RSS Parrot

https://bsky.app/profile/erictopol.bsky.social/post/3ltzatb4dw22b

Published: July 15, 2025 15:47

"In this cohort study, the use of GLP-1RAs semaglutide and tirzepatide was associated with a lower risk of dementia, stroke, and all-cause mortality in adults with type 2 diabetes and obesity."…

https://bsky.app/profile/erictopol.bsky.social/post/3ltz35dlrk22d

Published: July 15, 2025 14:05

US science, by Hilary Price

https://bsky.app/profile/erictopol.bsky.social/post/3ltz2it4k3s2i

Published: July 15, 2025 13:54

On the root cause of global obesity https://www.pnas.org/doi/suppl/10.1073/pnas.2420902122 https://www.science.org/content/article/new-study-blames-diet-not-physical-inactivity-obesity-crisis…

https://bsky.app/profile/erictopol.bsky.social/post/3ltxnk7i3xc2h

Published: July 15, 2025 00:29

The major progress in the science of aging relates to pace of aging clocks. Body-wide, organs, biomarkers. Not just for aging but also prevention of age-related diseases Here’s a new Q&A about them [contains quote post or other embedded content]

https://bsky.app/profile/erictopol.bsky.social/post/3ltx45ltpqk2k

Published: July 14, 2025 19:18

Given the increasing frequency of extreme heat and important health risks of dehydration, this wearable whole-body hydration sensor seems worthy of pursuit https://www.pnas.org/doi/abs/10.1073/pnas.2504278122

https://bsky.app/profile/erictopol.bsky.social/post/3ltwz42lnn22v

Published: July 14, 2025 18:24

The next phase of NotebookLM, with a featured notebook from me that integrates SUPER AGERS and Ground Truths posts, a total of 17 sources https://notebooklm.google.com/notebook/780a38ee-d0a6-4fb1-b255-aa03c8d67dce

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Published: July 14, 2025 16:16

How a bacterial strain from patients who responded to immunotherapy, when transferred to mice, revved up the immune response vs. tumors https://www.nature.com/articles/s41586-025-09249-8

https://bsky.app/profile/erictopol.bsky.social/post/3ltwp5rawgk2r

Published: July 14, 2025 15:26

GLP-1 drugs may provide benefit for idiopathic intracranial hypertension https://jamanetwork.com/journals/jamaneurology/fullarticle/2836065 https://jamanetwork.com/journals/jamaneurology/fullarticle/2836068

https://bsky.app/profile/erictopol.bsky.social/post/3ltwozsoebc2m

Published: July 14, 2025 15:23

A patient page for GLP-1 drugs and importance of integration of lifestyle factors with these meds https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2836527 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2836533

https://bsky.app/profile/erictopol.bsky.social/post/3ltwlhif2gc2i

Published: July 14, 2025 14:20

Our A.I. times ;-)

https://bsky.app/profile/erictopol.bsky.social/post/3ltwjfhxr5c2s

Published: July 14, 2025 13:43

The mechanisms by which ultra-processed foods (UPF) drive obesity, an outstanding review article "the evidence is sufficiently strong to justify immediate public health efforts to reduce UPF consumption." https://www.nature.com/articles/s41574-025-01143-7

https://bsky.app/profile/erictopol.bsky.social/post/3ltv5jlefak24

Published: July 14, 2025 00:37

Peptides. The ultimate pseudoscience. Here in San Diego you can go look at a house and get a free anti-aging peptide injection. And if you join membership at LIVV for $85K look at all the peptides you can get injected …

https://bsky.app/profile/erictopol.bsky.social/post/3ltuynichtk2q

Published: July 13, 2025 23:10

My conversation with Owen Tripp on finding the right doctor https://erictopol.substack.com/p/why-cant-i-find-the-right-doctor

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Published: July 13, 2025 19:01

How to modulate biological aging (body-wide, epigenetic) —Obesity accelerates…

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Published: July 12, 2025 16:03

With @walteri.bsky.social on @pbs.org @amanpourcopbs.bsky.social @camanpour.bsky.social on extending healthspan https://www.youtube.com/watch?v=WsnghQxZ7z0

https://bsky.app/profile/erictopol.bsky.social/post/3ltrpkvgxpk2g

Published: July 12, 2025 15:50

An 80-year-old is the oldest person to finish the 135 mile Ultramarathon from the lowest point in North America (Death Valley) to the shoulders of its highest peak (Whitney Portal, 8300 feet)!

https://bsky.app/profile/erictopol.bsky.social/post/3ltrmf6ym2c2i

Published: July 12, 2025 14:53

The US healthcare economy takeover https://nytimes.com/interactive/2025/07/03/business/economy/healthcare-jobs.html?unlocked_article_code=1.V08.4rJo.ydCPRA7Hr447&smid=url-share

https://bsky.app/profile/erictopol.bsky.social/post/3ltrkxxkxyc2v

Published: July 12, 2025 14:28

Last week I wrote about estrogen's new evidence for slowing aging of the immune system https://erictopol.substack.com/p/new-anti-aging-evidence-for-estrogen Today there's a WSJ feature on longevity in women (the new data aren't mentioned)…

https://bsky.app/profile/erictopol.bsky.social/post/3ltpz2xt2ok2r

Published: July 11, 2025 23:34

Preventing Alzheimer’s disease With @walteri.bsky.social @amanpourcopbs.bsky.social https://youtube.com/shorts/cLJOerktI6U?feature=share

https://bsky.app/profile/erictopol.bsky.social/post/3ltpffc26mc27

Published: July 11, 2025 17:42

An experience with a personalized nutrition company that costs $294 and $25 per month https://www.wsj.com/health/wellness/zoe-gut-health-test-9d950f8f?st=V1sn4a&reflink=desktopwebshare_permalink

https://bsky.app/profile/erictopol.bsky.social/post/3ltpaewzwbc2z

Published: July 11, 2025 16:13

Funny thing is that so many supplements and peptides claim benefit for the immune system. But it was never measured 😉

https://bsky.app/profile/erictopol.bsky.social/post/3ltp5q3qwys2j

Published: July 11, 2025 15:25

Basic research at NSF 56% cut planned, from $8.8 billion to $3.9 billion https://www.nytimes.com/2025/07/10/science/trump-science-budget-cuts.html?unlocked_article_code=1.Vk8.O3cG.nqV8cnK-Q9sI&smid=url-share

https://bsky.app/profile/erictopol.bsky.social/post/3ltp2ycznck2u

Published: July 11, 2025 14:36

On the potential risk of gabapentin (Neurontin) for mild cognitive impairment and dementia https://rapm.bmj.com/content/early/2025/07/02/rapm-2025-106577

https://bsky.app/profile/erictopol.bsky.social/post/3ltp26uv7l22l

Published: July 11, 2025 14:22

The gut hormone mimetic era in medicine is just getting started https://www.nature.com/articles/s42255-025-01343-5 https://erictopol.substack.com/p/the-gut-brain-axis-takes-center-stage

https://bsky.app/profile/erictopol.bsky.social/post/3ltoxeqo75c2p

Published: July 11, 2025 13:31

Reduced risk of all-cause and cardiovascular mortality with exercise (and dose-response) throughout adulthood from a systematic review of 85 studies https://bjsm.bmj.com/content/early/2025/07/02/bjsports-2024-109122-0

https://bsky.app/profile/erictopol.bsky.social/post/3ltnc3b63pk2b

Published: July 10, 2025 21:38

Yes, this is good news re: summer wave concerns [contains quote post or other embedded content]

https://bsky.app/profile/erictopol.bsky.social/post/3ltmww77kxc2u

Published: July 10, 2025 18:18

The cells as living drug story expands today with replacement of microglia, vital immune cells in the brain, to treat a rare neurologic condition (ALSP) @science.org https://www.science.org/doi/10.1126/science.adz0113…

https://bsky.app/profile/erictopol.bsky.social/post/3ltmwj3avts2k

Published: July 10, 2025 18:11

A brilliant @science.org review on the brain's glymphatics, the channels for eliminating metabolic waste products, and their relationship to Alzheimer's diseases https://www.science.org/doi/10.1126/science.adv8269

https://bsky.app/profile/erictopol.bsky.social/post/3ltmstymryk2v

Published: July 10, 2025 17:05

Our new @cellcellpress.bsky.social review on the generative A.I. era in medicine @rajpurkar.bsky.social https://www.cell.com/cell/fulltext/S0092-8674(25)00568-9

https://bsky.app/profile/erictopol.bsky.social/post/3ltmnmlyyb22x

Published: July 10, 2025 15:32

Single cell omics, initially conceived as a research tool, will have more impact in clinical medicine than was ever envisioned https://www.cell.com/cell/fulltext/S0092-8674(25)00676-2

https://bsky.app/profile/erictopol.bsky.social/post/3ltmms2szu227

Published: July 10, 2025 15:17

The more potent and bespoke immunotherapy vs cancer, the better. Today's example is a neoantigen vaccine vs melanoma https://cell.com/cell/fulltext/S0092-8674(25)00685-3

https://bsky.app/profile/erictopol.bsky.social/post/3ltl5ma4uqc2f

Published: July 10, 2025 01:12

https://www.iheart.com/podcast/143-factually-with-adam-conove-45798061/episode/rfk-is-shortening-our-lifespans-with-284975634/

https://bsky.app/profile/erictopol.bsky.social/post/3ltl2xqliys2q

Published: July 10, 2025 00:25

"The time has come for us to use what we know about cardiovascular risk ... to take action at the individual and population levels to promote cardiovascular health across the life span and substantially reduce the burden of cardiovascular disease…

https://bsky.app/profile/erictopol.bsky.social/post/3ltkzrc5l6k2v

Published: July 10, 2025 00:04

Great to see SUPER AGERS #5 on the NYT bestseller list, 4th week. Thanks for your support of this work to promote healthspan!

https://bsky.app/profile/erictopol.bsky.social/post/3ltkgsmizts2t

Published: July 9, 2025 18:24

1/3rd of US teens (>8 million kids) have prediabetes https://gis.cdc.gov/grasp/diabetes/diabetesatlas-spotlight.html

https://bsky.app/profile/erictopol.bsky.social/post/3ltkfammskc2j

Published: July 9, 2025 17:56

"Buff gym-bros and 'biohackers' inject themselves on TikTok while telling their audiences that they should be on 'T' even if their doctor disagrees." More on bro science …

https://bsky.app/profile/erictopol.bsky.social/post/3ltk5t5uqi226

Published: July 9, 2025 15:44

"A social compact between the People and the Experts has broken" "body politics are now, very much, party politics." https://nymag.com/intelligencer/article/why-calling-rfk-jr-maha-anti-science-misses-the-point.html @nymag.com

https://bsky.app/profile/erictopol.bsky.social/post/3ltk4lt52bs2w

Published: July 9, 2025 15:22

Weight loss provides far more benefit than just losing fat @nature.com https://www.nature.com/articles/s41586-025-09233-2 https://www.nature.com/articles/d41586-025-02056-1

https://bsky.app/profile/erictopol.bsky.social/post/3ltk3urf55s2o

Published: July 9, 2025 15:09

The dismantling of the National Cancer Institute and the FDA …

https://bsky.app/profile/erictopol.bsky.social/post/3ltk3aotgkc2p

Published: July 9, 2025 14:57

How exercise works through the gut microbiome to enhance response to cancer immunotherapy https://www.cell.com/cell/fulltext/S0092-8674(25)00684-1 @cellpress.bsky.social

https://bsky.app/profile/erictopol.bsky.social/post/3ltjzlzfwi22w

Published: July 9, 2025 14:28

It only took 20 years after 1 failed shoe bomb to stop shoe removal screening at US airports 😉

https://bsky.app/profile/erictopol.bsky.social/post/3ltjvqxv7zc2v

Published: July 9, 2025 13:19

The immune system and brain are uniquely associated with healthspan and longevity, the latest insights from organ clock proteomics @naturemedicine.bsky.social https://nature.com/articles/s41591-025-03798-1

https://bsky.app/profile/erictopol.bsky.social/post/3lthzu2wfjs2a

Published: July 8, 2025 19:27

What accounts for the increase of early-onset gastrointestinal cancer? A new review paper goes through the possible causes https://academic.oup.com/bjs/article/112/7/znaf102/8191209

https://bsky.app/profile/erictopol.bsky.social/post/3lthyt2ine22f

Published: July 8, 2025 19:09

Immunotherapy for cancer can cause Type 1 diabetes. Now there's a promising way that might be avoided. https://insight.jci.org/articles/view/188843

https://bsky.app/profile/erictopol.bsky.social/post/3lthvzumo622f

Published: July 8, 2025 18:19

Even though they may be seem hard to find, I look for the positive things in life science and medicine every day. You might not know they are occurring by scrolling through the social media platforms.

https://bsky.app/profile/erictopol.bsky.social/post/3lthk7lofd22c

Published: July 8, 2025 14:47

Higher inflammation burden by blood biomarkers and reduced lifespan, consistent findings in 3 cohorts https://www.cell.com/ajhg/fulltext/S0002-9297(25)00240-X

https://bsky.app/profile/erictopol.bsky.social/post/3lthfzt7g422f

Published: July 8, 2025 13:32

A new Pediatric Center for CRISPR Cures builds on the recent saved life of Baby KJ, who expeditiously had bespoke in vivo base genome editing @jenniferdoudna.bsky.social @doudna-lab.bsky.social @innovativegenomics.bsky.social @chanzuckerberg.bsky.social…

https://bsky.app/profile/erictopol.bsky.social/post/3ltfxeex3k222

Published: July 7, 2025 23:37

Why happens when you put SARS-CoV-2 in with human neural (retinal) tissue in culture (organoid)? It induces Alzheimer’s-like pathology. https://www.science.org/doi/10.1126/sciadv.ads5006

https://bsky.app/profile/erictopol.bsky.social/post/3ltfkl3u3pk2p

Published: July 7, 2025 19:48

Discovery of a genetic mutation that markedly enhances the response to cancer immunotherapy https://www.pnas.org/doi/epub/10.1073/pnas.2314258122

https://bsky.app/profile/erictopol.bsky.social/post/3ltewxk2tr22q

Published: July 7, 2025 13:57

On the first report of estrogen slowing the pace of aging of the immune system, with the background of flawed and misinterpreted clinical trials of hormone replacement therapy https://erictopol.substack.com/p/new-anti-aging-evidence-for-estrogen

https://bsky.app/profile/erictopol.bsky.social/post/3ltev4hzz222q

Published: July 7, 2025 13:24

One person's war on plastic, with review of many of the reasons something has to be done, by @annielowrey.bsky.social @theatlantic.com "Until our government acts to protect us, we are both the home chef using the Teflon pan and the budgie choking on the…

https://bsky.app/profile/erictopol.bsky.social/post/3lteubk7ids2b

Published: July 7, 2025 13:09

We keep learning new ways to block autoimmunity and potentially cure autoimmune diseases. Beyond engineered T cells, now natural killer (NK) cells https://www.nature.com/articles/d41586-025-02096-7

https://bsky.app/profile/erictopol.bsky.social/post/3ltet5it5ws2q

Published: July 7, 2025 12:49

Measles in the US https://www.washingtonpost.com/health/2025/07/07/measles-cases-hit-record/?utm_source=alert&utm_medium=email&utm_campaign=wp_news_alert_revere&location=alert

https://bsky.app/profile/erictopol.bsky.social/post/3ltcwdx3svk2v

Published: July 6, 2025 18:41

Can senolytics reverse or slow aging? Table of companies pursuing this goal. So far the results are questionable. @natbiotech.nature.com https://www.nature.com/articles/s41587-025-02740-7

https://bsky.app/profile/erictopol.bsky.social/post/3ltckqbt7uk26

Published: July 6, 2025 15:13

Summary Table of the massive defunding of biomedical research in the United States https://www.nytimes.com/interactive/2025/06/30/opinion/hhs-cuts-harming-american-health.html