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WNT1/ROR2 pathway enhances the Triple-Negative breast cancer invasion, migration, and Epithelial-Mesenchymal transition

https://pubmed.ncbi.nlm.nih.gov/39428718/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241021121903&v=2.18.0.post9+e462414

Published: October 21, 2024 10:00

It has been evidenced that ROR2 influences the growth of many tumors, including non-small cell lung cancer, osteosarcoma, and breast cancer. This research examined the effect of the WNT1/ROR2 signaling pathway on the progression of triple-negative breast…

Establishment of a tumor-associated fibroblast associated gene score based on scRNA-seq to predict prognosis in patients with triple-negative breast cancer

https://pubmed.ncbi.nlm.nih.gov/39418248/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241018031725&v=2.18.0.post9+e462414

Published: October 17, 2024 10:00

The tumor microenvironment (TME) is emerging as a tool for the development of improved patient prognosis and the development of novel antitumor drugs. As the most important stromal cells in the tumor microenvironment, cancer-associated fibroblasts (CAFs)…

Establishment of Translational Luciferase-Based Cancer Models to Evaluate Antitumoral Therapies

https://pubmed.ncbi.nlm.nih.gov/39408747/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241016081615&v=2.18.0.post9+e462414

Published: October 16, 2024 10:00

Luciferase (luc) bioluminescence (BL) is the most used light-emitting protein that has been engineered to be expressed in multiple cancer cell lines, allowing for the detection of tumor nodules in vivo as it can penetrate most tissues. The goal of this…

Macrophages: Key Players in the Battle against Triple-Negative Breast Cancer

https://pubmed.ncbi.nlm.nih.gov/39409110/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241016081615&v=2.18.0.post9+e462414

Published: October 16, 2024 10:00

Triple-negative breast cancer (TNBC) is a challenging subtype of breast cancer characterized by the absence of estrogen and progesterone receptors and HER2 expression, leading to limited treatment options and a poorer prognosis. TNBC is particularly…

High BMI Is Associated with Changes in Peritumor Breast Adipose Tissue That Increase the Invasive Activity of Triple-Negative Breast Cancer Cells

https://pubmed.ncbi.nlm.nih.gov/39408921/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241016081615&v=2.18.0.post9+e462414

Published: October 16, 2024 10:00

Breast cancer is the most common cancer in women with multiple risk factors including smoking, genetics, environmental factors, and obesity. Smoking and obesity are the top two risk factors for the development of breast cancer. The effect of obesity on…

Identification of the metabolic protein ATP5MF as a potential therapeutic target of TNBC

https://pubmed.ncbi.nlm.nih.gov/39402579/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241015191224&v=2.18.0.post9+e462414

Published: October 14, 2024 10:00

CONCLUSION: In summary, the metabolic protein ATP5MF plays a crucial role in the non-BRCA1/2 mutation TNBC cells, making it a potential novel diagnostic and therapeutic oncotarget for non-BRCA1/2 mutation TNBC.

Clinical research on triple-negative breast cancer that targets the PIK3CA pathway

https://pubmed.ncbi.nlm.nih.gov/39400773/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241015191224&v=2.18.0.post9+e462414

Published: October 14, 2024 10:00

No abstract

DNA damage response and neoantigens: A favorable target for triple-negative breast cancer immunotherapy and vaccine development

https://pubmed.ncbi.nlm.nih.gov/39396845/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241014010515&v=2.18.0.post9+e462414

Published: October 13, 2024 10:00

Triple-negative breast cancer (TNBC) poses a significant clinical challenge due to its aggressive nature and limited therapeutic options. The interplay between DNA damage response (DDR) mechanisms and the emergence of neoantigens represents a promising…

Therapeutic effects of DOX-loaded hydrogel MOF nanocarriers on triple negative breast cancer and derivative design via reinforcement learning

https://pubmed.ncbi.nlm.nih.gov/39397066/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241014010515&v=2.18.0.post9+e462414

Published: October 13, 2024 10:00

Triple negative breast cancer (TNBC) is one of the most difficult of all types of breast cancer to treat. TNBC is characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The development of…

Identification of an immune cell infiltration-related gene signature for prognosis prediction in triple-negative breast cancer

https://pubmed.ncbi.nlm.nih.gov/39380273/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1zA4h3Qg-ND_Lvx8qFap6dOGSjORqFX5gx1cFZpJGVFLXsasr2&fc=None&ff=20241009101256&v=2.18.0.post9+e462414

Published: October 9, 2024 10:00

Triple-negative breast cancer TNBC with higher immunogenicity and tumor-infiltrating lymphocyte (TIL) enrichment can benefit from immunotherapy relative to other breast cancer subtypes. Our work was designed to identify the TIL-related hub genes in TNBC…