains limited. We…
OGT-Mediated O-GlcNAcylation Stabilizes c-Myc Activity and Promotes Chemoresistance in Triple-Negative Breast Cancer
Published: March 2, 2026 11:00
The transcription factor c-Myc is often overexpressed in chemotherapy-resistant triple-negative breast cancer (TNBC). c-Myc function and stability are considered key factors regulating chemoresistance. Recent studies have revealed a potential link between…