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Disease Ontology: Latest results from PubMed
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Integrating network pharmacology, molecular docking, and experimental verification to investigate the mechanism of baicalein in colorectal cancer
Published: July 11, 2026 10:00
CONCLUSIONS: BA inhibits CRC progression by inhibiting EGFR activation and modulating MAPK and PI3K/AKT signaling pathways. These findings provide a theoretical basis for developing BA as a natural therapeutic agent for CRC treatment.
Assessment of tenecteplase target-associated pathogenic mechanisms underlying depression in acute ischemic stroke patients: insights from artificial intelligence-driven multi-omics analysis and in vitro validation
Published: July 1, 2026 10:00
CONCLUSION: Our study is the first to identify MDD-associated diagnostic and therapeutic candidates for AIS patients after TNK treatment, providing a novel strategy for their clinical management.
Crystalline silica particles exposure modulated miRNA expression profiles in human macrophage-like THP-1 cells
Published: June 30, 2026 10:00
Occupational and environmental exposure to crystalline silica particles is a major global health concern linked to silicosis, pulmonary fibrosis, autoimmune disease, and lung cancer. MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and…
Integrated metabolomic and transcriptomic analysis identifies enhanced phosphatidylcholine metabolism in placenta accreta spectrum
Published: June 24, 2026 10:00
CONCLUSIONS: PAS is characterized by significant alterations in lipid metabolism, particularly increased phosphatidylcholine biosynthesis via the Kennedy pathway. These findings provide new insights into the molecular pathogenesis of PAS and suggest…
Decoding chromatin regulator-LAIR1+ M2 like macrophage patterns in atherosclerosis and clinical outcomes of Lung adenocarcinoma patients: evidence from artificial intelligence-driven multi omics and in vitro validation
Published: June 19, 2026 10:00
Atherosclerosis (AS) is a common complication of lung adenocarcinoma (LUAD), but its underlying mechanisms in LUAD remain unclear. This study aimed to decipher the role of chromatin regulators in AS pathogenesis and their association with clinical outcomes…
Cerebrospinal fluid proteomics identifies calcyphosine and follistatin-like 1 as exploratory candidate proteins of interest in hydrocephalus
Published: June 15, 2026 10:00
BACKGROUND: Hydrocephalus comprises etiologically heterogeneous disorders that converge on ventricular enlargement but may be associated with distinct protein-abundance patterns within the cerebrospinal fluid (CSF) compartment. This exploratory study…
Agentic Authoring of OMOP Concept Sets from Natural Language
Published: June 12, 2026 10:00
Authoring OMOP concept sets from free-text descriptions remains a major bottleneck in scalable computable phenotyping for observational research. Existing tools support parts of this workflow but are designed primarily for interactive expert use rather…
Exploratory transcriptomic and network-based analysis of methylmercury exposure in human neuronal developmental models using GEO datasets and toxicogenomic resources
Published: June 9, 2026 10:00
CONCLUSION: This integrative transcriptomic and network-based analysis provides an exploratory framework to prioritize candidate genes and biological processes associated with methylmercury exposure across human neuronal developmental models. The results…
IID-KG: An ontology-aligned literature-derived knowledge graph for infectious and immune-mediated diseases
Published: June 5, 2026 10:00
Infectious and immune-mediated diseases (IIDs) represent a broad and rapidly expanding biomedical literature domain in which scalable evidence extraction, disease ontology refinement, and interpretable knowledge integration are essential for biomedical…
Identification of senescence-related biomarker for aortic dissection based on bioinformatics and machine learning algorithms
Published: May 30, 2026 10:00
Aortic dissection (AD) is a vascular surgical disease that seriously threatens human health. Due to a high misdiagnosis rate and unclear pathogenesis, it brings greater challenges to AD patients and vascular surgeons. This study aimed to explore sensitive…