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Metformin changes blood metal levels in humans, offering further insight into its mechanism of action

https://medicalxpress.com/news/2025-08-metformin-blood-metal-humans-insight.html

Published: August 31, 2025 20:00

The widely used diabetes drug metformin changes blood metal levels in humans. The Kobe University study is an important step in understanding the drug's many actions and designing better ones in the future.

Beta blockers may offer no benefit for heart attack patients, and women can have worse outcomes

https://medicalxpress.com/news/2025-08-beta-blockers-benefit-heart-patients.html

Published: August 30, 2025 11:00

Beta blockers—drugs commonly prescribed for a range of cardiac conditions, including heart attacks—provide no clinical benefit for patients who have had an uncomplicated myocardial infarction with preserved heart function. Beta blockers have been the…

Stubborn high blood pressure drops with an experimental drug that targets hormone imbalance

https://medicalxpress.com/news/2025-08-stubborn-high-blood-pressure-experimental.html

Published: August 30, 2025 10:20

A new treatment has been shown to significantly lower blood pressure in people whose levels stay dangerously high, despite taking several existing medicines, according to the results of a Phase III clinical trial led by a UCL Professor.

After a heart attack, women shown to have worse prognosis when treated with beta-blockers

https://medicalxpress.com/news/2025-08-heart-women-shown-worse-prognosis.html

Published: August 30, 2025 05:00

A major new analysis from the REBOOT (Treatment with Beta-blockers after Myocardial Infarction without Reduced Ejection Fraction) clinical trial, an international study coordinated by the Centro Nacional de Investigaciones Cardiovasculares (CNIC),…

Active ingredient from red foxglove helps with heart failure, clinical study confirms

https://medicalxpress.com/news/2025-08-ingredient-red-foxglove-heart-failure.html

Published: August 29, 2025 12:30

Digitalis has been used to treat heart failure for more than 200 years. The drug digitoxin also belongs to this group of active ingredients known as cardiac glycosides.

Common inflammation drug may slow blood mutation, related cardiovascular disease risk

https://medicalxpress.com/news/2025-08-common-inflammation-drug-blood-mutation.html

Published: August 29, 2025 12:20

Taking low-dose colchicine daily may slow the progression of a common acquired gene mutation found in the blood of older adults that can lead to certain blood cancers and increased risk of cardiovascular disease (CVD), according to a subanalysis of the…

There are pros and cons for weight loss medications like Ozempic

https://medicalxpress.com/news/2025-08-pros-cons-weight-loss-medications.html

Published: August 29, 2025 09:29

"Ozempic face." Five years ago, if you'd heard those words you would probably think it referred to an alien species.

Kentucky Republican proposes studying psychedelic drug ibogaine to curb addiction

https://medicalxpress.com/news/2025-08-kentucky-republican-psychedelic-drug-ibogaine.html

Published: August 29, 2025 06:40

A Kentucky lawmaker wants to revisit a previously abandoned idea for the state to fund research of an illegal psychedelic drug for its potential to treat drug addiction.

Repurposed multiple sclerosis drug could help bones heal faster

https://medicalxpress.com/news/2025-08-repurposed-multiple-sclerosis-drug-bones.html

Published: August 29, 2025 04:59

Researchers at the University of Arizona College of Medicine—Tucson found evidence that a drug that improves the ability to walk in people with multiple sclerosis can also make bone fractures heal faster.

Blood pressure calculator promises more precise medication choices for millions

https://medicalxpress.com/news/2025-08-blood-pressure-precise-medication-choices.html

Published: August 28, 2025 18:30

A first-of-its-kind Blood Pressure Treatment Efficacy Calculator built on data from nearly 500 randomized clinical trials in over 100,000 people allows doctors to see how much different medications are likely to lower blood pressure.

Broad use of psychedelic MDMA could ease devastating psychological trauma in Ukraine, study says

https://medicalxpress.com/news/2025-08-broad-psychedelic-mdma-ease-devastating.html

Published: August 28, 2025 16:23

Russia's invasion of Ukraine has killed tens of thousands of Ukrainian soldiers and civilians, and injured hundreds of thousands more. But the war has also taken a less visible toll, with millions suffering from acute PTSD. Now a study co-authored at UC…

Pregnant women face tough choices about medication. Medical research cuts will make it worse

https://medicalxpress.com/news/2025-08-pregnant-women-tough-choices-medication.html

Published: August 28, 2025 15:30

A panel convened in July 2025 by the Food and Drug Administration sparked controversy by casting doubt about the safety of commonly used antidepressants during pregnancy. But it also raised the broader issue of how little is known about the safety of many…

Clinical trial leads to FDA approval of drug for rare, deadly blood cancer

https://medicalxpress.com/news/2025-08-clinical-trial-fda-drug-rare.html

Published: August 28, 2025 11:56

Fewer than half of people diagnosed with a subtype of myeloid/lymphoid neoplasms are alive one year later. A multicenter Phase II trial, called FIGHT-203, led by Stanford Medicine, has led to FDA approval of a new drug treatment.

Study proposes new, more personalized methadone restart approach for opioid use disorder

https://medicalxpress.com/news/2025-08-personalized-methadone-restart-approach-opioid.html

Published: August 28, 2025 11:00

A new study by University of Colorado Anschutz and Denver Health researchers, published in JAMA Network Open, introduces a more individualized approach to restarting methadone treatment for people with opioid use disorder. The findings suggest that…

Novel therapy for pet cats with head and neck cancers could help humans

https://medicalxpress.com/news/2025-08-therapy-pet-cats-neck-cancers.html

Published: August 28, 2025 11:00

Researchers have reported results from the first-ever clinical trial of a new class of targeted therapy in pet cats with head and neck squamous cell carcinoma (HNSCC)—a cancer which is notoriously deadly and difficult to treat. Published in Cancer Cell,…

Parkinson's disease drug candidates induce unexpected damaging effects

https://medicalxpress.com/news/2025-08-parkinson-disease-drug-candidates-unexpected.html

Published: August 27, 2025 16:25

Parkinson's disease is the second most common neurodegenerative disease, affecting over 10 million people worldwide. Some forms of Parkinson's disease are characterized by an inability of cells to clean up dysfunctional mitochondria, particularly in neural…

Insomnia patients report better sleep when taking cannabis-based medical products

https://medicalxpress.com/news/2025-08-insomnia-patients-cannabis-based-medical.html

Published: August 27, 2025 14:00

Insomnia patients taking cannabis-based medical products reported better quality sleep after up to 18 months of treatment, according to a study published in PLOS Mental Health by Arushika Aggarwal from Imperial College London, U.K., and colleagues.

New GLP-1 pill helps people lose 23 pounds in study

https://medicalxpress.com/news/2025-08-glp-pill-people-pounds.html

Published: August 27, 2025 12:50

Eli Lilly says its new once-daily pill, orforglipron, helped people lose significant weight and lower blood sugar in a late-stage clinical trial.

Treating heart failure patients with anti-obesity medication can reduce emissions and improve clinical outcomes

https://medicalxpress.com/news/2025-08-heart-failure-patients-anti-obesity.html

Published: August 27, 2025 02:00

New research has found that the use of GLP-1 receptor agonists, a class of medications commonly prescribed for patients with obesity and diabetes, reduces the environmental footprint of health care and clinical outcomes when used to treat heart failure.

Most US neurologists prescribing multiple sclerosis drugs have received pharma industry cash, analysis finds

https://medicalxpress.com/news/2025-08-neurologists-multiple-sclerosis-drugs-pharma.html

Published: August 26, 2025 18:30

Nearly 80% of U.S. neurologists prescribing drugs for multiple sclerosis (MS) have received at least one pharma industry payment, with higher-volume prescribers more likely to be beneficiaries, finds a five-year analysis of Medicare database payments,…

Study examines the role of doctors' trust in their patients when requesting antibiotic prescriptions

https://medicalxpress.com/news/2025-08-role-doctors-patients-antibiotic-prescriptions.html

Published: August 26, 2025 14:10

Patients often push their doctors to prescribe antibiotics unnecessarily, increasing bacterial resistance. More trust in patients could help here. This is the surprising outcome of a study supported by the SNSF.

Monthly pill shows potential as pre-exposure prophylaxis HIV drug candidate

https://medicalxpress.com/news/2025-08-monthly-pill-potential-pre-exposure.html

Published: August 26, 2025 14:00

A new HIV antiretroviral shows promise as a long-acting, oral prophylactic agent, according to a new study by Izzat Raheem, Tracy Diamond and colleagues from Merck & Co., Inc., Rahway, NJ, U.S., published in the open-access journal PLOS Biology.

Natural compound could help fight aggressive leukemia and amplify the effect of chemotherapy drugs

https://medicalxpress.com/news/2025-08-natural-compound-aggressive-leukemia-amplify.html

Published: August 26, 2025 12:29

Forskolin, a natural compound derived from a plant, could significantly improve treatment outcomes for an aggressive form of leukemia, known as KMT2A-rearranged Acute Myeloid Leukemia (KMT2A-r AML), according to a new study from the University of Surrey.

Medicinal cannabis is most often prescribed for pain, anxiety and sleep—here's what the evidence says

https://medicalxpress.com/news/2025-08-medicinal-cannabis-pain-anxiety-evidence.html

Published: August 26, 2025 10:21

Medicinal cannabis use has increased rapidly in recent years in Australia. Since access pathways were expanded in 2016, more than 700,000 prescription approvals have been issued.

Common painkillers linked to antibiotic resistance

https://medicalxpress.com/news/2025-08-common-painkillers-linked-antibiotic-resistance.html

Published: August 26, 2025 08:57

New research from the University of South Australia shows that ibuprofen and acetaminophen are quietly fueling one of the world's biggest health threats: antibiotic resistance.