RSS Parrot

TAAR Immunopharmacology

https://pubmed.ncbi.nlm.nih.gov/42463873/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260717045314&v=2.20.0

Published: July 16, 2026 10:00

Trace amine-associated receptors (TAARs) were originally identified as G protein-coupled receptors involved in monoaminergic signaling within the central nervous system. However, accumulating evidence indicates that TAARs, particularly TAAR1 and TAAR2, are…

T Helper Cells and Cytokine Networks in the Immunopathogenesis of Multiple Sclerosis

https://pubmed.ncbi.nlm.nih.gov/42383100/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260701073438&v=2.20.0

Published: July 1, 2026 10:00

Multiple sclerosis (MS) is a chronic autoimmune disorder of CNS with demyelination, neurodegeneration and compartmentalized inflammatory disorder. Excessive T-helper cell (CD4^(+)) activation and unregulated cytokine signaling play a key role in its onset…

Mechanisms and therapeutic advances of gut metabolites in the regulation of neuroimmune inflammatory diseases

https://pubmed.ncbi.nlm.nih.gov/42311688/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260618072930&v=2.20.0

Published: June 18, 2026 10:00

Gut-derived metabolites function as critical signaling intermediaries that translate environmental cues into central nervous system (CNS) responses, playing an indispensable role in the pathogenesis and trajectory of neuroimmune inflammatory disorders. Key…

Bruton's tyrosine kinase inhibitors: a new class of multiple sclerosis therapeutics

https://pubmed.ncbi.nlm.nih.gov/42309088/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260618055706&v=2.20.0

Published: June 17, 2026 10:00

Bruton's tyrosine kinase (BTK) is an intracellular enzyme involved in a wide range of cellular functions. BTK inhibitors (BTKIs) are of interest in multiple sclerosis because they modulate various types of immune cells that have key roles in multiple…

Myelin debris uptake by macrophages and microglia: Resolution of foam cells with a series of novel cyclodextrins

https://pubmed.ncbi.nlm.nih.gov/42284980/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260613024009&v=2.20.0

Published: June 12, 2026 10:00

Foamy, lipid-laden macrophages are found in multiple sclerosis (MS) lesions, resulting from excessive phagocytosis of myelin debris following demyelination. These lipid-laden macrophages exhibit an inflammatory phenotype, inhibit remyelination, and likely…

Bifunctional ferritin nanoparticle blocks PD-1/PD-L1 pathway and alleviates oxidative stress for multi-target therapy of multiple sclerosis

https://pubmed.ncbi.nlm.nih.gov/42242097/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260605101943&v=2.20.0

Published: June 4, 2026 10:00

To address the limited immunotargeting specificity of PD-L1 antibodies and the exacerbated oxidative stress microenvironment in multiple sclerosis (MS), a bifunctional nanoplatform, Ru@Fn-PD-L1(IgV), was developed using an engineered ferritin nanocage.…

Sphingosine-1-Phosphate Is a Key Signaling Molecule in Normal Conditions and in Multiple Sclerosis

https://pubmed.ncbi.nlm.nih.gov/42219383/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260601020505&v=2.20.0

Published: May 31, 2026 10:00

Sphingosine-1-phosphate (S1P) is one of the most extensively studied bioactive signaling molecules of sphingolipid metabolism, which plays a pivotal role in regulating numerous processes in the central nervous system and immune system. Acting as an…

Mesenchymal stromal/stem cell-derived extracellular vesicles in brain disorders: mechanisms of repair and recovery

https://pubmed.ncbi.nlm.nih.gov/42179845/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260525153241&v=2.20.0

Published: May 25, 2026 10:00

Mesenchymal stem/stromal cell-derived small extracellular vesicles (MSC-sEVs) have emerged as promising cell-free therapeutics for central nervous system (CNS) disorders including stroke, traumatic brain injury (TBI), dementia, and multiple sclerosis (MS).…

Bibliometric Analysis of White Matter Disease and Novel Drug Therapy

https://pubmed.ncbi.nlm.nih.gov/42163667/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260521094603&v=2.20.0

Published: May 21, 2026 10:00

CONCLUSION: This study revealed trends in drug therapy for white matter disease through bibliometric analysis, guiding research priorities and evidence-based decisions, including mechanism-oriented precision medicine, risk algorithm optimization, and…

Transplantation of human glial cells into murine brains: A systematic review of efficacy and safety in neurodegenerative disorders

https://pubmed.ncbi.nlm.nih.gov/42158310/?utm_source=RSS-Parrot-Bot&utm_medium=rss&utm_campaign=None&utm_content=1fU8XZK4YhHEwwxHJPj0wias65oQqskKl3Us0d7KijXyJIFEEi&fc=None&ff=20260520090846&v=2.20.0

Published: May 20, 2026 10:00

Background: Neurodegenerative diseases impact millions of individuals globally. Over the years, brain research has predominantly focused on neurons, but attention is now shifting to glial cells, the brain's support cells, which play a vital role in…