The pharmacologic evolution of anticoagulants: From serendipity to precision therapy
Published: January 29, 2025 11:00
No abstract
🦜 serendipity
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serendipity: Latest results from PubMed
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YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer
Published: January 28, 2025 11:00
Hyperactivation of the YAP/TEAD transcriptional complex in cancers facilitates the development of an immunosuppressive tumor microenvironment. Herein, we observed that the transcription factor SP1 physically interacts with and stabilizes the YAP/TEAD…
From Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care
Published: January 25, 2025 11:00
Background/Objectives: The dual forces of structured inquiry and serendipitous discovery have long shaped neuropsychiatric research, with groundbreaking treatments such as lithium and ketamine resulting from unexpected discoveries. However, relying on…
Unraveling the synthetic strategy, structure activity relationship of azetidinones: Insights into their multidrug and toxin extrusion protein (MATE transporter) inhibition facilitating drug development against MDR
Published: January 23, 2025 11:00
Heterocyclic chemistry gathered a wide audience due to their presence in potential drug candidates and being attractive synthons initiating several retro-syntheses the organic as well as in medicinal chemistry fields. Among them, azetidinones have been a…
Daily briefing: Scientific serendipity is everywhere
Published: January 23, 2025 11:00
No abstract
The role of serendipity in our investigation of embryo implantation
Published: January 18, 2025 11:00
Serendipity plays a huge role in science, and having a prepared mind that can seize upon a serendipitous observation or occurrence can drive a project forward. This happened in my lab with a project centered on the regulation of trophoblast cell behavior…
Serendipitous Discovery of Dearomatized Dimers in Anthracene Derivative Oxidation
Published: January 14, 2025 11:00
We present the serendipitous discovery of an unusual dimer formed from anthracene-derived polyarenes. Unlike the typical oxidative coupling of substituted aromatic scaffolds, the reaction yielded a dearomatized enone dimer as the sole product. This…
Light People: Prof. Henry Snaith's (FRS) perovskite optoelectronics journey
Published: December 31, 2024 11:00
In 2012, Prof. Henry Snaith demonstrated the first solid-state perovskite solar cell (PSC) with an efficiency of 10.9%, igniting a surge of interest and research into perovskite materials for their potential to revolutionize the photovoltaic (PV) industry.…
Erratum. Serendipity in Science: 50+ Years of Designed, and Sometimes Lucky, Science
Published: December 24, 2024 11:00
No abstract
Third-Generation CD73 Inhibitors Based on a 4,6-Disubstituted-2-thiopyridine Scaffold
Published: December 13, 2024 11:00
Various series of 4,6-disubstituted-2-thiopyridine derivatives were synthesized and evaluated as potential ecto-5'-nucleotidase (CD73) inhibitors. Altogether, about ninety compounds were prepared using a general synthetic pathway involving one or two steps…