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Disease Ontology: Latest results from PubMed
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Posts: 10
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Multi-Omics and Machine Learning Analyses Reveal PIK3CG, PRKCD, and TRIM22 as Potential Markers of Poor Prognosis and Immune Activation in Glioblastoma
Published: April 28, 2026 10:00
CONCLUSION: This study identifies PIK3CG, PRKCD, and TRIM22 as potential biomarkers and therapeutic targets in IDH-wildtype GBM. Their paradoxical association with poor survival and immune activation may inform personalized treatment strategies that…
Core microRNAs bridging peripheral transcriptomic alterations, brain functional abnormalities, and clinical symptomatology in schizophrenia
Published: April 25, 2026 10:00
This study adopted a comprehensive multi-omics approach integrating blood microRNA (miRNA) transcriptomic profiles, resting-state functional magnetic resonance imaging (rs-fMRI) neuroimaging data, and clinical symptomatology to elucidate the molecular and…
Representing dental caries and dysbiosis within the oral microbiome in the Oral Health and Disease Ontology
Published: April 24, 2026 10:00
No abstract
Transcriptomic analysis suggests ferroptosis as a potential mechanism of fipronil-induced cytotoxicity in human glioblastoma cells
Published: April 21, 2026 10:00
Fipronil (FPN), a widely used phenylpyrazole insecticide, has been associated with neurotoxicity. However, the precise molecular mechanisms underlying its effects on human neural cells, particularly glioblastoma, remain poorly understood. This study aimed…
Representing dental restoration materials in the oral health and disease ontology
Published: April 17, 2026 10:00
No abstract
BSO-AD: An Ontology for Representing and Harmonizing Behavioral Social Knowledge in ADRD
Published: April 10, 2026 10:00
OBJECTIVE: Behavioral and social factors (BSFs) substantially influence the risk, onset, and progression of Alzheimer's disease and related dementias (ADRD). A systematic representation of their interplay is essential for advancing prevention and targeted…
Research article proteomics-based plasma biomarkers for predicting CRKP infection in ICU sepsis patients
Published: March 30, 2026 10:00
CONCLUSION: PLXNB1 and S100A1 serve as promising plasma biomarkers for early, non-culture-based differentiation of CRKP and CSKP infections. Their integration into clinical workflows could improve rapid diagnosis and guide targeted therapy in critically…
Long-term artificial sweetener exposure increases the risk of atherosclerosis
Published: March 25, 2026 10:00
This study aimed to elucidate the potential molecular mechanisms by which artificial sweeteners contribute to the initiation and progression of atherosclerosis, with the goal of providing a theoretical basis for the safety evaluation of artificial…
From genes to diagnosis: The impact of UNC5B and DOK5 in intracranial aneurysm detection and pathogenesis
Published: March 13, 2026 10:00
CONCLUSION: In conclusion, the UNC5B and DOK5 genes emerge as potential diagnostic biomarkers for intracranial aneurysms.There is a positive correlation between UNC5B expression and M1 macrophages and it is primarily found in fibroblasts, suggesting that…
Quantify unmet medical need across the disease landscape - A large language model-based methodology
Published: March 12, 2026 10:00
CONCLUSIONS: This accessible, scalable methodology enables funders and researchers, across governments, universities, healthcare organizations, and disease groups to tailor prioritization efforts according to unmet medical need in the context of their…