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Site URL: hypothes.is/stream

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6.2: Roots and Resistance- The Development of Chicanx and Latinx Studies

https://hypothes.is/a/E4lA4pHUEfG3PJuDiylR-A

Published: August 6, 2026 20:19

Students were frequently being punished for speaking Spanish, including corporal punishment such as physical whacking with a paddle.The walkouts were clearly completely justifiable and a monumental moment in the Chicano movement.

6.2: Roots and Resistance- The Development of Chicanx and Latinx Studies

https://hypothes.is/a/tz_nHpHTEfGLovcuDU3-XQ

Published: August 6, 2026 20:16

But perhaps even more than demonstrating that bilingualism could be a strengthIn many countries around the world it's not uncommon to have people fluent in multiple languages. America would be so much mor diverse if we put more effort in the other…

6.2: Roots and Resistance- The Development of Chicanx and Latinx Studies

https://hypothes.is/a/TsNUUJHTEfGCuzMNnhg0TQ

Published: August 6, 2026 20:13

The schools were unique in that they reinforced the children’s culture, rather than diminishing it, in order to build confidence in learning English.This is an important piece to take note of. While knowing the language of the country you live in is…

Prospective and multicenter study to assess the safety and effectiveness of a physiotherapy treatment through self-myofascial release with Foam Roller in patients with hemophilic ankle arthropathy. A randomized clinical trial.

https://hypothes.is/a/z8dunpHREfG9vjMwcLCLag

Published: August 6, 2026 20:02

Karen Bartholomew;  Dan Kirwana Kibuuka;  …

Lcp109

https://hypothes.is/a/NRD-wpHOEfGcxD-hw8COrQ

Published: August 6, 2026 19:37

capitalização é obrigatórioLembrar de quando eu estudei para a previdencia do RS, capitalização é o dinheiro guardado e investido, n o entra e sai (Repartição simples)

Brave Search

https://hypothes.is/a/K_KODJHHEfG8SzdUWb91LQ

Published: August 6, 2026 18:46

[💻/asus/🧊/me/📓/2026/8/🔍/ground.atomic.formula.cyc/@/Brave/ground.atomic.formula.cyc.Brave.html](https://bafybeib2w4zy55ovxqyhgef5uypk62emacule5bhe5zhyx3pcsk3f6t5tq.ipfs.dweb.link)

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/3nDaCpHEEfGVn38juH8Jkw

Published: August 6, 2026 18:30

6.6 The sandbox contractWhat about the simulator contract? I think there could be some things to discuss here, like how to control having Expo Go preinstalled after the split

Will AI Wealth Actually Flood AIS/EA Philanthropy Soon?

https://hypothes.is/a/hjkhPpHAEfGBlwfRQk9lDQ

Published: August 6, 2026 17:59

A steelman against the Bay-Area assumption that very large AI-lab-adjacent philanthropy will quickly become usable funding for AI safety and EA cause areas.I don't think it still really should be considered a "steelman". It's more of a model and a…

XXIV. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. In a letter to Francis Baily, Esq. F. R. S. &c

https://hypothes.is/a/gKLtWpG_EfGzMOfv6jd29A

Published: August 6, 2026 17:51

royal society law of human mortaility

XXIV. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. In a letter to Francis Baily, Esq. F. R. S. &c

https://hypothes.is/a/V_6zNJG_EfGDn4-RsptdZw

Published: August 6, 2026 17:50

from: https://royalsocietypublishing.org/rstl/article/doi/10.1098/rstl.1825.0026/117600/XXIV-On-the-nature-of-the-function-expressive-of law of human mortaility

Do Geometric Outliers Identify Important Genes in Single-Cell Foundation Models?

https://hypothes.is/a/NtsoDpG_EfGabMMTLBq9Cw

Published: August 6, 2026 17:49

Each gene is scored on four metrics: embedding norm, Euclidean distance to the vocabulary centroid, cosine similarity to the centroid, and mean distance to its k = 10 nearest neighbours (isolation).It seems likely the foundation model embedding geometries…

Zapit: Open Source Laser-Scanning Photostimulation For Neuroscience

https://hypothes.is/a/cBCIUpG2EfGJdxtshErMKg

Published: August 6, 2026 16:46

**Reviewer #3 (Public review):** Zappit is an open-source implementation of arbitrary-access laser-scanning optogenetics for manipulation of neuronal activity in mice. As the method requires expertise ranging from optics, hardware control and…

What Is It Like to Be a Bat?

https://hypothes.is/a/2ZzHHpG1EfG6gVMhx7NLkg

Published: August 6, 2026 16:42

Iam restricted to the resources of my own mind, and those re-sources are inadequate to the tasThe context of being a human lives in the human brain, deeply embedded in the very essence of our lively understanding. To mold that to understand what it *is* to…

What Is It Like to Be a Bat?

https://hypothes.is/a/avPWIpG1EfGkssM4UzS5jQ

Published: August 6, 2026 16:39

anyone who has spent sometime in an enclosed space with an excited bat knows what it is toencounter a fundamentally alien form of life.I've been attacked by bats twice in my life. This statement couldn't be more true.

What Is It Like to Be a Bat?

https://hypothes.is/a/Gy8iLJG1EfGnEqNvIMaWBQ

Published: August 6, 2026 16:37

hylogenetic treea branching diagram that shows the evolutionary history and relationships among different species or groups of organisms

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/At3X5JGxEfGJceMDeLdhkA

Published: August 6, 2026 16:08

das typische Produktmake this: eine typische Sportart

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/89hOFJGwEfGVXKPaYfrVSQ

Published: August 6, 2026 16:07

nichtmake this: ist dies nicht der Fall

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/4EFlApGwEfGEWUuVoRk8tg

Published: August 6, 2026 16:07

, und dmake this: . D

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/e54IxpGwEfG6ky_Xtt13GA

Published: August 6, 2026 16:04

, was in einem österreichischen Krankenhaus selten zutrifft.make this: . Das trifft in einem österreichischen Krankenhaus selten zu.

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/aMQK8pGwEfGDmxeSZv0ilQ

Published: August 6, 2026 16:03

Behandlung, Rücktransport und Evakuierung jeweils unbegrenztmake this: Behandlung, Rücktransport und Evakuierung werden je unbegrenzt gedeckt

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/VgFuWpGwEfGYkvs0cZLqWw

Published: August 6, 2026 16:03

, sodass unklar bleibt, ob Skifahren gedeckt istmake this: . So bleibt unklar, ob Skifahren gedeckt ist.

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/QucJ7JGwEfG8PEe2fMbvlQ

Published: August 6, 2026 16:02

, und dmake this: . D

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/7vvwLJGvEfGVxnOoKGcO1g

Published: August 6, 2026 16:00

, imake this: . I

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/4ZQpcpGvEfGst_uu4rtxYw

Published: August 6, 2026 16:00

Beim Personenkreis geht sie eigene Wege: bis zu sechs Mitreisende, unabhängig vom Verwandtschaftsgrad, für die Hüttenwoche mit Freunden die passendste Regelung im Feld.rephrase. make this two simple, proper German sentences

从零到能跑 Scaling Law 实验

https://hypothes.is/a/srWTIJGvEfGurPdooI7u-g

Published: August 6, 2026 15:58

python sample.py --out_dir=out-shakespeare-char针对mac环境的话，要改一下： 修改前： ```python …

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/joYHoJGvEfGlGXMSZe2ACw

Published: August 6, 2026 15:57

Beim Rücktransport gehört sie mit "medizinisch sinnvoll und ärztlich angeordnet" zur besseren Hälftemake this: Beim Rücktransport schneidet sie mit "medizinisch sinnvoll und ärztlich angeordnet" gut ab

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/0ExH6pGuEfG_Kfu8Kt0qGA

Published: August 6, 2026 15:52

response lost? the retry is idempotenton the key and returns the same idThis behavior is exactly why I am pushing back on REST a bit I've worked on a system I called "page2api", which was a wrapper for Playwright scripts to present as if a certain service…

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/yk_0wpGuEfG-aOMNxAl0FQ

Published: August 6, 2026 15:52

ist die engstemake this: folgt der engsten

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/smRUmJGuEfGuq4f60PeQHA

Published: August 6, 2026 15:51

, während alle anderen bei mindestens 100 Euro beginnen.make this: . Alle anderen beginnen bei mindestens 100 Euro.

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/KU03iJGuEfGeE0f3it-UZw

Published: August 6, 2026 15:47

auf Schneemangel reagiertmake this: Schneemangel berücksichtigt

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/-AStZJGtEfGJNJ9k40onFA

Published: August 6, 2026 15:46

run.cloud already has the pattern in tags.Not that anybody wanted to, but I'd like to say this: If we add metadata JSON, let's not kill tags, those aren't superseded by metadata, as they have their own neat rendering and they are algorithmic-ally cheap to…

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/2q5s5pGtEfGlMsdZekFgQQ

Published: August 6, 2026 15:45

Im zweiten BlockWhat is this referring to? Clarify or find another phrasing without the reference

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/VYKHWJGlEfGfSdc8Ngy54Q

Published: August 6, 2026 14:44

Sechs Kriterien bestimmen deshalb die Rangfolgemake this: Im Test bestimmen sechs Kriterien die Rangfolge

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/NvEHdJGlEfG5j1OeKFTTYA

Published: August 6, 2026 14:43

Kartemake this: Karten

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/MrYKBpGlEfG8OEf-3AN57Q

Published: August 6, 2026 14:43

jedermake this: jeder der hier verglichenen

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/KrpdXJGlEfGWhMv7g5Vu4g

Published: August 6, 2026 14:43

damitdelete

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/FHkS6pGlEfGOaIM5d1Nt0A

Published: August 6, 2026 14:42

und die zahlt er selbstmake this: die er selbst zahlen muss

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/Bud27pGlEfGZ--v_aNvm8A

Published: August 6, 2026 14:42

, undmake this: –

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/-177OpGkEfGa47_kQD2PGQ

Published: August 6, 2026 14:42

Am Berg entscheidet dann eine kaum bekannte Unterscheidungmake this: Am Berg ist dann eine oft unbekannte Unterscheidungen in der Formulierung der Police entscheidend:

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/neiCMpGkEfGQnhMoLqCBHw

Published: August 6, 2026 14:39

giltmake this: gilt für alle Krankenversicherungen und

SOMASTOA — Landing copy review

https://hypothes.is/a/ej8K6pGkEfGCpB9z5oVajw

Published: August 6, 2026 14:38

+ one plain line: “A daily practice: train, sit, and read, in about twenty minutes a day.”on a training day, exercise will take 30-45 minutes so to say 20 mins here is not true.

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/HXvggJGkEfGsqf-ZaI_hdA

Published: August 6, 2026 14:35

offengelegtenmake this: beschriebenen

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/Fth5gpGkEfGUkGdMerG_gA

Published: August 6, 2026 14:35

Sechs Karten, geprüft ausschließlich an den offiziellen VersicherungsbedingungenDieser Artikel vergleicht sechs Karten, geprüft ausschließlich an den offiziellen Versicherungsbedingungen.

DendroTweaks, an interactive approach for unraveling dendritic dynamics

https://hypothes.is/a/GuVcMJGjEfGK93dQ078prg

Published: August 6, 2026 14:28

August 6, 2026A new version of this article has been issued to update the affiliation order. *posted by eLife production staff*

Lesson 8 · Apply Measurement to Complete a Task — TESDA Foundational Skills

https://hypothes.is/a/AOzBKJGQEfG9FAN0OUunsQ

Published: August 6, 2026 12:11

@redz , thank you for your feedback! This is considered in the content piece that will be in the privately published KA course page.

Lesson 4 · Read Bar Charts and Diagrams — TESDA Foundational Skills

https://hypothes.is/a/6nUQHJGPEfGazpuQ0ANzLA

Published: August 6, 2026 12:11

@redz , thank you for your feedback! This is considered in the content piece that will be in the privately published KA course page.

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/OTEKwpGPEfGTlnuijT7CUg

Published: August 6, 2026 12:06

transport im Akiaakia wurde mindestsent zweimal genantn. was bedeutet dieses wort, ich kenne es nciht

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/_8m3ApGOEfGRj_8xvCZkmw

Published: August 6, 2026 12:04

sen, ohne dass definiert wäre, was darunter fällt.ohne dass es definirt wird shortens teh sentence

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/sFa04JGOEfGc26tfVBl5gA

Published: August 6, 2026 12:02

Privathaftpflicht, keine Unfallversicherung, dazu kein Reisegepäcreisegepaecksversicherung, i hope they still allow for reisegepaeck hahah

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/mzt3TpGOEfGRQ7PeD79RVw

Published: August 6, 2026 12:01

vor Ort ist der Unterschied zwischen Vorschuss und gar nichts erheblich.cut this part of the sentence and replace with "hilfreich"

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/eGw2_pGOEfGrkmvejQnDEg

Published: August 6, 2026 12:00

Kautionen und Mietwagenanmietungen praktisch relevant ist.zu problemen fuehren kann (statt praktisch relevan tist)

Supplementary Material | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/MvjlDpGOEfGj20fyGxLPoQ

Published: August 6, 2026 11:58

Planned: artifact preparation, documentation, reproducibility, publication, and maintenance checklists.eu acho que recomendaria isso para meus alunos. o texto em si achei muito esforco no sentido de ser completo, cobrir tudo, mas nem sempre isso é bom.…

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/HTzsJJGOEfGdKk89VO6-Pg

Published: August 6, 2026 11:58

Wer auf der Piste jemanden verletzt, steht damit ohne Deckung da, und das ist bei einem Kollisionsanteil von gut 20 Prozent kein Randfall.what do you mean mit kollisionsanteil?

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/qvc_rJGNEfGPJye3sZdFqA

Published: August 6, 2026 11:55

4.3 Data ownership orgs splits. Newly keeps orgs; run.cloud gets accounts carrying runcloud_stripe_customer_id, max_active_tunnels, credit_limit_usd, spend_limit_usd, and the sandbox meter rollups. They are linked by an opaque external_account_id — a…

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/mH9wYJGNEfG6g9vKDqkqVQ

Published: August 6, 2026 11:54

Was die Krankenkasse im Skiurlaub nicht zahlt Für die gesetzliche Krankenversicherung ist der Fall im Gesetz geregelt, und zwar knapp. In § 60 Absatz 4 SGB V steht wörtlich: "Die Kosten des Rücktransports in das Inland werden nicht übernommen." Das gilt…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/hdlVPpGNEfGq6tdWGnSO9A

Published: August 6, 2026 11:54

Publish the OpenAPI spec for the existing /run-cloud/* surface before moving any code, and generate Newly's client from it. This is deliberately the reverse of the tempting order, for two reasons. It makes the surface reviewable while it is still cheap to…

Module 4 - Reproducibility | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/dk2hGpGNEfGXHQ-mQANIHA

Published: August 6, 2026 11:53

Version control practicesrepete também o que foi dito em outra secao. seria melhor concentrar e apenas referenciar

Module 4 - Reproducibility | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/WTYgtpGNEfG9Eeu5lt3v7g

Published: August 6, 2026 11:52

Documenting parameters and configurationsduplica com a secao de documentacao

Module 4 - Reproducibility | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/QhQW9JGNEfGq6Z8PLalZ7w

Published: August 6, 2026 11:52

Provide a single command or script that runs the full experiment.apareceu antes, em outra seção

Module 2 - Preparation | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/8UOchpGMEfG6J3d8sjXewg

Published: August 6, 2026 11:49

Key takeawayscom tantas seções e subseções, sem numeração, a estrutura às vezes não ficou clara

Module 2 - Preparation | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/xT0fmpGMEfG4Mhc-dtQ3Gw

Published: August 6, 2026 11:48

Version controlmeio que aparece do nada. sinto falta de uma narrativa que conecte as partes, para não parecer uma lista de práticas desconectadas

Module 2 - Preparation | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/oM2NFpGMEfGCmy8c-osQxg

Published: August 6, 2026 11:47

Provide a single command or script that runs the full experiment.se eu vou fazer isso, as recomendações anteriores dessa seção já vão ser válidas. então não bastaria isso? ou isso não deveria ser primeiro. meu sentimento é de que houve uma priorização de…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/iQr_4pGMEfGu4_9QnRWnfQ

Published: August 6, 2026 11:47

One fact must be stated plainly because it is widely assumed the other way: today the session launcher does not run on run.cloud. It runs in a Modal Sandbox (control-plane/apps/worker/src/venueLauncher.ts:9-11 — the only drivers are modal, local, none;…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/QW_Q1pGMEfGLAN8wPFty4g

Published: August 6, 2026 11:45

The image is Modal-native. control-plane/runner-image.json is {"runnerImage": "cp-runner:v13", …} — a Modal tag with no registry host and no digest, built by scripts/build-runner-image.ts:196-204 through Modal's fromRegistry(...).dockerfileCommands(...).…

Module 2 - Preparation | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/Aez-ypGMEfGu4mdfe9BVNQ

Published: August 6, 2026 11:43

Always document the execution environment used to develop and test the artifact:muita gente documenta tudo isso num docker/container. pelo menos mencionar que pode ser interessante o uso de containers vi que depois menciona, mas a conexão é fraca, quase…

Module 1 - Foundations | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/extTnJGLEfGHwB9fzQOKUw

Published: August 6, 2026 11:39

Module 1 - Foundationsachei bem completo, mas longo e meio enfadonho. mas o que importa aqui é descobrir o que os alunos acham.

Module 1 - Foundations | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/QOlYwpGLEfGViv9GFzlMbQ

Published: August 6, 2026 11:37

Good artifacts are usable, reproducible, and reusable.gostei da terminologia. senti falta de dizer que a terminologia não é padrão, citar a da ACM, e tentar fazer uma relação grosseira entre as duas

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/sAu1WJGJEfGc2dtYDp_OfA

Published: August 6, 2026 11:26

agreed, it there should be a standard otel integration pathway with run.cloud for newly-tung that is the same as other users take

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/56lsrpGDEfGSRO8fMs5a1A

Published: August 6, 2026 10:45

which is why Metro observability needs nothing from run.cloud (§6.1).Metro part i understand, but what about otel spans/traces from sim fleet? how will they propagate back to newly?

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/h_9cFJGDEfG4oyOEXmE2tA

Published: August 6, 2026 10:42

Everything inside the box is one deploy, one process, one database. The two products do not call each other; they are each other. Receipts throughout — paths are repo-relative.what a reviewer might ask is "why is this a problem?" my answer: - imagine a…

SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

https://hypothes.is/a/_j6sHpGCEfGKDRui5hgajg

Published: August 6, 2026 10:38

**eLife Assessment** This manuscript presents important new findings showing that the transcription factor and regulator of lipid and glucose metabolism PPARγ is methylated by the enzyme SETD6. The data convincingly demonstrate that methylation of…

SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

https://hypothes.is/a/_gSZwJGCEfGRhgMB6pgotg

Published: August 6, 2026 10:38

**Reviewer #1 (Public review):** Summary: In this manuscript from the Levy lab, the authors investigate whether SETD6 regulates hepatic lipid accumulation through direct methylation of PPARγ. They show that SETD6 binds and mono-methylates PPARγ…

SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

https://hypothes.is/a/_dRflJGCEfG1y6cMCg-H3g

Published: August 6, 2026 10:38

**Reviewer #2 (Public review):** Summary: In this work, the authors investigated the regulation of the transcription factor PPARγ by the post-translational modification lysine methylation The data demonstrate that the lysine methyltransferase…

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