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(multiple sclerosis[TIAB] AND microglia [TIAB] AND (modulate [tiab] OR therapy [tiab]) ): Latest results from PubMed
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Shedding Light on Interaction Between Neurological Symptoms and Psychiatric Episodes in Multiple Sclerosis: Novel Hypothesis and Therapeutic Avenues
Published: September 19, 2026 10:00
Multiple sclerosis is a chronic neuroinflammatory disorder, with different central nervous system lesions being induced at distinct time points. Anxiety disorders and major depressive disorder are common comorbidities of multiple sclerosis. In such cases,…
Post-translational modifications in Neuroimmune cells during neuroinflammation: integrated regulatory networks and therapeutic opportunities
Published: September 12, 2026 10:00
Neuroinflammation represents a common pathological mechanism underlying a wide range of central nervous system (CNS) disorders, encompassing neurodegenerative disorders (NDDs), ischemic stroke (IS), traumatic brain injury (TBI), and demyelinating diseases…
Short-Chain Fatty Acids and FFAR2: Modulators of the Gut-Brain Axis in Neuroinflammatory Disorders
Published: September 11, 2026 10:00
Short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, are key microbial metabolites generated through the fermentation of indigestible carbohydrates by gut bacteria. Beyond their local actions in the intestinal environment, these…
A tolerogenic mRNA-LNP vaccine alleviates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis
Published: August 18, 2026 10:00
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). Current non-specific immunosuppressive therapies carry risks of infection and malignancy. Antigen-specific tolerance induction presents a promising…
Natural flavonoids in multiple sclerosis: molecular insights and emerging therapeutic strategies
Published: August 14, 2026 10:00
Multiple sclerosis is a chronic immune mediated disease in which current disease modifying therapies reduce inflammatory relapses but incompletely address neurodegeneration and remyelination. Natural flavonoids are pleiotropic polyphenols that can modulate…
Revisiting TREM2: from multi-omics signaling networks to clinical translation
Published: August 12, 2026 10:00
TREM2 is a cell surface receptor that plays a crucial role in regulating immune responses, particularly in myeloid cells such as macrophages, dendritic cells, and microglia. Initially studied for its involvement in neuroinflammation and neurodegenerative…
TAAR Immunopharmacology
Published: July 16, 2026 10:00
Trace amine-associated receptors (TAARs) were originally identified as G protein-coupled receptors involved in monoaminergic signaling within the central nervous system. However, accumulating evidence indicates that TAARs, particularly TAAR1 and TAAR2, are…
T Helper Cells and Cytokine Networks in the Immunopathogenesis of Multiple Sclerosis
Published: July 1, 2026 10:00
Multiple sclerosis (MS) is a chronic autoimmune disorder of CNS with demyelination, neurodegeneration and compartmentalized inflammatory disorder. Excessive T-helper cell (CD4^(+)) activation and unregulated cytokine signaling play a key role in its onset…
Mechanisms and therapeutic advances of gut metabolites in the regulation of neuroimmune inflammatory diseases
Published: June 18, 2026 10:00
Gut-derived metabolites function as critical signaling intermediaries that translate environmental cues into central nervous system (CNS) responses, playing an indispensable role in the pathogenesis and trajectory of neuroimmune inflammatory disorders. Key…
Bruton's tyrosine kinase inhibitors: a new class of multiple sclerosis therapeutics
Published: June 17, 2026 10:00
Bruton's tyrosine kinase (BTK) is an intracellular enzyme involved in a wide range of cellular functions. BTK inhibitors (BTKIs) are of interest in multiple sclerosis because they modulate various types of immune cells that have key roles in multiple…