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Disease Ontology: Latest results from PubMed
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The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data
Published: December 29, 2024 11:00
CONCLUSION: Our data suggest that genes belonging to G Protein-Coupled Receptors play a critical role in various aspects of glioblastoma progression and pathogenesis. Four members of GPCRs, including GPR162, GPR61, GPR68, and GPR157, can be considered…
Pharmacological Mechanisms of Cryptotanshinone: Recent Advances in Cardiovascular, Cancer, and Neurological Disease Applications
Published: December 20, 2024 11:00
Cryptotanshinone (CTS) is an important active ingredient of Salvia miltiorrhiza Bge. In recent years, its remarkable pharmacological effects have triggered extensive and in-depth studies. The aim of this study is to retrieve the latest research progress on…
Elucidating the molecular and immune interplay between head and neck squamous cell carcinoma and diffuse large B-cell lymphoma through bioinformatics and machine learning
Published: December 19, 2024 11:00
CONCLUSIONS: Leveraging bioinformatics and ML, this study identified four pivotal genes with significant diagnostic capabilities for DLBCL and HNSCC. The survival analysis corroborates their diagnostic accuracy, supporting the development of a diagnostic…
Toward clearer recognition and easier usefulness: development of a cross-lingual atherosclerotic cerebrovascular disease ontology
Published: December 10, 2024 11:00
Atherosclerotic cerebrovascular disease could result in a great number of deaths and disabilities. However, it did not acquire enough attention. Less information, statistics, or data on the disease has been revealed. Thus, no systematic concept datasets…
Diagnostic ecologies: Medical standards, tinkering, and worker health in Turkey
Published: December 2, 2024 11:00
In Turkey's occupational health system, doctors must use the International Labor Organization's (ILO) standards to classify the chest radiographs of workers at risk of lung diseases caused by dust exposure. Yet these standards do not provide a uniformity…
Ferroptosis-related biomarkers for adamantinomatous craniopharyngioma treatment: conclusions from machine learning techniques
Published: November 28, 2024 11:00
INTRODUCTION: Adamantinomatous craniopharyngioma (ACP) is difficult to cure completely and prone to recurrence after surgery. Ferroptosis as an iron-dependent programmed cell death, may be a critical process in ACP. The study aimed to screen diagnostic…
Comprehensive analysis of molecular mechanisms underlying kidney stones: gene expression profiles and potential diagnostic markers
Published: November 28, 2024 11:00
CONCLUSION: The study comprehensively analyzed gene expression profiles to uncover molecular mechanisms underlying kidney stones. KLK1 and MMP10 were identified as potential diagnostic markers and key players in kidney stone progression. Functional…
Feature genes identification and immune infiltration assessment in abdominal aortic aneurysm using WGCNA and machine learning algorithms
Published: November 27, 2024 11:00
CONCLUSION: Three feature genes (MRAP2, PPP1R14A, and PLN) related to the development of AAA were identified. These genes are linked to immune cell activity and the inflammatory microenvironment, providing potential biomarkers for early detection and a…
Graph databases in systems biology: a systematic review
Published: November 20, 2024 11:00
Graph databases are becoming increasingly popular across scientific disciplines, being highly suitable for storing and connecting complex heterogeneous data. In systems biology, they are used as a backend solution for biological data repositories,…
Time-course RNA sequencing reveals high similarity in mRNAome between hepatic stellate cells activated by agalactosyl IgG and TGF-β1
Published: November 16, 2024 11:00
Previous studies have demonstrated the clinical relevance of aberrant serum immunoglobulin G (IgG) N-glycomic profiles in liver fibrosis and the pathogenic effects of agalactosyl IgG on activating hepatic stellate cells (HSCs). However, the dynamics of…