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The latest news on neuroscience research

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A Pa. woman is receiving a new treatment for a rare form of ALS

Published: September 1, 2025 06:40

On a quiet farm in Erie County, Pennsylvania, 67-year-old Diane Zaczyk used to think nothing of hefting 50-pound sacks of chicken feed onto her shoulder. But not long ago, she found herself struggling to lift the feed bags she had carried for decades. Then…

Comprehensive molecular atlas of human hippocampus maps cell subtypes and organization

Published: September 1, 2025 06:30

The hippocampus is an important brain region known to support various cognitive (i.e., mental) processes, including the encoding and retrieval of memories, learning, decision-making and the regulation of emotional states. While extensive research has tried…

Stomach-brain communication predicts emotional symptoms and well-being, study finds

Published: August 30, 2025 09:30

Internal physiological states, such as digestion, breathing and heartbeat, have been consistently linked to mental, psychological and emotional experiences. This body-mind connection is known to be supported by interoception, the innate ability to sense…

Scientists create realistic brain-wide connection maps through digital modeling

Published: August 29, 2025 14:20

EPFL researchers have developed a powerful method to generate brain-wide, biologically realistic wiring maps of the mouse brain. Their approach bridges experimental data with mathematical and computational modeling to simulate how neurons connect across…

How the distinctive folds in the brain cortex, seen in humans, whales, other animals, form

Published: August 29, 2025 13:45

One of the defining features of humans is our brain's remarkable capacity for language, planning, memory, creativity, and more. These abilities stem not just from our large brain size, but also from the folded structure of the brain's outer layer, the…

Study finds post-stroke aerobic exercise is safe and can help preserve cognition

Published: August 29, 2025 09:44

Stroke survivors at increased risk of developing dementia do not have therapies to reduce that risk, but new Monash University-led research could help change that.

Two distinct microglia populations linked to autism-like and depression-like behaviors in mice

Published: August 29, 2025 07:20

The anterior insular cortex (aIC) is an important brain region known to contribute to the regulation of emotions, the integration of bodily sensations, decision-making and some other functions. Past studies have linked this brain region to some…

Placebo pain relief works differently across the human body, study finds

Published: August 28, 2025 15:10

Researchers from the University of Sydney have used placebo pain relief to uncover a map-like system in the brainstem that controls pain differently depending on where it's felt in the body. The findings may pave the way for safer, more targeted treatments…

Two fish species, two strategies—a new model to study working memory

Published: August 28, 2025 14:19

For over three decades, the zebrafish has advanced preclinical biomedical research: hundreds of individuals can be studied simultaneously, and even whole-brain activity can be recorded in living animals. Its limitation, however, lies in its social nature:…

Being fit in older age can support brain regions that help you reach for right words

Published: August 28, 2025 13:13

Moderate exercise in older age shapes brain activity which can reduce the number of "tip of the tongue" moments, as new research shows that higher cardiorespiratory fitness alters our brain's ability to reach for the right word at the right time.

The brain's activity at rest may provide clues to Alzheimer's disease progression and diagnosis

Published: August 28, 2025 12:41

Some regions of the brain in people with Alzheimer's reorganize more often while at rest than in people without the disease––and in healthy people this frequent reshuffling sometimes predicts who will develop the condition later, according to a new study…

Novel blood test for ALS can detect early signs years before symptoms appear

Published: August 28, 2025 12:30

By 2040, experts estimate that nearly 400,000 people worldwide will be living with amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease. This degenerative nervous system disease damages nerve cells responsible for controlling…

Researchers detail how neurotransmitter receptors in the fly brain change during development

Published: August 28, 2025 11:30

New proteomics research is enabling scientists to decipher how neurotransmitter receptors behave and change as an organism develops. The new work could help scientists better understand the formation and function of synapses—the junctions where…

Fragile X syndrome: Study details cellular and molecular activity that leads to cognitive chaos

Published: August 28, 2025 09:21

The genetic disorder Fragile X syndrome occurs when individuals don't make the Fragile X protein known as FMRP. Essential for normal brain development, FMRP helps control when and where proteins are made in the brain, supporting its ability to change and…

Mental time travel: A new case of autobiographical hypermnesia

Published: August 28, 2025 08:55

Remembering past events in minute detail, revisiting them methodically, and reliving past emotions—this is the peculiarity of people with an exceptional memory of their own lives, known as autobiographical hypermnesia, or hyperthymesia. This fascinating…

Microglia gene activity shifts across Alzheimer's stages, revealing possible therapy targets

Published: August 28, 2025 07:50

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder that causes progressive memory loss and a decline in mental (i.e., cognitive) abilities. Statistics suggest that between 500,000 and 900,000 people are diagnosed with this disease every…

Hormone therapy type matters for memory performance after menopause, finds study

Published: August 27, 2025 16:20

The type of estradiol-based hormone therapy taken during and after menopause, such as patches or pills, may be associated with differences in memory performance, according to a study published on August 27, 2025, in Neurology.

Study finds stroke risk highest among Native Hawaiian, Pacific Islander people

Published: August 27, 2025 16:10

A new study found that Native Hawaiian or Pacific Islander people had the highest rate of stroke among people from other race and ethnic groups, with a rate more than three times higher than that of white people. The study is published on August 27, 2025,…

Breathwork can induce altered states of consciousness linked with changes in brain blood flow

Published: August 27, 2025 14:00

Breathwork while listening to music may induce a blissful state in practitioners, accompanied by changes in blood flow to emotion-processing brain regions, according to a study published in the open-access journal PLOS One by Amy Amla Kartar from the…

Overworked brain cells may burn out in Parkinson's disease

Published: August 27, 2025 13:12

Certain brain cells are responsible for coordinating smooth, controlled movements of the body. But when those cells are constantly overactivated for weeks on end, they degenerate and ultimately die. This new observation made by scientists at Gladstone…

New treatment with designer proteins could disrupt cycle of addiction without stifling natural pleasure

Published: August 27, 2025 13:00

A new biochemical approach to combat addiction, developed by researchers at the University of California San Diego and the National Institute on Drug Abuse (NIDA), has shown promising results in reducing drug-seeking behavior.

Test detects brain cancers in cerebrospinal fluid with high accuracy

Published: August 27, 2025 11:20

A novel, multi-analyte test developed by researchers at the Johns Hopkins Kimmel Cancer Center, its Ludwig Center and the Johns Hopkins Department of Neurosurgery can accurately identify brain cancers using small samples of cerebrospinal fluid (CSF),…

Scientists uncover brain network controlling stress and social behavior in mice

Published: August 27, 2025 11:00

A UCLA study has mapped a critical brain hub in mice that regulates stress responses and social behavior, shedding new light on the neural roots of psychiatric conditions such as post-traumatic stress disorder, depression and anxiety.

Tracking anticipatory gaze offers new way to assess memory in silent patients

Published: August 27, 2025 07:10

To assess and study human memory, psychologists have so far primarily used tasks that require people to verbally recall objects they previously saw in images, past life events or other types of information. While these tasks are widely employed by…

Cognitive behavioral therapy can alter brain structure and boost gray matter volume, study shows

Published: August 26, 2025 20:00

Psychotherapy leads to measurable changes in brain structure. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Münster have demonstrated this for the first time in a study in Translational Psychiatry by using cognitive…

Immune cells in the brain help shape adolescent neural circuits

Published: August 26, 2025 17:01

Making a smoothie, going for an evening walk, or having empathy for a loved one are all examples of executive functions that are controlled by the brain's frontal cortex. This area of the brain goes through profound change throughout adolescence, and it is…

How cloves might help relieve pain and inflammation

Published: August 26, 2025 13:38

Cloves have long been a staple in kitchens and traditional medicine cabinets. Known for their warm, spicy flavor, they're typically found whole or ground, and as clove oil or extract. But beyond their culinary charm, cloves are gaining scientific attention…

Key protein complex drives nerve cell death in Alzheimer's disease, study finds

Published: August 26, 2025 12:24

A molecular mechanism that significantly contributes to the progression of Alzheimer's disease has been discovered by a research team led by neurobiologist Prof. Dr. Hilmar Bading of Heidelberg University. Their study is published in the journal Molecular…

Distinct prefrontal pathways shown to separate reward motivation from threat reactivity

Published: August 26, 2025 12:00

University of Cambridge researchers report that inactivating dorsolateral prefrontal cortex area 46 in marmosets blunts appetitive motivation and heightens threat reactivity, with effects mediated through asymmetric left-hemisphere pathways.

Mouse neurons that identify friends in need and friends indeed

Published: August 26, 2025 11:00

A special set of neurons directs mice's attention to or away from their peers, depending on the situation. The Kobe University discovery has implications for finding causes for neuropsychiatric conditions such as autism spectrum disorder or schizophrenia.

Fresh insights into the inner workings of the developing brain could lead to autism treatments

Published: August 26, 2025 07:30

While there is a vast amount of information about the human brain and how it develops and works, much of the organ is still uncharted territory. But new research published in the journal Nature is giving us new insights into a type of brain cell called the…

New insight into how the fruit fly brain creates spatial representations that support navigation

Published: August 26, 2025 06:30

To move around in their surroundings in meaningful and goal-directed ways, a skill known as navigation, humans and animals rely on a series of complex cognitive (i.e., mental) processes. Navigation is also supported by the so-called head direction system,…

Altered FGFR1 pathway in hippocampus may underlie depression, especially in elderly

Published: August 26, 2025 04:29

Major depressive disorder (MDD) is one of the most common psychiatric illnesses worldwide, but its molecular causes have still not been clearly identified. A research team has discovered that depression may not simply be caused by neuronal damage, but can…

Brain's blood flow could change how we understand and treat Alzheimer's

Published: August 25, 2025 16:15

Over seven million Americans are living with Alzheimer's disease (AD), and the heartbreaking day-to-day battle with the effects of cognitive decline. According to the Alzheimer's Association, the brain changes that cause the disease actually begin 20 years…

Apitegromab improves motor function in spinal muscular atrophy

Published: August 25, 2025 14:20

For patients with nonambulatory type 2 or type 3 spinal muscular atrophy, apitegromab, a monoclonal antibody that inhibits myostatin activation, improves motor function versus placebo, according to a study published online Aug. 13 in the Lancet Neurology.

Neural activity linked to self-preoccupied thinking

Published: August 25, 2025 13:00

People tend to be self-preoccupied. Self-interest is good when it ensures that one's needs are met, but it can also be maladaptive; research shows that the tendency to self-focus promotes the occurrence of depression and anxiety and can even prolong these…

Researchers identify key metric in delivering focused ultrasound to treat patients with high-grade gliomas

Published: August 25, 2025 11:00

Researchers found that acoustic emission dose—an acoustic signal from microbubbles—could predict how to adjust ultrasound power and open the blood-brain barrier for delivering drugs in patients with glioblastoma.

Most epilepsy patients wait a year after starting treatment for seizure relief, study shows

Published: August 25, 2025 11:00

Antiseizure medications help the majority of people with focal epilepsy, a common form of the neurological disorder. Yet most will still have episodes for at least a year after their treatment begins, until their doctors can find the right drug and dosage…

Study finds higher risk of malignant brain tumors after history of head injuries

Published: August 25, 2025 11:00

New research led by investigators at Mass General Brigham suggests a link between a history of traumatic brain injury (TBI) and the risk of developing a malignant brain tumor. By evaluating data from 2000–2024 of more than 75,000 people with a history of…

Molecular 'brake' in brain development could hold key to treating multiple sclerosis

Published: August 25, 2025 11:00

A team of scientists led by the Institute for Glial Sciences (IGS) at Case Western Reserve University's School of Medicine has discovered a built-in "brake" that controls when key brain cells mature. In multiple sclerosis (MS), this brake appears to stay…

Can immune cells stave off devastating neurodegenerative diseases? Scientists aim to find out

Published: August 25, 2025 10:49

An evolving form of therapy to treat devastating neurodegenerative disorders by injecting fresh immune cells—microglia—directly into the brain, promises a new lease on health by slowing the progression of mind-robbing conditions.

3D-printed scaffold process offers hope for spinal cord injury recovery

Published: August 25, 2025 09:41

For the first time, a research team at the University of Minnesota Twin Cities demonstrated a process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery.

Strangers whose brains respond alike to movie clips often become friends later, study finds

Published: August 25, 2025 09:10

People often bond with strangers over the books they read or the movies they watch and build friendships that last. Scientists may now have some insight into why this happens. A study published in Nature Human Behaviour found that participants who…

Human hippocampal neurogenesis shows unique gene expression patterns compared to other mammals

Published: August 25, 2025 07:30

While the process via which different types of neurons are produced, also known as neurogenesis, has been the focus of numerous neuroscience studies, its genetic and biological underpinnings in humans have not yet been fully elucidated. This is also true…

Neural dynamics shed light on how the brain adapts to and suppresses fearful memories

Published: August 24, 2025 09:00

Over the course of their lives, humans can sometimes acquire fear responses to specific stimuli, animals, objects or situations, typically following adverse experiences or traumatic events. Understanding the brain processes associated with the extinction…

How—and when—emotional responses to music influence memory

Published: August 23, 2025 10:00

Listening to music while doing something can make that activity more enjoyable. But listening to music after an experience or activity can make it more memorable if you have the optimal emotional response while listening to it, according to new research by…

A new genetic link to pain provides a promising drug target

Published: August 22, 2025 13:19

Chronic pain is life-changing and considered one of the leading causes of disability worldwide, making daily life difficult for millions of people around the world, and exacerbating personal and economic burdens. Despite established theories about the…

Some people just don't like music—it may be down to their brain wiring

Published: August 22, 2025 11:50

When I ask a lecture theater full of students how they would feel if they could never listen to a piece of music again, most are horrified. Many have been plugged into their headphones until the moment the class begins. But without fail, one or two will…

Psychedelic therapy may trigger visual imagery in people with aphantasia

Published: August 22, 2025 10:54

UNSW Sydney and Macquarie University psychology researchers have written an article warning that psychedelic therapies may switch on visual mental imagery in people with aphantasia and could raise the risk of intrusive thoughts, while calling for more…

Novel tissue preservation method enables brain–body studies in animal research

Published: August 21, 2025 16:39

Cardiovascular researchers at UC Davis Health have developed a novel technique that allows scientists to study how the brain communicates with other organs, like the heart or gut. The new method preserves the brain tissue in animal research while…

First mechanism for cognitive disorders in schizophrenia found

Published: August 21, 2025 11:48

Schizophrenia is a debilitating mental disorder affecting around 1% of the population worldwide, and is notoriously difficult to treat. Current medications for schizophrenia can ameliorate positive symptoms, such as hallucinations and delusions. However,…

CaMKIIα redox mechanism revealed as key to learning and memory

Published: August 21, 2025 11:16

A research team led by Prof. Chen Chang from the Institute of Biophysics of the Chinese Academy of Sciences, in collaboration with Prof. Huang Zhangjian of China Pharmaceutical University, has uncovered a previously unknown molecular mechanism essential…

Computational approach meets biology to connect neural progenitor cells with human disorders

Published: August 21, 2025 11:00

For much of the 20th century it was thought that the adult brain was incapable of regeneration. This view has since shifted dramatically and neurogenesis—the birth of new neurons—is now a widely accepted phenomenon in the adult brain, offering promising…

Gone but not forgotten: New research shows the brain's map of the body remains unchanged after amputation

Published: August 21, 2025 05:00

The brain holds a "map" of the body that remains unchanged even after a limb has been amputated, contrary to the prevailing view that it rearranges itself to compensate for the loss, according to new research from scientists in the UK and US.

Sleeping flies that still manage to escape shed light on inhibitory neuronal networks

Published: August 20, 2025 16:37

Flies too need their sleep. In order to be able to react to dangers, however, they must not completely phase out the environment. Researchers at Charité–Universitätsmedizin Berlin have now deciphered how the animal's brain produces this state. As they…

Study explores impacts of acute and chronic stress on mental health

Published: August 20, 2025 15:30

It is well established that stress can increase susceptibility to various neuropsychiatric disorders, such as depression and anxiety, which are highly prevalent worldwide and represent a significant economic burden and public health issue in our society.…

AI model redefines multiple sclerosis as a continuum with dynamic stages instead of subtypes

Published: August 20, 2025 14:58

Multiple sclerosis (MS) has long been regarded as a disease with different subtypes such as "relapsing" or "progressive." An international study, published on August 20, 2025, in Nature Medicine under the leadership of the Medical Center—University of…

What happens in the brain when it learns something new

Published: August 20, 2025 14:54

Memories of significant learning experiences—like the first time a driver gets a speeding ticket—are sharp, compared to the recollection of everyday events—like what someone ate for dinner two weeks ago. That's because the human brain is primed to learn…

Changing how we understand, and potentially treat, misophonia

Published: August 20, 2025 12:23

Throughout her career, Laurie Heller has listened closely—not just to words, but to sound itself. In the Auditory Lab at Carnegie Mellon University, the psychology professor explores how the brain interprets everything from environmental clatter to the…

Blocking brain damage may slow glioblastoma growth

Published: August 20, 2025 11:00

Blocking brain damage triggered by a glioblastoma, an aggressive brain cancer, may slow the growth of the cancer and allow the brain to keep working better for longer, according to a new study led by UCL (University College London) researchers.

Stem cell-derived dopamine neurons improve depression-like behaviors in mice

Published: August 20, 2025 10:40

The Institute of Neuroscience, Chinese Academy of Sciences, reports that human stem cell-derived A10-like midbrain dopaminergic neurons integrate into mouse mesocorticolimbic circuits and suppress anxiety and depression behaviors upon activation.