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serendipity: Latest results from PubMed
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Serendipity, steroids and science
Published: February 28, 2026 11:00
The androgen signaling pathway is probably the most important pathway in enabling prostate cancer progression but it also plays essential roles in numerous processes in normal physiology. Both testosterone and dihydrotestosterone are potent androgens that…
Dyshidrotic eczema associated with Upadacitinib use: a paradoxical adverse event or serendipity?
Published: February 25, 2026 11:00
We report the case of a 39-year-old man with long-standing ileocolonic Crohn's disease, with a history of prior ileocecal resection and secondary loss of response to infliximab and ustekinumab, who initiated treatment with upadacitinib (UPA) 45 mg/day due…
High-throughput ligand diversification to discover chemical inducers of proximity
Published: February 16, 2026 11:00
Chemical inducers of proximity (CIPs) stabilize biomolecular interactions, often causing an emergent rewiring of cellular biochemistry. While the discovery of heterobifunctional CIPs is expedited by rational design strategies, molecular glues have relied…
Drug repositioning in dermatology: from serendipity to strategy
Published: February 4, 2026 11:00
No abstract
From Serendipity to Strategy: Rationalizing Molecular Glue Discovery and Proximity-Induced Pharmacology through Chemical Biology
Published: February 2, 2026 11:00
Molecular glues represent a new paradigm in drug discovery, stabilizing novel protein-protein interactions between two proteins to elicit targeted cellular outcomes. Historically discovered through serendipity, molecular glue identification is becoming…
The potential role of COX-2/PGs signaling pathway in epileptogenesis and associated neuroinflammation: collusions or serendipity
Published: February 1, 2026 11:00
CONCLUSION: Consequently, targeting of the COX-2/PG axis has emerged as a potential therapeutic strategy.
CatDive: A simple yet effective method for maximizing category diversity in sequential recommendation
Published: January 30, 2026 11:00
How can we offer users items of diverse categories while considering their interests in sequential recommendation? Traditional sequential recommendation methods often prioritize accuracy over diversity, recommending only items similar to those with which…
The role of serendipity in nursing research
Published: January 21, 2026 11:00
This article explains the concept of serendipity and illustrates it in the field of nursing research.
Serendipity-Driven Telescoped Synthesis of 2-Aryl Glycidic Esters from Aldehydes
Published: January 19, 2026 11:00
A first general and practical method for the synthesis of valuable 2-(hetero)aryl glycidic ethyl esters has been developed using commercially available reagents and a catalyst. A telescoped three-step seven-reaction process, based on a…
Serendipity in psychiatric discoveries: historical lessons and future imperatives for clinical observation
Published: January 15, 2026 11:00
AIMS AND METHOD: Serendipity has driven many of psychiatry's most important treatments, yet contemporary systems may undermine clinicians' ability to notice and develop unexpected therapeutic effects. This selective narrative review synthesises landmark…