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🦜 Hypothesis

@hypothes.is.stream.q.user.lmichan@rss-parrot.net

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Site URL: hypothes.is/stream?q=user:lmichan

Feed URL: hypothes.is/stream.rss

Posts: 1495

Followers: 1

Brave Search

https://hypothes.is/a/K_KODJHHEfG8SzdUWb91LQ

Published: August 6, 2026 18:46

[💻/asus/🧊/me/📓/2026/8/🔍/ground.atomic.formula.cyc/@/Brave/ground.atomic.formula.cyc.Brave.html](https://bafybeib2w4zy55ovxqyhgef5uypk62emacule5bhe5zhyx3pcsk3f6t5tq.ipfs.dweb.link)

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/3nDaCpHEEfGVn38juH8Jkw

Published: August 6, 2026 18:30

6.6 The sandbox contractWhat about the simulator contract? I think there could be some things to discuss here, like how to control having Expo Go preinstalled after the split

Will AI Wealth Actually Flood AIS/EA Philanthropy Soon?

https://hypothes.is/a/hjkhPpHAEfGBlwfRQk9lDQ

Published: August 6, 2026 17:59

A steelman against the Bay-Area assumption that very large AI-lab-adjacent philanthropy will quickly become usable funding for AI safety and EA cause areas.I don't think it still really should be considered a "steelman". It's more of a model and a…

XXIV. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. In a letter to Francis Baily, Esq. F. R. S. &c

https://hypothes.is/a/gKLtWpG_EfGzMOfv6jd29A

Published: August 6, 2026 17:51

royal society law of human mortaility

XXIV. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. In a letter to Francis Baily, Esq. F. R. S. &c

https://hypothes.is/a/V_6zNJG_EfGDn4-RsptdZw

Published: August 6, 2026 17:50

from: https://royalsocietypublishing.org/rstl/article/doi/10.1098/rstl.1825.0026/117600/XXIV-On-the-nature-of-the-function-expressive-of law of human mortaility

Do Geometric Outliers Identify Important Genes in Single-Cell Foundation Models?

https://hypothes.is/a/NtsoDpG_EfGabMMTLBq9Cw

Published: August 6, 2026 17:49

Each gene is scored on four metrics: embedding norm, Euclidean distance to the vocabulary centroid, cosine similarity to the centroid, and mean distance to its k = 10 nearest neighbours (isolation).It seems likely the foundation model embedding geometries…

Zapit: Open Source Laser-Scanning Photostimulation For Neuroscience

https://hypothes.is/a/cBCIUpG2EfGJdxtshErMKg

Published: August 6, 2026 16:46

**Reviewer #3 (Public review):** Zappit is an open-source implementation of arbitrary-access laser-scanning optogenetics for manipulation of neuronal activity in mice. As the method requires expertise ranging from optics, hardware control and…

What Is It Like to Be a Bat?

https://hypothes.is/a/2ZzHHpG1EfG6gVMhx7NLkg

Published: August 6, 2026 16:42

Iam restricted to the resources of my own mind, and those re-sources are inadequate to the tasThe context of being a human lives in the human brain, deeply embedded in the very essence of our lively understanding. To mold that to understand what it *is* to…

What Is It Like to Be a Bat?

https://hypothes.is/a/avPWIpG1EfGkssM4UzS5jQ

Published: August 6, 2026 16:39

anyone who has spent sometime in an enclosed space with an excited bat knows what it is toencounter a fundamentally alien form of life.I've been attacked by bats twice in my life. This statement couldn't be more true.

What Is It Like to Be a Bat?

https://hypothes.is/a/Gy8iLJG1EfGnEqNvIMaWBQ

Published: August 6, 2026 16:37

hylogenetic treea branching diagram that shows the evolutionary history and relationships among different species or groups of organisms

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/At3X5JGxEfGJceMDeLdhkA

Published: August 6, 2026 16:08

das typische Produktmake this: eine typische Sportart

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/89hOFJGwEfGVXKPaYfrVSQ

Published: August 6, 2026 16:07

nichtmake this: ist dies nicht der Fall

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/4EFlApGwEfGEWUuVoRk8tg

Published: August 6, 2026 16:07

, und dmake this: . D

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/e54IxpGwEfG6ky_Xtt13GA

Published: August 6, 2026 16:04

, was in einem österreichischen Krankenhaus selten zutrifft.make this: . Das trifft in einem österreichischen Krankenhaus selten zu.

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/aMQK8pGwEfGDmxeSZv0ilQ

Published: August 6, 2026 16:03

Behandlung, Rücktransport und Evakuierung jeweils unbegrenztmake this: Behandlung, Rücktransport und Evakuierung werden je unbegrenzt gedeckt

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/VgFuWpGwEfGYkvs0cZLqWw

Published: August 6, 2026 16:03

, sodass unklar bleibt, ob Skifahren gedeckt istmake this: . So bleibt unklar, ob Skifahren gedeckt ist.

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/QucJ7JGwEfG8PEe2fMbvlQ

Published: August 6, 2026 16:02

, und dmake this: . D

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/7vvwLJGvEfGVxnOoKGcO1g

Published: August 6, 2026 16:00

, imake this: . I

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/-AStZJGtEfGJNJ9k40onFA

Published: August 6, 2026 15:46

run.cloud already has the pattern in tags.Not that anybody wanted to, but I'd like to say this: If we add metadata JSON, let's not kill tags, those aren't superseded by metadata, as they have their own neat rendering and they are algorithmic-ally cheap to…

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/2q5s5pGtEfGlMsdZekFgQQ

Published: August 6, 2026 15:45

Im zweiten BlockWhat is this referring to? Clarify or find another phrasing without the reference

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/2F8vhJGtEfGstGsV8HMcdQ

Published: August 6, 2026 15:45

, und dermake this: . Der

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/DIhsBJGtEfG5lh-yIo282w

Published: August 6, 2026 15:39

OpenAPIAs much as I like having REST API specs (especially for E2E tests, monitoring, etc.), I'd like to push back slightly, as this would slow our agents down, and it does not cleanly fit all of our features (i.e. log streaming would be poorly defined…

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/2lqnkpGsEfGA2sPwh-g3DA

Published: August 6, 2026 15:38

großzügiger als erwartetmake this: großzügig

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/iYW70pGrEfG3pLv9pnQQDw

Published: August 6, 2026 15:28

A separate service cannot hold Newly's prod secrets.Why not? As in "what failure scenario will justify having to rotate two sets of credentials if we have to"

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/_9FURpGqEfGnjfOqyMZl0w

Published: August 6, 2026 15:25

the coupling forces unwanted change on both products, in both directions:Can we clarify that this is only bad if it's a "change of an existing feature" and not an "addition"? I really liked how during my agentic loops that covered Newly, run.cloud and the…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/MyGz0pGqEfGrm4_F29OBCA

Published: August 6, 2026 15:19

Metro is Newly's code, wherever it runsOne thing I'd like to mention in run.cloud's product statement, that first-class support for some React Native-related and AI-related features should be included For example, the Metro bundler tunneling One might…

IAP retrotransposons contribute to the transcriptional diversity of the murine placenta

https://hypothes.is/a/UljrDpGpEfGZgb9b85rqRQ

Published: August 6, 2026 15:13

**Note:** This preprint has been reviewed by subject experts for *Review Commons*. Content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Referee \#2 #### Evidence, reproducibility and…

IAP retrotransposons contribute to the transcriptional diversity of the murine placenta

https://hypothes.is/a/UoIqWpGpEfGNhG_OikQf9g

Published: August 6, 2026 15:13

**Note:** This preprint has been reviewed by subject experts for *Review Commons*. Content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Referee \#3 #### Evidence, reproducibility and…

IAP retrotransposons contribute to the transcriptional diversity of the murine placenta

https://hypothes.is/a/Ur16sJGpEfGsrtPCCX1E9A

Published: August 6, 2026 15:13

**Note:** This response was posted by the corresponding author to *Review Commons*. The content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Reply to the reviewers We sincerely thank…

IAP retrotransposons contribute to the transcriptional diversity of the murine placenta

https://hypothes.is/a/Uik0QJGpEfG6Mnc5-_gygw

Published: August 6, 2026 15:13

**Note:** This preprint has been reviewed by subject experts for *Review Commons*. Content has not been altered except for formatting. Learn more at [Review Commons](https://reviewcommons.org) ----- ### Referee \#1 #### Evidence, reproducibility and…

report.md

https://hypothes.is/a/0x5RnpGoEfGEcVOiGUM1Yw

Published: August 6, 2026 15:09

图 4. 指标本身、它的分布、混杂项、以及低值与高值分别长什么样这个肿瘤区域的熵值能不能用于预测response或者os/pfs

How bad would human extinction be?

https://hypothes.is/a/OHTC5pGnEfGA1ovXSy-HSA

Published: August 6, 2026 14:58

The reasoning goes that if there is always a high level of background risk to humanity, then we should expect to go extinct soon anyway, which means the importance of avoiding any one particular risk is not as valuable as it may seem. For more details see…

Die besten Kreditkarten mit Reiseversicherung für den Skiurlaub 2026/27: Bergung, Haftpflicht und was abseits der Piste noch gilt

https://hypothes.is/a/CLaEhpGnEfGBiEelaDk_ww

Published: August 6, 2026 14:56

eine Zeile in der Karteneinsatz-Übersichtdelete

Die besten Kreditkarten mit Reiseversicherung für Fernreisen

https://hypothes.is/a/NzucEJGiEfGG6eP1rYJohQ

Published: August 6, 2026 14:22

Wer daraus schließt, es handle sich um dieselbe Deckung wie bei Amex, nur günstiger, liegt allerdings falsch.In Summe ist der Versicherungsschutz allerdings nicht vergleichbar mit der Platinum Card.

Die besten Kreditkarten mit Reiseversicherung für Fernreisen

https://hypothes.is/a/QOhPSJGhEfGq9-veOXGMDQ

Published: August 6, 2026 14:15

der überhaupt einen Wert ausweist, bei abgelegenen Zielen der Posten, an dem es scheitert.what is this supposed to mean. please rephrase to clarify

Die besten Kreditkarten mit Reiseversicherung für Fernreisen

https://hypothes.is/a/Bv2wepGhEfGINoeVNtzl-g

Published: August 6, 2026 14:13

bei der die medizinischen Kernpositionen durchgehend oben stehenmake this: die bei den medizinischen Kernpositionen durchgehend oben steht.

Die besten Kreditkarten mit Reiseversicherung für Fernreisen

https://hypothes.is/a/6Y_mypGgEfGrm8OuVt1a_g

Published: August 6, 2026 14:12

Die sechs Karten im ÜberblickThis is a lot to take in. I'm guessing none of all that info could be left out?

front-build | 秋天没有心

https://hypothes.is/a/4-5TapGfEfG5jF-ky5rP1Q

Published: August 6, 2026 14:05

这段 splitChunks 配置的核心目的，是：在多页面应用中抽离重复代码，减少每个页面 bundle 的体积，并利用浏览器缓存提升加载效率。 例如： page1 使用 vue、axios page2 使用 vue、axios page3 使用 vue、axios 如果不拆分，vue、axios 可能会分别被打进每个页面的 bundle 中。配置后会变成： vendor.js → vue、axios 等第三方依赖 page1.js → page1 自己的业务代码 page2.js → page2…

Die besten Kreditkarten mit Reiseversicherung für Fernreisen

https://hypothes.is/a/UC0FSpGfEfG4t6euZddd0Q

Published: August 6, 2026 14:01

steht in der Tabellemake this: zeigt die folgende Tabelle im Abschnitt "Medizinische Absicherung". Zudem gibt sie einen Überblick über die wichtigsten Fakten und Bedingungen pro Kreditkarte.

Lesson 8 · Apply Measurement to Complete a Task — TESDA Foundational Skills

https://hypothes.is/a/AOzBKJGQEfG9FAN0OUunsQ

Published: August 6, 2026 12:11

@redz , thank you for your feedback! This is considered in the content piece that will be in the privately published KA course page.

Lesson 4 · Read Bar Charts and Diagrams — TESDA Foundational Skills

https://hypothes.is/a/6nUQHJGPEfGazpuQ0ANzLA

Published: August 6, 2026 12:11

@redz , thank you for your feedback! This is considered in the content piece that will be in the privately published KA course page.

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/OTEKwpGPEfGTlnuijT7CUg

Published: August 6, 2026 12:06

transport im Akiaakia wurde mindestsent zweimal genantn. was bedeutet dieses wort, ich kenne es nciht

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/_8m3ApGOEfGRj_8xvCZkmw

Published: August 6, 2026 12:04

sen, ohne dass definiert wäre, was darunter fällt.ohne dass es definirt wird shortens teh sentence

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/sFa04JGOEfGc26tfVBl5gA

Published: August 6, 2026 12:02

Privathaftpflicht, keine Unfallversicherung, dazu kein Reisegepäcreisegepaecksversicherung, i hope they still allow for reisegepaeck hahah

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/mzt3TpGOEfGRQ7PeD79RVw

Published: August 6, 2026 12:01

vor Ort ist der Unterschied zwischen Vorschuss und gar nichts erheblich.cut this part of the sentence and replace with "hilfreich"

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/eGw2_pGOEfGrkmvejQnDEg

Published: August 6, 2026 12:00

Kautionen und Mietwagenanmietungen praktisch relevant ist.zu problemen fuehren kann (statt praktisch relevan tist)

Supplementary Material | GAPS - Guidance for Artifact Preparation and Sharing

https://hypothes.is/a/MvjlDpGOEfGj20fyGxLPoQ

Published: August 6, 2026 11:58

Planned: artifact preparation, documentation, reproducibility, publication, and maintenance checklists.eu acho que recomendaria isso para meus alunos. o texto em si achei muito esforco no sentido de ser completo, cobrir tudo, mas nem sempre isso é bom.…

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/HTzsJJGOEfGdKk89VO6-Pg

Published: August 6, 2026 11:58

Wer auf der Piste jemanden verletzt, steht damit ohne Deckung da, und das ist bei einem Kollisionsanteil von gut 20 Prozent kein Randfall.what do you mean mit kollisionsanteil?

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/qvc_rJGNEfGPJye3sZdFqA

Published: August 6, 2026 11:55

4.3 Data ownership orgs splits. Newly keeps orgs; run.cloud gets accounts carrying runcloud_stripe_customer_id, max_active_tunnels, credit_limit_usd, spend_limit_usd, and the sandbox meter rollups. They are linked by an opaque external_account_id — a…

Kreditkarte mit Reiseversicherung im Skiurlaub

https://hypothes.is/a/mH9wYJGNEfG6g9vKDqkqVQ

Published: August 6, 2026 11:54

Was die Krankenkasse im Skiurlaub nicht zahlt Für die gesetzliche Krankenversicherung ist der Fall im Gesetz geregelt, und zwar knapp. In § 60 Absatz 4 SGB V steht wörtlich: "Die Kosten des Rücktransports in das Inland werden nicht übernommen." Das gilt…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/hdlVPpGNEfGq6tdWGnSO9A

Published: August 6, 2026 11:54

Publish the OpenAPI spec for the existing /run-cloud/* surface before moving any code, and generate Newly's client from it. This is deliberately the reverse of the tempting order, for two reasons. It makes the surface reviewable while it is still cheap to…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/sAu1WJGJEfGc2dtYDp_OfA

Published: August 6, 2026 11:26

agreed, it there should be a standard otel integration pathway with run.cloud for newly-tung that is the same as other users take

Die besten Kreditkarten mit Reiseversicherung für Fernreisen

https://hypothes.is/a/Z0bHoJGIEfGZ6qfzlF2r7g

Published: August 6, 2026 11:17

Wer schwer verletzt ist, bleibt dann, bis er transportfähig ist, und das kann sich über Wochen ziehen.incorrect german rephrase

Die besten Kreditkarten mit Reiseversicherung für Fernreisen

https://hypothes.is/a/TXvIPpGIEfGYUhOk608Ytw

Published: August 6, 2026 11:16

Eine eigene Klausel gilt dem Ausbildungs-Lückenjahr. Kinder bis 25 sind während eines Gap Years, bei Working Holidays oder im Auslandsstudium für 365 aufeinanderfolgende Tage abgesichert, und zwar für sämtliche Reiseversicherungsleistungen. Das Kind muss…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/4GUP6pGGEfG_YRclqyv6sQ

Published: August 6, 2026 11:06

serve-sim host-side embed-token verification code (the submodule is declared update = none, ignore = all and is not checked out; §4.2's claim was read through the GitHub API against newly-app/serve-sim-fork@newly).Claude, can we verify this now? If yes,…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/p6bwsJGGEfGKEMNkMaOaMg

Published: August 6, 2026 11:04

Metro /events endpoint vs stdout parsing. §6.3 proposes parsing because the matcher exists and is tested. Metro's reporter hook would be less brittle. Worth a spike during B, before committing to either.i didn't quite get this question / problem

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/nh_ovJGGEfGCma-ewwoRKg

Published: August 6, 2026 11:04

Do we keep the local venue driver? It is the dev-container path and unaffected by the venue move, but a third driver is a third thing to keep working.the local venue driver is still booting desktop app local sessions from what i understand, so this is an…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/h3y4xJGGEfGJkzuSB6eVng

Published: August 6, 2026 11:04

Is the sandbox egress guarantee explicit? Modal sandboxes currently have unrestricted public egress and the launcher depends on it (npm, Expo CDN, cp-api). On run.cloud this must become a stated contract term, not an accident of configuration.i didn't…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/evPm4JGGEfGT_g90BaRZpQ

Published: August 6, 2026 11:03

If our sessions contend with paying run.cloud customers for capacity, someone has to decide who losesalways other runcloud customers win, its okay to have downtime on newly, its not okay to have downtime for customers

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/Y4YNYpGGEfGHvDvHW8K25Q

Published: August 6, 2026 11:03

Do we want run.cloud's spans in our trace at all, if run.cloud is willing? Propagate and echo says we must not require it. Accepting it when offered is strictly better for debugging but makes the two systems' retention and sampling policies interact.i…

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/UdUUjJGGEfG8IUdfaw7c9w

Published: August 6, 2026 11:02

bootstrap.run.cloud hardcodes the dev cp-api origin (_worker.js:1). Was that deliberate, and what should it point at post-split?good question, idk

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/SRWnTpGGEfGOrjczkviq6Q

Published: August 6, 2026 11:02

Newly's credits vs run.cloud's billing. If run.cloud owns metering end-to-end, does Newly pre-purchase capacity, or get invoiced in arrears like a customer? This is a commercial decision, not a technical one.Tim to decide

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/PvkHiJGGEfGwycOPjLA0mw

Published: August 6, 2026 11:01

Does run.cloud get its own Postgres instance, or a separate schema first? Schema-first is cheaper and reversible; instance-first is the honest end state. Recommendation: schema-first during F, instance before G.separate instance imo

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/M7esbJGGEfGKD6vVSml-Dw

Published: August 6, 2026 11:01

Who owns serve-sim? It serves Newly frontend, Newly desktop, modal-backend and run.cloud simulator sessions. This RFC keeps it shared, but "shared between two independent companies" needs an owner and a release cadence.run.cloud imo

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/Iv1gEJGGEfGwyNNxGifyHw

Published: August 6, 2026 11:01

Fix snapshot/restore before sessions depend on it, or explicitly declare sessions non-snapshotting on run.cloud for nowtim is already fixing it

RFC: Papaya — Splitting Newly and run.cloud

https://hypothes.is/a/OVc5kJGFEfG2WKsaYHGdKw

Published: August 6, 2026 10:54

Dotted edges are the breaks. Gap 2 is the cheap one: the sending half is written and the receiving half is written — only the SDK initialization is missing.this describes the current implementation (not the proposed one); and it proposes a few places with…

P66Shc Mediates SUMO2-induced Endothelial Dysfunction

https://hypothes.is/a/s-eMkpF_EfGfLndSeO4HsQ

Published: August 6, 2026 10:15

**eLife Assessment** This study offers valuable insights into the role of post-translational modifiers, specifically SUMO2ylation at K81 in p66Shc, and its impact on endothelial function through reactive oxygen species. A series of compelling…

P66Shc Mediates SUMO2-induced Endothelial Dysfunction

https://hypothes.is/a/s7HUHJF_EfGwxPOKtE1WzQ

Published: August 6, 2026 10:15

**Reviewer #2 (Public review):** Summary: The manuscript titled "p66Shc Mediates SUMO2-induced Endothelial Dysfunction" by Kumar et al. builds upon established literature demonstrating that both p66Shc and SUMOylation are essential players in…

P66Shc Mediates SUMO2-induced Endothelial Dysfunction

https://hypothes.is/a/s3467pF_EfG6IK8SLghHUQ

Published: August 6, 2026 10:15

**Author response:** The following is the authors’ response to the original reviews. > **Public Reviews:** > > **Reviewer #1 (Public review):** > > Summary: > > The authors describe a role of sumoylation at K81 in p66Shc which affects endothelial…

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