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Disease Ontology: Latest results from PubMed
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Posts: 10
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Integrated network pharmacology and RNA sequencing analysis to reveal the mechanisms of Qici Sanling decoction in the treatment of gemcitabine resistant bladder cancer
Published: April 15, 2025 10:00
Bladder cancer (BCa) is the most prevalent cancer of the urinary system in adults; the prognosis is dismal for BCa treated with gemcitabine (GEM) owing to intrinsic or acquired chemoresistance. This study investigated the potential of Qici Sanling…
Evaluating transcriptional alterations associated with ageing and developing age prediction models based on the human blood transcriptome
Published: April 4, 2025 10:00
Ageing-related DNA methylome and proteome changes and machine-learned ageing clock models have been described previously; however, there is a dearth of ageing clock prediction models based on human blood transcript information. Applying various machine…
EnrichDO: a global weighted model for Disease Ontology enrichment analysis
Published: March 26, 2025 10:00
CONCLUSIONS: EnrichDO provides an effective DO enrichment analysis model for gaining insight into the significance of a particular gene set in the context of disease. To increase the usability of EnrichDO, we have developed an R-based software package,…
PPDAMEGCN: Predicting piRNA-Disease Associations Based on Multi-Edge Type Graph Convolutional Network
Published: March 22, 2025 10:00
Recently, many studies have proven that Piwi-interacting RNAs (piRNAs) play key roles in various biological processes and also associate with human complicated diseases. Therefore, in order to accelerate the traditional biomedical experimental methods for…
Identification of GJC1 as a novel diagnostic marker for papillary thyroid carcinoma using weighted gene co-expression network analysis and machine learning algorithm
Published: March 17, 2025 10:00
CONCLUSIONS: GJC1 is highly expressed in PTC. Therefore, it is considered as a potential biomarker and is expected to become a new target for PTC gene therapy. However, it still needs to be supported and verified by more clinical data.
An investigation into the mechanism for Kaempferol improving melanocyte death based on network Pharmacology and experimental verification
Published: March 13, 2025 10:00
Melanocyte (MC) death represents the basic pathological change of vitiligo. Kaempferol (Kae) is one of the main active ingredients of Tribulus terrestris, which is a commonly used Chinese medicine in the treatment of vitiligo. However, it remains unclear…
Consistent Performance of GPT-4o in Rare Disease Diagnosis Across Nine Languages and 4967 Cases
Published: March 10, 2025 10:00
BACKGROUND: Large language models (LLMs) are increasingly used in the medical field for diverse applications including differential diagnostic support. The estimated training data used to create LLMs such as the Generative Pretrained Transformer (GPT)…
Evolutionary learning-derived lncRNA signature with biomarker discovery for predicting stage of colon adenocarcinoma
Published: March 5, 2025 11:00
In recent years, long non-coding RNAs (lncRNAs) have emerged as potential regulators of biological processes and genes, with the potential to serve as valuable biomarkers for cancer diagnosis and prognosis prediction. This work proposes an evolutionary…
S100P is a core gene for diagnosing and predicting the prognosis of sepsis
Published: February 25, 2025 11:00
Sepsis, characterized as a severe systemic inflammatory response syndrome, typically originates from an exaggerated immune response to infection that gives rise to organ dysfunction. Serving as one of the predominant causes of death among critically ill…
Exploring the molecular mechanism of Tripterygium Wilfordii Hook F in treating systemic lupus erythematosus via network pharmacology and molecular docking
Published: February 11, 2025 11:00
CONCLUSIONS: This research effectively anticipates the potent constituents, probable targets, and pathways implicated in treating SLE with TwHF, specifically addressing complications such as MI and AS. Comprehending the precise molecular mechanism…