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serendipity: Latest results from PubMed
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Accelerating the discovery of multicatalytic cooperativity
Published: November 3, 2025 11:00
Cooperative catalysis, in which multiple catalytic units operate synergistically, underpins a variety of synthetically and mechanistically important organic reactions^(1-4). Despite its potential utility in new reactivity contexts, approaches to the…
Linker Enantiomericity Engineering in Reticular Frameworks for Architecting Robust Materials with Synergetic Open Metal Sites for Efficient SF6 Capture
Published: October 29, 2025 10:00
Chiral linkers offer built-in enantiomericity capable of regulating pore microenvironments or even net dimensions and topologies of the resulting reticular frameworks. Whereas it has been established that enantiopure and racemic linkers can form…
LorBin: efficient binning of long-read metagenomes by multiscale adaptive clustering and evaluation
Published: October 24, 2025 10:00
Long-read sequencing has transformed metagenomics and improved the quality of metagenome-assembled genomes (MAGs). However, current binning methods struggle with identifying unknown species and managing imbalanced species distributions. Here, we present…
From Serendipity to Systematics: Tracing the Trails of Cockroach Research in India
Published: October 21, 2025 10:00
Globally, the cockroach diversity comprises approximately 4641 nominative species, 188 of which are reported in India classified under 73 genera. However, it remains a poorly studied and overlooked groups in terms of species documentation, taxonomy and…
Serendipity discrete complexes with enhanced regularity
Published: October 20, 2025 10:00
In this work we address the problem of finding serendipity versions of approximate de Rham complexes with enhanced regularity. The starting point is a new abstract construction of general scope which, given three complexes linked by extension and reduction…
Lessons for the surgeon from the early history of the Zollinger Ellison syndrome: The 6th Alexander Walt Historical Lecture Presented at the Midwest Surgical Association 68th Annual Meeting Delavan, Wisconsin July 27, 2025
Published: October 17, 2025 10:00
Long before 1955 and the description of the disease that bears the names of Zollinger and Ellison, surgeons feared complicated peptic ulcer disease refractory to all treatment short of total gastrectomy. This recounting of the initial description is…
Serendipity in antiseizure medication discovery: Unveiling accidental breakthroughs in epilepsy treatments
Published: October 2, 2025 10:00
Serendipity has played a significant role in the discovery of several key antiseizure medications, when unexpected observations have led to groundbreaking treatments. This narrative review explores the historical context of serendipitous discoveries in…
From serendipity to strategy: molecular glue degraders in cancer therapeutics
Published: October 1, 2025 10:00
Targeted protein degradation is an elegant therapeutic strategy that harnesses the cell's own degradation machinery to selectively eliminate target proteins. This approach marks a paradigm shift in drug discovery, moving beyond traditional occupancy-based…
Why are we awake? Algorithmic serendipity and the sociology of sleeplessness
Published: September 22, 2025 10:00
Algorithmic serendipity is the seemingly chance encounter with exactly the right content, engineered by online recommender systems, linking individuals to one another and to digital remedies. This phenomenon transforms the individual experience of insomnia…
Beyond serendipity: uncovering novel ratiometric urea.24DHBA cocrystals through mechanochemistry and MicroED
Published: September 16, 2025 10:00
Mechanochemical synthesis of urea cocrystals with 2,4-dihydroxybenzoic acid (24DHBA) reveals two new stoichiometric forms: (urea)(2)·(24DHBA) and (urea)(2)·(24DHBA)(2), not accessible via solution methods. The known (urea)(0.5)·(24DHBA) form remains the…