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Site URL: hypothes.is/stream?q=user:lmichan

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Posts: 908

Followers: 1

Science: A New Golden Age

https://hypothes.is/a/xxLIEo99EfGGsvNGyR1TLw

Published: August 3, 2026 20:56

expanding portable graduate fellowships like the National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP)Bet on the people, not just projects... gets students to commit to outcomes early, rather than coming at it like passive…

homage to my hips by Lucille Clifton | Poetry Foundation

https://hypothes.is/a/mJPgFo99EfGVjtcHBDdsnQ

Published: August 3, 2026 20:55

they don't fit into little petty placesclifton refuses to minimize herself and her hips to fit inot a standard that society has of her.

homage to my hips by Lucille Clifton | Poetry Foundation

https://hypothes.is/a/g7R_Uo99EfGyi8dYHBqO_w

Published: August 3, 2026 20:54

these hips are big hips they need space to move around in.it seems like clifton is using her hips as a metaphor. her hips are the largest part of her that she refuses to diminish. her hips reflect her sentiments about her self

Loop Engineering: A Crash Course | The AI Agent Factory

https://hypothes.is/a/eiOkco99EfGokPs5aEl5mQ

Published: August 3, 2026 20:54

"One full run of the small loop = one "beat" of the big loop" 1. does it mean the "big loop" has multiple small loops? 2. is there a min/max number of beats? 3. if one full run of the small loop is called a beat, then what we call a full run of a big…

Von Cicaplast bis Anthelios: Die La-Roche-Posay-Produkte, die Beauty-Fans lieben

https://hypothes.is/a/NkCRKo99EfGPQhNj87RGVQ

Published: August 3, 2026 20:52

Auch auf TikTok ist der Cicaplast Baume B5+ auffällig präsent: Videos zu dem Balsam sammeln sich dort in einem Dutzend Sprachen, die reichweitenstärksten davon kommen auf mehrere Millionen Aufrufe.Sounds too much like AI. Better: Auch auf TikTok taucht…

Von Cicaplast bis Anthelios: Die La-Roche-Posay-Produkte, die Beauty-Fans lieben

https://hypothes.is/a/AkrveI99EfGVvduJcuVAEQ

Published: August 3, 2026 20:50

Er kombiniert 5 % Panthenol mit Madecassoside sowie Zink und Mangan, dazu das Thermalwasser der Marke, und kommt ohne Alkohol aus.Somehow this sentence sounds very technical. Better: Die Formel enthält 5 % Panthenol sowie Madecassoside, Zink und Mangan.…

Von Cicaplast bis Anthelios: Die La-Roche-Posay-Produkte, die Beauty-Fans lieben

https://hypothes.is/a/4VW7wo98EfGCKW_tyvM2og

Published: August 3, 2026 20:49

Der Cicaplast Baume B5+ ist eine multifunktionale Pflege für trockene und beanspruchte Hautstellen, und er ist das La-Roche-Posay-Produkt, das ich am ehesten empfehle, wenn jemand gar nicht weiß, wo er anfangen soll.Sounds more natural: Der Cicaplast…

1  Manuscript – The problem with the OME metric

https://hypothes.is/a/Lf5alI97EfGbuJsw1u7Y_Q

Published: August 3, 2026 20:37

ackground drafted, some more citations on the various commentery on OME/metrics/issues from the literature to come.This is a test comment

A multimodal foundation model linking histopathology and DNA methylation

https://hypothes.is/a/H5LJNo97EfGVuavPdnhprw

Published: August 3, 2026 20:37

dding variants, colored by cancer type. b, Image-to-DNAmretrieval across GBM, LGG, HNSC, and BRCA using matched slide and methylation embeddings,shown as Recall@1, Recall@5, and Recall@10. These analyses use pre-trained embeddings beforesupervised…

A multimodal foundation model linking histopathology and DNA methylation

https://hypothes.is/a/zOmQPo96EfG_5v9ucOoCPA

Published: August 3, 2026 20:35

istoMethyl demonstrates that DNA methylation can be used not only as a molecularendpoint, but also as a biologically structured supervision signal for learning clini-cally useful whole-slide representations.Important contribution!

A multimodal foundation model linking histopathology and DNA methylation

https://hypothes.is/a/j6q8Ao96EfGO1w9yyxjP_g

Published: August 3, 2026 20:33

toMethyl overview. a, Cancer cohorts from TCGA [14] used for HistoMethyl pre-training.b, Pre-training inputs, including WSIs divided into tiles and paired DNAm beta values correspondingto each case. c, Pre-training with contrastive alignment. WSI and DNAm…

Characterization of acetate catabolism in Chlamydomonas reinhardtii reveals distinct roles for ACS1 and ACK2 in regulating cell growth and carbon storage

https://hypothes.is/a/VeXPII96EfG5mOc0ADQTRg

Published: August 3, 2026 20:31

This study investigated the roles of ACS1 and ACK2 in C. reinhardtii. The acs1 mutant exhibited accelerated growth but reduced early-stage TAG accumulation. In contrast, the ack2 mutant displayed diminished respiration and a slower growth rate, yet…

54191749

https://hypothes.is/a/QyymQo96EfGXnvPWF3TO8A

Published: August 3, 2026 20:31

Beyond cell annotation and spatial niche characterization, recovering unmeasured456proteins represents another important downstream application in spatial proteomics.How exactly would the authors go about tackling this given the approach presented in the…

54191749

https://hypothes.is/a/LZ5rRI96EfG2mQNB--hkWg

Published: August 3, 2026 20:30

vely, these analyses identify a reproducible collagen-rich ECM-remodeling449niche that can be robustly transferred across independent cohorts and is preferentially450enriched in recurrent colorectal cancerImportant application

A Machine Learning Tutorial for Operational Meteorology. Part I: Traditional Machine Learning

https://hypothes.is/a/65vl3I95EfGNi6MvF6rC-g

Published: August 3, 2026 20:28

linear regression, logistic regression, decision trees, random forest, gradient boosted decision trees, naïve Bayes, and support vector machines.ML for operational meteorologists

Elucidating enzyme-substrate specificity through co-folding foundation model

https://hypothes.is/a/A7HzYI95EfGOfE-IJIt7OA

Published: August 3, 2026 20:22

. From this simulated complex, the framework extracts interaction repre-sentations and a predicted structure to capture local biophysical constraints. Toreconcile this local structure with global biological context, Boltz2ESI fuses these geo-metric…

2.2: Developing Successful Study Habits

https://hypothes.is/a/5Fu8Io9yEfGNfwMVhMwxLg

Published: August 3, 2026 19:38

Your list may be like this one or it may be completely different. It is yours, so you can make it however you want. Do not be concerned about the length of your list or the number of items on it.This makes me think about...

Macrophages: emerging targets for ulcerative colitis

https://hypothes.is/a/atI1Yo9xEfGP4F9UHtlZDQ

Published: August 3, 2026 19:27

In both in vitro and in vivostudies, they validated the anti-UC properties of Se-CA, findingthat Se-CA significantly improves colonic pathology in colitis miceby enhancing epithelial repair, reducing inflammation, reversingmacrophage type 1 responses, and…

Kitchen Soap – Counterfactual Thinking, Rules, and The Knight Capital Accident

https://hypothes.is/a/ZPjcvo9mEfGbcCP-HyUXRw

Published: August 3, 2026 18:08

(Dekker, 2004, p.33) “Saying what people failed to do, or implying what they could or should have done to prevent the mishap, has no role in understanding human error.”  (Dekker, 2004, p.43)@jallspaw Would you happen to have a source for the Dekker quotes?…

report.md

https://hypothes.is/a/CUyBVo9kEfGqhHPmP5IX2A

Published: August 3, 2026 17:52

tables/T3_power_per_domain_trueauc080.csv 我希望能把这个 table 补全，也就是补充一些我们现在已经计算好的指标，整理成一张表放在这里。具体要求如下： 1. 每一个数据集原始文献中的 AUC： 这是一整列。下面已经列出了一些，不确定的部分先列“未确定”就好。 2. 我们现在真实的 AUC： 按照下面的值填进去，其他不用管。 3. 我们过去 report 的 AUC： 按照下面的值填进去，其他不用管。 4. 新增三行 in-domain…

Vintage Typewriter Enthusiasts | What would it take to learn how to properly service typewriters | Facebook

https://hypothes.is/a/s6r0FI9hEfG-DvdCb106jQ

Published: August 3, 2026 17:35

I’d be in for that. I’ve been doing it for awhile, but would love the networking and fun. I have areas I’m still learning about and know enough to probably make me dangerous at times. Add me to your list. I’m in the Central Valley.Tom Hansen interested in…

Deploy on Google Kubernetes Engine

https://hypothes.is/a/6vAFXI9eEfGAsMvmBOfxrQ

Published: August 3, 2026 17:15

--values charts/aggregates/migrationAssistantWithArgo/valuesGke.yamlvaluesGke.yaml is insufficient for the chart. Also need values which are specific for this installation ``` gcp: project: opensearch-migration serviceAccountEmail:…

Deploy on Google Kubernetes Engine

https://hypothes.is/a/DgnW-o9dEfGr8t98-j3stQ

Published: August 3, 2026 17:02

Step 3: Install the Migration Assistant Helm chartMissing step to add repo. There is no public URL for the Helm repo. curl -fL -o migration-assistant-3.3.5.tgz \ …

Deploy on Google Kubernetes Engine

https://hypothes.is/a/0q8roI9SEfG-uFOqAjoVLw

Published: August 3, 2026 15:48

The Artifact Registry API is enabled and the GKE node service account already has roles/artifactregistry.reader. What’s missing is the actual Docker repository and images. You need four things: 1. Create the migrations repository: gcloud…

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

https://hypothes.is/a/8GYZNo9PEfGzm-vGMcvlCA

Published: August 3, 2026 15:28

**Reviewer #1 (Public review):** \[Editors' note: this version has been assessed by the Reviewing Editor without further input from the original reviewers.\] This manuscript by Rudich ZD et al. systematically profiled the transcriptomic changes in…

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

https://hypothes.is/a/8Jf7Do9PEfGE8tMb1H-kQQ

Published: August 3, 2026 15:28

**eLife Assessment** This valuable study presents a comparative analysis of the transcriptomic features underlying C. elegans longevity, providing insights into how different changes in gene expression can promote longevity. The authors present solid…

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

https://hypothes.is/a/8CoTyI9PEfG5lHuP4jcr-A

Published: August 3, 2026 15:28

**Reviewer #2 (Public review):** Summary: In the manuscript titled "Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies", the authors investigated diverse genetic pathways that contribute…

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

https://hypothes.is/a/7-21Xo9PEfGqYn_COLWKCA

Published: August 3, 2026 15:28

**Author response:** The following is the authors’ response to the original reviews > **Reviewer #1 (Public review):** > In the revised manuscript, the authors have addressed most of my concerns. In the text of this manuscript, the authors should still…

Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

https://hypothes.is/a/pSzJKo9OEfGo_IeD6v7HFw

Published: August 3, 2026 15:18

**eLife Assessment** This valuable cross-sectional longitudinal study leverages high-definition transcranial direct current stimulation to the left dorsolateral prefrontal cortex to examine its effect on procrastination behavior over an extended time…

Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

https://hypothes.is/a/n9crUI9OEfG5khsF_pmbBA

Published: August 3, 2026 15:18

**Reviewer #1 (Public review):** Summary: The authors report the results of a tDCS brain stimulation study (verum vs sham stimulation of left DLPFC; between-subjects) in 46 participants, using an intense stimulation protocol over 2 weeks, combined with…

Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

https://hypothes.is/a/mBBqCI9OEfGlL_PEAKLtaQ

Published: August 3, 2026 15:18

**Reviewer #4 (Public review):** Summary: The current study tested the effects of repeated sessions of tDCS targeting the DLPFC on procrastination behavior. The main outcome is that anodal versus sham DLPFC tDCS reduces procrastination behavior on both a…

Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

https://hypothes.is/a/kTLXrI9OEfG3PEfqLn0FoA

Published: August 3, 2026 15:18

**Author response:** The following is the authors’ response to the previous reviews >**Public Reviews:** >**Reviewer #1 (Public review):** >Summary: >The authors report the results of a tDCS brain stimulation study (verum vs sham stimulation of left…

Quarterly financial report for the quarter ended June 30, 2026

https://hypothes.is/a/MDwGho9NEfGHQ1O-3oOT6w

Published: August 3, 2026 15:08

Risks and uncertaintiesThe section Risks and uncertainties needs to be review based on the amended version

Deploy on Google Kubernetes Engine

https://hypothes.is/a/D440HI9JEfGyXLdYFdV4jg

Published: August 3, 2026 14:38

The required GCP APIs enabled:Missing the following APIs in this list compute.googleapis.com storage.googleapis.com

Deploy on Google Kubernetes Engine

https://hypothes.is/a/xToq1o9FEfGkvnfnDAMzSQ

Published: August 3, 2026 14:15

Clone the release tag you want to deploy.Might want to provide specific commands using `git` and `gh` cli to checkout the release tag Using Git: git clone --branch 3.3.5 --depth 1 --single-branch \ …

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nOCYxI9DEfG5iDtp9e3nkg

Published: August 3, 2026 13:59

**Reviewer #2 (Public review):** Summary: The authors present a creative approach using visual anagrams matched on low-level image statistics to isolate animacy from low-level visual features and report consistent effects of animacy on visual…

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nUMSnI9DEfGkulOh2jU7FA

Published: August 3, 2026 13:59

**eLife Assessment** This important study uses an elegant visual-anagram approach to test whether perceived animacy shapes visual working memory and guides visual attention while tightly controlling for lower- and mid-level image properties. The…

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nRLVyI9DEfGhEdu8jqXXcw

Published: August 3, 2026 13:59

**Reviewer #1 (Public review):** \[Editors' note: this version has been assessed by the Reviewing Editor without further input from the original reviewers. The authors have addressed the comments raised in the previous round of review.\] This is a…

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nGuvoI9DEfGbIgc91ScHTQ

Published: August 3, 2026 13:59

**Author response:** The following is the authors’ response to the original reviews. > **eLife Assessment** > > This valuable study uses an elegant visual-anagram approach to test whether perceived animacy structures visual working memory and attention…

Perceiving animacy in ‘identical’ images

https://hypothes.is/a/nKppPo9DEfGvVK8YM3I8oQ

Published: August 3, 2026 13:59

**Reviewer #3 (Public review):** This study makes clever use of generative AI to create stimuli that are pixel-for-pixel identical but which have radically different meanings depending on their orientation, to investigate the perception of animacy…

Continuous partitioning of neuronal variability

https://hypothes.is/a/AuwwZo9DEfGj2kcGX60n2Q

Published: August 3, 2026 13:55

**eLife Assessment** This work of fundamental significance introduces a novel statistical model of spiking activity that incorporates continuous-time gain modulation. The authors provide exceptional evidence that the model outperforms earlier…

Continuous partitioning of neuronal variability

https://hypothes.is/a/AogPWo9DEfGUjc_0q51k1Q

Published: August 3, 2026 13:55

**Reviewer #2 (Public review):** Summary: Neurons have varied responses to external stimuli that cannot be explained by naive Poisson models. Previous work has quantified and partitioned higher-than-Poisson variability in the brain into different…

Continuous partitioning of neuronal variability

https://hypothes.is/a/ArVqNo9DEfGE48_zoHV6Dw

Published: August 3, 2026 13:55

**Reviewer #1 (Public review):** Summary: In this manuscript, Rupasinghe and co-authors introduce a new statistical model for spiking neurons. Building on earlier work, they propose to model spikes as arising from a Poisson process whereby the…

Continuous partitioning of neuronal variability

https://hypothes.is/a/Ak5Fco9DEfG6Jy_jr9LuXw

Published: August 3, 2026 13:55

**Author response:** The following is the authors’ response to the original reviews. In the revised manuscript, we have expanded the real-data analyses, clarified the relationship between CMP and prior modulated Poisson models, and added discussion of…

3  Estudio de Caso: Calibración Termodinámica, Eléctrica y Cinética de Degradación – Tesis

https://hypothes.is/a/1Odeto9CEfGj2fOCUx83gw

Published: August 3, 2026 13:54

Transformación Algebraica a Parámetros Log-Normalesse explicara a detalle en los preliminares y de alli se cita aca

3  Estudio de Caso: Calibración Termodinámica, Eléctrica y Cinética de Degradación – Tesis

https://hypothes.is/a/hqaavo9CEfG6Ht8gSZyGjQ

Published: August 3, 2026 13:52

(Cola pesada hacia la derecha)en los preliminares hay que explicar a detalles que significa cola pesada hacia la derecha

3  Estudio de Caso: Calibración Termodinámica, Eléctrica y Cinética de Degradación – Tesis

https://hypothes.is/a/Jpt6uI9CEfGO38cGESz3RQ

Published: August 3, 2026 13:49

La Canícula (Área Púrpura, Días 196≤t<227): Abarca aproximadamente 30 días, desde el 15 de julio hasta el 15 de agosto. Corresponde a la zona de transición e intersección entre ambas campanas gaussianas.esplicar que es la canicula

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2Xcy_o9BEfGNfn-v7diQhw

Published: August 3, 2026 13:47

**eLife Assessment** This study provides important insights into the neural mechanisms linking sleep and long-term memory consolidation. By combining behavioural, genetic, imaging, and connectomic approaches in Drosophila, it identifies a target…

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2Ud5Qo9BEfG6JCvbXtv1BQ

Published: August 3, 2026 13:47

**Reviewer #1 (Public review):** Summary: The authors aim to use state-of-the art behaviour, imaging and connectome techniques to identify the neural interaction between sleep and long-term memory consolidation in the PAM-DPM circuits, a…

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2Rrd7I9BEfGog5s8yaIviA

Published: August 3, 2026 13:47

**Reviewer #2 (Public review):** Summary: Sleep plays a critical role in memory consolidation, but the neural mechanisms underlying this relationship remain incompletely understood. The authors examined a specific subset of PAM dopaminergic…

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2ONJaI9BEfGkswdoEWR2cA

Published: August 3, 2026 13:47

**Reviewer #3 (Public review):** Summary: Understanding the neural circuits that link sleep and memory remains a fundamental challenge in neuroscience. In this study, Lin Yan and colleagues investigate how dopamine signaling in Drosophila…

Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

https://hypothes.is/a/2JRHtI9BEfGM9BOU3aC3wQ

Published: August 3, 2026 13:47

**Author response:** The following is the authors’ response to the original reviews > **eLife Assessment** > > This study approaches an important topic providing insight into the neuronal circuitry that interconnects memory consolidation and sleep. The…

Overt visual attention modulates decision-related signals in the frontal cortex

https://hypothes.is/a/Yz0Gzo8_EfGksSMvYc-zdg

Published: August 3, 2026 13:29

**eLife Assessment** This important work examines the effects of gaze on valuation signals in the human brain as participants choose between bundles of sequentially presented items food items. The paper provides convincing analyses of how gaze affects…

Overt visual attention modulates decision-related signals in the frontal cortex

https://hypothes.is/a/YwU5Go8_EfGN8HuQjeGmVQ

Published: August 3, 2026 13:29

**Reviewer #1 (Public review):** \[Editors' note: this version has been assessed by the Reviewing Editor without further input from the original reviewers. The authors have updated the labelling of Figure 7. As all of the reviewer comments have now been…

Overt visual attention modulates decision-related signals in the frontal cortex

https://hypothes.is/a/YqOroI8_EfGEjbumY5LTUg

Published: August 3, 2026 13:29

**Author response:** The following is the authors’ response to the previous reviews > **Public Reviews:** > > **Reviewer #1 (Public review):** > > Summary: > > This study builds upon a major theoretical account of value-based choice, the 'attentional…

Overt visual attention modulates decision-related signals in the frontal cortex

https://hypothes.is/a/YtRamI8_EfG96MOjicy-Xw

Published: August 3, 2026 13:29

**Reviewer #2 (Public review):** Summary: In this paper the authors seek to disentangle brain areas that encode the subjective value of individual stimuli/items (input regions) from those that accumulate those values into decision variables…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/bGrUzo86EfGE3dtR9YPVgA

Published: August 3, 2026 12:54

**eLife Assessment** This important study reports the development of the first tankyrase degrader and demonstrates its enhanced ability to inhibit β-catenin signaling compared to conventional tankyrase inhibitors. The evidence supporting the…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/bD6Kho86EfGsVbMljKcIWQ

Published: August 3, 2026 12:54

**Reviewer #1 (Public review):** \[Editors' note: the second round of revision has been assessed by the Reviewing Editor without further input from the original reviewers. The authors have addressed the minor comments raised in the previous round of…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/bAObko86EfGPm6NuZKP_RQ

Published: August 3, 2026 12:54

**Reviewer #2 (Public review):** Summary: The ADP-ribosyltransferase tankyrase controls many biological processes, many of which are relevant to human disease. This includes Wnt/beta-catenin signalling, which is dysregulated in many cancers, most…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/a8Xyzo86EfGucAccvyTjjQ

Published: August 3, 2026 12:54

**Reviewer #3 (Public review):** In this manuscript, Wang et al employ a chemical biology approach to investigate the differences between the enzymatic and scaffolding roles of tankyrase during Wnt β-catenin signalling. It was previously established…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/a4S6NI86EfG2BYMW3u4oTg

Published: August 3, 2026 12:54

**Reviewer #4 (Public review):** From the Reviewing Editor: This important study reports the development of the first PROTACs targeting the ADP-ribosyltransferases tankyrase 1 and 2, with the goal of inhibiting Wnt/β-catenin signaling more…

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

https://hypothes.is/a/a021eo86EfGN6eO4O8Omcw

Published: August 3, 2026 12:54

**Author response:** The following is the authors’ response to the previous reviews We thank the Reviewers for the favourable feedback. There is no additional comments from Reviewers 1, 3, and 4, and we address the minor concerns from Reviewer 2 as…

RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

https://hypothes.is/a/bqsO1o84EfGCOb_EYk7ftw

Published: August 3, 2026 12:39

**eLife Assessment** This revised paper provides solid evidence for HGF-induced trafficking of the HGF receptor, MET, together with metalloprotease MT1-MMP into invadopodia and the role of this trafficking in triple-negative breast cancer (TNBC) cell…

RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

https://hypothes.is/a/bkwu3o84EfGBzy9XSulMvw

Published: August 3, 2026 12:39

**Reviewer #2 (Public review):** Summary: In this manuscript, Khamari and colleagues investigate how HGF-MET signaling and the intracellular trafficking of the MET receptor tyrosine kinase influence invadopodia formation and invasion in…

RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

https://hypothes.is/a/bn0KaI84EfGPspe5rdmiAQ

Published: August 3, 2026 12:39

**Reviewer #1 (Public review):** Summary: This study identifies a mechanism responsible for the accumulation of the MET receptor in invadopodia, following stimulation of Triple-negative breast cancer (TNBC) cells with HGF. HGF-driven accumulation…

RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

https://hypothes.is/a/bfeQ9I84EfG5e3MUyevZmQ

Published: August 3, 2026 12:39

**Author response:** The following is the authors’ response to the current reviews. We thank the editor and the reviewers for their comments on the revised manuscript. Based on the comments, we decided to go for a minor revision which will address all…

Adding Splunk Integrations - User Guide

https://hypothes.is/a/ntFdMI80EfGzgyMo7b8img

Published: August 3, 2026 12:12

We've agreed to mention the required roles only in the parent article for the feature to ensure consistency. Otherwise, they should be present in each and every article. Then it means that other limitations should also be repeated on every page.

Structured stabilization in recurrent neural circuits through inhibitory synaptic plasticity

https://hypothes.is/a/wmICHo8zEfG3JnclXQcyEA

Published: August 3, 2026 12:06

**Author response:** We thank the editors for sending our work for review and the reviewers for their thorough and constructive evaluations. In response to their feedback, we will submit a revised version of the manuscript soon. Below, we provide…

Regulatedhomeworkshop

https://hypothes.is/a/t5dFlI8xEfGrR3dX_ejJaA

Published: August 3, 2026 11:51

That's what The Unfinished Community is - everything that helped, gathered in one place, for you.Because this life can feel lighter, joyful, and a whole lot less lonely. That's what I'm here for.Cheering you on, every step of the way.Update this with an…

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