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serendipity: Latest results from PubMed
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Did Serendipity Contribute to the Discovery of New Antidepressant Drugs? Historical Analysis Using Operational Criteria
Published: May 12, 2025 10:00
CONCLUSION: The majority of new antidepressants adhere to a type IV pattern, characterized by a rational and targeted design process where serendipity played no part, except moclobemide (type II pattern) and ketamine (type III pattern).
Computer-Generated, Mechanistic Networks Assist in Assigning the Outcomes of Complex Multicomponent Reactions
Published: April 28, 2025 10:00
The appeal of multicomponent reactions, MCRs, is that they can offer highly convergent, atom-economical access to diverse and complex molecules. Traditionally, such MCRs have been discovered "by serendipity" or "by analogy" but recently the first examples…
Serendipity in Neuro-Oncology: The Evolution of Chemotherapeutic Agents
Published: April 17, 2025 10:00
The development of novel therapeutics in neuro-oncology faces significant challenges, often marked by high costs and low success rates. Despite advances in molecular biology and genomics, targeted therapies have had limited impact on improving patient…
Technology Affordances, Social Media Engagement, and Social Media Addiction: An Investigation of TikTok, Instagram Reels, and YouTube Shorts
Published: April 12, 2025 10:00
Currently, time spent online viewing short-form video (SFV) has become an increasingly popular activity. SFV users spend over two hours daily across a variety of SFV platforms. Undergirded by the theory of technological affordances, the present study is…
Genome-wide association studies to assess genetic factors controlling cucumber resistance to CABYV and CMV in crop fields and the attractiveness for their Aphis gossypii vector
Published: April 8, 2025 10:00
Cucumber crops face high pressure from pathogens, including various viral species. Mapping quantitative trait loci (QTL) for vegetable resistance to viruses has primarily been conducted after mechanical inoculation in controlled environments, but not in…
Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii
Published: March 31, 2025 10:00
Serendipity Berry Sweet Protein (sweelin) is a novel hyper-sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI-CPD) to improve the stability and sensory profile of the protein found in serendipity berry…
The impact of playlist characteristics on coherence in user-curated music playlists
Published: March 24, 2025 10:00
Music playlist creation is a crucial, yet not fully explored task in music data mining and music information retrieval. Previous studies have largely focused on investigating diversity, popularity, and serendipity of tracks in human- or machine-generated…
Long-term studies provide unique insights into evolution
Published: March 20, 2025 10:00
From experimental evolution in the laboratory to sustained measurements of natural selection in the wild, long-term studies have revolutionized our understanding of evolution. By directly investigating evolutionary dynamics in real time, these approaches…
Making modafinil: Classification and serendipity in drug development
Published: March 18, 2025 10:00
How does a compound become a drug, and how do we decide for whom the drug is intended? Building a history of modafinil, this article examines how classification and serendipity affect drug development. We explore how mental health categories interact with…
Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays
Published: March 13, 2025 10:00
Uncompetitive inhibition is an effective strategy for suppressing dysregulated enzymes and their substrates, but discovery of suitable ligands depends on often-unavailable structural knowledge and serendipity. Hence, despite surging interest in mass…
Rational Design of Near-Infrared Reflective Pigments by Adjusting the Ni2+ Coordination Environment
Published: March 7, 2025 11:00
Inorganic pigments offer excellent potential because of their resilience in a variety of environments, and high-reflectance near-infrared (NIR) pigments are a useful tactic to reduce the heat island effect. Nonetheless, the design of inorganic pigments is…