RSS Parrot

Associations of per- and polyfluoroalkyl substances (PFAS) exposures and firefighting experience with microRNA signatures previously linked to Amyotrophic Lateral Sclerosis (ALS): a cross-sectional analysis of active-duty municipal and airport firefighters

https://pubmed.ncbi.nlm.nih.gov/42753929/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260918032257&v=2.20.1

Published: September 17, 2026 10:00

CONCLUSIONS: Significant associations between PFAS exposure, firefighting status, and ALS-related miRNAs suggest that PFAS exposure and firefighting characteristics are associated with miRNA expression patterns previously linked to ALS, warranting further…

Exploring Nonylphenol as a Potential Environmental Contributor to Alzheimer's Disease: A Hypothesis-Generating Study Integrating Computational Analyses and Experimental Evidence

https://pubmed.ncbi.nlm.nih.gov/42722075/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260910235453&v=2.20.1

Published: September 10, 2026 10:00

Nonylphenol (NP), an emerging environmental contaminant with neurotoxic potential, has been suggested to be associated with Alzheimer's disease (AD)-related pathological processes, although direct evidence remains limited. This study integrated network…

PolluCarc-MFSE: A Multi-Fingerprint Stacking Ensemble Learning Model for Chemical Pollutant Carcinogenicity

https://pubmed.ncbi.nlm.nih.gov/42679844/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260902004717&v=2.20.1

Published: September 1, 2026 10:00

Traditional carcinogenicity assessment relies on animal experiments, which are costly, time-consuming, and difficult to extrapolate across species. Consequently, the carcinogenic potential of most chemical pollutants remains uncharacterized, posing…

Multi-omic enriched blood-derived digital signatures reveal mechanistic and confounding disease clusters for differential diagnosis

https://pubmed.ncbi.nlm.nih.gov/42591264/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260813130132&v=2.20.1

Published: August 13, 2026 10:00

INTRODUCTION: Understanding disease relationships through blood biomarkers offers a pathway toward data-driven taxonomy and precision medicine.

Integrative bioinformatics analysis identifies APOE as a candidate link between lipid dysregulation and macrophage activation in inborn errors of metabolism

https://pubmed.ncbi.nlm.nih.gov/42555484/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260805194220&v=2.20.1

Published: August 5, 2026 10:00

CONCLUSION: This study identifies APOE as a highly prioritized candidate gene associated with lipid metabolism pathways and macrophage-related signatures in IEM. These findings support the hypothesis that APOE-associated lipid dysregulation may contribute…

From Cysts to Metabolism: Trading Metaphors in Medical Language for the Polycystic Ovary Syndrome to Polyendocrine Metabolic Ovarian Syndrome Shifts

https://pubmed.ncbi.nlm.nih.gov/42550941/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260804190124&v=2.20.0.post5+40e1b98

Published: August 4, 2026 10:00

CONCLUSION: PMOS marks meaningful scientific progress in aligning medical language with the systemic reality of the disorder, yet it is not a definitive terminological solution. Lasting semantic stability requires nomenclature that remains responsive to…

Integrating network pharmacology, molecular docking, and experimental verification to investigate the mechanism of baicalein in colorectal cancer

https://pubmed.ncbi.nlm.nih.gov/42434236/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260711110852&v=2.20.0

Published: July 11, 2026 10:00

CONCLUSIONS: BA inhibits CRC progression by inhibiting EGFR activation and modulating MAPK and PI3K/AKT signaling pathways. These findings provide a theoretical basis for developing BA as a natural therapeutic agent for CRC treatment.

Assessment of tenecteplase target-associated pathogenic mechanisms underlying depression in acute ischemic stroke patients: insights from artificial intelligence-driven multi-omics analysis and in vitro validation

https://pubmed.ncbi.nlm.nih.gov/42382105/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260701065215&v=2.20.0

Published: July 1, 2026 10:00

CONCLUSION: Our study is the first to identify MDD-associated diagnostic and therapeutic candidates for AIS patients after TNK treatment, providing a novel strategy for their clinical management.

Crystalline silica particles exposure modulated miRNA expression profiles in human macrophage-like THP-1 cells

https://pubmed.ncbi.nlm.nih.gov/42379284/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260701012909&v=2.20.0

Published: June 30, 2026 10:00

Occupational and environmental exposure to crystalline silica particles is a major global health concern linked to silicosis, pulmonary fibrosis, autoimmune disease, and lung cancer. MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and…

Integrated metabolomic and transcriptomic analysis identifies enhanced phosphatidylcholine metabolism in placenta accreta spectrum

https://pubmed.ncbi.nlm.nih.gov/42337473/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1naYwjERihpnD1ZeZQKCjFJMSCln1ZmAPF2zw7SxQst8hb9Mzq&fc=None&ff=20260624082316&v=2.20.0

Published: June 24, 2026 10:00

CONCLUSIONS: PAS is characterized by significant alterations in lipid metabolism, particularly increased phosphatidylcholine biosynthesis via the Kennedy pathway. These findings provide new insights into the molecular pathogenesis of PAS and suggest…