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Redefining Cognitive Domains in the Era of ChatGPT: A Comprehensive Analysis of Artificial Intelligence's Influence and Future Implications
Published: October 29, 2024 10:00
CONCLUSION: Building a socio-cognitive architecture for collective human-machine intelligence has significant potential. While ChatGPT offers impressive capabilities, over-reliance on it for cognitive tasks can lead to the erosion of essential skills. It…
Trend in serological and molecular diagnostic methods for Toxoplasma gondii infection
Published: October 29, 2024 10:00
CONCLUSIONS: By summarizing the advantages and disadvantages of different diagnostic techniques, it is hoped that the epidemiology, prevention, and control of toxoplasmosis will be improved in the future through the use of appropriate technologies.
Association between improved erectile function and dietary patterns: a systematic review and meta-analysis
Published: October 29, 2024 10:00
Erectile dysfunction (ED) is prevalent among men, but its relationship with dietary habits is uncertain. The aim of our study was to assess whether dietary patterns enhance erectile function by reviewing the literature published before August 1, 2022, via…
Efficacy and safety of stem cell therapy for fistula management: An overview of existing systematic reviews
Published: October 29, 2024 10:00
CONCLUSION: Stem cell therapy shows promise as an effective and safe treatment for fistulas, particularly in inducing remission and promoting closure of complex fistulas. The findings advocate for further high-quality research to confirm these benefits and…
Effects of virtual reality rehabilitation after spinal cord injury: a systematic review and meta-analysis
Published: October 29, 2024 10:00
CONCLUSION: VR has shown promise in enhancing walking ability and balance function in individuals with SCI. However, the existing evidence for VR interventions in SCI patients remains limited, highlighting the necessity for future studies in this area.
Deep learning approach to predict autism spectrum disorder: a systematic review and meta-analysis
Published: October 29, 2024 10:00
CONCLUSIONS: DL techniques has satisfactory sensitivity, specificity, and AUC in ASD classification. However, the major heterogeneity of the included studies limited the effectiveness of this meta-analysis. Further trials need to be performed to…
Risk factors associated with stunting incidence in under five children in Southeast Asia: a scoping review
Published: October 29, 2024 10:00
CONCLUSIONS: This scoping review determined the risk factors for childhood stunting in Southeast Asia, such as attributes of the child, traits of the parent, the amount of food the child consumes, the health of the child, feeding habits, access to health…
Assessment of meniscal extrusion with ultrasonography: a systematic review and meta-analysis
Published: October 29, 2024 10:00
CONCLUSIONS: This systematic review suggests ultrasonography can play an important role in the measurement of meniscal extrusion, with results comparable to that of MRI. However, to what extent it can differentiate between physiological and pathological…
Prevalence of adenomyosis in adolescents: diagnostic process and symptoms. Systematic review
Published: October 29, 2024 10:00
BACKGROUND: Adenomyosis is a uterine disorder commonly associated with painful menstrual cycles, abnormal uterine bleeding, and dyspareunia, which can significantly impact fertility, pregnancy outcomes and overall quality of life. Recent literature reports…
Role of serum kisspeptin as a biomarker to detect miscarriage: a systematic review and meta-analysis
Published: October 29, 2024 10:00
Miscarriage is a common adverse pregnancy outcome with physical and emotional effects. Identifying predictive miscarriage biomarkers should improve early detection and management. Serum kisspeptin, known for its critical role in reproductive biology, has…
Normal ranges of left atrial phasic strains and strain rates by 2D speckle-tracking echocardiography in pediatrics: a systematic review and meta-analysis
Published: October 29, 2024 10:00
Establishing normal values of left atrial (LA) phasic strains and strain rates is essential for distinguishing between normal and abnormal functions, determining the degree of abnormality, and understanding the clinical significance of reported values in…
Enablers and Barriers of Healthcare Services for Community-Dwelling Elderly in Rural Indonesia: A Qualitative Evidence Synthesis: Facilitadores e barreiras dos serviços de saĂşde para os idosos das comunidades nas zonas rurais da IndonĂ©sia: uma sĂntese qualitativa das provas
Published: October 29, 2024 10:00
CONCLUSION: A collaboration between communities, healthcare institutions, families, and government authorities was needed to support the success of the program and maintain the sustainability of services, which will result in adequate healthcare for the…
Associations between amyloid-β load and cognition in cerebrovascular disease beyond cerebral amyloid angiopathy: a systematic review and meta-analysis of positron emission tomography studies
Published: October 29, 2024 10:00
CONCLUSIONS: Amyloid-β load is associated with cognitive decline in non-CAA CVD patients. This is more pronounced in patients with subcortical vascular disease than in post-stroke patients. Executive function is the most susceptible domain in VCI when the…
Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data
Published: October 29, 2024 10:00
BACKGROUND: Polycystic ovary syndrome (PCOS) represents a prevalent endocrine disorder affecting numerous females worldwide. Dysbiosis of gut microbiota has been linked to the occurrence of PCOS; however, research into the characteristics of gut microbiota…
Weight-control compensatory behaviors patterns and correlates: a scoping review
Published: October 29, 2024 10:00
CONCLUSION: Weight-control compensatory behaviors may be a widely used weight management strategy and can be presented in diverse ways. Although believed to be promoting health, such behaviors appear to be associated with poor psychological well-being.…
Periodontal disease and cardiovascular disease: umbrella review
Published: October 29, 2024 10:00
CONCLUSIONS: Systematic reviews with high overall confidence support the association between PD, tooth loss, and cardiovascular diseases. However, it is crucial to interpret these results with caution due to methodological limitations. The potential public…
What is known about patients' quality of life with Phenylketonuria and their caregivers? A scoping review
Published: October 29, 2024 10:00
CONCLUSION: Patients of pediatric age and their caregivers, younger caregivers, and female patients and caregivers seem to be especially vulnerable to QoL impairments. The social and emotional dimensions were the most affected. These results emphasize the…
Efficacy of Fresh Versus Preserved Amniotic Membrane Grafts for Ocular Surface Reconstruction: META = meta-analysis
Published: October 29, 2024 10:00
Amniotic membrane transplantation is commonly employed in ophthalmology to mend corneal epithelial and stromal defects. Its effectiveness in restoring the ocular surface has been widely acknowledged in clinical practice. Nevertheless, there is ongoing…
Cost-effectiveness of Evolocumab in Cardiovascular Disease: A Systematic Review
Published: October 29, 2024 10:00
CONCLUSIONS: Our systematic review concludes that Evolocumab could be a cost-effective treatment, particularly for high-risk patient groups, but this varies by disease category, risk level, and evaluation methods. Future studies should investigate the…
PET imaging of pheochromocytoma and paraganglioma - 18F-FDOPA vs. somatostatin analogues
Published: October 29, 2024 10:00
CONCLUSION: 18F-FDOPA and 68Ga-SSA PET are both sensitive for localizing PPGL. However, 18F-FDOPA is the most sensitive for detecting pheochromocytoma, while 68Ga-SSA is superior to 18F-FDOPA for metastatic sympathetic and head-neck paraganglioma and…
Sleep disorders associated with cranial radiation - a systematic review
Published: October 29, 2024 10:00
CONCLUSIONS: This systematic review highlights the ongoing challenges with sleep symptoms/disorders related to cranial irradiation treatment in the primary brain tumor population. Further investigations on the interconnectedness of sleep disturbance…
Deprescribing Antidepressants in Children and Adolescents: A Systematic Review of Discontinuation Approaches, Cross-Titration, and Withdrawal Symptoms
Published: October 29, 2024 10:00
Background: Antidepressant medications, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), are commonly used to treat depressive, anxiety, and obsessive-compulsive disorders in youth. Yet,…
Translation, Cultural Adaptation, and Content Validation of a Pleural Mesothelioma Questionnaire to Portuguese Context - A Key Tool for Epidemiological Surveillance
Published: October 29, 2024 10:00
CONCLUSION: A validated FNSPPM questionnaire for the Portuguese context is now available to study individuals with pleural mesothelioma (PM) and asbestos exposure.
A Comparative Analysis of Botulinum Toxin Use Versus Other Therapies for Temporomandibular Disorders: A Systematic Review
Published: October 29, 2024 10:00
Existing literature regarding the efficacy of Botulinum toxin A (BoNT-A) therapy in improving the clinical outcomes of temporomandibular disorders (TMDs) is ambiguous and lacks consistency. Thus, this study aimed to evaluate the efficacy of BoNT-A in…
Problems Related to Endotracheal Intubation as an Input for the Design of a New Endotracheal Tube
Published: October 29, 2024 10:00
OBJECTIVE: The purpose of the current review is to identify the main problems of endotracheal intubation, which will serve as a basis for the design requirements for a novel endotracheal tube.
Outcomes of Intramedullary Nailing Versus Plate Fixation in the Management of Humeral Shaft Fractures: A Systematic Review and Meta-Analysis
Published: October 29, 2024 10:00
This systematic review and meta-analysis aimed to compare the outcomes of intramedullary nailing (IMN) and open reduction with internal fixation (ORIF) in treating traumatic humeral shaft fractures in adults (18 years and above). A comprehensive literature…
Improving patient safety and access to healthcare: The role of pharmacist-managed clinics in optimizing therapeutic outcomes
Published: October 29, 2024 10:00
Contemporary patient care requires a multidisciplinary approach to monitoring, assessing, and managing diseases. Promoting multidisciplinary approaches encourages the purposeful participation of many healthcare professionals and harnessing their combined…
The Effects of Subsidies for Healthy Foods on Food Purchasing Behaviors, Consumption Patterns, and Obesity/Overweight: A Systematic Review
Published: October 29, 2024 10:00
CONCLUSION: Although the subsidies appear to encourage purchase and consumption of healthier foods, enhancing the quality and diversity of dietary choices, the removal of subsidies can lead to a decline in the consumption of healthier foods. Additionally,…
Upfront Surgery Versus Upfront Concurrent Chemoradiotherapy as Primary Modality in Hypopharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
Published: October 29, 2024 10:00
CONCLUSIONS AND RELEVANCE: The results demonstrated that upfront surgery showed better OS and DFS than concurrent chemoradiation and remind the clinicians of the potential reduction in survival outcomes when choosing concurrent chemoradiotherapy as primary…
The role of Chinese herbal medicine in the regulation of oxidative stress in treating hypertension: from therapeutics to mechanisms
Published: October 29, 2024 10:00
CONCLUSIONS: CHM display a beneficial multi-target, multi-component, overall and comprehensive regulation characteristics, and have potential value for clinical application in the treatment of hypertension by regulating the level of oxidative stress.
The effect of different dietary restriction on weight management and metabolic parameters in people with type 2 diabetes mellitus: a network meta-analysis of randomized controlled trials
Published: October 29, 2024 10:00
CONCLUSIONS: Both IF and CER exert positive influences on weight control and metabolic profile enhancement in individuals with T2DM, with FMD as part of IF demonstrating the greatest impact. To substantiate these findings, more rigorous randomized…
The Implementation of the International Health Regulations on Vector-Borne Diseases: A Scoping Review of the Qualitative Evidence Performed Worldwide
Published: October 29, 2024 10:00
CONCLUSION: There are severe asymmetries across countries on the implementation of international regulations with regards to vector-borne diseases, particularly on the issue of surveillance systems. State Parties should consider the lessons learned from…
Post-Amputation Pain: Combined Analyses of Randomized Controlled Trials Evaluating Opioids and Gabapentinoids versus Placebo
Published: October 29, 2024 10:00
CONCLUSION: Patients undergoing limb amputation have a clear unmet need for more adequate chronic pain control. Given that post-amputation pain is often diagnosed as a chronic condition, persisting for at least 90 days, our data highlight the need for…
Perioperative use of enteral nutrition with ω-3 polyunsaturated fatty acid in patients with gastric cancer: a meta-analysis
Published: October 29, 2024 10:00
CONCLUSION: enteral nutrition with ω-3 polyunsaturated fatty acid preparation has advantages in the efficacy and safety of perioperative nutritional therapy in patients with gastric cancer, and can be used as a clinical choice. Due to the limited number…
Management Strategies for Immature Teeth with Pulp Necrosis: An Umbrella Review of Systematic Reviews
Published: October 29, 2024 10:00
CONCLUSIONS: MTA apexification and RET are viable alternatives to CH apexification, with RET showing greater potential for root development and apical healing. Future research should focus on developing standardized protocols and uniform RET guidelines,…
What Are the Barriers to Telerehabilitation in the Treatment of Musculoskeletal Diseases?
Published: October 29, 2024 10:00
CONCLUSION: The barriers to telerehabilitation, which were more related to Internet access, telecommunication devices, personal relationships, and adequate monitoring of the exercise protocol, were overcome by diversifying the means of communication and…
Safety and efficacy of intravenous thrombolytic therapy in the extended window up to 24 hours: A systematic review and meta-analysis
Published: October 29, 2024 10:00
OBJECTIVE: About 25% of patients with acute ischemic stroke (AIS) present within the intravenous thrombolytic (IVT) therapeutic window of <4.5 h. This study is to elucidate the safety and efficacy of IVT in the extended therapeutic window (ETW) in patients…
Clinical Outcomes of Exercise Rehabilitation for Degenerative Tibial Meniscal Tears: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Published: October 29, 2024 10:00
CONCLUSION: Exercise therapy has shown potential in alleviating pain, enhancing lower limb muscle strength, and improving mobility in patients with degenerative meniscal lesions of the tibia (DMLT). Functional training and varied rehabilitation exercises…
Patient-reported outcomes of chimeric antigen receptor T-cell therapy in hematologic malignancies: a systematic review and meta-analysis
Published: October 29, 2024 10:00
Few studies evaluated patient-reported outcomes (PROs) for patients with hematologic malignancies receiving with Chimeric Antigen Receptor T (CAR-T) cell therapy. We performed a systematic review and meta-analysis to evaluate the benefits of CAR-T cell…
Cost-effectiveness of oral versus injectable disease modifying therapies in relapsing multiple sclerosis: a systematic review analysis
Published: October 29, 2024 10:00
CONCLUSION: A large number of health economic evaluations of disease-modifying therapies (DMTs) in MS were available at the international level, the comparison of which was difficult and sometimes contradictory. However, despite the difference in the…
Updating the Pharmacological Effects of α-Mangostin Compound and Unraveling Its Mechanism of Action: A Computational Study Review
Published: October 29, 2024 10:00
α-Mangostin, initially identified in 1855, is a xanthone derivative compound predominantly located in the pericarp of the mangosteen fruit (Garcinia mangostana L). This compound is known for its beneficial properties as an antioxidant and anti-inflammatory…
Meta-analysis of the effects of probiotics on hyperlipidemia
Published: October 29, 2024 10:00
CONCLUSION: The findings from this meta-analysis suggest that probiotics can enhance SCFA content in the body, decrease lipid levels in animals, improve oxidative stress and inflammation, reduce liver damage, and effectively alleviate hyperlipidemia.
Oral Health Research in the WHO African Region between 2011 and 2022: A Scoping Review
Published: October 29, 2024 10:00
The status of oral health research in the World Health Organization (WHO) African region is unclear, yet the need for such information is central to moving an oral health agenda forward. Such an agenda is essential for effectively translating research into…
Artificial Intelligence in Forensic Sciences: A Systematic Review of Past and Current Applications and Future Perspectives
Published: October 29, 2024 10:00
The aim of this study is to review the available knowledge concerning the use of artificial Intelligence (AI) in general in different areas of Forensic Sciences from human identification to postmortem interval estimation and the estimation of different…
Global Cancer Nurse's Experiences and Perceptions of Potential Occupational Exposure to Cytotoxic Drugs: Mixed Method Systematic Review With Framework Synthesis
Published: October 29, 2024 10:00
CONCLUSIONS: The review conclude that individuals espouse safe handling and administration of CDs. Synthesis highlights a complex interplay between self-reported perception and the observed experience of potential occupational exposure to cytotoxic drugs.
Focal myositis: a literature review of clinical and immunopathological aspects
Published: October 29, 2024 10:00
CONCLUSIONS: Clinical, laboratory, neurophysiological and imaging findings can allow a correct diagnosis. However, muscle biopsy seems to be the only diagnostic tool to differentiate among FM and other localized soft tissue masses.
Exploring the Impact of Fasting and Fasting-Mimicking Diets on Type 2 Diabetes Management in Adults: A Systematic Review
Published: October 29, 2024 10:00
Type 2 diabetes poses significant global health challenges, affecting both the quality of life and healthcare systems. This systematic review evaluates the efficacy of fasting and fasting-mimicking diets (FMD) in managing type 2 diabetes, with a focus on…
Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
Published: October 29, 2024 10:00
CONCLUSION: There is high evidence to support the relationships between asbestos and MPM. However, the relatively scant information provided by the studies reinforces the need for well-conducted research and implementation of National Mesothelioma…
Duration and Efficiency of Combined versus Isolated Aerobic Training Interventions in Post-Stroke Cognition: A Systematic Review
Published: October 29, 2024 10:00
BACKGROUND: This study aimed to evaluate the effects of physical activity on the cognition of patients with stroke, comparing the effectiveness of using isolated or combined rehabilitation, as well as the duration and intensity of training, to identify the…
Antimicrobial Effects of Formulations of Various Nanoparticles and Calcium Hydroxide as Intra-canal Medications Against Enterococcus faecalis: A Systematic Review
Published: October 29, 2024 10:00
The combination of calcium hydroxide (Ca(OH)₂) and nanoparticles (NPs) offers a promising approach to improving the efficacy of intra-canal treatments. Their synergistic effects can enhance antimicrobial action, improve penetration, and promote better…
Prevalence and Impact of Chronic Obstructive Pulmonary Disease in Ischemic Heart Disease: A Systematic Review and Meta-Analysis of 18 Million Patients
Published: October 28, 2024 10:00
CONCLUSION: This meta-analysis demonstrated that COPD is prevalent in IHD, involving 12.0% of IHD patients, and is linked to a lower prescription of BBs, an increased burden of comorbidities, and worse acute phase outcomes and long-term mortality.
Serum Calcium and Magnesium Levels in Women Presenting with Pre-eclampsia: A Systematic Review and Meta-analysis Based on Observational Studies
Published: October 28, 2024 10:00
CONCLUSION: This meta-analysis demonstrates that the circulating levels of calcium and magnesium in patients with preeclampsia are significantly lower than those in the control group.
The microbiome of the neovagina: a systematic review and comparison of surgical techniques
Published: October 28, 2024 10:00
Introduction : Vaginoplasty is performed to create a neovagina for transgender individuals who seek surgical transition or for cisgender individuals with congenital or acquired absence of a vagina (or "cisvagina"). The current knowledge of the bacterial…
Childhood amblyopia: A systematic review of recent management options
Published: October 28, 2024 10:00
This study reviews the current information on treatment of childhood amblyopia, with the goal of improving visual functions. The authors searched various online databases including PubMed, Web of Science, ProQuest, Scopus, Google Scholar, Ebsco, and…
Research output from India's Siddha system of medicine during 1972-2019: Bibliometric analysis points need to focus on quantity and quality
Published: October 28, 2024 10:00
CONCLUSION: A bibliometric review of research output from SSM suggests that the publications have increased in the last two decades. The review recommends improving research output from SSM in terms of quantity and quality.
Recommendations for long-term follow-up care of secondary health conditions in spinal cord injury/disorder: a systematic review
Published: October 28, 2024 10:00
CONCLUSION: Based on the comprehensive and extensive literature research conducted, regular (annual) follow-up care appointments at specialized SCI clinics are recommended. There is a notable absence of a comprehensive CPG covering all relevant health…
Risk Factors Affecting the Psychological Resilience of Adolescents in Institutional Care: A Systematic Review
Published: October 28, 2024 10:00
CONCLUSION: Adolescents in institutional care were more vulnerable and had more mental and behavioral problems than their peers. This systematic review found no studies evaluating preventive programs, interventions, or interventions designed to reduce the…
Dietary strategies and nutritional supplements in the management of heart failure: a systematic review
Published: October 28, 2024 10:00
CONCLUSION: Certain dietary interventions and nutritional supplements may provide some benefit to patients with HF. However, there is no relevant definitive evidence on the impact of nutritional interventions on the prognosis of HF, and more high-quality…
Prevalence of hyperopia in school-aged children in eastern Mediterranean region: A systematic review and meta-analysis
Published: October 28, 2024 10:00
CONCLUSION: The prevalence of hyperopia among children in the EMR was high compared to other regions, particularly in younger children. More studies are required using standardized methods in different regions where there is a lack of information on…
A Commentary: Invisibility of Older African-American Adults in Electrophysiological Research on Alzheimer's Disease
Published: October 28, 2024 10:00
CONCLUSION: Research is growing to support the integration of electrophysiological biomarkers into clinical practice. The invisibility of older African-American adults in this research affects the reliability of electrophysiological biomarkers and their…
The Use of Rhinomanometry in Mouth Breathing: A Systematic Review of the Literature
Published: October 28, 2024 10:00
Introduction Mouth breathing generates imbalances in the musculature, in craniofacial morphofunctionality, and in the stomatognathic system. Therefore, it is essential to make a diagnosis of mouth breathing through the quantitative assessment of nasal…
Cost-effectiveness of Neonatal Hearing Screening Programs: Systematic Review
Published: October 28, 2024 10:00
Introduction Universal newborn hearing screening (UNHS) has been widely and strongly advocated as an early detection strategy for hearing loss in children. This intervention aims to prevent delays in speech and language development, which, in turn, has…
Modeling and empirical evidence of the impact of implementation of sugar sweetened-beverages tax to reduce non-communicable diseases prevalence: a systematic review
Published: October 28, 2024 10:00
INTRODUCTION: The surge in non-communicable diseases (NCDs) has been linked to excessive sugar-sweetened beverage (SSB) consumption. In response, the World Health Organization advocates for SSB taxes as a preventive measure. This study conducts a…
Therapeutic patient education for severe mental disorders: A systematic review
Published: October 28, 2024 10:00
CONCLUSION: The findings underscore the potential of TPE in psychiatric care, revealing its multifaceted nature and varied impact. TPE not only addresses deficits but also leverages patients' existing strengths and capabilities. Despite the reported…
Effect of Decompressive Craniectomy on Intracranial Pressure Waveforms and Vascular Reactivity: A Systematic Scoping Review
Published: October 28, 2024 10:00
Decompressive craniectomy (DC) primarily aims at decreasing intracranial pressure (ICP) by allowing for the brain tissue to expand. However, it is uncertain to what extent DC impacts the transmission of vasogenic slow waves and thus the validity and…
Effect of intermittent theta burst stimulation on upper limb function in stroke patients: a systematic review and meta-analysis
Published: October 28, 2024 10:00
CONCLUSIONS: The comprehensive evidence suggests that iTBS has superior effects in improving upper limb function and activities of daily living in stroke patients.
The challenge of identifying family carers in general practice at an early stage and measuring their burden: A scoping review of possible tools and their actual use
Published: October 28, 2024 10:00
Informal care, provided unpaid by family members or friends is a crucial source for providing care at home due to chronic illnesses, disability, or long-lasting health issues. An increasing burden on informal carers largely determines the already proven…
Effectiveness of mandibular advancement orthodontic appliances with maxillary expansion device in children with obstructive sleep apnea: a systematic review
Published: October 28, 2024 10:00
CONCLUSIONS: The limited quantity and quality of existing studies necessitate caution when drawing conclusions about the effectiveness of mandibular advancement and maxillary expansion for OSA. In the future, larger and well-designed randomized controlled…
Sleep and Learning: A Systematic Review
Published: October 28, 2024 10:00
Introduction Sleep deprivation has a great impact on the learning process in physicians in training. Therefore, inquiring on this phenomenon in the most recent investigations will facilitate the provision of evidence on the influence regarding the absence…
Comprehensive systematic review and meta-analysis of microplastic prevalence and abundance in freshwater fish species: the effect of fish species habitat, feeding behavior, and Fulton's condition factor
Published: October 28, 2024 10:00
Microplastics are emerging pollutants that cause health problems for aquatic organisms. Fish is one of the important organisms because of its consumption by humankind. The present study examines the abundance and prevalence of microplastics in freshwater…
Prognostic significance of the modified Glasgow Prognostic Score in NSCLC patients undergoing immune checkpoint inhibitor therapy: a meta-analysis
Published: October 28, 2024 10:00
CONCLUSION: mGPS can be used as a good noninvasive biomarker to demonstrate prognostic and clinical significance in patients with NSCLC undergoing immunotherapy.
Multicancer Early Detection Tests: A State-of-the-Art Review for Otolaryngologists
Published: October 28, 2024 10:00
CONCLUSION: Long-term robust data regarding the performance characteristics, effects on clinical outcomes, and cost-utility of MCED tests for head and neck cancer are currently lacking. Otolaryngologists should be aware of the implications of MCED tests as…
Evaluation of Minimum Recording Time and the Influence of Time in the Supine Position on Out-of-Center Sleep Tests
Published: October 28, 2024 10:00
Introduction The prevalence of moderate to severe sleep-disordered breathing is of 17% among men aged between 50 and 70-years, and of 9% among women in the same age group. In Brazil, obstructive sleep apnea (OSA) is also highly prevalent, and it is…
Persistent ENT Manifestations in Individuals who Recovered from COVID-19: A Systematic Review
Published: October 28, 2024 10:00
Introduction Long coronavirus disease (COVID) refers to the persistence of symptoms long after the recovery from the acute phase of the illness, and it is due to the interplay of various inflammatory mechanisms. This has led to emergence of new deficits,…
Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in patients with type 2 diabetes mellitus: a network meta-analysis of population-based cohort studies
Published: October 28, 2024 10:00
CONCLUSION: Our study's collective findings suggest a significant association of the low risk of fracture with the use of SGLT2i with other GLMs combination, SGLT2i alone, GLP-1RA, and DPP-4i, respectively. This population-based analysis offers the best…
Immunomodulatory Effects of SGLT2 Inhibitors and Metformin in Managing Rheumatic Diseases: A Narrative Review
Published: October 28, 2024 10:00
Limited studies summarise the immunomodulatory effects of SGLT2 inhibitors and Metformin in managing rheumatic diseases. The present narrative review aims to fill this knowledge gap by gathering information based on existing clinical evidence. A narrative…
The Future of Cervical Cancer Screening
Published: October 28, 2024 10:00
CONCLUSION: Screening for HPV and CD plays a pivotal role in reducing the risk of cervical cancer-related mortality. The development of novel technologies, along with efforts to enhance global health equity and integrate cervical cancer prevention with HIV…
Efficacy and safety of different drugs for the treatment of bacterial vaginosis: a systematic review and network meta-analysis
Published: October 28, 2024 10:00
CONCLUSIONS: The results of this systematic review and network meta-analysis suggest that ornidazole may be an effective alternative for the treatment of BV, and that sucrose and probiotics are potential BV treatments that need to be validated by more…
The Effects of Selective Serotonin Reuptake Inhibitors on Neurological and Depressive Symptoms in Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Published: October 28, 2024 10:00
CONCLUSION: This study shows that the consumption of SSRIs in MS patients compared to the control group does not bring about a significant change in the indices related to neurological and depressive symptoms. Further meta-analyses are required in order to…
Automatic Detection and Extraction of Key Resources from Tables in Biomedical Papers
Published: October 28, 2024 10:00
Tables are useful information artifacts that allow easy detection of data "missingness" by humans and have been deployed by several publishers to improve the amount of information present for key resources and reagents such as antibodies, cell lines, and…
Inflammatory bowel disease, colitis, and cancer: unmasking the chronic inflammation link
Published: October 28, 2024 10:00
CONCLUSION: Sustained inflammation in the colon fosters a pro-tumorigenic environment, leading to the initiation and progression of CA-CRC. Prevention strategies must focus on controlling chronic inflammation, optimizing IBD management, and implementing…
The Role of Extracorporeal Shock Wave Therapy in Keloids and Hypertrophic Scars: A Systematic Review
Published: October 28, 2024 10:00
Keloids and hypertrophic scars are pathological scars that result from a prolonged and aberrant response to wound healing, resulting in raised and thickened skin lesions. Traditional treatments include occlusive dressings, compression therapy,…
Treatments for Olfactory Dysfunction in COVID-19: A Systematic Review
Published: October 28, 2024 10:00
Introduction Olfactory dysfunction (OD) has emerged as a notable symptom among coronavirus disease 2019 (COVID-19) patients, with its prevalence varying among different populations. Recognizing the need to provide therapeutic solutions for these…
Diagnostic and prognostic role of NLR in testicular cancer
Published: October 28, 2024 10:00
BACKGROUND: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa).
Clinical management of transgender and non-binary patients in the fertility preservation service: Current evidence
Published: October 28, 2024 10:00
Background: Transgender and non-binary individuals face unique challenges when it comes to fertility preservation (FP). Objective: Despite the growing prevalence of gender dysphoria (GD) and gender transitioning, there is a lack of clear guidelines and…
Prevalence and impact of rapid eye movement sleep behavior disorder in multiple system atrophy: a systematic review and meta-analysis
Published: October 28, 2024 10:00
CONCLUSION: The prevalence of polysomnography-confirmed RBD in MSA is 79.9%. The prevalence in Asian population was lower than in Europe and America, which might be related to an underestimation in Asian populations. Additionally, patients with MSA and RBD…
Microvascular invasion is associated with poor prognosis in renal cell carcinoma: a retrospective cohort study and meta-analysis
Published: October 28, 2024 10:00
CONCLUSIONS: The presence of MVI in renal cell carcinoma patients is linked to poorer survival outcomes and worse clinicopathological features. In spite of this, it does not seem to be an independent predictor for cancer survival mortality in renal cell…
Combining tibial tubercle osteotomy with medial patellofemoral ligament reconstruction often yields better outcomes in treating patellofemoral instability: a systematic review and meta-analysis of case-control studies
Published: October 28, 2024 10:00
CONCLUSION: The combination of MPFLR and TTO for treating PFI yields knee joint function comparable to that achieved with MPFLR alone. The approach does not elevate the failure rate of the surgery or the incidence of other adverse events. However, the…
Assessing health risks of polycyclic aromatic hydrocarbons (PAHs) in cooked fish using monte carlo simulation: a global review and meta-analysis
Published: October 28, 2024 10:00
Cooking food at high temperatures can lead to the formation of harmful chemical compounds called polycyclic aromatic hydrocarbons (PAHs). The purpose of this study was to conduct a systematic review and meta-analysis to evaluate the concentrations of 16…
Distinctive characteristics, risk factors, and prevention of premature myocardial infarction: A narrative review
Published: October 28, 2024 10:00
The proportion of young individuals that present with acute myocardial infarction is a major problem that keeps increasing. The specific characteristics of premature coronary artery disease and its differences between young and older individuals need to be…
Traumatic Dental Injuries' Prevalence across Diverse Healthcare Settings: A Systematic Review and Meta-Analysis
Published: October 28, 2024 10:00
CONCLUSIONS: This systematic review underscores the high prevalence of TDI and highlights the need for targeted preventive strategies and evidence-based interventions in dental trauma care.
How does Public Financial Management (PFM) influence health system efficiency: A scoping review
Published: October 28, 2024 10:00
CONCLUSION: The entire budget process influences health system efficiency. However, most of the findings are drawn from studies that focused on aspects of the budget process. Studies that look at PFM in totality will help explore other cross-cutting issues…
Impact of whole-body and skeletal muscle composition on peak oxygen uptake in heart failure: a systematic review and meta-analysis
Published: October 28, 2024 10:00
CONCLUSION: Individuals with HF display abnormalities in body and skeletal muscle composition including reduced lean mass, oxidative Type I fibres, and capillary-to-fibre ratio that negatively impact VO(2)peak.
Association of CTLA-4 polymorphisms with hematologic malignancy susceptibility: a meta-analysis
Published: October 28, 2024 10:00
CONCLUSION: CTLA-4 49A/G and 319C/T polymorphisms were associated with hematologic malignancy susceptibility.
A systematic review of the effect of sandplay therapy on social communication deficits in children with autism spectrum disorder
Published: October 28, 2024 10:00
OBJECTIVE: To explore the efficacy of sandplay therapy in intervening social communication deficits in children with autism spectrum disorders (ASD), and whether this efficacy is influenced by the age of the children and the dosage of sandplay therapy…
A mobile health application use among diabetes mellitus patients: a systematic review and meta-analysis
Published: October 28, 2024 10:00
CONCLUSIONS: Our meta-analysis results show that over one-third of individuals use mobile health applications for diabetic self-management, and more than half of individuals would like to manage their diabetes mellitus in the future by using mobile health…
Violet light transmission through eyeglasses and its effects on myopic children: A systematic review and meta-analysis
Published: October 28, 2024 10:00
CONCLUSION: VL transmission glasses play a significant role in controlling myopia among children, resulting in axial shortening, reduction of SER, and improvement in VA. However, further investigation is required to examine the long-term rebound effect.
Investigating the potential application of organic and non-organic nanoparticles for gastric cancer treatment: An evidence-based review
Published: October 28, 2024 10:00
Gastric cancer, which is considered a major health concern, is the sixth most frequent cancer and the second leading cause of cancer-related mortality across the globe. The present survey aimed to systematically review the anti-gastric cancer effect of all…
Perfluoroalkyl and polyfluoroalkyl substances and Cancer risk: results from a dose-response Meta-analysis
Published: October 28, 2024 10:00
CONCLUSIONS: The findings suggest that PFAS exposure is a potential cancer risk factor, with the carcinogenic potential of PFDA being dose-dependent.
Evolving Assessment in Medical Education: Exploring the Role of Open-Book Examinations
Published: October 28, 2024 10:00
CONCLUSION: The findings indicate that open-book examinations are a crucial component in the evolving landscape of medical education. While certain reservations remain, open-book examinations have shown significant potential in fostering critical thinking,…
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