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Optic nerve innervation promotes Wnt/β-catenin pathway activity and progenitor cell proliferation in the zebrafish optic tectum

Published: October 24, 2026 08:13

**Note:** This response was posted by the corresponding author to *Review Commons*. The content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Reply to the reviewers __Reviewer #1__…

Optic nerve innervation promotes Wnt/β-catenin pathway activity and progenitor cell proliferation in the zebrafish optic tectum

Published: October 24, 2026 08:13

**Note:** This preprint has been reviewed by subject experts for *Review Commons*. Content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Referee \#2 #### Evidence, reproducibility and…

Optic nerve innervation promotes Wnt/β-catenin pathway activity and progenitor cell proliferation in the zebrafish optic tectum

Published: October 24, 2026 08:13

**Note:** This preprint has been reviewed by subject experts for *Review Commons*. Content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Referee \#3 #### Evidence, reproducibility and…

Optic nerve innervation promotes Wnt/β-catenin pathway activity and progenitor cell proliferation in the zebrafish optic tectum

Published: October 24, 2026 08:13

**Note:** This preprint has been reviewed by subject experts for *Review Commons*. Content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Referee \#1 #### Evidence, reproducibility and…

Paper — Monotonicity

Published: October 24, 2026 07:53

by the effect of placing a case on a prison track at all.i would not frame it this ways, my understanding is that judges (prosecuotrs) dont think in this two-stage process...

Paper — Monotonicity

Published: October 24, 2026 07:52

When sentencing, a prosecutor chooses first whether to impose a prison term at all—a custody decision, which may be suspended or unsuspended—and then, for a prison term, whether to suspend it.more general: Examiners often choose among several alternatives…

SUMMA THEOLOGIAE: The existence of God (Prima Pars, Q. 2)

Published: October 24, 2026 07:43

Reply"That we seek the completion which only God can give is implanted within us, however this is separate from knowledge of God, or how we can be completed."

1.2: Struggle and Protest for Chicanx and Latinx Studies

Published: October 24, 2026 07:11

Legislators have passed statewide bans on Critical Race Theory to intimidate K-12 educators who discuss race and ethnicity in their classrooms in any format, including ethnic studies.as my partner who works in higher academia informed me, this ban has been…

1.2: Struggle and Protest for Chicanx and Latinx Studies

Published: October 24, 2026 07:09

Eventually, the ban was overturned in 2017, as it was deemed racist and unconstitutional.student and community engagement is necessary to protect the rights we have fought for in our education

1.2: Struggle and Protest for Chicanx and Latinx Studies

Published: October 24, 2026 07:07

which directly increased graduation rates and grades in all classes.this correlation is a real-world example of the beneficial impact that ethnic studies has on student engagement and success in their education

Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites

Published: October 24, 2026 06:49

The correct variant here is NM_000132.3(F8):c.3091_3094del (p.Lys1031fs); ClinVar:369689

Molecular Analysis of Factor VIII and Factor IX Genes in Hemophilia Patients: Identification of Novel Mutations and Molecular Dynamics Studies

Published: October 24, 2026 06:49

This proband actually has the NM_001313913.1:c.580G>A (p.Asp194Asn) variant.

Application of a molecular diagnostic algorithm for haemophilia A and B using next-generation sequencing of entire F8, F9 and VWF genes

Published: October 24, 2026 06:49

Please include the HGNC tags.

Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites

Published: October 24, 2026 06:49

It is likely that this is the variant the authors are referring to, NM_000132.3:c.6133G>T (p.Gly2045Ter) [CAID:CA414904182], and perhaps it was a typo in the position printed in the paper. However, we don't have a way of confirming this. So, you can leave…

A homozygous female hemophilia A

Published: October 24, 2026 06:49

Nice work. Make sure there are no spaces between the colon and the next word for the tags. They should read Gene:F8 and HGNCID:3546

Molecular pathology of haemophilia B

Published: October 24, 2026 06:49

mutation**Case#:** Green_Malmo_6 (assumed male) **DiseaseAssertion:** Severe Hemophillia B **FamilyInfo:** N/A **ParentalTesting:** N/A **CasePresentingHPOs:** HP:0011858 **CaseHPOsFreeText:** reduced factor IX activity (FIX:C <1%, FIX:Ag: 26-34) …

https://www-thieme-connect-de.libproxy.lib.unc.edu/media/10.1055-s-00035024/202105/supmat/10-1055-s-0040-1721385-s200426.pdf

Published: October 24, 2026 06:49

009–1005 **Case#**: 009-1005 **DiseaseAssertion**: Hemophilia A, **FamilyInfo**: NA **ParentalTesting**: NA **CasePresentingHPOs**: HP:0003125 **CaseHPOFreeText**: FVIII:C ..., Inhibitor present **CaseNotHPOs**: NA **CaseNotHPOFreeText**: NA …

Assay discrepancy in mild haemophilia A due to a factor VIII missense mutation (Asn694Ile) in a large Danish family

Published: October 24, 2026 06:49

Today, the Danish family consists of 275 known persons, all of whom are the offspring of six original proband siblings born in the middle of the nineteenth century ( Fig 1); at present, 28 living cases of mild haemophilia are known in the family. A…

Mutation detection and inhibitor risk in Iranian patients with Hemophilia A: Six novel mutations

Published: October 24, 2026 06:49

S3 **Case#**: S3, Iranian **DiseaseAssertion**: Hemophilia A, severe **FamilyInfo**: NA **ParentalTesting**: NA **CasePresentingHPOs**: HP:0003125, HP:0005261 **CaseHPOFreeText**: FVIII:C < 1%, Inhibitor present **CaseNotHPOs**: NA …

https://www-thieme-connect-de.libproxy.lib.unc.edu/media/10.1055-s-00035024/202105/supmat/10-1055-s-0040-1721385-s200426.pdf

Published: October 24, 2026 06:49

001–2046**Case#**: 001-2046 **DiseaseAssertion**: Hemophilia A, moderate **FamilyInfo**: NA **ParentalTesting**: NA **CasePresentingHPOs**: HP:0003125 **CaseHPOFreeText**: 1% < FVIII:C < 5% **CaseNotHPOs**: NA **CaseNotHPOFreeText**: NA …

An intronic mutation c.6430-3C>G in the F8 gene causes splicing efficiency and premature termination in hemophilia A

Published: October 24, 2026 06:49

young boy diagnosed with moderate hemophilia A**Case #:** young male, China **DiseaseAssertion:** Hemophilia A, moderate (FVIII:C 2.6%) **FamilyInfo:** Grandfather had Hemophilia A, making his mother an obligate carrier **ParentalTesting:** Mother was…

https://www-thieme-connect-de.libproxy.lib.unc.edu/media/10.1055-s-00035024/202105/supmat/10-1055-s-0040-1721385-s200426.pdf

Published: October 24, 2026 06:49

004–2003**Case#**: 004-2003 **DiseaseAssertion**: Hemophilia A, severe **FamilyInfo**: NA **ParentalTesting**: NA **CasePresentingHPOs**: HP:0003125 **CaseHPOFreeText**: FVIII:C < 1% **CaseNotHPOs**: NA **CaseNotHPOFreeText**: NA …

Molecular pathology of haemophilia B in Turkish patients: identification of a large deletion and 33 independent point mutations

Published: October 24, 2026 06:49

Cys-19Tyr**Case#:** 52HBT167 (Turkish; assumed male) **DiseaseAssertion:** Moderate Hemophilia B **FamilyInfo:** N/A **ParentalTesting:** Not provided **CasePresentingHPOs:** HP:0011858 **CaseHPOsFreeText:** Reduced factor IX activity (FIX:C:3.9) …

FVIII inhibitor risk correlated with F8 gene variants in 296 unrelated male Chinese patients with haemophilia A

Published: October 24, 2026 06:49

FVIII inhibitor risk correlated with F8 gene variants in 296 unrelated male Chinese patients with haemophilia A Hongfei Kang, orcid.org/0000-0001-8350-9563 Genetic and Prenatal…

Signal Peptide Variants that Impair Secretion of Pancreatic Secretory Trypsin Inhibitor (SPINK1) Cause Autosomal Dominant Hereditary Pancreatitis

Published: October 24, 2026 06:49

Signal Peptide Variants that Impair Secretion of Pancreatic Secretory Trypsin Inhibitor (SPINK1) Cause Autosomal Dominant Hereditary Pancreatitis**PMID:** 17274009 **Gene:** F9 **HGNC:** 3551

hae14141-sup-0001-tables1.pdf

Published: October 24, 2026 06:49

71**Case#**: 71, male, 6 years old, Chinese **DiseaseAssertion**: Hemophilia A, moderate **FamilyInfo**: Noted Family History **ParentalTesting**: Maternity confirmed **CasePresentingHPOs**: HP:0003125 **CaseHPOFreeText**: FVIII:C = 4.2% …

Targeted re-sequencing of F8, F9 and VWF: Characterization of Ion Torrent data and clinical implications for mutation screening

Published: October 24, 2026 06:49

HB_132**Case#:** HB_132 (assumed male) **DiseaseAssertion:** Mild-Moderate Hemophilia B **FamilyInfo:** Not provided **ParentalTesting:** Not provided **CasePresentingHPOs:** N/A **CasePresentingHPOsFreeText:** Mild-Moderate Hemophilia B, Quality…

ajhg00106-0108.pdf

Published: October 24, 2026 06:49

Functionally Important Regions of the Facr IX Gene Have aLow Rate of Polymorphism and a High Rate of Mutation in theDinucleotide CpG**PMID:** 2773937 **Gene:** F9 **HGNC:** 3551

https://www-thieme-connect-de.libproxy.lib.unc.edu/media/10.1055-s-00035024/202105/supmat/10-1055-s-0040-1721385-s200426.pdf

Published: October 24, 2026 06:49

004–2015 **Case#**: 004-2015 **DiseaseAssertion**: Hemophilia A, severe **FamilyInfo**: NA **ParentalTesting**: NA **CasePresentingHPOs**: HP:0003125 **CaseHPOFreeText**: FVIII:C < 1% **CaseNotHPOs**: NA **CaseNotHPOFreeText**: NA …

hae14141-sup-0001-tables1.pdf

Published: October 24, 2026 06:49

112**Case#**: 112, male, 31 years old, Chinese **DiseaseAssertion**: Hemophilia A, moderate **FamilyInfo**: NA **ParentalTesting**: Maternity confirmed **CasePresentingHPOs**: HP:0003125 **CaseHPOFreeText**: FVIII:C = 1.8% **CaseNotHPOs**: NA …

SUMMA THEOLOGIAE: The existence of God (Prima Pars, Q. 2)

Published: October 24, 2026 05:41

Therefore the proposition "God exists" is self-evident."Self-evidence is when everything is known from the terms. God is 'that which no greater can be conceived'. Something actually existing is better than a mere thought, so since God must be the greatest,…

Wide Span Storage Racks - Particle Board in Stock - ULINE

Published: October 24, 2026 05:41

https://www.uline.com/BL_3867/Wide-Span-Storage-Racks-Particle-Board James Grooms uses something similar in his typewriter collection.

IAB-State-of-Data-2024.pdf

Published: October 24, 2026 05:36

Prioritize this investment via new collection methods on O&O channels and/or through external partnerships to foster direct relationships with consumers. Ensure clear user consent for data usage.first

Five habits of effective English language learners | British Council

Published: October 24, 2026 05:35

Find interesting things in English to watch, read and listen toI learned a lot of English words from movies and reading books

IAB-State-of-Data-2024.pdf

Published: October 24, 2026 05:32

wo-thirds to three-fourths of tech advertisers are less confident in the accuracy of data from social, programmatic, and ad servers.accuracy of data third party

Five habits of effective English language learners | British Council

Published: October 24, 2026 05:31

Review your lessons and self-study notes regularlyWhen I review my lessons regularly I remember the information clearly and I don’t forget it quickly

IAB-State-of-Data-2024.pdf

Published: October 24, 2026 05:31

Nearly two-thirds are also providing training on the collection and usage of first-party data—a premium resource due to its direct, more-compliant way to maintain high-quality consumer interactionsquality of first party data

Five habits of effective English language learners | British Council

Published: October 24, 2026 05:26

Record new vocabulary in a way that's easy to reviewAdding new words can help me remember them and review them easily.

Five habits of effective English language learners | British Council

Published: October 24, 2026 05:25

Plan your learning and set realistic goalsI think organizing my study time and setting simple goals helps me improve my English language skills.

Five habits of effective English language learners | British Council

Published: October 24, 2026 05:22

Here are five habits that have helped my students achieve their aims.guess the goal of this article is to help people learn English in a better way.

Five habits of effective English language learners | British Council

Published: October 24, 2026 05:21

Making mistakes is a natural part of the learning processThis sentence seems it’s right because it agrees with my experience learning English.

SUMMA THEOLOGIAE: The existence of God (Prima Pars, Q. 2)

Published: October 24, 2026 05:19

Thus, when the nature of a whole and of a part is known, it is at once recognized that every whole is greater than its part.I believe that this is an example of the formerly established principle.

Five habits of effective English language learners | British Council

Published: October 24, 2026 05:15

Martin SketchleyMartin Sketchley wrote this article for the British Council, a trusted website.

Five habits of effective English language learners | British Council

Published: October 24, 2026 05:13

Be active and take control of your own learningThis part is related to my research because it shows the importance of speaking in English and learning from mistakes

14 Expert Online Marketing Strategies For Minimizing The Impact Of Ad Blockers

Published: October 24, 2026 04:31

Ad blockers negatively affect the reach of a campaign. So, ad agencies should make sure they reach the right audiences.ad blocker

AI in Fintech | IBM

Published: October 24, 2026 04:25

Algorithmic trading and portfolio managementAI analyses market trends and financial information to support investment decisions.

AI in Fintech | IBM

Published: October 24, 2026 04:25

Credit risk assessment and managementAI analyses income, credit history and financial transactions to help banks assess whether customers can repay loans.

AI in Fintech | IBM

Published: October 24, 2026 04:25

Virtual assistantsonline test or evaluation used by a company, college, or organization to assess a person's knowledge, skills, and abilities.

Bhagavad-gītā As It Is 9.21

Published: October 24, 2026 04:10

ते तं भुक्त्वा स्वर्गलोकं विशालं क्षीणे पुण्ये मर्त्यलोकं विशन्ति । एवं त्रयीधर्ममनुप्रपन्ना गतागतं कामकामा लभन्ते ॥ २१ ॥Except those who go back to Godhead, everyone else need to return to this material world.

Market-Oriented Disinformation Research; Digital Advertising, Disinformation and Fake News on Social Media

Published: October 24, 2026 03:58

The unnecessary complexity comes from the system’s byzantine structure, which obscures which fees are charged, and for what reasons. Insiders of the advertising industry refer to this situation as the “AdTech tax,” describing the arbitrary fees charged by…

🔴 La ministre des Sports, de la jeunesse et de la vie associative, sur les crédits de son ministère

Published: October 24, 2026 03:54

Note de Cadrage Budgétaire : Mission « Sport, Jeunesse et Vie Associative » (PLF 2027) * * * Synthèse Exécutive La présente note de cadrage synthétise les débats et données présentés lors de l'audition de la ministre des Sports, de la Jeunesse et de la…

9789289057950-eng.pdf

Published: October 24, 2026 03:20

oogle AdX 20–30 Google AdMob 10–20 FAN 10–20 Google AdSense 0–10 Xandr 0–10 Teads 0–10 Taboola 0–10 Others (Rubicon Project, Index Exchange, Outbrain, OpenX, Pubmatic, Triplelift, Smart, Frssps

9789289057950-eng.pdf

Published: October 24, 2026 03:17

Google offers in-depth targeting options driven by its unique and vast sources of data, while Facebook has the advantage of offering the ability to target specific audiences based on demographic characteristics, interests and location. This creates a…

9.1 How Monopolies Form: Barriers to Entry - Principles of Economics 3e | OpenStax

Published: October 24, 2026 03:03

Government limitations on competition used to be more common in the United States. For most of the twentieth century, only one phone company—AT&T—was legally allowed to provide local and long distance service. From the 1930s to the 1970s, one set of…

2.3: Historical Roots of Ethnic Studies

Published: October 24, 2026 02:52

Elizabeth Eckford is shown walking to school in sunglasses while she is surrounded by an angry white mob, with Hazel Bryan Massery behind her, shouting hateful comments.Elizabeth is part of movement in little rock central high school. This can be related…

The Sociology of Health, Healing, and Illness

Published: October 24, 2026 02:20

When hospitals demanded public assistance with caring for the ill, demands for formal training of nurses accelerated. Programs were developed around the philosophy of Florence Nightingale, an upper-class British reformer who believed that the proper moral,…

Organizational Communication Sylalbus

Published: October 24, 2026 01:25

It really shows how strict the professional expectations are in this class, from using 12-point font and double-spacing on papers, all the way to maintaining proper syntax even in casual quick emails. It definitely makes you realize how important attention…

Organizational Communication Sylalbus

Published: October 24, 2026 01:22

It is definitely tricky when your natural communication style relies on humor, so being mindful of how text reads without facial expressions is super important for keeping things professional. nice.

Organizational Communication Sylalbus

Published: October 24, 2026 01:21

Nice summary, It really makes you think about how understanding these communication types will help us handle real-world workplace situations much better.

Organizational Communication Sylalbus

Published: October 24, 2026 01:19

Really good point, really makes you wonder how traditional management styles can adapt when employees are working remotely and don't have those face-to-face interactions every day.

Organizational Communication Sylalbus

Published: October 24, 2026 01:17

MY ROLEA question I have is, what do you find is the biggest trap or mistake students usually fall into when they're trying to keep up with the weekly case studies in this online format?

Organizational Communication Sylalbus

Published: October 24, 2026 01:16

POLICY ON ARTIFICIAL INTELLIGENCEThe big idea here is that we have to do 100% of our own original thinking and writing without using AI tools or shortcuts.

Organizational Communication Sylalbus

Published: October 24, 2026 01:15

ACADEMIC RESOURCE CENTERI got confused when looking at how the small online assignments add up because there are so many different little things to keep track of.

Organizational Communication Sylalbus

Published: October 24, 2026 01:14

EXPECTATIONSThis reminds me of how strict online communication rules can be in professional jobs when you're interacting with coworkers over Slack or email.

Organizational Communication Sylalbus

Published: October 24, 2026 01:12

REQUIRED TEXTBOOKS:I picture sitting down with these textbooks and a cup of coffee trying to break down how big companies actually handle workplace drama and communication.

Organizational Communication Sylalbus

Published: October 24, 2026 01:08

OBJECTIVES:In the next part, I think we are going to learn a lot of practical tools that we can actually use in real-world jobs and teamwork.

8.7. Data Poisoning

Published: October 24, 2026 01:07

I thought the Kellogg’s example was interesting because it shows how data poisoning can be used for more than just causing problems. In this case, people were using fake job applications to support workers who wanted better working conditions. I can…

8.9. Bibliography

Published: October 24, 2026 01:06

I thought that h22 was interesting and surprising because one TikTok video was able to affect thousands of scientific studies when it wasnt the intention in the first place. What stood out to me was that so many people in a similar age group started taking…

8.9. Bibliography

Published: October 23, 2026 23:41

h(9) Social media can reveal way more about us than we think, even if we never share certain things ourselves. The article explains how people can use our friends and connections to guess private information, even about people who don’t have social media.…

8.5. Activity: What platforms think of you — Social Media, Ethics, and Automation

Published: October 23, 2026 23:38

Honestly, I just do not care what google knows about me, like I get that some people are afraid of privacy concerns, totally valid but I honestly just don’t care. Also my ad profile is very accurate lol

13.1: Angles

Published: October 23, 2026 23:19

e we define an angle in standard position by its initial side, we have a special type of angle whose terminal side lies on an axis, a quadrantal angle. This type of angle can havWhy show the quadrants and not explain them?

The phosphatidylserine-binding proteins Turandots protect neurons from antimicrobial peptides

Published: October 23, 2026 23:13

**Note:** This preprint has been reviewed by subject experts for *Review Commons*. Content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Referee \#3 #### Evidence, reproducibility and…

The phosphatidylserine-binding proteins Turandots protect neurons from antimicrobial peptides

Published: October 23, 2026 23:13

**Note:** This response was posted by the corresponding author to *Review Commons*. The content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Reply to the reviewers > > Reviewer #1…

The phosphatidylserine-binding proteins Turandots protect neurons from antimicrobial peptides

Published: October 23, 2026 23:13

**Note:** This preprint has been reviewed by subject experts for *Review Commons*. Content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Referee \#2 #### Evidence, reproducibility and…

The phosphatidylserine-binding proteins Turandots protect neurons from antimicrobial peptides

Published: October 23, 2026 23:13

**Note:** This preprint has been reviewed by subject experts for *Review Commons*. Content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Referee \#1 #### Evidence, reproducibility and…

1.1 What Is Sociology? - Introduction to Sociology 3e | OpenStax

Published: October 23, 2026 23:01

Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived.I find this to be fascinating because…

1.1 What Is Sociology? - Introduction to Sociology 3e | OpenStax

Published: October 23, 2026 22:53

However, even when results contradict a sociologist’s prediction of a study’s outcome, these results still contribute to sociological understandingI think this is a good reminder that just because something doesn’t happen the way we expect it to, doesn’t…

1.1 What Is Sociology? - Introduction to Sociology 3e | OpenStax

Published: October 23, 2026 22:47

A researcher needs to avoid steering or prompting the subject to respond in a specific way; otherwise, the results will prove to be unreliableI think this is important because people might not feel comfortable being completely honest if they think they are…

12.4: Derivatives

Published: October 23, 2026 22:42

–68 ft/sec, it is dropping back to Earth at a rate of 68 ft/s.tempting to say it is slowing at 68 ft/s, but the negative sign points to the downward trajectory.

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