RSS Parrot

Third-Generation CD73 Inhibitors Based on a 4,6-Disubstituted-2-thiopyridine Scaffold

https://pubmed.ncbi.nlm.nih.gov/39670314/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241213143744&v=2.18.0.post9+e462414

Published: December 13, 2024 11:00

Various series of 4,6-disubstituted-2-thiopyridine derivatives were synthesized and evaluated as potential ecto-5'-nucleotidase (CD73) inhibitors. Altogether, about ninety compounds were prepared using a general synthetic pathway involving one or two steps…

Serendipity in Science: 50+ Years of Designed, and Sometimes Lucky, Science

https://pubmed.ncbi.nlm.nih.gov/39637846/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241206095126&v=2.18.0.post9+e462414

Published: December 5, 2024 11:00

Normal science is about assessing what is already known about a topic, about what needs to be known, and careful methods to collect the data required to answer the scientific question. It is the mainstay of scientific progress. But sometimes, luck or…

Potent and Selective Human 5-HT(2B) Serotonin Receptor Antagonists: 4'-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity

https://pubmed.ncbi.nlm.nih.gov/39589936/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241126230353&v=2.18.0.post9+e462414

Published: November 26, 2024 11:00

Rigidified nucleoside derivatives with (N)-methanocarba replacement of ribose have been repurposed as peripheral subtype-selective 5-HT(2B) serotonin receptor antagonists for heart and lung fibrosis and intestinal/vascular conditions. 4'-Cyano derivative…

Dofetilde and flecainide combination: the serendipity of successful treatment of atrial fibrillation after failed ablation

https://pubmed.ncbi.nlm.nih.gov/39549951/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241117023602&v=2.18.0.post9+e462414

Published: November 16, 2024 11:00

Antiarrhythmic drugs (AADs) and catheter ablation (CA) are guideline-directed rhythm control treatment for atrial fibrillation (AF). AADs are rarely used in combination to treat AF. Dofetilde (class III agent) and flecainide (class Ic agent) are…

Letter to the Editor: Solastalgia and Serendipity-at Altitude and in Academia

https://pubmed.ncbi.nlm.nih.gov/39540205/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241114204327&v=2.18.0.post9+e462414

Published: November 14, 2024 11:00

No abstract

Roadside serendipity: an accident can lead to a rare diagnosis

https://pubmed.ncbi.nlm.nih.gov/39534490/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241113184924&v=2.18.0.post9+e462414

Published: November 13, 2024 11:00

Find out about some of the diagnostic considerations in the field of rare pleural disease https://bit.ly/3xYefzA.

Dataset on Vietnamese students' impulse buying behavior on TikTok shop

https://pubmed.ncbi.nlm.nih.gov/39525659/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241113184924&v=2.18.0.post9+e462414

Published: November 11, 2024 11:00

This article aims to provide a dataset on the factors affecting the online impulse buying behavior of university and college students in Vietnam. The examined factors include scarcity (SC), serendipity information (SI), trust (TR), hedonic motivation (HM),…

A comprehensive two-hybrid analysis to explore the Legionella pneumophila effector-effector interactome

https://pubmed.ncbi.nlm.nih.gov/39526800/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241113184924&v=2.18.0.post9+e462414

Published: November 11, 2024 11:00

Legionella pneumophila uses over 300 translocated effector proteins to rewire host cells during infection and create a replicative niche for intracellular growth. To date, several studies have identified L. pneumophila effectors that indirectly and…

Uneasiness in interdisciplinary research and the importance of metaphors: A case story on building an interdisciplinary chronic pain research team

https://pubmed.ncbi.nlm.nih.gov/39513184/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241113184924&v=2.18.0.post9+e462414

Published: November 8, 2024 11:00

Interdisciplinary research is increasingly recognized as a key method to tackle complex societal challenges and stimulate creativity to find innovative solutions. Our key goal when starting our collaboration was to come to innovative ways of treating…

How technical and situational cues affect impulse buying behavior in social commerce? Evidence from bored consumers

https://pubmed.ncbi.nlm.nih.gov/39417023/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1nwkqzEtY5u_6fo79woxBsnRZCJiA07pXIz5ZHOeh83WUBQkDf&fc=None&ff=20241017145310&v=2.18.0.post9+e462414

Published: October 17, 2024 10:00

INTRODUCTION: With the rise of social media and web technologies, users are increasingly spending time on browsing and purchasing on social commerce, particularly during idle moments of casual scrolling. Social commerce applications with sophisticated…