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🦜 Hypothesis Stream

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The Web. Annotated

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Site URL: hypothes.is/stream

Feed URL: hypothes.is/stream.rss#ToDo/@lma%23ToDo/@lma@mstdn.social%23ToDo/@lma

Posts: 932

Followers: 1

Elucidating enzyme-substrate specificity through co-folding foundation model

https://hypothes.is/a/A7HzYI95EfGOfE-IJIt7OA

Published: August 3, 2026 20:22

. From this simulated complex, the framework extracts interaction repre-sentations and a predicted structure to capture local biophysical constraints. Toreconcile this local structure with global biological context, Boltz2ESI fuses these geo-metric…

AI labs can't keep their stars

https://hypothes.is/a/4iFiso94EfGvFEMCl12v6A

Published: August 3, 2026 20:21

A source familiar told Axios that Anthropic CEO Dario Amodei has expressed concern about new talent coming to the firm for the money rather than the mission.Oh really??? Poor Dario. Maybe he could give up his salary first to set an example. As…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-xqM9I93EfGeaQfH9kEcUQ

Published: August 3, 2026 20:14

What can we learn about what other people are thinking, about their mental models of the world, by paying very careful attention to the words they use?This is such a great basic skill for (I think) anyone to have, whether it's while working, talking with…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-0Cv4o93EfGH359lw_VeUg

Published: August 3, 2026 20:14

I already know with time constraints I'm going to mostly focus on my initial thoughts, but I think reading this alongside Cronon's "Only Connect" essay would be a great exercise.

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-oUtno93EfG2xtcNlK_AHw

Published: August 3, 2026 20:14

Isn’t it only free, fully privileged, self-determining people who also need a liberal arts education?I sometimes get stuck on what appears to be a societal preference for things like radical individualism, and also a denigration of education. As if…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-vJMYo93EfGVtKeMY4vsGA

Published: August 3, 2026 20:14

Here’s the hidden truth of education: You don’t know what you’re preparing for.I have ranted a lot, while I was teaching and after, about the various "coding for Kindergarteners" initiatives I saw back in the day. And primarily my rants were about how no…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-ujP6I93EfG5eUsYdtBUmg

Published: August 3, 2026 20:14

When I’m on a software project, I try to listen hard to what everyone is saying, to the words they choose. “Don’t blame me! They asked for it!” is never good enough.Absolutely. If your goal is to make a good product, it's not enough to build it to spec…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-o88-I93EfGLP_OFQMVL8g

Published: August 3, 2026 20:14

don’t they need only vocational educationIn fact, I'd bet the people doing the enslaving don't want them having anything other than vocational skills.

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-sHl9I93EfGuO3tUoWzHCg

Published: August 3, 2026 20:14

I rarely use (and have largely forgotten) the specific knowledge from it; I use its approach, its patterns of thought, constantly.As a teacher, my goal was to make sure my students would no longer need me. That meant giving them specific knowledge when…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-rORhI93EfGcEldA6nrLWQ

Published: August 3, 2026 20:14

What “liberal arts” means is centering that serendipity, making it not just a happy coincidence but a primary goal. It’s about preparing students with the expectation that they’ll have to adapt to an unknown future they’re helping to shape.I've see a…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-p5VMI93EfGqIosK0fDq0g

Published: August 3, 2026 20:14

Contrary to popular belief, “liberal arts” does not mean “humanities and fine arts.”For the folks who haven't read this yet: https://www.bu.edu/cas/files/2015/06/Cronon_The-Goals-of-a-Liberal-Education.pdf. And in case that link goes dead one day, it's…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-qmruo93EfG5fNPdF8p4cQ

Published: August 3, 2026 20:14

I am preparing whole students for their whole lives, in ways neither they nor I can know in the moment. Liberal arts education.Absolutely! Whole students for their whole lives. I'd bet that software engineers who are well-read, thoughtful, engaged in their…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-nNKto93EfGP__u8aUVIKg

Published: August 3, 2026 20:14

I’m highly skeptical of society’s current hyperfocus on college as an educational pathI don't think society is fixated on college as an educational path, I think society is fixated on a college education as a form of credentialling to divide workers into…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-s1Dro93EfGPjJtsIrYZhQ

Published: August 3, 2026 20:14

Not just specific skills or subjects, but kinds of learning: approaches rooted in curiosity, exploration, seeing closely, questioning, critical examination, taking multiple perspectives, using multiple kinds of tools, synthesis, communication, dialogue,…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-tabmI93EfG2iBeOJqHb2w

Published: August 3, 2026 20:14

ephemeralMaybe less ephemeral if you find yourself somewhat immediately and repeatedly use that same acquired knowledge over and over again, but generally I agree.

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-l30fI93EfGPPsvl4kKunw

Published: August 3, 2026 20:14

“Which students does society view as fully privileged, free human beings, and which does it view as cut out for a life of servitude?”When I taught in a less economically advantaged north shore MA city, a step rep at our of our neighbor (and much more…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-mcQ6I93EfGTVcuaUt_3ew

Published: August 3, 2026 20:14

“Because you are free, you must prepare for the unknown”Bang on slogan. Man, if nothing else, I'd love every student to view every course they take (higher ed and not) though that lens. And realize that the unknown encompasses both known unknowns, and…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-k2-uI93EfGq2hdULk_5Zg

Published: August 3, 2026 20:14

Think: What structures in schools let students pursue their curiosity? What structures actively thwart it?That could be its own essay, and I'd throw in what structures that thwart curiously are intentionally difficult to undermine, and are designed to…

What Liberal Arts Education Is For – Teaching – innig.net

https://hypothes.is/a/-lWiVI93EfGi2W_QJ8q3BA

Published: August 3, 2026 20:14

Curiosity — and accessYeah. Both of these. Because even chromebooks and programming classes for kids isn't necessarily "access". It's **more** than some of them would have had on their own, yes, but it's a lot less than the kids who get to try everything…

Elucidating enzyme-substrate specificity through co-folding foundation model

https://hypothes.is/a/u8O4Mo93EfG757fdyG0nQA

Published: August 3, 2026 20:13

first localizes the active-sitepocket using Multiple sequence alignment (MSA) guided co-folding, and subsequentlyre-folds the active site and substrate in an MSA-free regime to capture ligand-inducedside-chain and backbone adaptationsStage 2 being MSA-free…

Kitchen Soap – Counterfactual Thinking, Rules, and The Knight Capital Accident

https://hypothes.is/a/ZPjcvo9mEfGbcCP-HyUXRw

Published: August 3, 2026 18:08

(Dekker, 2004, p.33) “Saying what people failed to do, or implying what they could or should have done to prevent the mishap, has no role in understanding human error.”  (Dekker, 2004, p.43)@jallspaw Would you happen to have a source for the Dekker quotes?…

report.md

https://hypothes.is/a/CUyBVo9kEfGqhHPmP5IX2A

Published: August 3, 2026 17:52

tables/T3_power_per_domain_trueauc080.csv 我希望能把这个 table 补全，也就是补充一些我们现在已经计算好的指标，整理成一张表放在这里。具体要求如下： 1. 每一个数据集原始文献中的 AUC： 这是一整列。下面已经列出了一些，不确定的部分先列“未确定”就好。 2. 我们现在真实的 AUC： 按照下面的值填进去，其他不用管。 3. 我们过去 report 的 AUC： 按照下面的值填进去，其他不用管。 4. 新增三行 in-domain…

Vintage Typewriter Enthusiasts | What would it take to learn how to properly service typewriters | Facebook

https://hypothes.is/a/s6r0FI9hEfG-DvdCb106jQ

Published: August 3, 2026 17:35

I’d be in for that. I’ve been doing it for awhile, but would love the networking and fun. I have areas I’m still learning about and know enough to probably make me dangerous at times. Add me to your list. I’m in the Central Valley.Tom Hansen interested in…

Deploy on Google Kubernetes Engine

https://hypothes.is/a/6vAFXI9eEfGAsMvmBOfxrQ

Published: August 3, 2026 17:15

--values charts/aggregates/migrationAssistantWithArgo/valuesGke.yamlvaluesGke.yaml is insufficient for the chart. Also need values which are specific for this installation ``` gcp: project: opensearch-migration serviceAccountEmail:…

Deploy on Google Kubernetes Engine

https://hypothes.is/a/DgnW-o9dEfGr8t98-j3stQ

Published: August 3, 2026 17:02

Step 3: Install the Migration Assistant Helm chartMissing step to add repo. There is no public URL for the Helm repo. curl -fL -o migration-assistant-3.3.5.tgz \ …

Deploy on Google Kubernetes Engine

https://hypothes.is/a/0q8roI9SEfG-uFOqAjoVLw

Published: August 3, 2026 15:48

The Artifact Registry API is enabled and the GKE node service account already has roles/artifactregistry.reader. What’s missing is the actual Docker repository and images. You need four things: 1. Create the migrations repository: gcloud…

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

https://hypothes.is/a/8GYZNo9PEfGzm-vGMcvlCA

Published: August 3, 2026 15:28

**Reviewer #1 (Public review):** \[Editors' note: this version has been assessed by the Reviewing Editor without further input from the original reviewers.\] This manuscript by Rudich ZD et al. systematically profiled the transcriptomic changes in…

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

https://hypothes.is/a/8Jf7Do9PEfGE8tMb1H-kQQ

Published: August 3, 2026 15:28

**eLife Assessment** This valuable study presents a comparative analysis of the transcriptomic features underlying C. elegans longevity, providing insights into how different changes in gene expression can promote longevity. The authors present solid…

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

https://hypothes.is/a/8CoTyI9PEfG5lHuP4jcr-A

Published: August 3, 2026 15:28

**Reviewer #2 (Public review):** Summary: In the manuscript titled "Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies", the authors investigated diverse genetic pathways that contribute…

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

https://hypothes.is/a/7-21Xo9PEfGqYn_COLWKCA

Published: August 3, 2026 15:28

**Author response:** The following is the authors’ response to the original reviews > **Reviewer #1 (Public review):** > In the revised manuscript, the authors have addressed most of my concerns. In the text of this manuscript, the authors should still…

Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

https://hypothes.is/a/pSzJKo9OEfGo_IeD6v7HFw

Published: August 3, 2026 15:18

**eLife Assessment** This valuable cross-sectional longitudinal study leverages high-definition transcranial direct current stimulation to the left dorsolateral prefrontal cortex to examine its effect on procrastination behavior over an extended time…

Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

https://hypothes.is/a/n9crUI9OEfG5khsF_pmbBA

Published: August 3, 2026 15:18

**Reviewer #1 (Public review):** Summary: The authors report the results of a tDCS brain stimulation study (verum vs sham stimulation of left DLPFC; between-subjects) in 46 participants, using an intense stimulation protocol over 2 weeks, combined with…

Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

https://hypothes.is/a/mBBqCI9OEfGlL_PEAKLtaQ

Published: August 3, 2026 15:18

**Reviewer #4 (Public review):** Summary: The current study tested the effects of repeated sessions of tDCS targeting the DLPFC on procrastination behavior. The main outcome is that anodal versus sham DLPFC tDCS reduces procrastination behavior on both a…

Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

https://hypothes.is/a/kTLXrI9OEfG3PEfqLn0FoA

Published: August 3, 2026 15:18

**Author response:** The following is the authors’ response to the previous reviews >**Public Reviews:** >**Reviewer #1 (Public review):** >Summary: >The authors report the results of a tDCS brain stimulation study (verum vs sham stimulation of left…

Quarterly financial report for the quarter ended June 30, 2026

https://hypothes.is/a/MDwGho9NEfGHQ1O-3oOT6w

Published: August 3, 2026 15:08

Risks and uncertaintiesThe section Risks and uncertainties needs to be review based on the amended version

Deploy on Google Kubernetes Engine

https://hypothes.is/a/D440HI9JEfGyXLdYFdV4jg

Published: August 3, 2026 14:38

The required GCP APIs enabled:Missing the following APIs in this list compute.googleapis.com storage.googleapis.com

Deploy on Google Kubernetes Engine

https://hypothes.is/a/xToq1o9FEfGkvnfnDAMzSQ

Published: August 3, 2026 14:15

Clone the release tag you want to deploy.Might want to provide specific commands using `git` and `gh` cli to checkout the release tag Using Git: git clone --branch 3.3.5 --depth 1 --single-branch \ …

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nOCYxI9DEfG5iDtp9e3nkg

Published: August 3, 2026 13:59

**Reviewer #2 (Public review):** Summary: The authors present a creative approach using visual anagrams matched on low-level image statistics to isolate animacy from low-level visual features and report consistent effects of animacy on visual…

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nUMSnI9DEfGkulOh2jU7FA

Published: August 3, 2026 13:59

**eLife Assessment** This important study uses an elegant visual-anagram approach to test whether perceived animacy shapes visual working memory and guides visual attention while tightly controlling for lower- and mid-level image properties. The…

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nRLVyI9DEfGhEdu8jqXXcw

Published: August 3, 2026 13:59

**Reviewer #1 (Public review):** \[Editors' note: this version has been assessed by the Reviewing Editor without further input from the original reviewers. The authors have addressed the comments raised in the previous round of review.\] This is a…

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nGuvoI9DEfGbIgc91ScHTQ

Published: August 3, 2026 13:59

**Author response:** The following is the authors’ response to the original reviews. > **eLife Assessment** > > This valuable study uses an elegant visual-anagram approach to test whether perceived animacy structures visual working memory and attention…

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nKppPo9DEfGvVK8YM3I8oQ

Published: August 3, 2026 13:59

**Reviewer #3 (Public review):** This study makes clever use of generative AI to create stimuli that are pixel-for-pixel identical but which have radically different meanings depending on their orientation, to investigate the perception of animacy…

Continuous partitioning of neuronal variability

https://hypothes.is/a/AuwwZo9DEfGj2kcGX60n2Q

Published: August 3, 2026 13:55

**eLife Assessment** This work of fundamental significance introduces a novel statistical model of spiking activity that incorporates continuous-time gain modulation. The authors provide exceptional evidence that the model outperforms earlier…

Continuous partitioning of neuronal variability

https://hypothes.is/a/AogPWo9DEfGUjc_0q51k1Q

Published: August 3, 2026 13:55

**Reviewer #2 (Public review):** Summary: Neurons have varied responses to external stimuli that cannot be explained by naive Poisson models. Previous work has quantified and partitioned higher-than-Poisson variability in the brain into different…

Continuous partitioning of neuronal variability

https://hypothes.is/a/ArVqNo9DEfGE48_zoHV6Dw

Published: August 3, 2026 13:55

**Reviewer #1 (Public review):** Summary: In this manuscript, Rupasinghe and co-authors introduce a new statistical model for spiking neurons. Building on earlier work, they propose to model spikes as arising from a Poisson process whereby the…

Continuous partitioning of neuronal variability

https://hypothes.is/a/Ak5Fco9DEfG6Jy_jr9LuXw

Published: August 3, 2026 13:55

**Author response:** The following is the authors’ response to the original reviews. In the revised manuscript, we have expanded the real-data analyses, clarified the relationship between CMP and prior modulated Poisson models, and added discussion of…

3  Estudio de Caso: Calibración Termodinámica, Eléctrica y Cinética de Degradación – Tesis

https://hypothes.is/a/1Odeto9CEfGj2fOCUx83gw

Published: August 3, 2026 13:54

Transformación Algebraica a Parámetros Log-Normalesse explicara a detalle en los preliminares y de alli se cita aca

3  Estudio de Caso: Calibración Termodinámica, Eléctrica y Cinética de Degradación – Tesis

https://hypothes.is/a/hqaavo9CEfG6Ht8gSZyGjQ

Published: August 3, 2026 13:52

(Cola pesada hacia la derecha)en los preliminares hay que explicar a detalles que significa cola pesada hacia la derecha

3  Estudio de Caso: Calibración Termodinámica, Eléctrica y Cinética de Degradación – Tesis

https://hypothes.is/a/Jpt6uI9CEfGO38cGESz3RQ

Published: August 3, 2026 13:49

La Canícula (Área Púrpura, Días 196≤t<227): Abarca aproximadamente 30 días, desde el 15 de julio hasta el 15 de agosto. Corresponde a la zona de transición e intersección entre ambas campanas gaussianas.esplicar que es la canicula

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2Xcy_o9BEfGNfn-v7diQhw

Published: August 3, 2026 13:47

**eLife Assessment** This study provides important insights into the neural mechanisms linking sleep and long-term memory consolidation. By combining behavioural, genetic, imaging, and connectomic approaches in Drosophila, it identifies a target…

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2Ud5Qo9BEfG6JCvbXtv1BQ

Published: August 3, 2026 13:47

**Reviewer #1 (Public review):** Summary: The authors aim to use state-of-the art behaviour, imaging and connectome techniques to identify the neural interaction between sleep and long-term memory consolidation in the PAM-DPM circuits, a…

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2Rrd7I9BEfGog5s8yaIviA

Published: August 3, 2026 13:47

**Reviewer #2 (Public review):** Summary: Sleep plays a critical role in memory consolidation, but the neural mechanisms underlying this relationship remain incompletely understood. The authors examined a specific subset of PAM dopaminergic…

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2ONJaI9BEfGkswdoEWR2cA

Published: August 3, 2026 13:47

**Reviewer #3 (Public review):** Summary: Understanding the neural circuits that link sleep and memory remains a fundamental challenge in neuroscience. In this study, Lin Yan and colleagues investigate how dopamine signaling in Drosophila…

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2JRHtI9BEfGM9BOU3aC3wQ

Published: August 3, 2026 13:47

**Author response:** The following is the authors’ response to the original reviews > **eLife Assessment** > > This study approaches an important topic providing insight into the neuronal circuitry that interconnects memory consolidation and sleep. The…

Overt visual attention modulates decision-related signals in the frontal cortex

https://hypothes.is/a/Yz0Gzo8_EfGksSMvYc-zdg

Published: August 3, 2026 13:29

**eLife Assessment** This important work examines the effects of gaze on valuation signals in the human brain as participants choose between bundles of sequentially presented items food items. The paper provides convincing analyses of how gaze affects…

Overt visual attention modulates decision-related signals in the frontal cortex

https://hypothes.is/a/YwU5Go8_EfGN8HuQjeGmVQ

Published: August 3, 2026 13:29

**Reviewer #1 (Public review):** \[Editors' note: this version has been assessed by the Reviewing Editor without further input from the original reviewers. The authors have updated the labelling of Figure 7. As all of the reviewer comments have now been…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/bGrUzo86EfGE3dtR9YPVgA

Published: August 3, 2026 12:54

**eLife Assessment** This important study reports the development of the first tankyrase degrader and demonstrates its enhanced ability to inhibit β-catenin signaling compared to conventional tankyrase inhibitors. The evidence supporting the…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/bD6Kho86EfGsVbMljKcIWQ

Published: August 3, 2026 12:54

**Reviewer #1 (Public review):** \[Editors' note: the second round of revision has been assessed by the Reviewing Editor without further input from the original reviewers. The authors have addressed the minor comments raised in the previous round of…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/bAObko86EfGPm6NuZKP_RQ

Published: August 3, 2026 12:54

**Reviewer #2 (Public review):** Summary: The ADP-ribosyltransferase tankyrase controls many biological processes, many of which are relevant to human disease. This includes Wnt/beta-catenin signalling, which is dysregulated in many cancers, most…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/a8Xyzo86EfGucAccvyTjjQ

Published: August 3, 2026 12:54

**Reviewer #3 (Public review):** In this manuscript, Wang et al employ a chemical biology approach to investigate the differences between the enzymatic and scaffolding roles of tankyrase during Wnt β-catenin signalling. It was previously established…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/a4S6NI86EfG2BYMW3u4oTg

Published: August 3, 2026 12:54

**Reviewer #4 (Public review):** From the Reviewing Editor: This important study reports the development of the first PROTACs targeting the ADP-ribosyltransferases tankyrase 1 and 2, with the goal of inhibiting Wnt/β-catenin signaling more…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/a021eo86EfGN6eO4O8Omcw

Published: August 3, 2026 12:54

**Author response:** The following is the authors’ response to the previous reviews We thank the Reviewers for the favourable feedback. There is no additional comments from Reviewers 1, 3, and 4, and we address the minor concerns from Reviewer 2 as…

RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

https://hypothes.is/a/bqsO1o84EfGCOb_EYk7ftw

Published: August 3, 2026 12:39

**eLife Assessment** This revised paper provides solid evidence for HGF-induced trafficking of the HGF receptor, MET, together with metalloprotease MT1-MMP into invadopodia and the role of this trafficking in triple-negative breast cancer (TNBC) cell…

RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

https://hypothes.is/a/bkwu3o84EfGBzy9XSulMvw

Published: August 3, 2026 12:39

**Reviewer #2 (Public review):** Summary: In this manuscript, Khamari and colleagues investigate how HGF-MET signaling and the intracellular trafficking of the MET receptor tyrosine kinase influence invadopodia formation and invasion in…

RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

https://hypothes.is/a/bn0KaI84EfGPspe5rdmiAQ

Published: August 3, 2026 12:39

**Reviewer #1 (Public review):** Summary: This study identifies a mechanism responsible for the accumulation of the MET receptor in invadopodia, following stimulation of Triple-negative breast cancer (TNBC) cells with HGF. HGF-driven accumulation…

RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

https://hypothes.is/a/bfeQ9I84EfG5e3MUyevZmQ

Published: August 3, 2026 12:39

**Author response:** The following is the authors’ response to the current reviews. We thank the editor and the reviewers for their comments on the revised manuscript. Based on the comments, we decided to go for a minor revision which will address all…

Adding Splunk Integrations - User Guide

https://hypothes.is/a/ntFdMI80EfGzgyMo7b8img

Published: August 3, 2026 12:12

We've agreed to mention the required roles only in the parent article for the feature to ensure consistency. Otherwise, they should be present in each and every article. Then it means that other limitations should also be repeated on every page.

Structured stabilization in recurrent neural circuits through inhibitory synaptic plasticity

https://hypothes.is/a/wmICHo8zEfG3JnclXQcyEA

Published: August 3, 2026 12:06

**Author response:** We thank the editors for sending our work for review and the reviewers for their thorough and constructive evaluations. In response to their feedback, we will submit a revised version of the manuscript soon. Below, we provide…

Regulatedhomeworkshop

https://hypothes.is/a/t5dFlI8xEfGrR3dX_ejJaA

Published: August 3, 2026 11:51

That's what The Unfinished Community is - everything that helped, gathered in one place, for you.Because this life can feel lighter, joyful, and a whole lot less lonely. That's what I'm here for.Cheering you on, every step of the way.Update this with an…

Regulatedhomeworkshop

https://hypothes.is/a/DVzVHI8xEfG2fz_5W7dewQ

Published: August 3, 2026 11:47

WhatAdd a section above this that sort of mirrors the top section and gives a written overview of what exactly they'll learn. During the regulated home workshop, you'll learn practical strategies that you'll actually remember in the moment to help…

Motif Builder Academy

https://hypothes.is/a/PFJlgI8sEfGrnH8tSoxLVQ

Published: August 3, 2026 11:12

imaginedAdd a button. Plus add a new section: Normally, participating in a program with live coaching with me would cost hundreds more. This is your chance to get personal guidance, answers, and encouragement - included with your enrolment in Motif…

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