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Preterm infant with drug-resistant seizures responds to antisense oligonucleotide treatment

https://medicalxpress.com/news/2025-05-preterm-infant-drug-resistant-seizures.html

Published: May 5, 2025 10:00

Ludwig-Maximilians-Universität München-led researchers have induced a greater than 60% reduction in seizure frequency in a preterm infant with early-onset SCN2A developmental and epileptic encephalopathy (DEE). Seizures initially occurred at a rate of 20…

Promising Parkinson's drug decoded

https://medicalxpress.com/news/2025-05-parkinson-drug-decoded.html

Published: May 5, 2025 09:55

How well our brain functions depends heavily on the performance of our nerve cells. That is why they are regularly checked for their proper function—defective cell components are marked, disposed of and recycled. This includes the mitochondria, the…

EU pharmaceutical regulation reforms needed to drive innovation and investment, experts suggest

https://medicalxpress.com/news/2025-05-eu-pharmaceutical-reforms-investment-experts.html

Published: May 2, 2025 12:29

New research from Bayes Business School, in collaboration with biopharmaceuticals company Merck KGaA, suggests member states from the European Union (EU) must work more closely together, provide better incentives for the development of new medicines and…

Large-scale heart failure initiative boosts use of lifesaving medications

https://medicalxpress.com/news/2025-05-large-scale-heart-failure-boosts.html

Published: May 2, 2025 12:26

About 6.7 million adults in the U.S. are living with heart failure, and that number is expected to increase to more than 8 million by 2030.

Scientists introduce new engineered drug candidate for Mycobacterium abscessus, a dangerous cousin of TB

https://medicalxpress.com/news/2025-05-scientists-drug-candidate-mycobacterium-abscessus.html

Published: May 2, 2025 10:55

In a classic example of scientific problem solving, scientists from the Hackensack Meridian Center for Discovery and Innovation (CDI) and colleagues have published a paper introducing a promising new drug candidate they engineered to target a deadly and…

Study marks rise in psychotherapy outpatient visits and declines in medication use for mental health care

https://medicalxpress.com/news/2025-05-psychotherapy-outpatient-declines-medication-mental.html

Published: May 1, 2025 15:00

Psychotherapy assumed a larger role in outpatient mental health care while psychiatric medication without psychotherapy became less common, according to a study at Columbia University Mailman School of Public Health and Columbia University Irving Medical…

Kānuka extract shows promise in reducing organ transplant medication's side effects

https://medicalxpress.com/news/2025-05-knuka-transplant-medication-side-effects.html

Published: May 1, 2025 14:44

Researchers have identified a compound in an extract from native kānuka that may have the potential to limit the adverse effects of rapamycin, a drug primarily used as an immune suppressant in kidney transplants.

Which medications are commonly prescribed for autistic people and why?

https://medicalxpress.com/news/2025-05-medications-commonly-autistic-people.html

Published: May 1, 2025 12:25

Autism is a neurodevelopmental condition. Someone may have social and communication differences, sensory issues and/or restricted, repetitive patterns of behavior or interests.

A generation at risk: Prenatal opioid exposure tied to hidden health problems

https://medicalxpress.com/news/2025-05-generation-prenatal-opioid-exposure-hidden.html

Published: May 1, 2025 12:00

Exposure to opioids during pregnancy could be causing long-term, unknown health conditions for a generation of children, a University of Dundee expert has warned.

Revealing the impact of tirzepatide treatment on muscle composition in type 2 diabetes

https://medicalxpress.com/news/2025-05-revealing-impact-tirzepatide-treatment-muscle.html

Published: May 1, 2025 11:48

A recent analysis of the SURPASS-3 trial unravels the impact of treatment with the drug tirzepatide on muscle volume and fat infiltration in individuals with type 2 diabetes.

FDA-designated orphan drug could increase radiation efficacy in lung cancer

https://medicalxpress.com/news/2025-05-fda-orphan-drug-efficacy-lung.html

Published: May 1, 2025 10:10

An FDA-designated orphan drug that can target a key vulnerability in lung cancer shows promise in improving the efficacy of radiation treatments in preclinical models, according to a study by UT Southwestern Medical Center researchers. The findings,…

Gabapentinoids unlikely to be directly linked to self-harm risk, study finds

https://medicalxpress.com/news/2025-04-gabapentinoids-linked.html

Published: April 30, 2025 18:30

Treatment with gabapentinoids—drugs such as gabapentin and pregabalin—is not directly associated with an increased risk of self-harm, finds a UK study published by The BMJ.

Semaglutide effectively treats liver disease in two thirds of patients, research finds

https://medicalxpress.com/news/2025-04-semaglutide-effectively-liver-disease-thirds.html

Published: April 30, 2025 17:00

Results from the ESSENCE Phase III clinical trial published in the New England Journal of Medicine show treating patients with semaglutide can halt and even reverse liver disease.

National-level actions found to be effective at tackling antibiotic resistance

https://medicalxpress.com/news/2025-04-national-actions-effective-tackling-antibiotic.html

Published: April 30, 2025 14:00

National-level policies can reduce the impact of antibiotic resistance across diverse countries, according to a study published in the open-access journal PLOS Global Public Health by Peter Søgaard Jørgensen from Stockholm University and the Royal Swedish…

Old drug, new tricks: Why an anti-psychotic could help treat brain cancer

https://medicalxpress.com/news/2025-04-drug-anti-psychotic-brain-cancer.html

Published: April 30, 2025 10:17

New research from SAHMRI and Flinders University has shed light on how the decades-old antipsychotic drug, trifluoperazine (TFP), works against glioblastoma (GBM), the most aggressive form of brain cancer.

Broader antibiotic use could change the course of cholera outbreaks

https://medicalxpress.com/news/2025-04-broader-antibiotic-cholera-outbreaks.html

Published: April 29, 2025 20:00

Cholera kills thousands of people and infects hundreds of thousands every year—and cases have spiked in recent years, leaving governments with an urgent need to find the best ways to control outbreaks.

Cross-border ePrescription is perceived to improve access to medicines

https://medicalxpress.com/news/2025-04-border-eprescription-access-medicines.html

Published: April 29, 2025 15:14

Estonian and Finnish pharmacists recognize the positive impact on access to medicines as the most important benefit of cross-border ePrescription. The study, published in the journal Research in Social and Administrative Pharmacy, investigates the first…

Drug combination inhibits genes that drive aggressive pancreatic cancer, study finds

https://medicalxpress.com/news/2025-04-drug-combination-inhibits-genes-aggressive.html

Published: April 29, 2025 11:24

HonorHealth Research Institute's new downtown Phoenix laboratory has produced its first study, centered on a promising new treatment for pancreatic cancer, one of the most aggressive and difficult to treat of all malignancies.

The 'nocebo gap' in health care: Exploring discrimination's impact on medication side effects

https://medicalxpress.com/news/2025-04-nocebo-gap-health-exploring-discrimination.html

Published: April 29, 2025 10:08

A new study has uncovered a link between patients' experiences of discrimination in health care settings and the likelihood of them experiencing negative side effects from their medication.

Antibody-based drug dismantles a metabolic barrier to anti-tumor immunity

https://medicalxpress.com/news/2025-04-antibody-based-drug-dismantles-metabolic.html

Published: April 28, 2025 16:36

A Ludwig Cancer Research study has identified a specific mode of fat uptake by immune cells within tumors that serves as a metabolic checkpoint against anti-cancer immune responses. Harnessing that insight, researchers led by Ludwig Lausanne's Ping-Chih Ho…

Ketamine nasal spray will be subsidized for treatment-resistant depression—what you need to know about Spravato

https://medicalxpress.com/news/2025-04-ketamine-nasal-spray-subsidized-treatment.html

Published: April 28, 2025 12:48

An antidepressant containing a form of the drug ketamine has been added to the Pharmaceutical Benefits Scheme (PBS), making it much cheaper for the estimated 30,000 Australians with treatment-resistant depression. This is when a patient has tried multiple…

Could this molecule be 'checkmate' for coronaviruses like SARS-CoV-2?

https://medicalxpress.com/news/2025-04-molecule-checkmate-coronaviruses-sars-cov.html

Published: April 25, 2025 10:42

A team at UC San Francisco and Gladstone Institutes has developed new drug candidates that show great promise against the virus that causes COVID-19 and potentially other coronaviruses that could cause future pandemics.