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serendipity: Latest results from PubMed
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Posts: 11
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Beyond serendipity: uncovering novel ratiometric urea.24DHBA cocrystals through mechanochemistry and MicroED
Published: September 16, 2025 10:00
Mechanochemical synthesis of urea cocrystals with 2,4-dihydroxybenzoic acid (24DHBA) reveals two new stoichiometric forms: (urea)(2)·(24DHBA) and (urea)(2)·(24DHBA)(2), not accessible via solution methods. The known (urea)(0.5)·(24DHBA) form remains the…
High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity
Published: September 15, 2025 10:00
Chemical inducers of proximity (CIPs) stabilize biomolecular interactions, often causing an emergent rewiring of cellular biochemistry. While rational design strategies can expedite the discovery of heterobifunctional CIPs, monovalent, molecular glue-like…
Message in a Bottle
Published: September 15, 2025 10:00
Description The title of the image is inspired by a famous old song by the British rock band The Police. The song featured Sting's evocative lyrics and captures a profound sense of isolation and longing. The song tells the story of a castaway who sends out…
Noncompetitive Inhibition of DNA Polymerase β by a Nonnative Nucleotide
Published: September 7, 2025 10:00
Base excision repair (BER) is a DNA repair pathway responsible for protecting the genome against modified nucleotides. DNA polymerase β (Pol β) participates in this process by removing the remnants of a damaged nucleotide and filling in the resulting gap.…
The tale of donanemab: God is in the details
Published: September 3, 2025 10:00
Alzheimer's disease is a major cause of dementia, that affects approximately 7-8% of people aged 65 years and older (according to WHO & Alzheimer's Disease International) and thus is a major concern in public health world-wide. This review chronicles the…
SEAHORSE: A Serendipity Engine Assaying Heterogeneous Omics-Related Sampling Experiments
Published: September 2, 2025 10:00
Large-scale, open-access data sets such as the Genotype Tissue Expression Project (GTEx) and The Cancer Genome Atlas (TCGA) include multi-omic data on large numbers of samples along with extensive clinical and phenotypic information. These datasets provide…
ACCEPTANCE OF THE EMINENT PARASITOLOGIST AWARD MY JOURNEY THROUGH PARASITE LAND: EIGHT SIMPLE TIPS FOR SUCCESS FOR EARLY-CAREER RESEARCHERS
Published: August 30, 2025 10:00
My journey from mediocre undergraduate with zero interest in parasitology to this year's recipient of the American Society of Parasitologists' Eminent Parasitologist Award has been shaped by serendipity, lucky breaks, and near misses. It is a story…
Allan Basbaum: third Editor-in-Chief of PAIN and finding joy in pain research
Published: August 21, 2025 10:00
Allan Basbaum entered the field of pain research as an undergraduate at McGill University shortly after Pat Wall and Ron Melzack proposed Gate Control Theory. He has not wandered far from the field since then. Although Allan believes that serendipity has…
A Review: The Beauty of Serendipity Between Integrated Circuit Security and Artificial Intelligence
Published: August 14, 2025 10:00
Integrated circuits are the core of a cyber-physical system, where tens of billions of components are integrated into a tiny silicon chip to conduct complex functions. To maximize utilities, the design and manufacturing life cycle of integrated circuits…
Serendipity, Flexibility, Calling and Commitment: How Clinicians Navigate the Path to Clinician-Coach
Published: August 13, 2025 10:00
CONCLUSIONS: The stages of practice evolution and the notions of serendipity, calling, flexibility, and commitment offer a framework for understanding how EM physicians successfully embark on and navigate the path from clinician to clinician-coach.
How we stumbled upon the rat play vocalizations: A recollection
Published: August 8, 2025 10:00
Over a quarter of a century later, most rodent researchers know that specific types of rat UltraSonic Vocalizations (USVs) appear to index distinct affective states endowed with arousal, value, and motivational force. Few know the story, however, of how we…