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(multiple sclerosis[TIAB] AND microglia [TIAB] AND (modulate [tiab] OR therapy [tiab]) ): Latest results from PubMed
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Myelin debris uptake by macrophages and microglia: Resolution of foam cells with a series of novel cyclodextrins
Published: June 12, 2026 10:00
Foamy, lipid-laden macrophages are found in multiple sclerosis (MS) lesions, resulting from excessive phagocytosis of myelin debris following demyelination. These lipid-laden macrophages exhibit an inflammatory phenotype, inhibit remyelination, and likely…
Bifunctional ferritin nanoparticle blocks PD-1/PD-L1 pathway and alleviates oxidative stress for multi-target therapy of multiple sclerosis
Published: June 4, 2026 10:00
To address the limited immunotargeting specificity of PD-L1 antibodies and the exacerbated oxidative stress microenvironment in multiple sclerosis (MS), a bifunctional nanoplatform, Ru@Fn-PD-L1(IgV), was developed using an engineered ferritin nanocage.…
Sphingosine-1-Phosphate Is a Key Signaling Molecule in Normal Conditions and in Multiple Sclerosis
Published: May 31, 2026 10:00
Sphingosine-1-phosphate (S1P) is one of the most extensively studied bioactive signaling molecules of sphingolipid metabolism, which plays a pivotal role in regulating numerous processes in the central nervous system and immune system. Acting as an…
Mesenchymal stromal/stem cell-derived extracellular vesicles in brain disorders: mechanisms of repair and recovery
Published: May 25, 2026 10:00
Mesenchymal stem/stromal cell-derived small extracellular vesicles (MSC-sEVs) have emerged as promising cell-free therapeutics for central nervous system (CNS) disorders including stroke, traumatic brain injury (TBI), dementia, and multiple sclerosis (MS).…
Bibliometric Analysis of White Matter Disease and Novel Drug Therapy
Published: May 21, 2026 10:00
CONCLUSION: This study revealed trends in drug therapy for white matter disease through bibliometric analysis, guiding research priorities and evidence-based decisions, including mechanism-oriented precision medicine, risk algorithm optimization, and…
Transplantation of human glial cells into murine brains: A systematic review of efficacy and safety in neurodegenerative disorders
Published: May 20, 2026 10:00
Background: Neurodegenerative diseases impact millions of individuals globally. Over the years, brain research has predominantly focused on neurons, but attention is now shifting to glial cells, the brain's support cells, which play a vital role in…
Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species
Published: May 8, 2026 10:00
Reactive oxygen species (ROS) produced by mononuclear phagocytes (MPs) are widely believed to drive tissue damage in multiple sclerosis (MS), yet the distinct roles of central nervous system (CNS)-resident versus CNS-invading MPs remain unclear. Here, we…
Piezo1 in the central nervous system: decoding the mechanical signature of neuroinflammation
Published: May 2, 2026 10:00
Neuroinflammation has historically been viewed through a biochemical lens, governed by cytokines and danger signals. While this paradigm has provided foundational insights, integrating the physical dimension of tissue stiffening, hemodynamic shear stress,…
Neural Stem Cell-Derived Extracellular Vesicles: The Next Frontier in Neurological and Neurodegenerative Diseases
Published: April 30, 2026 10:00
The present manuscript provides a comprehensive overview of neural stem cell (NSC)-derived extracellular vesicles (NSC-EVs( as a cell-free approach to treating central nervous system (CNS) disorders. The study noted that NSCs are regenerative and…