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serendipity: Latest results from PubMed
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Dr. Laura Marcu on Serendipity, Science, and the Power of Interdisciplinary Vision
Published: June 4, 2026 10:00
Professor Laura Marcu (UC Davis Departments of Neurological Surgery and Biomedical Engineering), Director the NIH-NIBIB P41 National Center for Interventional Biophotonics Technologies (NCIBT), discusses her career in biophotonics in an interview with…
Harnessing gut microbiome enzymes: Segatella copri and Stenotrophomonas maltophilia prolyl peptidases degrade gliadin peptides and improve epithelial barrier function in a celiac disease model
Published: May 29, 2026 10:00
Celiac disease (CeD) is an autoimmune enteropathy triggered by gluten-derived peptides that resist gastrointestinal digestion, notably the proline-rich 33-mer and 11-mer gliadin epitopes. Here, we describe a rational, metagenome-based strategy to identify…
From an Interest in Molecules to a Fascination with Microbes
Published: May 19, 2026 10:00
My scientific career has followed a meandering path centered on the structures and functions of microbial metabolites. These microbes included bacteria, fungi, and single-celled eukaryotes, and the metabolites included representatives from most metabolite…
A Scalable, Direct-to-Biology Platform for Accelerated Discovery of Cereblon-Based Molecular Glue Degraders
Published: May 18, 2026 10:00
Molecular glue degraders (MGDs) offer transformative potential for expanding the druggable proteome; however, their discovery is severely impeded by mechanistic complexities that hinder rational design and synthetic bottlenecks that restrict the scale and…
From Serendipity to Rationality: Expanding Druggability by Molecular Glue Discovery
Published: May 15, 2026 10:00
No abstract
How One Single Eureka Moment Can Dictate a Full Scientific Career in Bioelectricity
Published: May 14, 2026 10:00
In science, one needs to have a eureka moment from time to time, in order to avoid falling into depression-it is not easy every day to be a researcher. Sometimes, these eurekas are the result of SERENDIPITY. However, in most of the cases, these eurekas are…
From Serendipity to Exploration: Synthesis and Properties of PtSiSb
Published: May 6, 2026 10:00
PtSiSb is a compound with covalent Si-Sb bonds, which are relatively rare instances in solid-state materials. The original report on PtSiSb indicates synthetic challenges for the isolation of single-phase samples, as well as potential discrepancies in the…
The Computational Revolution in Natural Product Research: A Data-Driven Roadmap for Next-Generation Drug Development
Published: April 27, 2026 10:00
Natural products (NPs) have historically provided the foundational scaffolds for drug development, yet traditional bioprospecting faces critical limitations: high rediscovery rates, laborious isolation workflows, and substantial attrition during clinical…
Serendipity on surveillance: an unusual transbronchial biopsy finding in a lung transplant recipient
Published: April 15, 2026 10:00
Flexible bronchoscopy is routinely utilized to monitor allograft function after lung transplantation (LT). While transbronchial lung biopsy (TBLB) is valuable as it permits direct histological assessment of the allograft, unexpected findings are…
Computation-Driven Experimental Discovery of Reactivity Space of Organoboron Compounds
Published: April 9, 2026 10:00
ConspectusOrganoboron compounds serve as fundamental building blocks in the construction of diverse functional molecules, ranging from pharmaceuticals to materials. The discovery of boron-related new chemical transformations serves as a pivotal driving…