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living systematic review OR living systematic reviews: Latest results from PubMed
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Posts: 11
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Comparison between RoB-1 and RoB-2 tool and impact on network meta-analysis results - a case study from a living Cochrane review on psoriasis
Published: December 6, 2025 11:00
CONCLUSION: The transition to RoB-2 in a large Cochrane systematic review revealed fair to moderate inter-rater agreement, underscoring the need for consensus among reviewers. The shift from RoB-1 to RoB-2 led to changes in risk-of-bias judgments in our…
Longitudinal Outcome Evaluations of Interdisciplinary Multimodal Pain Treatment Programs for Patients With Chronic Primary Musculoskeletal Pain: A Living Systematic Review
Published: November 28, 2025 11:00
CONCLUSIONS: IMPT programs provide durable improvements in physical, emotional and social functioning, among which HRQoL, though the evidence remains of very low certainty and program variability persists.
Interventions for quitting vaping
Published: November 25, 2025 11:00
RATIONALE: There is limited guidance on how to stop using nicotine-containing vapes (otherwise known as e-cigarettes) and ensure long-term abstinence, whilst minimising the risk of tobacco smoking and other unintended consequences. Treatments could include…
Including nonrandomized evidence in living systematic reviews: lessons learned from the COVID-NMA initiative
Published: November 23, 2025 11:00
CONCLUSION: To remain responsive during public health emergencies, living systematic reviews should implement processes that enable the timely identification, evaluation, and integration of both randomized and nonrandomized evidence where appropriate.
Development of a continuously updating evidence map in surgical education: study protocol for a living systematic review
Published: November 17, 2025 11:00
INTRODUCTION: Despite the growing volume of research in surgical education (SurgED), the integration of evidence into teaching practice remains fragmented and inconsistent. A structured and continuously updated synthesis is needed to support data-informed…
Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis
Published: November 14, 2025 11:00
CONCLUSIONS: These automated reports leverage a large database to provide accessible data for national and regional policy makers and researchers to assess the clinical consequences of different primaquine regimens in different endemic settings. The…
Electronic cigarettes for smoking cessation
Published: November 10, 2025 11:00
RATIONALE: Electronic cigarettes (EC) are handheld electronic vaping devices that produce an aerosol by heating a liquid. People who smoke, healthcare providers, and regulators want to know if EC can help people quit smoking, and if they are safe to use…
Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis
Published: November 8, 2025 11:00
Serotonergic psychedelics and 3,4-methylendioxtmethamphetamine (MDMA) are promising treatments for mental disorders with a continuously evolving evidence base. We searched Pubmed/Scopus/clinical trial registries up to 08july2025 for double-blind randomized…
GALENOS approach to triangulating evidence (GATE): transforming the landscape of psychiatric research
Published: November 7, 2025 11:00
There is an urgent need for better evidence-based interventions in mental health. High-quality randomised controlled trials in humans are often lacking, especially when dealing with complex situations or novel therapeutic targets. Other potentially useful…
Comparative Survival in Metastatic Hormone-sensitive Prostate Cancer by Volume of Disease and Timing of Metastasis: A Living Network Meta-analysis
Published: November 5, 2025 11:00
CONCLUSIONS AND CLINICAL IMPLICATIONS: Current evidence suggests that triplet systemic therapy is preferred for patients with SHV mHSPC who are fit for docetaxel. Androgen receptor pathway doublet therapy is preferred for all other patient subgroups…
Pro-dopaminergic pharmacological interventions for anhedonia in depression: a living systematic review and network meta-analysis of human and animal studies
Published: October 30, 2025 10:00
BACKGROUND: It is unclear whether pro-dopaminergic drugs reduce anhedonia in major depressive disorder (MDD) and further, if so, to what extent this is the case.