Beyond the Eureka Moment: Serendipity and the Discovery of Heparin
Published: August 4, 2026 10:00
No abstract
🦜 serendipity
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serendipity: Latest results from PubMed
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Stereotactic Body Radiotherapy for Refractory Ventricular Tachycardia: From Serendipity to Precision Biological Ablation
Published: July 31, 2026 10:00
Ventricular arrhythmias (VAs), particularly refractory ventricular tachycardia (VT), pose a significant therapeutic challenge and are associated with high morbidity and mortality. For patients who do not respond to conventional therapies, including…
Human Foetal Neuroblasts Exhibit BK Channel-Dependent Membrane Voltage Oscillations upon Depolarization
Published: July 24, 2026 10:00
Immature neurobalsts might present peculiar electrical activities before developing standard neuronal-like excitability. We previously described electrophysiological properties of primary neuroblast cultures isolated from the nucleus basalis of Meynert…
Catalyst Design for Sustainable Reactions: A Primer toward Knowledge-Driven Innovation
Published: July 20, 2026 10:00
When aiming at designing performant catalysts for existing or novel (sustainable) reactions, a wide variety of methodologies can be adopted, turning catalyst design into a science on its own. However, fundamental knowledge and clear guidelines for the…
A Shopping List
Published: July 15, 2026 10:00
A story of nourishment, serendipity, and the unexpected bonds that connect us with patients.
Artificial intelligence in biologic drug discovery: A review of methodological evolution and therapeutic applications
Published: July 15, 2026 10:00
Biologic drugs, primarily comprising proteins and nucleic acids, have emerged as powerful therapeutic modalities; however, their discovery and optimization are often hindered by their inherent complexity. The advent of artificial intelligence (AI),…
Toward the Synthesis of Pestalustaine A: Structural Revision and Formation of Original Strained Tricyclic Architectures
Published: July 9, 2026 10:00
We report our quest toward the total synthesis of the reported structure of the sesquiterpene pestalustaine A and its unprecedented tricyclic skeleton. Our retrosynthesis involved a transannular Michael addition of a 1,3-keto-ester and enal-containing…
Targeted enzyme discovery using metal-coordination mining
Published: July 1, 2026 10:00
The recent revolution in genome sequencing and protein structure prediction has opened new frontiers in understanding, predicting and designing enzyme function^(1,2). Central to these efforts is the discovery and functional annotation of novel enzymes,…
Biomedical Research in an Age of Anxiety: Four Papers for Worried Minds
Published: June 26, 2026 10:00
In this essay I review and summarize four older "thought" papers about how science is communicated and practiced. These papers were written by the Nobel Prize winner Peter Medawar, the eminent physiologist Julious Comroe, Eugene Robin a renowned clinical…
Why reporting requires more than findings
Published: June 19, 2026 10:00
No abstract