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Disease Ontology: Latest results from PubMed
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Consistent performance of large language models in rare disease diagnosis across ten languages and 4917 cases
Published: October 15, 2025 10:00
BACKGROUND: Large language models (LLMs) are increasingly used medicine for diverse applications including differential diagnostic support. The training data used to create LLMs such as the Generative Pretrained Transformer (GPT) predominantly consist of…
Bee venom promotes exosome secretion and alters miRNA cargo in T cells
Published: October 13, 2025 10:00
Exosomes are important mediators of intercellular communication, primarily through the transfer of miRNAs. However, the mechanisms regulating exosome secretion and miRNA cargo loading in T cells remain incompletely understood. In this study, we…
Mondo: Integrating Disease Terminology Across Communities
Published: October 6, 2025 10:00
Precision medicine aims to enhance diagnosis, treatment, and prognosis by integrating multimodal data at the point of care. However, challenges arise due to the vast number of diseases, differing methods of classification, and conflicting terminological…
Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation
Published: October 3, 2025 10:00
CONCLUSIONS: Our study identified four hub IRDEGs that may serve as potential diagnostic indicators and therapeutic targets for PE. These findings suggest an important role of immune dysregulation in PE pathogenesis and offer new perspectives for treatment…
Emerging plasticizer induced lipid metabolism disorders revealed by network toxicology molecular docking and dynamics simulation
Published: October 3, 2025 10:00
Acetyl tributyl citrate (ATBC) and epoxidized soybean oil (ESBO) are widely used emerging plasticizers, but their potential to induce lipid metabolism disorders remains poorly understood. In this study, we explored their toxicological mechanisms using a…
Exploring CCND1 as a Key Target of Acorus calamus Against RSV Infection: Network Pharmacology, Molecular Docking, and Bioinformatics Analysis
Published: September 29, 2025 10:00
Acorus calamus, a traditional Tibetan medicine with potential antiviral activity but undefined mechanisms, was studied for its anti-respiratory syncytial virus (RSV) mechanisms using network pharmacology and molecular docking, given RSV's substantial…
Representing Dental Caries and Dysbiosis within the Oral Microbiome in the Oral Health and Disease Ontology
Published: September 26, 2025 10:00
Background. Dental caries is an oral health condition in which cariogenic bacteria demineralize and decay teeth. It arises due to interaction between the host, environment, and oral microbiome. Current terminologies and ontologies, however, do not…
Integrating transcriptomic and epigenomic data to identify potential biomarkers in gestational diabetes mellitus patients
Published: September 25, 2025 10:00
Gestational diabetes mellitus (GDM), one of the prevalent pregnancy-related metabolic disorders, have shown immediate or long-term adverse health outcomes for maternal and fetal health. Therefore, it is crucial to understand the ongoing cellular and…
eccDNABase: a comprehensive and high-quality database for extrachromosomal circular DNA
Published: September 19, 2025 10:00
Extrachromosomal circular DNA (eccDNA) refers to small, circular DNA molecules that originate from chromosomal sequences and are prevalent across nearly all eukaryotic organisms. In humans, eccDNAs are widely distributed in normal tissues, cancerous…
Antisense RNAs (asRNAs) as key players in gallbladder cancer progression: a bioinformatics analysis
Published: September 12, 2025 10:00
CONCLUSION: This study identified 14 asRNAs for the first time and showed that asRNAs targeting mRNAs strongly associated with tumor development in GBC through the PI3KCA and TP53 pathways.