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Disease Ontology: Latest results from PubMed
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A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions
Published: June 11, 2025 10:00
CONCLUSIONS: These findings advance our understanding of PPARG's regulatory network and underscore its potential as a therapeutic target, establishing a robust framework for future research in PPARG-related pathways.
PMLocMSCAM: Predicting miRNA Subcellular Localisations by miRNA Similarities and Cross-Attention Mechanism
Published: June 9, 2025 10:00
Many studies have shown that microRNAs (miRNAs) play key roles in some important processes and human complicated diseases. In addition, they also have specific physiological roles at different cellular sites. Therefore, identifying their subcellular…
Tracing the molecular landscape of diabetic nephropathy: Insights from machine learning and experiment verification
Published: June 5, 2025 10:00
OBJECTIVE: Diabetes is a chronic disease resulting from insufficient insulin secretion or impaired insulin function. Diabetic nephropathy (DN) is one of the most common complications of diabetes and a leading cause of end-stage renal disease. Early…
Functional Insights Through Gene Ontology, Disease Ontology, and KEGG Pathway Enrichment
Published: June 2, 2025 10:00
Understanding gene function and pathways is a key goal in genomics. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) provide frameworks to annotate genes based on their roles, cellular locations, and functions. These classifications…
Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration
Published: May 29, 2025 10:00
CONCLUSION: The present study identified ECM1, NPC1L1 and RSPO3 as new diagnostic biomarkers for HCC based on normal and diseased samples from HCC, meanwhile the pro-oncogenic function of RSPO3 and its regulation on immune infiltration have been confirmed.
Integrated proteomic network analysis reveals PTPRC as a central hub protein orchestrating co-expression modules and metabolic dysregulation in renal carcinoma: PTPRC protein molecular action
Published: May 9, 2025 10:00
The occurrence of renal carcinoma is closely related to a variety of molecular mechanisms and metabolic disorders. PTPRC (protein tyrosine phosphatase receptor C), as an important regulatory protein, was studied to reveal the role of PTPRC in renal…
Plasma proteomic analysis reveals altered protein abundances in HIV/HBV co-infection individuals with HCC and with liver cirrhosis
Published: May 7, 2025 10:00
To develop a risk prediction model for hepatocellular carcinoma (HCC) by screening differentially expressed proteins (DEPs) in HIV/HBV coinfected patients with HCC and liver cirrhosis using proteomic techniques. DEPs were identified in plasma from HIV/HBV…
A Fourfold Pathogen Reference Ontology Suite
Published: May 2, 2025 10:00
Infectious diseases remain a critical global health challenge, and the integration of standardized ontologies plays a vital role in managing related data. The Infectious Disease Ontology (IDO) and its extensions, such as the Coronavirus Infectious Disease…
OntoTiger: a platform of ontology-based application tools for integrative biomedical exploration
Published: April 29, 2025 10:00
Biomedical ontologies, such as Gene Ontology (GO), Disease Ontology (DO), and the Human Phenotype Ontology (HPO), have been extensively applied to characterize molecular roles and their semantic relationships in biomedical research and clinical practice.…
Comprehensive circRNA expression profile and hub genes screening during human liver development
Published: April 26, 2025 10:00
CONCLUSIONS: Our findings provide the first insights into the roles and regulatory networks of circRNAs in human liver development, laying the groundwork for further investigations of molecular and signalling networks.