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living systematic review OR living systematic reviews: Latest results from PubMed
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PROTOCOL: Comparative Effectiveness of Tools for Communicating Health Research Results to Study Participants and Others With Relevant Lived Experience: A Living Systematic Review of Randomized Controlled Trials
Published: June 12, 2026 10:00
Introduction: Research results are often not effectively communicated to study participants or others with relevant lived experience. Effective communication of research results would help study participants understand their contribution to research and…
Reporting of structural population assumptions in prevalence-based studies of animal feeding operations and community health
Published: June 8, 2026 10:00
Research on community health effects of Animal Feeding Operations (AFOs) frequently relies on prevalence-based effect measures, particularly for chronic respiratory outcomes. Interpreting these measures as indicators of comparative disease occurrence…
Validation of Synthesa AI, a Large Language Model-Based Screening Tool for Systematic Reviews: Results from Nine Pharmacologic Studies
Published: June 8, 2026 10:00
Systematic review screening underpins the evidence base for pharmacology and drug development but remains burdensome, error-prone, and resource-intensive. Synthesa AI, a large language model (LLM)-based abstract screening tool, was developed to streamline…
The GALENOS approach to triangulating evidence: a structured approach for integrating information from human and animal studies
Published: June 3, 2026 10:00
CONCLUSIONS: Based on findings from this literature and our experience with GATE, we updated our approach.
Light-based adjuncts to determine the need for biopsy for early detection of oral squamous cell carcinoma and potentially malignant disorders: An evidence summary of a living systematic review, Version 2026 1.0
Published: June 2, 2026 10:00
CONCLUSIONS AND PRACTICAL IMPLICATIONS: The clinical usefulness of light-based adjuncts cannot be determined with a high degree of certainty for patients with or without mucosal abnormalities. Unnecessary anxiety, biopsies, and costs related to…
Living evidence-informed guideline on the early detection of oral squamous cell carcinoma and potentially malignant disorders: Light-based adjuncts to determine the need for biopsy, Version 2026 1.0
Published: June 2, 2026 10:00
CONCLUSIONS AND PRACTICAL IMPLICATIONS: Biopsy remains the reference standard for establishing a definitive diagnosis of an oral potentially malignant disorder and oral squamous cell carcinoma. All adults should undergo a clinical oral examination in…
SARS-CoV-2 vaccination and attenuation of breakthrough infection severity: A systematic global review and meta-analysis
Published: June 1, 2026 10:00
CONCLUSIONS: COVID-19 vaccination markedly reduces the risk of progression from symptomatic infection to hospitalization. Attenuation of severity was sustained over time and did not differ significantly by vaccine platform, but was lower in older adults…
The survival impact of combining radiotherapy and immune checkpoint inhibitors in patients with solid tumors: A systematic review and living meta-analysis of randomized controlled trials
Published: May 28, 2026 10:00
CONCLUSIONS: This meta-analysis provides a field-wide overview of randomized trials on combining radiotherapy and ICIs. Addition of ICIs to a radiotherapy backbone improves PFS/EFS and yields an OS benefit after exclusion of glioblastoma trials,…
Protocol for a living systematic review of randomised controlled trials on the clinical efficacy of transcranial pulse stimulation in neurological and psychiatric conditions
Published: May 21, 2026 10:00
INTRODUCTION: Transcranial pulse stimulation (TPS) is a novel technology with therapeutic promise for Alzheimer's disease. Given its novelty and the rapidly evolving research in neurology and mental health using this technology, large randomised controlled…
Perioperative use of disease-modifying anti-rheumatic drugs (DMARDs) in people with inflammatory arthritis
Published: May 20, 2026 10:00
RATIONALE: Disease-modifying anti-rheumatic drugs (DMARDs) are the cornerstone of pharmacologic treatment for inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis). DMARDs are immunomodulatory drugs which may…