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🦜 Hypothesis

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Site URL: hypothes.is/stream?q=user:lmichan

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Posts: 2009

Followers: 1

Arts Integration and Differentiated Instruction

https://hypothes.is/a/St_WGGdVEfGO778TqZqUOQ

Published: June 13, 2026 18:25

I agree that differentiated instruction should always be expected from teachers. Students should have the most opportunity that they can to receive information in the way that makes the most sense for them. Students have different learning styles from one…

Arts Integration and Differentiated Instruction

https://hypothes.is/a/kk4RbmdUEfGisWt2CPZKdQ

Published: June 13, 2026 18:20

Through arts integration, students use alternative ways (e.g., dancing, acting, writing, speaking, drawing, singing) to make sense of content they are learning and to demonstrate their understandings.This is the whole idea behind arts integration! The…

Arts Integration and Differentiated Instruction

https://hypothes.is/a/07y79mdTEfGAWpPJ0y97RA

Published: June 13, 2026 18:15

“Differentiation doesn’t suggest that a teacher can be all things to all individuals all the time. It does, however, mandate that a teacher create a reasonable range of approaches to learning much of the time, so that most students find learning a fit much…

digiGO Informatiemodel Woongebouwen (IMWO)

https://hypothes.is/a/tOBFVGdJEfGHhgNu2AY1Kg

Published: June 13, 2026 17:02

Hier zit de kern van het probleem. We proberen goed te doen aan alle bestaande normen, maar die rammelen dus. Ik zou het graag omdraaien. Zet het goed neer, en geef aan waar de bestaande normen te kort schieten. BbL, Nen enzovoort.

Hypothesis

https://hypothes.is/a/Qlm6cmdBEfGXJRu9N2hPww

Published: June 13, 2026 16:02

> Recognizing the value of the academic disciplines, an interdisciplinary approach that considers multiple areas together is typically more meaningful than teaching content areas separately.

Which typewriter had the best font?

https://hypothes.is/a/tYEEAGc9EfGTEutHF6G7-w

Published: June 13, 2026 15:36

reply to u/someblokeonhere at https://www.reddit.com/r/typewriters/comments/1u4ftix/which_typewriter_had_the_best_font/ The vast majority of typewriters were sold with a traditional mono-spaced Courier-like face in either pica or elite pitch (often with…

It’s working!

https://hypothes.is/a/-qNSrGc6EfGlohMGgyl8VQ

Published: June 13, 2026 15:17

For the Sears Holiday Petite Child’s toy typewriter. Spools are 4cm in diameter, and 1 cm width. Uses a fabric 0.6mm ribbon.https://www.reddit.com/r/typewriters/comments/1u4gbul/its_working/ I suspect they meant 6mm width on the fabric ribbon?

It’s working!

https://hypothes.is/a/tJoT9Gc6EfGLztcd0vdO7w

Published: June 13, 2026 15:15

https://www.reddit.com/r/typewriters/comments/1u4gbul/its_working/ To create an account on the typewriter database, visit https://typewriterdatabase.com/register-today.php (Ted Munk manually approves new accounts within a day or two.) Joe Van Cleave has…

Statement on the US government directive to suspend access to Fable 5 and Mythos 5

https://hypothes.is/a/jkKxDGc6EfGTB3dwyY5XTg

Published: June 13, 2026 15:14

This action does not adhere to those principles.大多数人认为政府有权出于国家安全考虑暂停AI模型访问，但作者认为政府的行动缺乏透明度、公平性和技术依据。这挑战了政府监管的权威性，暗示即使出于国家安全，政府行为也应受到严格约束。

Statement on the US government directive to suspend access to Fable 5 and Mythos 5

https://hypothes.is/a/jU-vNGc6EfGys7cxeb_ALQ

Published: June 13, 2026 15:14

We stand by this defense in depth strategy. It reduces the risks posed by Fable, making them comparable to the risks of existing models already deployed across the…

Statement on the US government directive to suspend access to Fable 5 and Mythos 5

https://hypothes.is/a/jGG0UGc6EfGJ8jvBF4ZQVQ

Published: June 13, 2026 15:14

We suspect that perfect jailbreak resistance is not currently possible for any model provider.大多数人认为AI公司应该追求完美的安全防护，但作者坦承完美防护是不可能的。这挑战了AI安全领域的期望，即公司应该能够完全防止其模型被滥用，转而采用更现实的防御策略。

Statement on the US government directive to suspend access to Fable 5 and Mythos 5

https://hypothes.is/a/i3ErcGc6EfGz0Ze6Cmi-lA

Published: June 13, 2026 15:14

If this standard was applied across the industry, we believe it would essentially halt all new model deployments for all frontier model providers.大多数人认为政府应该严格监管AI模型以确保安全，但作者认为这种监管标准会阻碍整个行业的发展。这挑战了监管与安全平衡的常规认知，暗示过度监管可能扼杀创新。

Statement on the US government directive to suspend access to Fable 5 and Mythos 5

https://hypothes.is/a/in6GaGc6EfGVfzOphj8Zuw

Published: June 13, 2026 15:14

We have found that other publicly-available models are able to discover them as well without requiring a bypass.大多数人认为发现AI模型的漏洞是严重的安全问题，需要立即采取措施，但作者认为这些漏洞在其他公开模型中也存在，暗示政府的反应过度。这挑战了AI安全领域的共识，即任何漏洞都应被视为重大威胁。

Comment renoncer à être un parent parfait (2/2) | Vivons heureux - ARTE Radio Podcast

https://hypothes.is/a/KhDviGc0EfGNqYP1tgIbcA

Published: June 13, 2026 14:28

**Briefing : Renoncer à l'Idéal du Parent Parfait** ## Résumé Exécutif Ce document analyse les paradoxes et les pressions inhérents à l'éducation positive, tels qu'explorés dans le podcast d'ARTE Radio. Initialement perçue comme une méthode miracle…

Parents, aidants, handicap : comment intégrer ces réalités sans créer d’injustice perçue ?

https://hypothes.is/a/eJ2z0GczEfGsELsmh1iwrQ

Published: June 13, 2026 14:23

**Inclusion, Aidance et Moments de Vie : Concilier Personnalisation et Équité en Entreprise** Ce document de synthèse analyse les interventions et les retours d'expérience de la table ronde organisée par HR Technologies France, portant sur l'intégration…

The biological relevance of PCSK9: when less is better…

https://hypothes.is/a/F3G40GcvEfGjp3soOGg2gw

Published: June 13, 2026 13:52

Non è malissimo, dice fondamentalmente che PCSK9 quando causa problemi è dovuta a una produzione cronica. Utile per confermare ulteriormente che non ci sono effetti avversi alla sua soppressione. Guarda le conclusioni

3.1D: Magnification and Resolution

https://hypothes.is/a/sq17PGcuEfG9At-Mqj_15w

Published: June 13, 2026 13:49

microbiologists depend more on resolution, as they want to be able to determine differences between microbes or parts of microbes.That explains it

3.1D: Magnification and Resolution

https://hypothes.is/a/iGuaPmcuEfGHXTPsMHWC8A

Published: June 13, 2026 13:48

While high magnification without high resolution may make very small microbes visible, it will not allow the observer to distinguishbetween microbes or sub-cellular parts of a microbe.Wtf does this mean

Elon Musk's Grok AI Was Asked About Jesus'Resurrection in the Ethiopian Bible—Its Answer Is Haunti

https://hypothes.is/a/rVEThGcoEfGBrffiqbv37g

Published: June 13, 2026 13:06

// explorimence - save youtube videos - 💻/asus/🧊/me/📓/2026/6/1/3/ [grok-ai-ethiopean-bible-resurrection~youtube.com](https://bafybeihirskvhdvilgzaiwdryacgpo3ulvt5pcqnm6442667fq7of5fhia.ipfs.inbrowser.link/grok-ai-ethiopean-bible-resurrection/) …

Elon Musk's Grok AI Was Asked About Jesus'Resurrection in the Ethiopian Bible—Its Answer Is Haunti

https://hypothes.is/a/SV6FQGckEfGBcn9b2r8pbA

Published: June 13, 2026 12:34

💻/asus/🧊/me/📓/2026/6/1/3/youtube.com [grok-ai-ethiopean-bible-resurrection/](https://bafybeihirskvhdvilgzaiwdryacgpo3ulvt5pcqnm6442667fq7of5fhia.ipfs.inbrowser.link/grok-ai-ethiopean-bible-resurrection/)

Elon Musk's Grok AI Was Asked About Jesus'Resurrection in the Ethiopian Bible—Its Answer Is Haunti

https://hypothes.is/a/EMjZhGcjEfGymNuSDoSpRQ

Published: June 13, 2026 12:26

Elon Musk's Grok AI Was Asked About Jesus'Resurrection in the Ethiopian Bible—Its Answer Is Haunti ![](https://i.ytimg.com/vi/drov5tZ6srw/maxresdefault.jpg)

金融评级机构大模型安全应用体系研究 · 审阅版

https://hypothes.is/a/AOpw9mchEfGWvOd2_jEuDQ

Published: June 13, 2026 12:11

最终报告建议统一采用以下总口径： 本报告提出的是金融评级机构引入大模型能力的受控 POC 与分阶段试点方案。总体路径为：以数据分级为前置，以本地脱敏与 Data Access Proxy 为唯一受控出域通道，以 RAG 权限过滤和 SQL Guard…

金融评级机构大模型安全应用体系研究 · 审阅版

https://hypothes.is/a/1hIfRmcgEfGrvAcYZExcGw

Published: June 13, 2026 12:10

6. 每章应吸收哪些文件内容应该首先说明，遇到的问题，纯本地模型的优势劣势，纯云端模型的，内容应该是相对针对本地模型与云端模型结合的话题，建议从以下逻辑展开： 1. 问题背景： - 当前遇到的核心问题是什么？ - 本地模型与纯云端模型的优缺点分析。 - 为何需要两者结合使用？ - 结合使用时的优势与劣势。 2. 痛点解决与合规分析： - 如何解决结合使用带来的劣势？ - 劣势的分类探讨： - 法律层面的挑战。 -…

金融评级机构大模型安全应用体系研究 · 审阅版

https://hypothes.is/a/VBtkmGcgEfGBpMsYoukIYQ

Published: June 13, 2026 12:06

执行摘要：为什么是受控 POC，而非立即生产上线这种不用你说啊= = 谁都知道，直接阐述内容就可以

金融评级机构大模型安全应用体系研究 · 审阅版

https://hypothes.is/a/50hlZGcfEfGVaKNAaPS31w

Published: June 13, 2026 12:03

供 SID 阅读确认应该完全删去类似的描述，目的就是要呈现结果，可以给任何人看的

The iPhone’s Last Stand

https://hypothes.is/a/38n3TmcaEfGrszMNwZj_rA

Published: June 13, 2026 11:27

There are actually a lot of interesting technical details about how Apple rebuilt Siri, including expanding Private Cloud Compute to include Nvidia chips running in Google data centers, as well as a 20 billion parameter on-device mixture-of-experts model…

Will AI Wealth Actually Flood AIS/EA Philanthropy Soon?

https://hypothes.is/a/a2IHcGcaEfGS42892zR3ig

Published: June 13, 2026 11:24

Modeled disbursement by end-2026some visulaizations (bar or donut or mosaic graph) would be helpful here

Will AI Wealth Actually Flood AIS/EA Philanthropy Soon?

https://hypothes.is/a/L-XonGcaEfGEePMXUH3UJg

Published: June 13, 2026 11:22

Interactive uncertainty modelI don't htink this is a stochastic model? Perhaps an extension of this should give these (correlated?) distributions. ... Squiggle-type modeling There should also be discplay of the actual equation behind the model, and a…

Terms of Use - Lemon.io

https://hypothes.is/a/vEs8amcGEfGcHL9sJE_Cog

Published: June 13, 2026 09:03

TERMS OF USEFrom a freelancer's (Developer's) perspective, here's how these terms shake out. A few provisions tilt meaningfully against you, and several are worth understanding before you sign up. Payment risk is the biggest concern You only get paid if…

Sex-specific organization and synaptic signaling in prefrontal-hypothalamic circuitry

https://hypothes.is/a/ESmTpmcEEfGgL_Mv1UxLFA

Published: June 13, 2026 08:44

107738DOI: 10.64898/2026.04.29.721673 Resource: RRID:Addgene_107738 Curator: @olekpark SciCrunch record: RRID:Addgene_107738 What is this?

Therapeutic targeting of fibrin–microglia interactions ameliorates Alzheimer’s disease-related hyperexcitability and brain network dysfunction

https://hypothes.is/a/EU6MiGcEEfGhjtNhnGu59g

Published: June 13, 2026 08:44

MMRRC Strain 034848-JAX130DOI: 10.64898/2026.05.01.722324 Resource: (MMRRC Cat# 034848-JAX,RRID:MMRRC_034848-JAX) Curator: @AleksanderDrozdz SciCrunch record: RRID:MMRRC_034848-JAX What is this?

Sex-specific organization and synaptic signaling in prefrontal-hypothalamic circuitry

https://hypothes.is/a/EQIKhGcEEfGLmE8bQNh86g

Published: June 13, 2026 08:44

AAV Nuc-flox(mCherry)-eGFP virusDOI: 10.64898/2026.04.29.721673 Resource: RRID:Addgene_112677 Curator: @olekpark SciCrunch record: RRID:Addgene_112677 What is this?

Defining a Midgestational Window for In Utero Genome Editing of the Fetal Murine Cortex

https://hypothes.is/a/ENU1ImcEEfGsEuMe0Jya8A

Published: June 13, 2026 08:44

103005DOI: 10.64898/2026.04.28.721509 Resource: RRID:Addgene_103005 Curator: @olekpark SciCrunch record: RRID:Addgene_103005 What is this?

Defining a Midgestational Window for In Utero Genome Editing of the Fetal Murine Cortex

https://hypothes.is/a/EKdhJGcEEfG7aKe3YGob6Q

Published: June 13, 2026 08:44

83279DOI: 10.64898/2026.04.28.721509 Resource: RRID:Addgene_83279 Curator: @olekpark SciCrunch record: RRID:Addgene_83279 What is this?

A High-Throughput Method for Quantifying Drosophila Fecundity

https://hypothes.is/a/EBxdXmcEEfGq5-snw08nkA

Published: June 13, 2026 08:44

BDSC Stock # 3605DOI: 10.3390/toxics12090658 Resource: RRID:BDSC_3605 Curator: @bdscstockkeepers SciCrunch record: RRID:BDSC_3605 What is this?

CRISPR inhibition of activity-dependent Arc expression in the adult mouse brain has limited effects on plasticity in visual cortex and nucleus accumbens

https://hypothes.is/a/EGPK_mcEEfGFQYeS842Y4Q

Published: June 13, 2026 08:44

187441DOI: 10.64898/2026.04.26.720914 Resource: RRID:Addgene_187441 Curator: @olekpark SciCrunch record: RRID:Addgene_187441 What is this?

Alzheimer’s Disease and circadian disruption sex-specifically contribute to a loss of bone maintenance in APP/PS1 model mice

https://hypothes.is/a/EIjR8GcEEfGLl39r9Ynp5g

Published: June 13, 2026 08:44

APPswe/PS1, JAX MMRRC Stock #034829DOI: 10.64898/2026.05.01.722089 Resource: (MMRRC Cat# 034829-JAX,RRID:MMRRC_034829-JAX) Curator: @AleksanderDrozdz SciCrunch record: RRID:MMRRC_034829-JAX What is this?

Top2a-dependent neuronal regulation of social behavior and persistent rescue of social deficit through PRC2-mediated epigenetic reprogramming

https://hypothes.is/a/EEFOmGcEEfGZpYsKJ5DWWw

Published: June 13, 2026 08:44

MMRRC; stock no. 064016-UCDDOI: 10.64898/2026.02.24.707855 Resource: RRID:MMRRC_064016-UCD Curator: @AleksanderDrozdz SciCrunch record: RRID:MMRRC_064016-UCD What is this?

Effects of Wheat Malt Extract on Molecular and Behavioral Markers in Aged APP/PS1 and Wild-Type Mice

https://hypothes.is/a/D_ZfAGcEEfGLlpdMSgfKww

Published: June 13, 2026 08:44

MMRRC Strain #034829-JAXDOI: 10.3390/ijms27114994 Resource: (MMRRC Cat# 034829-JAX,RRID:MMRRC_034829-JAX) Curator: @AleksanderDrozdz SciCrunch record: RRID:MMRRC_034829-JAX What is this?

Angiotensin II type 1 and type 2 receptors modulate TWIK1 channel expression and pain sensitivity in a rat model of neuropathic pain

https://hypothes.is/a/D65IjGcEEfGNqKtf1XXB_A

Published: June 13, 2026 08:44

RRID:AB_11018151DOI: 10.3389/fphar.2026.1833813 Resource: (Novus Cat# NBP1-77368, RRID:AB_11018151) Curator: @evieth SciCrunch record: RRID:AB_11018151 What is this?

Sex Hormone-Binding Globulin Prevents Carbon Tetrachloride-Induced Liver Fibrosis Development

https://hypothes.is/a/D9EvPGcEEfG2Lfeaf6w2Zw

Published: June 13, 2026 08:44

RRID:CVCL_0027DOI: 10.3390/ijms27114893 Resource: (TKG Cat# TKG 0205, RRID:CVCL_0027) Curator: @evieth SciCrunch record: RRID:CVCL_0027 What is this?

Proteasomal inhibition compromises microvascular integrity via distinct effects on non-immune endothelial cells and immune cells

https://hypothes.is/a/D40jCmcEEfG8hwtTx_MOuw

Published: June 13, 2026 08:44

RRID: AB_561381DOI: 10.3389/fimmu.2026.1759368 Resource: (Cell Signaling Technology Cat# 9496, RRID:AB_561381) Curator: @evieth SciCrunch record: RRID:AB_561381 What is this?

UBC/UBA52 silencing restores PINK1-Parkin-mediated mitochondrial autophagy in allergic rhinitis

https://hypothes.is/a/D2rAEmcEEfG-XhedIwlgDg

Published: June 13, 2026 08:44

AB_2107448DOI: 10.1371/journal.pone.0350815 Resource: (Abcam Cat# ab8245, RRID:AB_2107448) Curator: @evieth SciCrunch record: RRID:AB_2107448 What is this?

Endosomal maturation is controlled by the trimeric Bulli–Mon1–Ccz1 Rab7 GEF complex and the Rab5 GTPase-activating protein GAPsec

https://hypothes.is/a/DyBcmGcEEfG3svcnQWoWBg

Published: June 13, 2026 08:44

RRID:BDSC_62545DOI: 10.1242/jcs.264460 Resource: RRID:BDSC_62545 Curator: @evieth SciCrunch record: RRID:BDSC_62545 What is this?

UBC/UBA52 silencing restores PINK1-Parkin-mediated mitochondrial autophagy in allergic rhinitis

https://hypothes.is/a/D0lG2mcEEfGU9A-5BSGXJg

Published: June 13, 2026 08:44

AB_2927726DOI: 10.1371/journal.pone.0350815 Resource: (Abcam Cat# ab216144, RRID:AB_2927726) Curator: @evieth SciCrunch record: RRID:AB_2927726 What is this?

Endosomal maturation is controlled by the trimeric Bulli–Mon1–Ccz1 Rab7 GEF complex and the Rab5 GTPase-activating protein GAPsec

https://hypothes.is/a/Dv2nSGcEEfGJTeOu4G4WBQ

Published: June 13, 2026 08:44

RRID:BDSC_9778DOI: 10.1242/jcs.264460 Resource: RRID:BDSC_9778 Curator: @evieth SciCrunch record: RRID:BDSC_9778 What is this?

Endosomal maturation is controlled by the trimeric Bulli–Mon1–Ccz1 Rab7 GEF complex and the Rab5 GTPase-activating protein GAPsec

https://hypothes.is/a/DtzEamcEEfG3LHue1qgztg

Published: June 13, 2026 08:44

RRID:BDSC_95282DOI: 10.1242/jcs.264460 Resource: RRID:BDSC_95282 Curator: @evieth SciCrunch record: RRID:BDSC_95282 What is this?

Endosomal maturation is controlled by the trimeric Bulli–Mon1–Ccz1 Rab7 GEF complex and the Rab5 GTPase-activating protein GAPsec

https://hypothes.is/a/DpHc3mcEEfG3sWsI2NhAtA

Published: June 13, 2026 08:44

RRID:BDSC_24616DOI: 10.1242/jcs.264460 Resource: RRID:BDSC_24616 Curator: @evieth SciCrunch record: RRID:BDSC_24616 What is this?

Endosomal maturation is controlled by the trimeric Bulli–Mon1–Ccz1 Rab7 GEF complex and the Rab5 GTPase-activating protein GAPsec

https://hypothes.is/a/DrZNgGcEEfGsEffZ0educw

Published: June 13, 2026 08:44

RRID:BDSC_9771DOI: 10.1242/jcs.264460 Resource: RRID:BDSC_9771 Curator: @evieth SciCrunch record: RRID:BDSC_9771 What is this?

Video: Le grand défi de la parentalité au XXIè siècle par Isabelle Roskam (DocDrop)

https://hypothes.is/a/_Zmkfmb1EfG45qcJpXk4MQ

Published: June 13, 2026 07:03

Le Grand Défi de la Parentalité au XXIè Siècle : Analyse et Prévention du Burn-out Parental Résumé Analytique La parentalité contemporaine fait face à un défi inédit : la montée du burn-out parental. Si élever un enfant a toujours été associé au bonheur…

Annotating the law | Hypothes.is

https://hypothes.is/a/ING4OGbwEfGp_O-VAqa_Sw

Published: June 13, 2026 06:21

Unlike commenting systems, the annotations are anchored to specific fragments of text. Hypothesis is also a great tool for Journal Clubs to annotate in public or using private groups. Here are some examples:Some example of annotations

Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study

https://hypothes.is/a/Wr3-ImbvEfGrNCPNPGaEJQ

Published: June 13, 2026 06:16

P002F002M40.81CHAI CTLA4 2:203871449c.531_544delp.Phe179Cysfs*29ENST00000648405.2HetPathogenicSubject no. 87 or MM.II.1 (24, 25)**Case#:** **DiseaseAssertion:** **FamilyInfo:** **CasePresentingHPOs:** **CaseHPOFreeText:** **CaseNotHPOs:** …

Primary Immunodeficiencies in India: Molecular Diagnosis and the Role of Next-Generation Sequencing

https://hypothes.is/a/Wt3k0GbvEfGTz-d8gujtpA

Published: June 13, 2026 06:16

Primary Immunodeficiencies in India: Molecular Diagnosis and the Role of Next-Generation Sequencing**Case#:** 13, M, Age of Onset: 2 y.o., Ethnicity: Indian. **CasePresentingHPOs:** HP:0001954 (Recurrent fever), HP:0001876 (Pancytopenia) …

Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study

https://hypothes.is/a/Wl5DdGbvEfGadwvFotV9_A

Published: June 13, 2026 06:16

P017F017M25.0CHAI CTLA4 2:203870883c.407C>Tp.Pro136LeuENST00000648405.2HetPathogenicSubject no. 17 (24, 25)**Case#:** **DiseaseAssertion:** **FamilyInfo:** **CasePresentingHPOs:** **CaseHPOFreeText:** **CaseNotHPOs:** **CaseNotHPOFreeText:** …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/Wj3Z4GbvEfG0q49IeL_HcQ

Published: June 13, 2026 06:16

P01FGerman4556c.109+1 G>TReduced0.88Pathogenic22.5Pathogenic[4]10.42Mildly affectedAlive**Case#:** P01, Female, clinical diagnosis at the age of 45, genetic diagnosis at the age of 56, German, alive at the time of article's publication …

Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study

https://hypothes.is/a/WnwvfmbvEfGNf1OhDvStdw

Published: June 13, 2026 06:16

P015F014F42.87CHAI CTLA4 2:203868052c.109+1G>TNAENST00000648405.2HetPathogenicFamily C (18, 24, 25)**Case#:** **DiseaseAssertion:** **FamilyInfo:** **CasePresentingHPOs:** **CaseHPOFreeText:** **CaseNotHPOs:** **CaseNotHPOFreeText:** …

Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study

https://hypothes.is/a/WqIM5GbvEfGfUbPtignyXQ

Published: June 13, 2026 06:16

P014F014F56.0CHAI CTLA4 2:203868052c.109+1G>TNAENST00000648405.2HetPathogenicFamily C (18, 24, 25)**Case#:** **DiseaseAssertion:** **FamilyInfo:** **CasePresentingHPOs:** **CaseHPOFreeText:** **CaseNotHPOs:** **CaseNotHPOFreeText:** …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/Wg-7HmbvEfGuewvrZNKOiw

Published: June 13, 2026 06:16

P23FGerman4646.2*S171RReduced6.35Pathogenic45.1Pathogenicuk15.56Severely affectedAlive**Case#:** P23, Female, German, 46 years old at the time of clinical diagnosis, 46.2 years old at the time of genetic diagnosis, alive at the time of publication …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WfNVFGbvEfG9GtsLJnWIKA

Published: June 13, 2026 06:16

P24Fuk20uk*S172LNormal16.4Non-pathogenic––uk6.67UnaffectedAlive**Case#:** P24, Female, 20 years old at the time of genetic diagnosis, alive at the time of publication **DiseaseAssertion:** Unaffected based on a CHAI score of 6.67% **FamilyInfo:** N/A…

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WZMpZGbvEfG-wVMn8swgJg

Published: June 13, 2026 06:16

P26MGerman9ukT207ANormal––65.5Non-pathogenic[9]10.42Mildly affectedAlive**Case#:** P26, male, German, 9 years old at the time of clinical diagnosis, alive at the time of publication **DiseaseAssertion:** Mildly affected based on a CHAI score of 10.42% …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WdZjFGbvEfGWLjMjK1GmzQ

Published: June 13, 2026 06:16

P25MGerman1640.8F179Cfs*29Reduced5.44Pathogenic39.4Pathogenic[9]43.75Severely affectedAlive**Case#:** P25, male, German, 16 years old at the time of clinical diagnosis, 40.8 years old at the time of genetic diagnosis, alive at the time of publication …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WPiDoGbvEfG7QY8K0naSFg

Published: June 13, 2026 06:16

P06FGerman52uk*T72PReduced2.39Pathogenic––uk47.37Severely affectedAlive**Case#:** P06. Female, German, 52 years old at the time of clinical diagnosis, Alive at the time of publication **DiseaseAssertion:** classified as "Severely affected" based on a…

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WTtzQGbvEfGjn9PK3CzWEA

Published: June 13, 2026 06:16

P04Mukuk71.4A54TReduced2.04Pathogenic49.8Pathogenic[9]NANADead**Case#:** P04, male, genetic diagnosis at the age of 71.4, ethnicity: N/A, Dead at the time of article's publication **DiseaseAssertion:** N/A **FamilyInfo:** N/A **CasePresentingHPOs:**…

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WVcf3GbvEfG2EsuMjUqJ-g

Published: June 13, 2026 06:16

P03Mukukuk*G52DReduced––17.2PathogenicukNANAAlive**Case#:** P03, Male, Age: N/A, ethnicity: N/A, Alive at the time of article's publication **DiseaseAssertion:** N/A **FamilyInfo:** N/A **CasePresentingHPOs:** N/A **CaseHPOFreeText:** N/A …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WRXeWmbvEfGfmOtT6BUWKA

Published: June 13, 2026 06:16

P05MukukukR70WReduced––30.6Pathogenic[4]NANAAlive**Case#:** P05, Male, age: n/a, ethnicity:n/a, alive at the time of publication **DiseaseAssertion:** N/A **FamilyInfo:** N/A **CasePresentingHPOs:** N/A **CaseHPOFreeText:** N/A **CaseNotHPOs:**N/A …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WXI9RGbvEfGqv9PTrfRvOA

Published: June 13, 2026 06:16

P02FFinnishukuk*c.109+2 T>AReduced––45.9PathogenicukNANAAlive**Case#:** P02, Female, the age of clinical and genetic diagnosis: Unknown, Finnish, alive at the time of article's publication **DiseaseAssertion:** N/A **FamilyInfo:** N/A …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WNQr4GbvEfGxhJ-CCyJJQQ

Published: June 13, 2026 06:15

P07MGerman1824.2R75QReduced7.29Pathogenic––[5]17.65Mildly affectedAlive**Case#:** P07, Male, German, 18 years old at the time of clinical diagnosis and 24.2 years old at the time of genetic diagnosis, alive at the time of publication **DiseaseAssertion:**…

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WI13DmbvEfGX_XtEIssIZw

Published: June 13, 2026 06:15

P09Mukukuk*Y89HNormal––58.5Non-pathogenicukNANAAlive**Case#:** P09, Male, age: n/a, ethnicity: n/a, alive at the time of publication **DiseaseAssertion:** n/a **FamilyInfo:** N/A **CasePresentingHPOs:** N/A **CaseHPOFreeText:** N/A …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WGgL4GbvEfGFGOvzEzc5YQ

Published: June 13, 2026 06:15

P10FGerman2425G109EReduced7.58Pathogenic––[5]33.33Severely affectedAlive**Case#:** P10, Female, German, 24 years old at the time of clinical diagnosis, 25 years old at the time of genetic diagnosis, alive at the time of publication **DiseaseAssertion:** …

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry

https://hypothes.is/a/WKx71mbvEfGYuv-aQBGcLA

Published: June 13, 2026 06:15

P08FCanadianukukA86VReduced9.18Pathogenic60.8Non-pathogenic[5]NANAAlive**Case#:** P08, Female, Canadian, age: n/a, alive at the time of publication **DiseaseAssertion:** N/A **FamilyInfo:** N/A **CasePresentingHPOs:** N/A **CaseHPOFreeText:** N/A …

精心手工制作：阿尔弗雷德的核心价值观 - 阿尔弗雷德博客

https://hypothes.is/a/UmsyvmboEfGhVVN2vtc2_w

Published: June 13, 2026 05:25

our objective has been to keep Alfred lightweight, as fast as possible, and practically invisible when not in use.Alfred's value.

Is Google Making Us Stupid?

https://hypothes.is/a/DqLSpGbdEfGrDQMja1Jr8g

Published: June 13, 2026 04:05

Now my concentration often starts to drift after two or three pagesI feel bad for Gen Alpha and kids going through grade school with no need to actually think, so much so that many of them can't even read.

Ghosts - Believer Magazine

https://hypothes.is/a/bhGR8mbZEfGNcdOXXBPraA

Published: June 13, 2026 03:39

Once upon a time, she taught me to exist.To go through all the emotion and feeling like she did so much for you , this comment was very powerful.

"Why Is the American Diet So Deadly?": 2026/SP ENGL-C1001-6486

https://hypothes.is/a/rqwhVmbYEfGnrO9-4Ey_Cg

Published: June 13, 2026 03:33

in the second week that participants ate an ultra-processed diet, for example, their excess calorie consumption started to fall.I think the effects of eating UPFs excessively makes you not want to eat them as much because they give you irritable systems…

SageMaker Studio Lab

https://hypothes.is/a/1VzvnmbMEfGIjAcsSroSLw

Published: June 13, 2026 02:08

While this is subject to change, we are currently using G4dn.xlarge instances for GPU and T3.xlarge for CPU.The GPU use in SSL.

Nervous Conditions - Tsitsi Dangarembga

https://hypothes.is/a/cXsu2mbJEfGjVBOQO7tP8g

Published: June 13, 2026 01:44

me a bad joke.it seems as if her brother began thinking he was to good for the family , or at least to educated to be around his family at this point.

The Gloria Anzaldua Reader (Latin America Otherwise) -- Gloria E_ Anzaldúa; AnaLouise Keating, editor -- Latin america otherwise, Durham, North -- isbn13 9780822345558 -- 174cbeb4050c197ee1c8612d5a94fdf6 -- Anna’s Archive

https://hypothes.is/a/kASihGbHEfGh-vNEnaDtow

Published: June 13, 2026 01:31

My dear hermanas, the dangers we face as women writers of color are not the same as those ofwhite womenI completely agree as there are more problems that other women face not just because they are women, but because they are not white..

The Gloria Anzaldua Reader (Latin America Otherwise) -- Gloria E_ Anzaldúa; AnaLouise Keating, editor -- Latin america otherwise, Durham, North -- isbn13 9780822345558 -- 174cbeb4050c197ee1c8612d5a94fdf6 -- Anna’s Archive

https://hypothes.is/a/YxZFmGbHEfGtufPBT9VYqQ

Published: June 13, 2026 01:29

We cannot educate white women and take them by the hand. Most ofus are willing to help, but we can't do the white woman's homework for her.I feel as though this sentence is empowering in a way that they do not understand their advantage, especially in…

The Gloria Anzaldua Reader (Latin America Otherwise) -- Gloria E_ Anzaldúa; AnaLouise Keating, editor -- Latin america otherwise, Durham, North -- isbn13 9780822345558 -- 174cbeb4050c197ee1c8612d5a94fdf6 -- Anna’s Archive

https://hypothes.is/a/kzdySGbGEfGuvF8q5mTWJA

Published: June 13, 2026 01:24

he act ofwriting is the act ofmaking souBeautiful way of putting it.

The Gloria Anzaldua Reader (Latin America Otherwise) -- Gloria E_ Anzaldúa; AnaLouise Keating, editor -- Latin america otherwise, Durham, North -- isbn13 9780822345558 -- 174cbeb4050c197ee1c8612d5a94fdf6 -- Anna’s Archive

https://hypothes.is/a/gyAJxGbGEfGXtpuCo8l_SQ

Published: June 13, 2026 01:23

Finally, I write because I'm scared ofwriting but I'm more scared ofnot writing.I get what they mean, since its like I kind of don't know what exactly to write about or how to articulate what I wanna express in my writing, but also scared that if I don't…

The Gloria Anzaldua Reader (Latin America Otherwise) -- Gloria E_ Anzaldúa; AnaLouise Keating, editor -- Latin america otherwise, Durham, North -- isbn13 9780822345558 -- 174cbeb4050c197ee1c8612d5a94fdf6 -- Anna’s Archive

https://hypothes.is/a/PEAHUmbGEfGoWnccHpK62w

Published: June 13, 2026 01:21

No one's going to do my shitwork, I pick up after myself.Period, this part made me feel like this is giving taking a bit of accountability and is very mature of them.

The Gloria Anzaldua Reader (Latin America Otherwise) -- Gloria E_ Anzaldúa; AnaLouise Keating, editor -- Latin america otherwise, Durham, North -- isbn13 9780822345558 -- 174cbeb4050c197ee1c8612d5a94fdf6 -- Anna’s Archive

https://hypothes.is/a/m8H6YGbFEfG2tP_Kz3a-JA

Published: June 13, 2026 01:17

Find the muse within you. The voice that lies buried under you, dig it up.be dangerous and just fuck, hell, let it out and let everybody hear whether Do not fake it,This highlighted both sides but I really like both of these quotes. For me the being loud…

Supporting Co-Adaptive Machine Teaching through Human Concept Learning and Cognitive Theories

https://hypothes.is/a/cCLE8mbFEfGNWmuQpkF6Eg

Published: June 13, 2026 01:16

Users teach models theirconcept definition through data labeling, while refining their ownunderstandings throughout the process

Virginia Bar Exam | The Ultimate VA Exam Guide 2026-27

https://hypothes.is/a/NAE5EGa-EfGZ23_MzkewpQ

Published: June 13, 2026 00:24

purpose – the desireAssault requires (both): Defendant intends to cause the plaintiff to anticipate imminent, harmful contact to their person AND (2) Defendant's conduct caused them to anticipate such contact. (Defendant's ACTIONS caused them to think…

3.4: Language, Society, and Culture

https://hypothes.is/a/_TU4fma8EfGZjb_d6T92ig

Published: June 13, 2026 00:15

Additionally, people who work or live in multilingual settings may code-switch many times throughout the day, or even within a single conversation.I watched code-switching a lot growing up in a bilingual household. Specifically, from my mother who not only…

urn:x-pdf:392e7604f6b8a53daed420a9ee011dcd

https://hypothes.is/a/YI1G9ma8EfGusD9JBhc2BA

Published: June 13, 2026 00:11

goal is to construct a computational model of the neuralcircuits involved in VWM function that can simulate abroad range of existing data and provides a frameworkfor understanding the functional mechanisms involved invisual memory storage.goal of binding…

urn:x-pdf:392e7604f6b8a53daed420a9ee011dcd

https://hypothes.is/a/RDiNHGa8EfGnfkeQzBkrOQ

Published: June 13, 2026 00:10

(VWM), which specifically addresses the abilityto store and retrieve visual pattern information and isdistinct from a broader class of working memory capabil-ities (e.g., Baddeley & Hitch, 1974; Oberauer, 2009).more on VWM

A 40 años de Malvinas, cómo fue la verdadera economía de guerra que enfrentó la Argentina: causas y consecuencias

https://hypothes.is/a/yVE8mGa7EfGtoocUtRNLZw

Published: June 13, 2026 00:06

Sin embargo, puertas adentro del país, Alemann tuvo que soportar la reacción antisemita de algunos integrantes de la Junta Militar, indignados por los fuertes vínculos del estudio Weil, Gothsam & Manges con la comunidad judía de Nueva York.!

A 40 años de Malvinas, cómo fue la verdadera economía de guerra que enfrentó la Argentina: causas y consecuencias

https://hypothes.is/a/uUbpBma7EfGQqFvUjhNcww

Published: June 13, 2026 00:06

Esta solución se le ocurrió al abogado Richard Davis, socio del estudio neoyorquino Weil, Gothsam & Manges, ex subsecretario de Finanzas del Tesoro durante la administración de James Carter y experto en sanciones económicas internacionales, contratado por…

3.4: Language, Society, and Culture

https://hypothes.is/a/lhb72ma5EfGC-isBvLLAyw

Published: June 12, 2026 23:51

Conversations often begin with a standard greeting and then proceed to “safe” exchanges about things in the immediate field of experience of the communicators (a comment on the weather or noting something going on in the scene). At this point, once the ice…

https://arstechnica.com/tech-policy/2026/06/130-billion-in-data-center-projects-blocked-by-protests-so-far-this-year/

https://hypothes.is/a/sZreWGa0EfGkhpv9GNsIAA

Published: June 12, 2026 23:16

53 million square feet of data centers have been constructed over the past 20 years劳登县在过去20年建造了5300万平方英尺的数据中心，平均每年约265万平方英尺。这一规模相当于约244个标准足球场的大小，表明该地区已成为重要的数据中心集群。然而，缺乏与全国其他地区的比较数据，无法确定这一规模是否异常突出。

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