RSS Parrot

The Computational Revolution in Natural Product Research: A Data-Driven Roadmap for Next-Generation Drug Development

https://pubmed.ncbi.nlm.nih.gov/42041910/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260427160833&v=2.19.0.post6+133c1fe

Published: April 27, 2026 10:00

Natural products (NPs) have historically provided the foundational scaffolds for drug development, yet traditional bioprospecting faces critical limitations: high rediscovery rates, laborious isolation workflows, and substantial attrition during clinical…

Serendipity on surveillance: an unusual transbronchial biopsy finding in a lung transplant recipient

https://pubmed.ncbi.nlm.nih.gov/41981989/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260415072824&v=2.19.0.post6+133c1fe

Published: April 15, 2026 10:00

Flexible bronchoscopy is routinely utilized to monitor allograft function after lung transplantation (LT). While transbronchial lung biopsy (TBLB) is valuable as it permits direct histological assessment of the allograft, unexpected findings are…

Computation-Driven Experimental Discovery of Reactivity Space of Organoboron Compounds

https://pubmed.ncbi.nlm.nih.gov/41952304/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260409090002&v=2.19.0.post6+133c1fe

Published: April 9, 2026 10:00

ConspectusOrganoboron compounds serve as fundamental building blocks in the construction of diverse functional molecules, ranging from pharmaceuticals to materials. The discovery of boron-related new chemical transformations serves as a pivotal driving…

Oxybutynin treatment for episodic hyperhidrosis in Parkinson disease

https://pubmed.ncbi.nlm.nih.gov/41944203/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260407170428&v=2.19.0.post6+133c1fe

Published: April 7, 2026 10:00

Not all medications arrive from a disciplined path of translational drug development; sometimes, the route of discovery involves serendipity. A drug developed for controlling urinary urgency, oxybutynin, is reviewed here as a highly effective treatment for…

Serendipitous Discoveries in Biomedical Sciences (Revisited)

https://pubmed.ncbi.nlm.nih.gov/41917385/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260401074340&v=2.19.0.post6+133c1fe

Published: March 31, 2026 10:00

Serendipity is to come across a nice coincidence or to discover something unexpected. Also, it is to look for something and happen to find something of value other than what you are looking for. In simple, it is to seize upon good fortune by a random…

Editor's view: What makes a scientist successful?

https://pubmed.ncbi.nlm.nih.gov/41911026/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260331084837&v=2.19.0.post6+133c1fe

Published: March 30, 2026 10:00

This editorial examines the nature of scientific discovery by studying the characteristics, methods, and tools that have historically defined a 'successful scientist'. It first considers the traditional hypothesis-driven model of science founded on…

Leveraging Molecular Dynamics Simulations to Study Psychedelics and Their Receptors in Future Drug Development

https://pubmed.ncbi.nlm.nih.gov/41860173/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260320162322&v=2.19.0.post6+133c1fe

Published: March 20, 2026 10:00

INTRODUCTION: Psychedelics show great promise for treating Central Nervous System (CNS) disorders but are limited by side effects like hallucinations. Molecular dynamics (MD) simulations offer atomic-level insights into receptor interactions, helping to…

Incarcerated geriatric inmates' experiences of aging and healthcare

https://pubmed.ncbi.nlm.nih.gov/41807483/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260311204525&v=2.19.0.post6+133c1fe

Published: March 11, 2026 10:00

Older adults comprise the fastest growing demographic in correctional facilities in the United States. Studies have shown older adults in prison report difficulty accessing healthcare and navigating the prison environment. Little is known about how older…

Serendipity, steroids and science

https://pubmed.ncbi.nlm.nih.gov/41763410/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260301064135&v=2.19.0.post6+133c1fe

Published: February 28, 2026 11:00

The androgen signaling pathway is probably the most important pathway in enabling prostate cancer progression but it also plays essential roles in numerous processes in normal physiology. Both testosterone and dihydrotestosterone are potent androgens that…

Dyshidrotic eczema associated with Upadacitinib use: a paradoxical adverse event or serendipity?

https://pubmed.ncbi.nlm.nih.gov/41738791/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20260225230225&v=2.18.0.post22+67771e2

Published: February 25, 2026 11:00

We report the case of a 39-year-old man with long-standing ileocolonic Crohn's disease, with a history of prior ileocecal resection and secondary loss of response to infliximab and ustekinumab, who initiated treatment with upadacitinib (UPA) 45 mg/day due…