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Disease Ontology: Latest results from PubMed
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Integrated proteomic network analysis reveals PTPRC as a central hub protein orchestrating co-expression modules and metabolic dysregulation in renal carcinoma: PTPRC protein molecular action
Published: May 9, 2025 10:00
The occurrence of renal carcinoma is closely related to a variety of molecular mechanisms and metabolic disorders. PTPRC (protein tyrosine phosphatase receptor C), as an important regulatory protein, was studied to reveal the role of PTPRC in renal…
Plasma proteomic analysis reveals altered protein abundances in HIV/HBV co-infection individuals with HCC and with liver cirrhosis
Published: May 7, 2025 10:00
To develop a risk prediction model for hepatocellular carcinoma (HCC) by screening differentially expressed proteins (DEPs) in HIV/HBV coinfected patients with HCC and liver cirrhosis using proteomic techniques. DEPs were identified in plasma from HIV/HBV…
A Fourfold Pathogen Reference Ontology Suite
Published: May 2, 2025 10:00
Infectious diseases remain a critical global health challenge, and the integration of standardized ontologies plays a vital role in managing related data. The Infectious Disease Ontology (IDO) and its extensions, such as the Coronavirus Infectious Disease…
OntoTiger: a platform of ontology-based application tools for integrative biomedical exploration
Published: April 29, 2025 10:00
Biomedical ontologies, such as Gene Ontology (GO), Disease Ontology (DO), and the Human Phenotype Ontology (HPO), have been extensively applied to characterize molecular roles and their semantic relationships in biomedical research and clinical practice.…
Comprehensive circRNA expression profile and hub genes screening during human liver development
Published: April 26, 2025 10:00
CONCLUSIONS: Our findings provide the first insights into the roles and regulatory networks of circRNAs in human liver development, laying the groundwork for further investigations of molecular and signalling networks.
Network pharmacology of Epilobium angustifolium metabolites in relation to in vitro analyses of its extracts
Published: April 21, 2025 10:00
Epilobium angustifolium L. is a perennial herbaceous plant known for various therapeutic properties, however its biological activity is not fully explored. In this study, we examined antioxidant activities of extracts of different polarity (n-hexane, ethyl…
Integrated network pharmacology and RNA sequencing analysis to reveal the mechanisms of Qici Sanling decoction in the treatment of gemcitabine resistant bladder cancer
Published: April 15, 2025 10:00
Bladder cancer (BCa) is the most prevalent cancer of the urinary system in adults; the prognosis is dismal for BCa treated with gemcitabine (GEM) owing to intrinsic or acquired chemoresistance. This study investigated the potential of Qici Sanling…
Evaluating transcriptional alterations associated with ageing and developing age prediction models based on the human blood transcriptome
Published: April 4, 2025 10:00
Ageing-related DNA methylome and proteome changes and machine-learned ageing clock models have been described previously; however, there is a dearth of ageing clock prediction models based on human blood transcript information. Applying various machine…
EnrichDO: a global weighted model for Disease Ontology enrichment analysis
Published: March 26, 2025 10:00
CONCLUSIONS: EnrichDO provides an effective DO enrichment analysis model for gaining insight into the significance of a particular gene set in the context of disease. To increase the usability of EnrichDO, we have developed an R-based software package,…
PPDAMEGCN: Predicting piRNA-Disease Associations Based on Multi-Edge Type Graph Convolutional Network
Published: March 22, 2025 10:00
Recently, many studies have proven that Piwi-interacting RNAs (piRNAs) play key roles in various biological processes and also associate with human complicated diseases. Therefore, in order to accelerate the traditional biomedical experimental methods for…