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((Triple Negative Breast Neoplasmspathology[MAJR])): Latest results from PubMed

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The antimetastatic effects of calorie restriction are negated by voluntary exercise in an aggressive breast cancer mouse model

Published: April 28, 2026 10:00

The role of lifestyle interventions in treatment success has become essential for nearly every disease. Healthy dietary habits, regular exercise, and stress management are key pillars that can improve quality of life during treatment, as well as delay…

Vitexicarpin Directly Targets RSK2 to Attenuate Migration and Invasion of Triple-Negative Breast Cancer Through Modulating HIF-1α/MMP-9 Pathway

Published: April 27, 2026 10:00

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high metastatic potential and lacking effective treatment strategies. Vitexicarpin (VIT) has been reported to have excellent inhibitory effects on several types of cancer,…

Comprehensive analysis of prognostic characteristics based on T cell-mediated tumor killing related genes in triple negative breast cancer

Published: April 27, 2026 10:00

CONCLUSION: We constructed a robust prognostic model based on four T cell-mediated tumor killing (TTK)-related genes. Beyond predicting survival, this signature effectively decodes the immunosuppressive tumor microenvironment (TME) in TNBC, characterized…

Stage I Triple-Negative Breast Cancer: Moving From One-Size-Fits-All to a Personalized Approach

Published: April 24, 2026 10:00

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by lack of estrogen receptor expression, progesterone receptor expression, and human epidermal growth factor 2 overexpression/amplification. Given its generally…

Integrating bulk, single-cell, and spatial transcriptomics to identify a novel pyroptosis-related gene signature for predicting prognosis and tumor immune landscape in triple-negative breast cancer

Published: April 23, 2026 10:00

CONCLUSION: We developed a reliable PRG prognostic signature for TNBC. The signature genes demonstrate significant cellular and spatial heterogeneity within the TIME. They drive interactions between T cells and macrophages through the MIF pathway to…

Molecular subtypes of breast carcinoma and their association with clinicopathological parameters

Published: April 22, 2026 10:00

CONCLUSIONS: Luminal B was found to be the predominant molecular subtype. Molecular subtype had a significant association with grade and proliferation index.

Integrin Beta 4 Protein Expression Bimodally Predicts Sensitivity to CDK4/6 Inhibition and Resistance to Immunotherapy in Breast Cancer

Published: April 22, 2026 10:00

CONCLUSION: ITGB4 protein expression serves as a bimodal biomarker in breast cancer, predicting CDK4/6 inhibitor sensitivity in luminal subtypes while indicating immunotherapy resistance in TNBC. ITGB4 protein thus represents a critical biomarker for…

Advanced CD276-Targeting Dual-Payload Antibody-Drug Conjugates for Cancer Therapy

Published: April 21, 2026 10:00

Antibody-drug conjugate (ADC) represents an effective therapeutic strategy for cancer, leveraging a cancer-targeting monoclonal antibody (mAb) linked to a potent payload. In this study, we report novel dual-payload ADCs (DualADC), which harness one…

Cryptocaryone Exhibits ROS/MAPK-Dependent Antiproliferative and Apoptosis-Inducing Effects on Triple-Negative Breast Cancer Cells and Proof-of-Concept Breast Cancer Mouse Model

Published: April 20, 2026 10:00

Omics' technologies have enabled clinicians to gain previously unprecedented insights into the molecular complexity and clinical heterogeneity of triple-negative breast cancer (TNBC). Increasingly it is being realized that TNBC does not respond well to…

PINK1‑mediated mitophagy enhances breast cancer proliferation through metabolic reprogramming

Published: April 17, 2026 10:00

Breast cancer is a predominant cause of cancer‑related mortality among women, particularly aggressive subtypes such as triple‑negative breast cancer (TNBC), which currently lack effective targeted therapies. While PTEN‑induced kinase 1 (PINK1) is known for…